| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Corentin Le Magueresse, Victoria Safiulina, Jean-Pierre Changeux, Enrico Cherubin. Nicotinic modulation of network and synaptic transmission in the immature hippocampus investigated with genetically modified mice. The Journal of physiology. vol 576. issue Pt 2. 2006-11-28. PMID:16901939. |
early in postnatal development, activation of nachrs by nicotine or endogenous acetylcholine contributes to enhance synaptic signalling. |
2006-11-28 |
2023-08-12 |
mouse |
| Juan Arredondo, Alex I Chernyavsky, Sergei A Grand. Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells. Cancer biology & therapy. vol 5. issue 5. 2006-11-21. PMID:16582591. |
nicotine and its derivatives may contribute to tumorigenesis through stimulation of nicotinic acetylcholine receptors (nachrs) in target cells. |
2006-11-21 |
2023-08-12 |
mouse |
| G Dunbar, A Demazières, A Monreal, C Cisterni, D Metzger, R Kuchibhatla, R Luthringe. Pharmacokinetics and safety profile of ispronicline (TC-1734), a new brain nicotinic receptor partial agonist, in young healthy male volunteers. Journal of clinical pharmacology. vol 46. issue 7. 2006-11-21. PMID:16809797. |
recent research suggests that drugs activating nicotine acetylcholine receptors might be promising therapy in cognitive decline seen in the elderly, including alzheimer's disease. |
2006-11-21 |
2023-08-12 |
human |
| Elisabetta Sola, Simona Capsoni, Marcelo Rosato-Siri, Antonino Cattaneo, Enrico Cherubin. Failure of nicotine-dependent enhancement of synaptic efficacy at Schaffer-collateral CA1 synapses of AD11 anti-nerve growth factor transgenic mice. The European journal of neuroscience. vol 24. issue 5. 2006-11-14. PMID:16987213. |
whereas in wild-type mice nicotine induced a persistent increase of synaptic efficacy via alpha7 nicotine acetylcholine receptors, in ad11 mice this alkaloid failed to modify synaptic strength. |
2006-11-14 |
2023-08-12 |
mouse |
| Elisabetta Sola, Simona Capsoni, Marcelo Rosato-Siri, Antonino Cattaneo, Enrico Cherubin. Failure of nicotine-dependent enhancement of synaptic efficacy at Schaffer-collateral CA1 synapses of AD11 anti-nerve growth factor transgenic mice. The European journal of neuroscience. vol 24. issue 5. 2006-11-14. PMID:16987213. |
these data suggest that in ad11 mice, abeta interferes with nicotine acetylcholine receptors at the level of presynaptic glutamatergic terminals, inhibiting their function possibly through calcium signalling via presynaptic alpha7 nicotine acetylcholine receptors. |
2006-11-14 |
2023-08-12 |
mouse |
| Christopher T Simons, Yves Boucher, Mirela Iodi Carstens, E Carsten. Nicotine suppression of gustatory responses of neurons in the nucleus of the solitary tract. Journal of neurophysiology. vol 96. issue 4. 2006-11-02. PMID:16837661. |
the results indicate that nicotine directly excites nts units by gustatory nerves and inhibits their tastant-evoked responses by a nicotinic acetylcholine receptor-mediated excitation of trigeminal afferents that inhibit nts units centrally. |
2006-11-02 |
2023-08-12 |
rat |
| Clark A Briggs, Earl J Gubbins, Michael J Marks, C Brent Putman, Rama Thimmapaya, Michael D Meyer, Carol S Surow. Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors. Molecular pharmacology. vol 70. issue 1. 2006-10-24. PMID:16569710. |
alpha4beta2 nicotinic acetylcholine receptors (nachrs) are recognized as the principal nicotine binding site in brain. |
2006-10-24 |
2023-08-12 |
mouse |
| Juan Arredondo, Alexander I Chernyavsky, David L Jolkovsky, Kent E Pinkerton, Sergei A Grand. Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 12. 2006-10-20. PMID:17012261. |
nicotine and tobacco-derived nitrosamines have been shown to exhibit their pathobiologic effects due in part to activation of the nicotinic acetylcholine (ach) receptors (nachrs), mainly alpha7 nachr, expressed by oral keratinocytes (kcs). |
2006-10-20 |
2023-08-12 |
Not clear |
| Shelley L Davies, Elisa Ferrer, Maria Angels Mora. Chronicles in drug discovery. Drug news & perspectives. vol 19. issue 5. 2006-10-16. PMID:16941050. |
finally, we discuss the utility of allosteric-potentiating ligands to modulate nicotinic acetylcholine receptors, mimicking the reward/addictive effects of nicotine, as potential strategies for smoking cessation. |
2006-10-16 |
2023-08-12 |
Not clear |
| A M Aleisa, K H Alzoubi, K A Alkadh. Chronic but not acute nicotine treatment reverses stress-induced impairment of LTP in anesthetized rats. Brain research. vol 1097. issue 1. 2006-10-06. PMID:16725127. |
nicotine reduces stress-induced impairment of ltp, probably, through activation of nicotinic acetylcholine receptors in the hippocampus. |
2006-10-06 |
2023-08-12 |
rat |
| Julie K Staley, Suchitra Krishnan-Sarin, Kelly P Cosgrove, Erica Krantzler, Erin Frohlich, Edward Perry, Joel A Dubin, Kristina Estok, Eric Brenner, Ronald M Baldwin, Gilles D Tamagnan, John P Seibyl, Peter Jatlow, Marina R Picciotto, Edythe D London, Stephanie O'Malley, Christopher H van Dyc. Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928859. |
nicotine, the addictive chemical in tobacco smoke, initiates its actions in brain through nicotinic acetylcholine receptors (nachrs). |
2006-09-28 |
2023-08-12 |
human |
| Ramana Gutala, Ju Wang, Yoon Y Hwang, Riaz Haq, Ming D L. Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells. Brain research. vol 1093. issue 1. 2006-09-12. PMID:16707114. |
in addition, in vitro nicotine treatment of sh-sy5y neuroblastoma cells resulted in a significant increase in expression of app protein, soluble app, and aplp2, whereas co-treatment with mecamylamine (an antagonist of nicotinic acetylcholine receptors) attenuated the stimulating effect of nicotine on app and aplp2 expression. |
2006-09-12 |
2023-08-12 |
mouse |
| Ozra Dehkordi, Prabha Kc, Kannan V Balan, Musa A Haxhi. Airway-related vagal preganglionic neurons express multiple nicotinic acetylcholine receptor subunits. Autonomic neuroscience : basic & clinical. vol 128. issue 1-2. 2006-09-08. PMID:16616705. |
nicotine acting centrally increases bronchomotor tone and airway secretion, suggesting that airway-related vagal preganglionic neurons (avpns) within the rostral nucleus ambiguus (rna) express nicotinic acetylcholine receptors (nachrs). |
2006-09-08 |
2023-08-12 |
Not clear |
| Tomohisa Suzuki, Izumi Hide, Akiyo Matsubara, Chihiro Hama, Kana Harada, Kanako Miyano, Matthias Andrä, Hiroaki Matsubayashi, Norio Sakai, Shinichi Kohsaka, Kazuhide Inoue, Yoshihiro Nakat. Microglial alpha7 nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotective role. Journal of neuroscience research. vol 83. issue 8. 2006-09-08. PMID:16652343. |
here we report that, in rat primary cultured microglia, nicotine enhances p2x(7) receptor-mediated tnf release, whilst suppressing lps-induced tnf release but without affecting tnf mrna expression via activation of alpha7 nicotinic acetylcholine receptors (alpha7 nachrs). |
2006-09-08 |
2023-08-12 |
rat |
| Mirko Moroni, Ruud Zwart, Emanuele Sher, Bruce K Cassels, Isabel Bermude. alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Molecular pharmacology. vol 70. issue 2. 2006-08-28. PMID:16720757. |
alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. |
2006-08-28 |
2023-08-12 |
human |
| Lorise C Gahring, Scott W Roger. Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. The AAPS journal. vol 7. issue 4. 2006-08-16. PMID:16594641. |
nicotine is a lipophilic molecule whose effects on neuronal nicotinic acetylcholine receptors (nachr) have been primarily focused on its physiologic impact within the confines of the brain and peripheral nervous system. |
2006-08-16 |
2023-08-12 |
Not clear |
| Robert E Vann, John R James, John A Rosecrans, Susan E Robinso. Nicotinic receptor inactivation after acute and repeated in vivo nicotine exposures in rats. Brain research. vol 1086. issue 1. 2006-08-10. PMID:16626643. |
nicotine tolerance is often accompanied by an upregulation of brain area nicotinic acetylcholine receptors (nachrs) in both animal and human subjects. |
2006-08-10 |
2023-08-12 |
human |
| Sietse Jonkman, Athina Marko. Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats. Neuroscience letters. vol 400. issue 1-2. 2006-08-04. PMID:16563623. |
blockade of nicotinic acetylcholine or dopamine d1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats. |
2006-08-04 |
2023-08-12 |
rat |
| Monica Mameli-Engvall, Alexis Evrard, Stéphanie Pons, Uwe Maskos, Torgny H Svensson, Jean-Pierre Changeux, Philippe Faur. Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron. vol 50. issue 6. 2006-07-25. PMID:16772172. |
nicotine elicits dopamine release by stimulating nicotinic acetylcholine receptors (nachrs) on dopaminergic neurons. |
2006-07-25 |
2023-08-12 |
mouse |
| I I Krivoĭ, T M Drabkina, A N Vasil'ev, V V Kravtsova, F Mande. [Analysis of the interaction between nicotinic acetylcholine receptor and Na+,K(+)-ATPase in the rat skeletal muscle and the Torpedo electric organ membrane preparation]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 92. issue 2. 2006-07-21. PMID:16739652. |
three specific agonists of the nicotinic receptor: acetylcholine, nicotine and carbamylcholine (100 nmol/l each), all hyperpolarized the non-synaptic membranes of muscle fibers by up to 4 mv. |
2006-07-21 |
2023-08-12 |
rat |