| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L M Koval', S I Romaniuk, D V Kolybo, M V Skok, S V Komisarenk. [The role of nicotine in regulation of lymphocyte proliferation]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 77. issue 2. 2006-01-10. PMID:16335241. |
the effect of nicotine on both the expression of nicotinic acetylcholine receptors (nachrs) and proliferation of hybridoma cells and normal mouse lymphocytes has been investigated. |
2006-01-10 |
2023-08-12 |
mouse |
| Emilie Landais, Victoria El-Khoury, Alain Prevost, Jean Dufer, Françoise Liautaud-Roge. Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells. Oncology reports. vol 14. issue 6. 2006-01-09. PMID:16273255. |
this increase is inhibited by mecamylamine, a nicotinic receptor antagonist, suggesting that nicotine alters cellular function directly via nicotinic acetylcholine receptors and may then play a role in cell physiology and tumor promotion. |
2006-01-09 |
2023-08-12 |
human |
| Jian-Zhong Guo, Yingbing Liu, Eva M Sorenson, Vincent A Chiappinell. Synaptically released and exogenous ACh activates different nicotinic receptors to enhance evoked glutamatergic transmission in the lateral geniculate nucleus. Journal of neurophysiology. vol 94. issue 4. 2005-12-30. PMID:15972832. |
exogenously applied nicotine (0.5 microm), choline (1 mm), or acetylcholine (ach, 100 microm) markedly increased (>3-fold) these evoked pscs. |
2005-12-30 |
2023-08-12 |
chicken |
| Harmanjatinder S Sekhon, Pingfang Song, Yibing Jia, Jon Lindstrom, Eliot R Spinde. Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. Cell and tissue research. vol 320. issue 2. 2005-12-23. PMID:15778850. |
the expression of nicotinic acetylcholine receptors (nachr) in fetal lung suggests maternal smoking during pregnancy effects newborn lung structure and function by the direct interaction of nicotine with nachr in the developing lung. |
2005-12-23 |
2023-08-12 |
monkey |
| Ola Hafström, Joseph Milerad, Kenneth L Sandberg, Håkan W Sundel. Cardiorespiratory effects of nicotine exposure during development. Respiratory physiology & neurobiology. vol 149. issue 1-3. 2005-12-20. PMID:15970470. |
nicotine interacts with endogenous acetylcholine receptors in the brain and lung, and developmental exposure produces structural changes as well as alterations in neuroregulation. |
2005-12-20 |
2023-08-12 |
Not clear |
| Joseph M Fuentes, Eric J Hanly, Alexander R Aurora, Antonio De Maio, Mark A Talamin. Anesthesia-specific protection from endotoxic shock is not mediated through the vagus nerve. Surgery. vol 138. issue 4. 2005-11-29. PMID:16269307. |
because acetylcholine's interaction with nicotine receptors on tissue macrophages during vagus nerve stimulation has been implicated in the modulation of lps-stimulated tumor necrosis factor alpha (tnf-alpha) production, we hypothesized that the mechanism of anesthetic immunoprotection is mediated through the vagus nerve. |
2005-11-29 |
2023-08-12 |
Not clear |
| Diego Rayes, Guillermo Spitzmaul, Steven M Sine, Cecilia Bouza. Single-channel kinetic analysis of chimeric alpha7-5HT3A receptors. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16118362. |
both the open and closed time distributions are described as the sum of multiple exponential components, but these do not change over a wide range of acetylcholine (ach), nicotine, or choline concentrations. |
2005-11-28 |
2023-08-12 |
Not clear |
| Falk W Lohoff, Thomas N Ferraro, Leilah McNabb, Candice Schwebel, John P Dahl, Glenn A Doyle, Russell J Buono, Wade H Berrettin. No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder. Psychiatry research. vol 135. issue 3. 2005-10-20. PMID:15996750. |
given the biological role of the neuronal nicotinic acetylcholine receptors and the substantial comorbidity of nicotine dependence in psychiatric disorders, the chrna2 gene is a plausible candidate gene for bipolar disorder (bpd). |
2005-10-20 |
2023-08-12 |
Not clear |
| Theodore A Slotkin, Matthew C Southard, Stacey J Adam, Mandy M Cousins, Frederic J Seidle. Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. Brain research bulletin. vol 64. issue 3. 2005-09-30. PMID:15464859. |
alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. |
2005-09-30 |
2023-08-12 |
rat |
| John W Dal. Nicotinic agonists, antagonists, and modulators from natural sources. Cellular and molecular neurobiology. vol 25. issue 3-4. 2005-09-29. PMID:16075378. |
acetylcholine receptors were initially defined as nicotinic or muscarinic, based on selective activation by two natural products, nicotine and muscarine. |
2005-09-29 |
2023-08-12 |
Not clear |
| Paula Proença, Helena Teixeira, Fernando Castanheira, João Pinheiro, Paula V Monsanto, Estela P Marques, Duarte Nuno Vieir. Two fatal intoxication cases with imidacloprid: LC/MS analysis. Forensic science international. vol 153. issue 1. 2005-09-22. PMID:15922528. |
it is the first highly effective insecticide that, like nicotine, acts on the nervous system, causing blockage of postsynaptic nicotinergic acetylcholine receptors. |
2005-09-22 |
2023-08-12 |
Not clear |
| Andreas Bauer, Karl Zilles, Andreas Matusch, Carsten Holzmann, Olaf Riess, Stephan von Hörste. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation. Journal of neurochemistry. vol 94. issue 3. 2005-09-19. PMID:16033418. |
heterozygous animals expressed increased densities of m(2) acetylcholine (increase of 148 +/- 16% of controls; p > 0.001; n = 7), nicotine (increase of 149 +/- 16% of controls; p > 0.01; n = 6), and alpha(2) noradrenergic receptors (increase of 141 +/- 15% of controls; p > 0.001; n = 6), respectively. |
2005-09-19 |
2023-08-12 |
human |
| María Eugenia Gómez-Casati, Paul A Fuchs, Ana Belén Elgoyhen, Eleonora Kat. Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells. The Journal of physiology. vol 566. issue Pt 1. 2005-09-16. PMID:15860528. |
nicotine did not activate but rather blocked the acetylcholine (ach)-evoked currents with an ic50 of 1 +/- 0.1 microm. |
2005-09-16 |
2023-08-12 |
rat |
| Namik Delibas, Duygu Kumbul Doguc, Recep Sutcu, Erol Eroglu, Osman Gökal. EFFECT of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats. The International journal of neuroscience. vol 115. issue 8. 2005-09-15. PMID:16040357. |
effect of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and nmda receptor subunits 2a and 2b expression in young and old rats. |
2005-09-15 |
2023-08-12 |
rat |
| G Vázquez-Palacios, H Bonilla-Jaim. [Nicotine acetylcholine receptors and neuropsychiatric disorders]. Revista de neurologia. vol 39. issue 12. 2005-09-12. PMID:15625635. |
[nicotine acetylcholine receptors and neuropsychiatric disorders]. |
2005-09-12 |
2023-08-12 |
Not clear |
| Jukka S Pakkanen, Eija Jokitalo, Raimo K Tuomine. Up-regulation of beta2 and alpha7 subunit containing nicotinic acetylcholine receptors in mouse striatum at cellular level. The European journal of neuroscience. vol 21. issue 10. 2005-08-17. PMID:15926916. |
nicotine releases dopamine in the brain by activating neuronal nicotinic acetylcholine receptors (nachrs). |
2005-08-17 |
2023-08-12 |
mouse |
| Ram Sack, Alona Gochberg-Sarver, Uri Rozovsky, Merav Kedmi, Serena Rosner, Avi Orr-Urtrege. Lower core body temperature and attenuated nicotine-induced hypothermic response in mice lacking the beta4 neuronal nicotinic acetylcholine receptor subunit. Brain research bulletin. vol 66. issue 1. 2005-08-12. PMID:15925141. |
diverse physiological and pathological effects of nicotine, including the alteration of body temperature, are presumably mediated by neuronal nicotinic acetylcholine receptors (nachr). |
2005-08-12 |
2023-08-12 |
mouse |
| Sasa M Trailovic, Cheryl L Clark, Alan P Robertson, Richard J Marti. Brief application of AF2 produces long lasting potentiation of nAChR responses in Ascaris suum. Molecular and biochemical parasitology. vol 139. issue 1. 2005-08-04. PMID:15610819. |
since levamisole preferentially activates l-type acetylcholine receptors, we also tested the effect of nicotine (selective activator of n-type acetylcholine receptors) and bephenium (selective activator of b-type acetylcholine receptors) and found again no effect of af2 on peak membrane potential responses. |
2005-08-04 |
2023-08-12 |
Not clear |
| Junji Tsurutani, S Sianna Castillo, John Brognard, Courtney A Granville, Chunyu Zhang, Joell J Gills, Jacqueline Sayyah, Phillip A Denni. Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis. vol 26. issue 7. 2005-07-29. PMID:15790591. |
since nicotine or nnk bind to cell surface nicotinic acetylcholine receptors (nachr), we used rt-pcr to assess expression of nine alpha and three beta nachr subunits in five nsclc cell lines and two types of primary lung epithelial cells. |
2005-07-29 |
2023-08-12 |
Not clear |
| Hai Wang, Xiulan Su. Desensitized nicotinic receptors in brain. Brain research. Brain research reviews. vol 48. issue 3. 2005-07-26. PMID:15914250. |
desensitization of nicotinic receptors can occur as a result of extended nicotine exposure during smoking or prolonged acetylcholine when treatment of alzheimer's disease (ad) with cholinesterase inhibitors, or anticholinesterase agent poisoning. |
2005-07-26 |
2023-08-12 |
Not clear |