| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Rahman, J Zhang, E A Engleman, W A Corrigal. Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: a microdialysis study. Neuroscience. vol 129. issue 2. 2005-01-13. PMID:15501598. |
the reduced elevation of extracellular dopamine levels in the acb upon nicotine challenge suggests a functional desensitization or downregulation phenomenon involving acetylcholine receptors (nicotinic nachrs). |
2005-01-13 |
2023-08-12 |
rat |
| Daniel G Wüstenberg, Bernd Grünewal. Pharmacology of the neuronal nicotinic acetylcholine receptor of cultured Kenyon cells of the honeybee, Apis mellifera. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 190. issue 10. 2004-12-22. PMID:15309481. |
acetylcholine or carbamylcholine were full agonists, nicotine, epibatidine and cytisine were only partial agonists. |
2004-12-22 |
2023-08-12 |
Not clear |
| Sarah L King, Barbara J Caldarone, Marina R Picciott. Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464132. |
beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. |
2004-12-20 |
2023-08-12 |
mouse |
| Sarah L King, Barbara J Caldarone, Marina R Picciott. Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology. vol 47 Suppl 1. 2004-12-20. PMID:15464132. |
it has been hypothesized that the initial effect of nicotine on the dopamine system is to activate high affinity nicotinic acetylcholine receptors (nachrs) containing the beta2 subunit, but that these receptors rapidly desensitize and are not critical for ongoing dopaminergic activation. |
2004-12-20 |
2023-08-12 |
mouse |
| Jie Wu, Andrew A George, Katherine M Schroeder, Lin Xu, Syndia Marxer-Miller, Linda Lucero, Ronald J Luka. Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 311. issue 1. 2004-12-15. PMID:15178698. |
however, roles played by nicotinic acetylcholine receptors, including those composed of alpha7-subunits [alpha7-nicotinic acetylcholine receptors (nachrs)], in modulation of da signaling and in nicotine dependence are not clearly understood. |
2004-12-15 |
2023-08-12 |
human |
| M I Palmatier, J L Peterson, J L Wilkinson, R A Bevin. Nicotine serves as a feature-positive modulator of Pavlovian appetitive conditioning in rats. Behavioural pharmacology. vol 15. issue 3. 2004-12-08. PMID:15187576. |
in experiment 2, centrally acting antagonists of nicotinic acetylcholine and opiate receptors (mecamylamine and naloxone, respectively) dose-dependently blocked nicotine's control of the cr, whereas the peripherally acting nicotinic antagonist hexamethonium had no effect. |
2004-12-08 |
2023-08-12 |
rat |
| Marja Van Kampen, Karin Selbach, Renate Schneider, Elleonore Schiegel, Frank Boess, Rudy Schreibe. AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors. Psychopharmacology. vol 172. issue 4. 2004-11-29. PMID:14727003. |
nicotine and agonists at alpha(4)beta(2) and alpha(7) nicotinic acetylcholine receptors (nachrs) improve learning and memory. |
2004-11-29 |
2023-08-12 |
rat |
| Andrew R Tapper, Sheri L McKinney, Raad Nashmi, Johannes Schwarz, Purnima Deshpande, Cesar Labarca, Paul Whiteaker, Michael J Marks, Allan C Collins, Henry A Leste. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science (New York, N.Y.). vol 306. issue 5698. 2004-11-26. PMID:15528443. |
selective activation of a4* nicotinic acetylcholine receptors with low doses of agonist recapitulates nicotine effects thought to be important in dependence, including reinforcement in response to acute nicotine administration, as well as tolerance and sensitization elicited by chronic nicotine administration. |
2004-11-26 |
2023-08-12 |
mouse |
| Clément Léna, Daniela Popa, Régis Grailhe, Pierre Escourrou, Jean-Pierre Changeux, Joëlle Adrie. Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 25. 2004-11-24. PMID:15215293. |
to evaluate the contribution of nicotinic acetylcholine receptors (nachrs) to these functions, we studied with polygraphic recordings the regulation of sleep in mice lacking the beta2 subunit gene of the nachrs, a major component of high-affinity nicotine binding sites in the brain. |
2004-11-24 |
2023-08-12 |
mouse |
| Ramiro Salas, Kimberly D Cook, Laura Bassetto, Mariella De Bias. The alpha3 and beta4 nicotinic acetylcholine receptor subunits are necessary for nicotine-induced seizures and hypolocomotion in mice. Neuropharmacology. vol 47. issue 3. 2004-11-24. PMID:15275829. |
binding of nicotine to nicotinic acetylcholine receptors (nachrs) elicits a series of dose-dependent behaviors that go from altered exploration, sedation, and tremors, to seizures and death. |
2004-11-24 |
2023-08-12 |
mouse |
| Xiulan Sun, Yue Liu, Gang Hu, Hai Wan. Activities of cAMP-dependent protein kinase and protein kinase C are modulated by desensitized nicotinic receptors in the rat brain. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308289. |
when rats were treated with different dosages of nicotine, nicotinic acetylcholine receptors (nachrs) were observed in activated, sub-acute desensitized, acute desensitized, and chronic desensitized states. |
2004-11-24 |
2023-08-12 |
rat |
| Karen A Bell, Kenneth J O'Riordan, J David Sweatt, Kelly T Dinele. MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447668. |
in contrast to the effects of acute application of oligomeric beta-amyloid(1-42), nicotine activated erk mapk via alpha7 nicotinic acetylcholine receptors utilizing protein kinase a as an intermediate. |
2004-11-15 |
2023-08-12 |
Not clear |
| Karen A Bell, Kenneth J O'Riordan, J David Sweatt, Kelly T Dinele. MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447668. |
we also found that nicotine and beta-amyloid activate erk mapk via alpha7 nicotinic acetylcholine receptors but use distinct intermediate kinases. |
2004-11-15 |
2023-08-12 |
Not clear |
| Gülay Uzüm, A Sarper Díler, Nesrín Bahçekapili, Mustafa Tasyüreklí, Y Zíya Zíyla. Nicotine improves learning and memory in rats: morphological evidence for acetylcholine involvement. The International journal of neuroscience. vol 114. issue 9. 2004-10-18. PMID:15370181. |
nicotine improves learning and memory in rats: morphological evidence for acetylcholine involvement. |
2004-10-18 |
2023-08-12 |
rat |
| S Fucile, M Renzi, C Lauro, C Limatola, T Ciotti, F Euseb. Nicotinic cholinergic stimulation promotes survival and reduces motility of cultured rat cerebellar granule cells. Neuroscience. vol 127. issue 1. 2004-10-14. PMID:15219668. |
despite many studies on the functional expression of neuronal nicotinic acetylcholine receptors (nachrs), an exhaustive description of the long-term effects of nicotine (nic) stimulation in cerebellar granules is still far to be completed. |
2004-10-14 |
2023-08-12 |
rat |
| Reiji Yoshimura, Lu Xu, Baoyong Sun, A William Tan. Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. Brain research. Molecular brain research. vol 126. issue 2. 2004-09-30. PMID:15249143. |
nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. |
2004-09-30 |
2023-08-12 |
rat |
| Reiji Yoshimura, Lu Xu, Baoyong Sun, A William Tan. Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. Brain research. Molecular brain research. vol 126. issue 2. 2004-09-30. PMID:15249143. |
nicotine induces tyrosine hydroxylase (th) mrna by interacting with nicotinic acetylcholine receptors (nachrs) in cultured adrenal medullary cell systems; however, the mechanisms responsible for the induction of adrenal th in response to systemically administered nicotine under in vivo conditions are more complex. |
2004-09-30 |
2023-08-12 |
rat |
| Reiji Yoshimura, Lu Xu, Baoyong Sun, A William Tan. Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. Brain research. Molecular brain research. vol 126. issue 2. 2004-09-30. PMID:15249143. |
in the present study, we tested whether nachrs and muscarinic acetylcholine receptors (machrs) participate in the induction of adrenal th observed after long-term treatment with nicotine. |
2004-09-30 |
2023-08-12 |
rat |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine, acting on nicotinic acetylcholine receptors (nachrs) expressed at pre-synaptic dopaminergic terminals, has been shown to stimulate the release of dopamine in the neostriatum. |
2004-09-30 |
2023-08-12 |
mouse |
| G van den HEUVEL-HEYMAN. Mechanism of the hyperglycemic action of acetylcholine, morphine and nicotine. Archives internationales de pharmacodynamie et de therapie. vol 83. issue 3. 2004-09-30. PMID:15426405. |
mechanism of the hyperglycemic action of acetylcholine, morphine and nicotine. |
2004-09-30 |
2023-08-12 |
Not clear |