| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H S Sekhon, B J Proskocil, J A Clark, E R Spinde. Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels. The European respiratory journal. vol 23. issue 6. 2004-09-23. PMID:15219006. |
these findings suggest that with smoking during pregnancy, nicotine is transported across the placenta and directly interacts with nicotinic acetylcholine receptors in pulmonary vessels to alter connective tissue expression and therefore produce vascular structural alterations. |
2004-09-23 |
2023-08-12 |
monkey |
| K G Paradiso, Joe Henry Steinbac. Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors. The Journal of physiology. vol 553. issue Pt 3. 2004-08-31. PMID:14555718. |
we examined desensitization by acetylcholine (ach) and nicotine at the rat alpha4beta2 neuronal nicotinic receptor stably expressed in hek cells. |
2004-08-31 |
2023-08-12 |
rat |
| b' Misty J Eaton, Claudia A Ospina, Abimael D Rodr\\xc3\\xadguez, Vesna A Eterovi\\xc4\\x8. Differential inhibition of nicotine- and acetylcholine-evoked currents through alpha4beta2 neuronal nicotinic receptors by tobacco cembranoids in Xenopus oocytes. Neuroscience letters. vol 366. issue 1. 2004-08-26. PMID:15265598.' |
the dose-response curves for acetylcholine and nicotine were hyperbolic and bell-shaped, respectively. |
2004-08-26 |
2023-08-12 |
rat |
| b' Misty J Eaton, Claudia A Ospina, Abimael D Rodr\\xc3\\xadguez, Vesna A Eterovi\\xc4\\x8. Differential inhibition of nicotine- and acetylcholine-evoked currents through alpha4beta2 neuronal nicotinic receptors by tobacco cembranoids in Xenopus oocytes. Neuroscience letters. vol 366. issue 1. 2004-08-26. PMID:15265598.' |
the finding that cembranoids preferentially inhibit nicotine-induced currents over those elicited by the natural neurotransmitter acetylcholine may have important implications when developing strategies to prevent nicotine addiction and tobacco use. |
2004-08-26 |
2023-08-12 |
rat |
| Theodore A Slotki. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicology and applied pharmacology. vol 198. issue 2. 2004-08-24. PMID:15236950. |
the current review discusses three exposure scenarios involving acetylcholine systems: nicotine from maternal smoking during pregnancy, exposure to environmental tobacco smoke (ets), and exposure to the organophosphate insecticide, chlorpyrifos (cpf). |
2004-08-24 |
2023-08-12 |
Not clear |
| Angelique J Ferayorni, Cameron F Gunville, Wade A Gro. Nicotine decreases agrin signaling and acetylcholine receptor clustering in C2C12 myotube culture. Journal of neurobiology. vol 60. issue 1. 2004-08-17. PMID:15188272. |
previous studies have determined that the frequency of spontaneous achr clustering is decreased and achrs are partially inactivated when bound by the acetylcholine agonist nicotine. |
2004-08-17 |
2023-08-12 |
human |
| Delphine Gimonet, Regis Grailhe, Paul Coninx, Frank Antonicelli, Bernard Haye, Françoise Liautaud-Roge. Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660001. |
in addition to these results, the detectable presence of alpha 7-mrna supports a key role of alpha 7-nicotinic acetylcholine receptors in the modulation of the induced apoptosis by nicotine. |
2004-08-16 |
2023-08-12 |
Not clear |
| Jeremy C Owens, Seth A Balogh, Tristan D McClure-Begley, Christopher M Butt, Cesar Labarca, Henry A Lester, Marina R Picciotto, Jeanne M Wehner, Allan C Collin. Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response. Alcoholism, clinical and experimental research. vol 27. issue 12. 2004-08-13. PMID:14691373. |
alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response. |
2004-08-13 |
2023-08-12 |
Not clear |
| Naguib Mechawar, Armen Saghatelyan, Régis Grailhe, Linda Scoriels, Gilles Gheusi, Marie-Madeleine Gabellec, Pierre-Marie Lledo, Jean-Pierre Changeu. Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 26. 2004-08-12. PMID:15210938. |
conversely, in vivo chronic nicotine exposure significantly decreased the number of newborn granule cells in beta(2)(+/+) but not beta(2)(-/-) adult mice, confirming that the survival of newborn neurons can be controlled by the activation of beta(2)-containing nicotinic acetylcholine receptors. |
2004-08-12 |
2023-08-12 |
mouse |
| Lydia M Mäthger, Toby F T Collins, Pedro A Lim. The role of muscarinic receptors and intracellular Ca2+ in the spectral reflectivity changes of squid iridophores. The Journal of experimental biology. vol 207. issue Pt 11. 2004-08-03. PMID:15107431. |
the spectral changes that can be seen in living squid, can also be brought about by superfusing whole skin preparations with acetylcholine (ach) (20 micro mol l(-1)) and muscarine (30 micro mol l(-1)) but not nicotine (up to 50 mmol l(-1)), suggesting that cholinergic muscarinic receptors are involved. |
2004-08-03 |
2023-08-12 |
squid |
| Hitoshi Nakayama, Toshikatu Nakashim. [Calcium signaling mediated by nicotine receptors in neurons]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 2. 2004-07-30. PMID:15164609. |
nicotine treatment activates neuronal nicotinic acetylcholine receptors (nachr) in peripheral and central nervous systems leading to depolarization and elevation of intracellular calcium levels, which are considered to cause stimulation of neurotransmitter release, synaptic transmission, intracellular signal transduction and gene expression. |
2004-07-30 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Donia, Ali Abdel-Rahman, Larry B Goldstein, Anjelika M Dechkovskaia, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. Archives of toxicology. vol 77. issue 8. 2004-07-22. PMID:12937891. |
sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. |
2004-07-22 |
2023-08-12 |
rat |
| Mohamed B Abou-Donia, Ali Abdel-Rahman, Larry B Goldstein, Anjelika M Dechkovskaia, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats. Archives of toxicology. vol 77. issue 8. 2004-07-22. PMID:12937891. |
a significant increase in ligand binding to nicotinic acetylcholine receptors (nachr) was observed in brainstem and cortex following exposure to nicotine or chlorpyrifos. |
2004-07-22 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
nicotine reinforces smoking behaviour by activating nicotinic acetylcholine receptors in the midbrain dopaminergic reward centres. |
2004-07-22 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, Mischa De Rover, Daniel S McGehee, Arjen B Brussaar. Cholinergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623355. |
the nicotinic acetylcholine receptors that mediate this control are likely to desensitise upon preexposure to the nicotine concentrations found in the blood of smokers. |
2004-07-22 |
2023-08-12 |
Not clear |
| Hui Zhang, David Sulze. Frequency-dependent modulation of dopamine release by nicotine. Nature neuroscience. vol 7. issue 6. 2004-07-20. PMID:15146187. |
although nicotine activation of dopamine release is implicated in addiction, it also desensitizes nicotinic acetylcholine receptors (nachrs), leading to a prolonged depression of evoked dopamine release. |
2004-07-20 |
2023-08-12 |
Not clear |
| Florian Amtage, Bogdan Neughebauer, J Michael McIntosh, Thomas Freiman, Josef Zentner, Thomas J Feuerstein, Rolf Jackisc. Characterization of nicotinic receptors inducing noradrenaline release and absence of nicotinic autoreceptors in human neocortex. Brain research bulletin. vol 62. issue 5. 2004-07-09. PMID:15168907. |
in both tissues a similar rank order of potency of nicotinic agonists was found: epibatidine >> dmpp > nicotine approximately cytisine > or = acetylcholine; choline was ineffective. |
2004-07-09 |
2023-08-12 |
human |
| Patrick J Mulholland, Barton R Harris, Lincoln H Wilkins, Rachel L Self, John A Blanchard, Robert C Holley, John M Littleton, Mark A Prendergas. Opposing effects of ethanol and nicotine on hippocampal calbindin-D28k expression. Alcohol (Fayetteville, N.Y.). vol 31. issue 1-2. 2004-07-06. PMID:14615005. |
further, in these studies, we examined the ability of nicotine, through action at alpha(7)(*)-bearing nicotinic acetylcholine receptors (nachrs), to antagonize the effects of ethanol exposure on calbindin-d(28k) expression. |
2004-07-06 |
2023-08-12 |
rat |
| Peter P Rowell, Kelly A Vol. Nicotinic activation of mesolimbic neurons assessed by rubidium efflux in rat accumbens and ventral tegmentum. Neuro-Signals. vol 13. issue 3. 2004-07-06. PMID:15067198. |
the application of nicotine to either the vta or nac produces an increase in dopamine release; however, the positive reinforcement produced by the systemic injection of nicotine is primarily due to stimulation of nicotinic acetylcholine receptors (nachrs) in the vta. |
2004-07-06 |
2023-08-12 |
rat |
| Douglas P Dohrman And, Cindy K Reite. Chronic ethanol reduces nicotine-induced dopamine release in PC12 cells. Alcoholism, clinical and experimental research. vol 27. issue 11. 2004-06-29. PMID:14634503. |
one important aspect of nicotine addiction appears to be the activation of nicotinic acetylcholine receptors on dopaminergic neurons projecting from the ventral tegmental area to the nucleus accumbens. |
2004-06-29 |
2023-08-12 |
Not clear |