| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dominik Feuerbach, Kurt Lingenhöhl, Peter Dobbins, Johannes Mosbacher, Nicola Corbett, Joachim Nozulak, Daniel Hoye. Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells. Neuropharmacology. vol 48. issue 2. 2005-04-13. PMID:15695160. |
in this cellular system, agonists revealed the following rank order of potency: epibatidine>anatoxin a>aar17779>abt-594>dmpp>nicotine>gts-21>cytisine>abt-418>acetylcholine>choline>abt-089. |
2005-04-13 |
2023-08-12 |
human |
| Ruin Moaddel, Krzysztof Jozwiak, Rika Yamaguchi, Christopher Cobello, Kevin Whittington, Tarun K Sarkar, Sankar Basak, Irving W Waine. On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the alpha3beta4- and alpha4beta2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 813. issue 1-2. 2005-04-11. PMID:15556538. |
liquid chromatography columns containing stationary phases based upon immobilized nicotinic acetylcholine receptors (nachrs) were used to screen a series of conformationally constrained nicotine and anabasine derivatives for agonist activity. |
2005-04-11 |
2023-08-12 |
Not clear |
| Stephanie L Collins, Dean Wade, Jennifer Ledon, Sari Izenwasse. Neurochemical alterations produced by daily nicotine exposure in periadolescent vs. adult male rats. European journal of pharmacology. vol 502. issue 1-2. 2005-04-08. PMID:15464092. |
in adult rats pretreated with nicotine, there was an increase in nicotinic acetylcholine densities, but no change in dopamine transporter, dopamine d1 or d2 receptor, or serotonin transporter densities. |
2005-04-08 |
2023-08-12 |
rat |
| Michelle Chu, Jinjin Guo, Chang-Yan Che. Long-term exposure to nicotine, via ras pathway, induces cyclin D1 to stimulate G1 cell cycle transition. The Journal of biological chemistry. vol 280. issue 8. 2005-04-08. PMID:15574422. |
in this study, we have shown that, via nicotinic acetylcholine receptors, persistent exposure of mouse epithelial cells to nicotine elicits ras signaling and subsequent raf/map kinase activity, accompanied by a significant increase in cyclin d1 promoter activity and its protein expression. |
2005-04-08 |
2023-08-12 |
mouse |
| Igor Putrenko, Mahvash Zakikhani, Joseph A Den. A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans. The Journal of biological chemistry. vol 280. issue 8. 2005-04-08. PMID:15579462. |
two subunits, acc-1 and acc-2, form homomeric channels for which acetylcholine and arecoline, but not nicotine, are efficient agonists. |
2005-04-08 |
2023-08-12 |
caenorhabditis_elegans |
| Gary Cohen, Jean-Christophe Roux, Régis Grailhe, Girvan Malcolm, Jean-Pierre Changeux, Hugo Lagercrant. Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 10. 2005-04-07. PMID:15738419. |
we investigated the role played by beta2-containing neuronal nicotinic receptors [nicotinic acetylcholine receptors (nachrs)] in mediating nicotine's side effects in the fetus and newborn. |
2005-04-07 |
2023-08-12 |
mouse |
| Jesse Roman, Jeffrey D Ritzenthaler, Alcides Gil-Acosta, Hilda N Rivera, Susanne Roser-Pag. Nicotine and fibronectin expression in lung fibroblasts: implications for tobacco-related lung tissue remodeling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 12. 2005-04-05. PMID:15247149. |
the stimulatory effect of nicotine on fibronectin expression was abolished by alpha-bungarotoxin, an inhibitor of alpha7 nicotinic acetylcholine receptors (alpha7 achrs). |
2005-04-05 |
2023-08-12 |
Not clear |
| Juan Arredondo, Alexander I Chernyavsky, Lisa M Marubio, Arthur L Beaudet, David L Jolkovsky, Kent E Pinkerton, Sergei A Grand. Receptor-mediated tobacco toxicity: regulation of gene expression through alpha3beta2 nicotinic receptor in oral epithelial cells. The American journal of pathology. vol 166. issue 2. 2005-03-29. PMID:15681842. |
nicotine (nic) is a likely culprit of pathobiological effects because it displaces the local cytotransmitter acetylcholine from the nicotinic receptors (nachrs) expressed by oral keratinocytes (kcs). |
2005-03-29 |
2023-08-12 |
mouse |
| Anne Cormier, Yoav Paas, Roland Zini, Jean-Paul Tillement, Gilbert Lagrue, Jean-Pierre Changeux, Régis Grailh. Long-term exposure to nicotine modulates the level and activity of acetylcholine receptors in white blood cells of smokers and model mice. Molecular pharmacology. vol 66. issue 6. 2005-03-24. PMID:15383622. |
long-term exposure to nicotine modulates the level and activity of acetylcholine receptors in white blood cells of smokers and model mice. |
2005-03-24 |
2023-08-12 |
mouse |
| S Yamamoto, T Kanno, T Nagata, T Yaguchi, A Tanaka, T Nishizak. The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals. Neuroscience. vol 130. issue 1. 2005-03-22. PMID:15561436. |
fr236924 increased the rate of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor-mediated miniature excitatory postsynaptic currents, without affecting the amplitude, triggered by nicotine in ca1 pyramidal neurons of rat hippocampal slices, that is inhibited by gf109203x, a selective protein kinase c (pkc) inhibitor or alpha-bungarotoxin, an inhibitor of alpha7 acetylcholine (ach) receptors. |
2005-03-22 |
2023-08-12 |
rat |
| M I Damaj, P Flood, K K Ho, E L May, B R Marti. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. The Journal of pharmacology and experimental therapeutics. vol 312. issue 2. 2005-03-18. PMID:15356218. |
in oocytes expressing various neuronal acetylcholine nicotinic receptors (nachr), dextrometorphan and dextrorphan blocked nicotine activation of expressed alpha(3)beta(4), alpha(4)beta(2), and alpha(7) subtypes with a small degree of selectivity. |
2005-03-18 |
2023-08-12 |
mouse |
| Eugeny E Nikolsky, Frantisek Vyskocil, Ella A Bukharaeva, Dmitry Samigullin, Lev G Magazani. Cholinergic regulation of the evoked quantal release at frog neuromuscular junction. The Journal of physiology. vol 560. issue Pt 1. 2005-03-01. PMID:15254150. |
acetylcholine (ach, 5 x 10(-4) m), carbachol (cch, 1 x 10(-5) m) or nicotine (5 x 10(-6) m) increased the numbers of epcs with long release latencies mainly in the distal region of the endplate (90-120 microm from the last node of ranvier), where the synchronization of transmitter release was the most pronounced. |
2005-03-01 |
2023-08-12 |
Not clear |
| Katsuya Suemaru, Kayo Yasuda, Kenta Umeda, Hiroaki Araki, Kazuhiko Shibata, Tominari Choshi, Satoshi Hibino, Yutaka Gomit. Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors. British journal of pharmacology. vol 142. issue 5. 2005-02-28. PMID:15197106. |
nicotine has been reported to normalize deficits in auditory sensory gating in the cases of schizophrenia, suggesting an involvement of nicotinic acetylcholine receptors in attentional abnormalities. |
2005-02-28 |
2023-08-12 |
rat |
| Laura Maggi, Elisabetta Sola, Federico Minneci, Corentin Le Magueresse, Jean Pierre Changeux, Enrico Cherubin. Persistent decrease in synaptic efficacy induced by nicotine at Schaffer collateral-CA1 synapses in the immature rat hippocampus. The Journal of physiology. vol 559. issue Pt 3. 2005-02-11. PMID:15272042. |
in previous work on the immature hippocampus we have shown that, at low probability (p) synapses, activation of alpha7 nachrs by nicotine or by endogenously released acetylcholine persistently enhanced glutamate release and converted 'presynaptically silent' synapses into functional ones. |
2005-02-11 |
2023-08-12 |
rat |
| Benjamin Boutrel, George F Koo. What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep. vol 27. issue 6. 2005-02-08. PMID:15532213. |
nicotine enhances acetylcholine neurotransmission in the basal forebrain and dopamine release. |
2005-02-08 |
2023-08-12 |
Not clear |
| Hong Wang, Hong Liao, Mahendar Ochani, Marilou Justiniani, Xinchun Lin, Lihong Yang, Yousef Al-Abed, Haichao Wang, Christine Metz, Edmund J Miller, Kevin J Tracey, Luis Ullo. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nature medicine. vol 10. issue 11. 2005-02-04. PMID:15502843. |
nicotine, a selective cholinergic agonist, is more efficient than acetylcholine and inhibits hmgb1 release induced by either endotoxin or tumor necrosis factor-alpha (tnf-alpha). |
2005-02-04 |
2023-08-12 |
human |
| Theodore A Slotkin, Mandy M Cousins, Frederic J Seidle. Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. Brain research. vol 1030. issue 1. 2005-02-03. PMID:15567348. |
administration of nicotine to adolescent rats evokes regionally selective upregulation of cns alpha 7 nicotinic acetylcholine receptors. |
2005-02-03 |
2023-08-12 |
rat |
| Theodore A Slotkin, Frederic J Seidler, Dan Qiao, Justin E Aldridge, Charlotte A Tate, Mandy M Cousins, Becky J Proskocil, Harmanjatinder S Sekhon, Jennifer A Clark, Stacie L Lupo, Eliot R Spinde. Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 1. 2005-01-26. PMID:15316571. |
studies in developing rodents indicate that nicotine is a neuroteratogen that disrupts brain development by stimulating nicotinic acetylcholine receptors (nachrs) that control neural cell replication and differentiation. |
2005-01-26 |
2023-08-12 |
monkey |
| Ashley A Frazer-Abel, Shairaz Baksh, Susan P Fosmire, Derall Willis, Angela M Pierce, Heather Meylemans, Darwin S Linthicum, Steven J Burakoff, Teresa Coons, Donald Bellgrau, Jaime F Modian. Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15231866. |
we postulate that cross talk between nicotinic acetylcholine receptors and growth factor receptor-activated pathways offers a novel mechanism by which nicotine may directly impinge on cell cycle progression. |
2005-01-25 |
2023-08-12 |
mouse |
| J M Wehner, J J Keller, A B Keller, M R Picciotto, R Paylor, T K Booker, A Beaudet, S F Heinemann, S A Balog. Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience. vol 129. issue 1. 2005-01-13. PMID:15489024. |
the specific brain nicotinic acetylcholine receptors (nachrs) that mediate nicotine's effects on contextual learning and whether any of ethanol's actions are mediated by nachrs are unknown. |
2005-01-13 |
2023-08-12 |
mouse |