| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Florian Amtage, Bogdan Neughebauer, J Michael McIntosh, Thomas Freiman, Josef Zentner, Thomas J Feuerstein, Rolf Jackisc. Characterization of nicotinic receptors inducing noradrenaline release and absence of nicotinic autoreceptors in human neocortex. Brain research bulletin. vol 62. issue 5. 2004-07-09. PMID:15168907. |
in both tissues a similar rank order of potency of nicotinic agonists was found: epibatidine >> dmpp > nicotine approximately cytisine > or = acetylcholine; choline was ineffective. |
2004-07-09 |
2023-08-12 |
human |
| Patrick J Mulholland, Barton R Harris, Lincoln H Wilkins, Rachel L Self, John A Blanchard, Robert C Holley, John M Littleton, Mark A Prendergas. Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression. Alcohol (Fayetteville, N.Y.). vol 31. issue 1-2. 2004-07-06. PMID:14615005. |
further, in these studies, we examined the ability of nicotine, through action at alpha(7)(*)-bearing nicotinic acetylcholine receptors (nachrs), to antagonize the effects of ethanol exposure on calbindin-d(28k) expression. |
2004-07-06 |
2023-08-12 |
rat |
| Peter P Rowell, Kelly A Vol. Nicotinic activation of mesolimbic neurons assessed by rubidium efflux in rat accumbens and ventral tegmentum. Neuro-Signals. vol 13. issue 3. 2004-07-06. PMID:15067198. |
the application of nicotine to either the vta or nac produces an increase in dopamine release; however, the positive reinforcement produced by the systemic injection of nicotine is primarily due to stimulation of nicotinic acetylcholine receptors (nachrs) in the vta. |
2004-07-06 |
2023-08-12 |
rat |
| Douglas P Dohrman And, Cindy K Reite. Chronic ethanol reduces nicotine-induced dopamine release in PC12 cells. Alcoholism, clinical and experimental research. vol 27. issue 11. 2004-06-29. PMID:14634503. |
one important aspect of nicotine addiction appears to be the activation of nicotinic acetylcholine receptors on dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. |
2004-06-29 |
2023-08-12 |
Not clear |
| Thomas Grutter, Nicolas Le Novère, Jean-Pierre Changeu. Rational understanding of nicotinic receptors drug binding. Current topics in medicinal chemistry. vol 4. issue 6. 2004-06-18. PMID:14965300. |
recently, we constructed three-dimensional models of the n-terminal part of nachr and docked in the putative ligand-binding pocket, different agonists (acetylcholine, nicotine and epibatidine) and antagonist (snake alpha-bungarotoxin). |
2004-06-18 |
2023-08-12 |
Not clear |
| Jérôme Sallette, Sébastien Bohler, Pierre Benoit, Martine Soudant, Stéphanie Pons, Nicolas Le Novère, Jean-Pierre Changeux, Pierre Jean Corringe. An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14764595. |
an extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. |
2004-06-10 |
2023-08-12 |
Not clear |
| Jérôme Sallette, Sébastien Bohler, Pierre Benoit, Martine Soudant, Stéphanie Pons, Nicolas Le Novère, Jean-Pierre Changeux, Pierre Jean Corringe. An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14764595. |
in smoker's brain, rodent brain, and in cultured cells expressing nicotinic receptors, chronic nicotine treatment induces an increase in the total number of high affinity receptors for acetylcholine and nicotine, a process referred to as up-regulation. |
2004-06-10 |
2023-08-12 |
Not clear |
| Jérôme Sallette, Sébastien Bohler, Pierre Benoit, Martine Soudant, Stéphanie Pons, Nicolas Le Novère, Jean-Pierre Changeux, Pierre Jean Corringe. An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14764595. |
(ii) only residues belonging to two beta2 segments, 74-89 and 106-115, confer up-regulation to beta4, mainly by decreasing the amount of binding sites in the absence of nicotine; on an atomic three-dimensional model of the alpha3beta2 receptor these amino acids form a compact microdomain that mainly contributes to the subunit interface and also faces the acetylcholine binding site. |
2004-06-10 |
2023-08-12 |
Not clear |
| Anne-Marie Salmon, Alexis Evrard, Imad Damaj, Jean-Pierre Changeu. Reduction of withdrawal signs after chronic nicotine exposure of alpha-calcitonin gene-related peptide knock-out mice. Neuroscience letters. vol 360. issue 1-2. 2004-06-04. PMID:15082182. |
nicotine, the main substance responsible for the addictive behavior of smokers, binds to a variety of nicotinic acetylcholine receptors (nachrs) diversely distributed in the brain, notably in areas involved in motivation and reward mechanisms. |
2004-06-04 |
2023-08-12 |
mouse |
| L A C Reno, W Zago, R P Marku. Release of [(3)H]-L-glutamate by stimulation of nicotinic acetylcholine receptors in rat cerebellar slices. Neuroscience. vol 124. issue 3. 2004-06-03. PMID:14980735. |
this is a neurochemical study which shows that nicotine acting through alpha7-containing nicotinic acetylcholine receptors promotes the release of [(3)h]-glutamate from rat cerebellar slices. |
2004-06-03 |
2023-08-12 |
rat |
| Kewal K Jai. Modulators of nicotinic acetylcholine receptors as analgesics. Current opinion in investigational drugs (London, England : 2000). vol 5. issue 1. 2004-06-03. PMID:14983978. |
the analgesic properties of nicotine have prompted attempts to develop compounds that specifically target nicotinic acetylcholine receptors (nachrs) in the nervous system, with the beneficial effects of nicotine but without its side effects. |
2004-06-03 |
2023-08-12 |
Not clear |
| Rafael J Salín-Pascual, Natasha V Alcocer-Castillejos, Gabriel Alejo-Galarz. Nicotine dependence and psychiatric disorders. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. vol 55. issue 6. 2004-06-01. PMID:15011738. |
nicotine receptors in cns are located mainly in presynaptic membrane and in that way they regulated the release of several neurotransmitters, among them acetylcholine, dopamine, serotonin, and norepinephrine. |
2004-06-01 |
2023-08-12 |
rat |
| Russell W Brown, Kenyatta D Thompson, Kimberly N Thompson, J Jeffrey Ward, Stephanie K Thacker, Michael T Williams, Richard M Kostrzew. Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression. The European journal of neuroscience. vol 19. issue 6. 2004-05-28. PMID:15066159. |
adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression. |
2004-05-28 |
2023-08-12 |
rat |
| Patrick H N Celie, Sarah E van Rossum-Fikkert, Willem J van Dijk, Katjusa Brejc, August B Smit, Titia K Sixm. Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron. vol 41. issue 6. 2004-05-20. PMID:15046723. |
nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in achbp crystal structures. |
2004-05-20 |
2023-08-12 |
Not clear |
| Christianne E Strang, Franklin R Amthor, Kent T Keyse. Rabbit retinal ganglion cell responses to nicotine can be mediated by beta2-containing nicotinic acetylcholine receptors. Visual neuroscience. vol 20. issue 6. 2004-05-11. PMID:15088718. |
rabbit retinal ganglion cell responses to nicotine can be mediated by beta2-containing nicotinic acetylcholine receptors. |
2004-05-11 |
2023-08-12 |
rabbit |
| Merav Kedmi, Arthur L Beaudet, Avi Orr-Urtrege. Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures. Physiological genomics. vol 17. issue 2. 2004-05-10. PMID:14996991. |
nicotine acts through the nicotinic acetylcholine receptors (nachrs). |
2004-05-10 |
2023-08-12 |
mouse |
| M V Hejmadi, F Dajas-Bailador, S M Barns, B Jones, S Wonnacot. Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes. Molecular and cellular neurosciences. vol 24. issue 3. 2004-05-05. PMID:14664825. |
activation of neuronal nicotinic acetylcholine receptors (nachr) by nicotine has been suggested to protect neurons against a hypoxic insult. |
2004-05-05 |
2023-08-12 |
rat |
| R Douglas Shytle, Takashi Mori, Kirk Townsend, Martina Vendrame, Nan Sun, Jin Zeng, Jared Ehrhart, Archie A Silver, Paul R Sanberg, Jun Ta. Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. Journal of neurochemistry. vol 89. issue 2. 2004-05-04. PMID:15056277. |
acetylcholine and nicotine pre-treatment inhibit lipopolysaccharide (lps)-induced tnf-alpha release in murine-derived microglial cells, an effect attenuated by alpha 7 selective nicotinic antagonist, alpha-bungarotoxin. |
2004-05-04 |
2023-08-12 |
Not clear |
| Vasile Hefco, Kiyofumi Yamada, Andreea Hefco, Lucian Hritcu, Adrian Tiron, Ana Olariu, Toshitaka Nabeshim. Effects of nicotine on memory impairment induced by blockade of muscarinic, nicotinic and dopamine D2 receptors in rats. European journal of pharmacology. vol 474. issue 2-3. 2004-04-23. PMID:12921867. |
nicotine, by activating the nicotinic acetylcholine receptors, attenuated the impairment of short-term memory induced by muscarinic or dopamine d2 receptor blockade. |
2004-04-23 |
2023-08-12 |
rat |
| Isabel J Hildebrandt, Jennifer L Termeer, Delilah Toledo, Randy W Cohe. Characterization of chronic nicotine exposure on the survival of the spastic Han-Wistar rat. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 5. issue 6. 2004-04-22. PMID:14668067. |
cell culture studies have shown that neuroprotection can be induced by preincubation with the acetylcholine agonist nicotine. |
2004-04-22 |
2023-08-12 |
rat |