| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming D Li, Joke Beuten, Jennie Z Ma, Thomas J Payne, Xiang-Yang Lou, Veronica Garcia, Aristeo S Duenes, Karen M Crews, Robert C Elsto. Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence. Human molecular genetics. vol 14. issue 9. 2005-07-21. PMID:15790597. |
we tested six single nucleotide polymorphisms (snps) in the alpha4 subunit gene (chrna4) and four snps in the beta2 subunit gene (chrnb2) of nicotinic acetylcholine receptors (nachrs) for association with nicotine dependence (nd), which was assessed by smoking quantity (sq), the heaviness of smoking index (hsi) and the fagerstrom test for nd (ftnd) in 2037 subjects from 602 nuclear families of either european-american (ea) or african-american (aa) ancestry. |
2005-07-21 |
2023-08-12 |
human |
| William Marszalec, Jay Z Yeh, Toshio Narahash. Desensitization of nicotine acetylcholine receptors: modulation by kinase activation and phosphatase inhibition. European journal of pharmacology. vol 514. issue 2-3. 2005-07-21. PMID:15878498. |
desensitization of nicotine acetylcholine receptors: modulation by kinase activation and phosphatase inhibition. |
2005-07-21 |
2023-08-12 |
rat |
| William Marszalec, Jay Z Yeh, Toshio Narahash. Desensitization of nicotine acetylcholine receptors: modulation by kinase activation and phosphatase inhibition. European journal of pharmacology. vol 514. issue 2-3. 2005-07-21. PMID:15878498. |
thirty-minute perfusions of nicotine reduced currents evoked by short test pulses of 300 microm acetylcholine over a range of 3 to 300 nm, with an ic50 of 51 nm. |
2005-07-21 |
2023-08-12 |
rat |
| Helen L Alderson, Mary P Latimer, Philip Win. Involvement of the laterodorsal tegmental nucleus in the locomotor response to repeated nicotine administration. Neuroscience letters. vol 380. issue 3. 2005-07-20. PMID:15862913. |
the locomotor altering properties of nicotine depend on activation of nicotinic acetylcholine receptors in the ventral tegmental area (vta). |
2005-07-20 |
2023-08-12 |
rat |
| U Maskos, B E Molles, S Pons, M Besson, B P Guiard, J-P Guilloux, A Evrard, P Cazala, A Cormier, M Mameli-Engvall, N Dufour, I Cloëz-Tayarani, A-P Bemelmans, J Mallet, A M Gardier, V David, P Faure, S Granon, J-P Changeu. Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature. vol 436. issue 7047. 2005-07-19. PMID:16001069. |
we demonstrate the efficient re-expression of electrophysiologically responsive, ligand-binding nicotinic acetylcholine receptors in dopamine-containing neurons of the vta, together with the recovery of nicotine-elicited dopamine release and nicotine self-administration. |
2005-07-19 |
2023-08-12 |
mouse |
| Göksel Sener, A Ozer Sehirli, Yeşim Ipçi, Sule Cetinel, Esra Cikler, Nursal Gedik, Inci Alica. Taurine treatment protects against chronic nicotine-induced oxidative changes. Fundamental & clinical pharmacology. vol 19. issue 2. 2005-07-18. PMID:15810895. |
chronic nicotine treatment impaired both the contraction and relaxation responses of the aortic rings to phenylephrine and acetylcholine, respectively. |
2005-07-18 |
2023-08-12 |
rat |
| Harald Fischer, Avi Orr-Urtreger, Lorna W Role, Sigismund Huc. Selective deletion of the alpha5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse. The Journal of physiology. vol 563. issue Pt 1. 2005-06-24. PMID:15611037. |
we have examined the responses to the nicotinic agonists acetylcholine, nicotine, cytisine, dimethylphenylpiperazinium iodide (dmpp) and epibatidine. |
2005-06-24 |
2023-08-12 |
mouse |
| Massimo Grilli, Monica Parodi, Maurizio Raiteri, Mario March. Chronic nicotine differentially affects the function of nicotinic receptor subtypes regulating neurotransmitter release. Journal of neurochemistry. vol 93. issue 5. 2005-06-24. PMID:15934954. |
exposure of hippocampal synaptosomes prelabelled with [3h]choline to nicotine elicited release of [3h]acetylcholine; this effect was almost abolished in synaptosomes from animals administered nicotine for 10 days, suggesting down-regulation of nicotinic autoreceptors. |
2005-06-24 |
2023-08-12 |
rat |
| Ramiro Salas, Fredalina Pieri, Mariella De Bias. Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 45. 2005-06-10. PMID:15537871. |
our results demonstrate a major role for beta4-containing nicotinic acetylcholine receptors in the appearance of nicotine withdrawal symptoms. |
2005-06-10 |
2023-08-12 |
mouse |
| Jotham W Coe, Paige R Brooks, Michael G Vetelino, Michael C Wirtz, Eric P Arnold, Jianhua Huang, Steven B Sands, Thomas I Davis, Lorraine A Lebel, Carol B Fox, Alka Shrikhande, James H Heym, Eric Schaeffer, Hans Rollema, Yi Lu, Robert S Mansbach, Leslie K Chambers, Charles C Rovetti, David W Schulz, F David Tingley, Brian T O'Neil. Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation. Journal of medicinal chemistry. vol 48. issue 10. 2005-06-07. PMID:15887955. |
neuronal nicotinic acetylcholine receptors (nachrs) mediate the dependence-producing effects of nicotine. |
2005-06-07 |
2023-08-12 |
Not clear |
| Ali Abdel-Rahman, Anjelika M Dechkovskaia, Jazmine M Sutton, Wei-Chung Chen, Xiangrong Guan, Wasiuddin A Khan, Mohamed B Abou-Doni. Maternal exposure of rats to nicotine via infusion during gestation produces neurobehavioral deficits and elevated expression of glial fibrillary acidic protein in the cerebellum and CA1 subfield in the offspring at puberty. Toxicology. vol 209. issue 3. 2005-05-27. PMID:15795061. |
the results show that although 60-day-old male and female rat offspring of mothers exposed to nicotine during gestation did not differ from control in body weight gain or nicotinic acetylcholine receptors ligand binding, they exhibited significant sensorimotor deficits that were consistent with the neuropathological alterations seen in the brain. |
2005-05-27 |
2023-08-12 |
rat |
| C M Hernandez, A V Terr. Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor. Neuroscience. vol 130. issue 4. 2005-05-11. PMID:15652996. |
however, to date, comprehensive studies of nicotine's effects on the expression of specific acetylcholine (ach) receptor subtypes, key cholinergic proteins (that are regulated by ngf) such as choline acetyltransferase (chat) and the vesicular ach transporter (vacht) are lacking. |
2005-05-11 |
2023-08-12 |
rat |
| Qin Fang, Hong Sun, William G Mayha. L-arginine prevents impaired endothelium-dependent cerebral arteriolar dilatation during acute infusion of nicotine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 6. issue 6. 2005-05-10. PMID:15801573. |
we measured the diameter of pial arterioles in response to nos-dependent (5'-adenosine diphosphate [adp] and acetylcholine) and nos-independent (nitroglycerin) agonists before and after infusion of vehicle or nicotine (2 microg/kg/min intravenously for 30 min followed by a maintenance dose of 0.35 microg/kg/min) in the absence or presence of l-arginine (10(-3) m). |
2005-05-10 |
2023-08-12 |
Not clear |
| P Rada, D F Johnson, M J Lewis, B G Hoebe. In alcohol-treated rats, naloxone decreases extracellular dopamine and increases acetylcholine in the nucleus accumbens: evidence of opioid withdrawal. Pharmacology, biochemistry, and behavior. vol 79. issue 4. 2005-04-29. PMID:15582668. |
as with the withdrawal from morphine, nicotine, diazepam and sugar, the ethanol withdrawal state may involve an increase in nucleus accumbens (nac) acetylcholine (ach) causing an alteration of the dopamine (da)-ach balance in favor of ach. |
2005-04-29 |
2023-08-12 |
rat |
| Volodia D Gueorguiev, Christopher M Frenz, Kimberly M Ronald, Esther L Sabba. Nicotine and epibatidine triggered prolonged rise in calcium and TH gene transcription in PC12 cells. European journal of pharmacology. vol 506. issue 1. 2005-04-28. PMID:15588622. |
in contrast to nicotine, the epibatidine-triggered increase in [ca2+]i was independent of activation of alpha7 nicotinic acetylcholine receptors, as it was not altered by either methyllycaconitine or alpha-bungarotoxin. |
2005-04-28 |
2023-08-12 |
Not clear |
| Edward O Mann, Takashi Tominaga, Michinori Ichikawa, Susan A Greenfiel. Cholinergic modulation of the spatiotemporal pattern of hippocampal activity in vitro. Neuropharmacology. vol 48. issue 1. 2005-04-28. PMID:15617733. |
in contrast, the activation of nicotinic acetylcholine receptors (10 microm nicotine) had no significant effect on single evoked responses, but selectively increased facilitation at perisomatic sites. |
2005-04-28 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Atsuko Inoue, Taku Amano, Takahiro Seki, Yoshihiro Nakata, Masashi Sasa, Norio Saka. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469877. |
nicotine (1 mm) also induced three types of inward currents which were similar to those induced by acetylcholine (1 mm) plus atropine (1 microm). |
2005-04-19 |
2023-08-12 |
Not clear |
| Hiroaki Matsubayashi, Atsuko Inoue, Taku Amano, Takahiro Seki, Yoshihiro Nakata, Masashi Sasa, Norio Saka. Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Brain research. Molecular brain research. vol 129. issue 1-2. 2005-04-19. PMID:15469877. |
these results suggest that nicotine directly acts on postsynaptic alpha7- and alpha4beta2-type nicotinic acetylcholine receptors and induces inward current, which result in the excitation of dopaminergic neurons in the substantia nigra. |
2005-04-19 |
2023-08-12 |
Not clear |
| Hiroshi Tsuneki, Kana Ito, Naoto Sekizaki, En-Long Ma, Yueren You, Junichi Kawakami, Isao Adachi, Toshiyasu Sasaoka, Ikuko Kimur. Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells. Biological & pharmaceutical bulletin. vol 27. issue 12. 2005-04-15. PMID:15577211. |
the stimulation by acetylcholine (1 microm, with atropine) or nicotine (10 nm) induced the phosphorylation of a mitogen-activated protein (map) kinase (extracellular-signal regulated kinase: erk) in the serum-starved endothelial cells. |
2005-04-15 |
2023-08-12 |
cattle |
| Layla Azam, J Michael McIntos. Effect of novel alpha-conotoxins on nicotine-stimulated [3H]dopamine release from rat striatal synaptosomes. The Journal of pharmacology and experimental therapeutics. vol 312. issue 1. 2005-04-13. PMID:15316087. |
nicotine's action on the midbrain dopaminergic neurons is mediated by nicotinic acetylcholine receptors (nachrs) that are present on the cell bodies and the terminals of these neurons. |
2005-04-13 |
2023-08-12 |
rat |