| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cherry Wongtrakool, Susanne Roser-Page, Hilda N Rivera, Jesse Roma. Nicotine alters lung branching morphogenesis through the alpha7 nicotinic acetylcholine receptor. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 3. 2007-10-17. PMID:17545491. |
explants deficient in alpha(7) nicotinic acetylcholine receptors did not respond to nicotine. |
2007-10-17 |
2023-08-12 |
Not clear |
| Cherry Wongtrakool, Susanne Roser-Page, Hilda N Rivera, Jesse Roma. Nicotine alters lung branching morphogenesis through the alpha7 nicotinic acetylcholine receptor. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 3. 2007-10-17. PMID:17545491. |
altogether, these studies suggest that nicotine stimulates lung branching morphogenesis through alpha(7) nicotinic acetylcholine receptors and may contribute to dysanaptic lung growth, which in turn may predispose the host to airway disease in the postnatal period. |
2007-10-17 |
2023-08-12 |
Not clear |
| Merav Kedmi, Avi Orr-Urtrege. Expression changes in mouse brains following nicotine-induced seizures: the modulation of transcription factor networks. Physiological genomics. vol 30. issue 3. 2007-10-16. PMID:17456735. |
nicotine, acting through the neuronal nicotinic acetylcholine receptors (nachrs), can induce seizures in mice. |
2007-10-16 |
2023-08-12 |
mouse |
| Qunzhou Zhang, Xudong Tang, Zuo-Feng Zhang, Rita Velikina, Shihong Shi, Anh D L. Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 13. issue 16. 2007-09-25. PMID:17699846. |
nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. |
2007-09-25 |
2023-08-12 |
human |
| Pia Steensland, Jeffrey A Simms, Joan Holgate, Jemma K Richards, Selena E Bartlet. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 30. 2007-09-10. PMID:17626178. |
alcohol and nicotine are commonly abused together, and there is evidence that neuronal nicotinic acetylcholine receptors (nachrs) play a role in both alcohol and nicotine dependence. |
2007-09-10 |
2023-08-12 |
Not clear |
| David C Perry, Danyan Mao, Allison B Gold, J Michael McIntosh, John C Pezzullo, Kenneth J Kella. Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17446303. |
we investigated the effects of chronic nicotine on alpha6- and beta3-containing nicotinic acetylcholine receptors (nachrs) in two rat brain regions using three methodological approaches: radioligand binding, immunoprecipitation, and nicotine-stimulated synaptosomal release of dopamine. |
2007-08-30 |
2023-08-12 |
rat |
| Raad Nashmi, Cheng Xiao, Purnima Deshpande, Sheri McKinney, Sharon R Grady, Paul Whiteaker, Qi Huang, Tristan McClure-Begley, Jon M Lindstrom, Cesar Labarca, Allan C Collins, Michael J Marks, Henry A Leste. Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 31. 2007-08-28. PMID:17670967. |
understanding effects of chronic nicotine requires identifying the neurons and synapses whose responses to nicotine itself, and to endogenous acetylcholine, are altered by continued exposure to the drug. |
2007-08-28 |
2023-08-12 |
mouse |
| T K Booker, Christopher M Butt, Jeanne M Wehner, Stephen F Heinemann, Allan C Collin. Decreased anxiety-like behavior in beta3 nicotinic receptor subunit knockout mice. Pharmacology, biochemistry, and behavior. vol 87. issue 1. 2007-08-06. PMID:17509676. |
nicotine, via a family of nicotinic acetylcholine receptors, elicits many physiological responses, including alterations in anxiety. |
2007-08-06 |
2023-08-12 |
mouse |
| Ortrud K Steinlei. Genetic disorders caused by mutated acetylcholine receptors. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17434185. |
they are widely distributed in both the nervous system and non-neuronal tissues, and can be activated by endogenous agonists such as acetylcholine or exogenous ligands such as nicotine. |
2007-08-01 |
2023-08-12 |
Not clear |
| M I Damaj, C Fonck, M J Marks, P Deshpande, C Labarca, H A Lester, A C Collins, B R Marti. Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17371806. |
our results indicate that alpha(4)beta(2)(*) acetylcholine nicotinic receptors (nachr) are important in mediating nicotine analgesia in supraspinal responses, while also showing that alpha(4)beta(2)(*)-nachr and at least one other nachr subtype appear to modulate spinal actions. |
2007-07-30 |
2023-08-12 |
mouse |
| Virginie Arnaud, Michel Berthelot, Jean-Yves Le Queste. Hydrogen-bond accepting strength of protonated nicotine. The journal of physical chemistry. A. vol 109. issue 17. 2007-07-27. PMID:16833690. |
recent crystal structures of nicotine bound to the acetylcholine binding protein (achbp) ended a long debate confirming that the pyridine nitrogen of nicotine is indeed hydrogen-bonded to receptor residues through a bridging water molecule. |
2007-07-27 |
2023-08-12 |
Not clear |
| Nimish Sidhpura, Peter Redfern, Susan Wonnacot. Comparison of the effects of bupropion on nicotinic receptor-evoked [(3)H]dopamine release from rat striatal synaptosomes and slices. European journal of pharmacology. vol 567. issue 1-2. 2007-07-27. PMID:17477919. |
tobacco smoking is a nicotine addiction, mediated in part by the ability of nicotine to elicit dopamine release, as a result of the stimulation of nicotinic acetylcholine receptors associated with dopaminergic pathways. |
2007-07-27 |
2023-08-12 |
rat |
| David Chi-Leung Lam, Luc Girard, Ruben Ramirez, Wing-Shun Chau, Wai-sing Suen, Shelley Sheridan, Vicky P C Tin, Lap-ping Chung, Maria P Wong, Jerry W Shay, Adi F Gazdar, Wah-kit Lam, John D Minn. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer research. vol 67. issue 10. 2007-07-03. PMID:17510389. |
nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nachr) on bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the akt pathway. |
2007-07-03 |
2023-08-12 |
human |
| L-Y Lee, N K Burki, D C Gerhardstein, Q Gu, Y R Kou, J X. Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors. Pulmonary pharmacology & therapeutics. vol 20. issue 4. 2007-06-26. PMID:17137814. |
our results showed that nicotine evoked an abrupt and transient increase in [ca(2+)](i) in approximately 34% of the 522 neurons tested, and 1,1-dimethyl-4-phenylpiperazinium, a selective agonist of the neuronal nicotinic acetylcholine receptors (nnachrs), evoked a similar pattern of response as that of nicotine in these neurons. |
2007-06-26 |
2023-08-12 |
human |
| Matthias Vömel, Christian Wegene. Neurotransmitter-induced changes in the intracellular calcium concentration suggest a differential central modulation of CCAP neuron subsets in Drosophila. Developmental neurobiology. vol 67. issue 6. 2007-06-26. PMID:17443825. |
in short-term culture, almost all n(ccap) showed increases of the free intracellular calcium concentration after application of acetylcholine (ach) and nicotine, whereas only some n(ccap) responded to glutamate and gaba. |
2007-06-26 |
2023-08-12 |
drosophila_melanogaster |
| Jennifer A Davis, Thomas J Goul. beta2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice. Psychopharmacology. vol 190. issue 3. 2007-06-18. PMID:17136517. |
pharmacological inhibition of alpha4beta2 nicotinic acetylcholine receptors (nachrs), but not alpha7 nachrs, blocked the enhancing effect of nicotine on contextual fear conditioning. |
2007-06-18 |
2023-08-12 |
mouse |
| Corentin Le Magueresse, Enrico Cherubin. Presynaptic calcium stores contribute to nicotine-elicited potentiation of evoked synaptic transmission at CA3-CA1 connections in the neonatal rat hippocampus. Hippocampus. vol 17. issue 4. 2007-06-13. PMID:17330864. |
nicotine acetylcholine (ach) receptors (nachrs) are ligand-gated ion channels that are widely expressed throughout the central nervous system. |
2007-06-13 |
2023-08-12 |
rat |
| Virginie Arnaud, Michel Berthelot, Michel Evain, Jérôme Graton, Jean-Yves Le Queste. Hydrogen-bond interactions of nicotine and acetylcholine salts: a combined crystallographic, spectroscopic, thermodynamic and theoretical study. Chemistry (Weinheim an der Bergstrasse, Germany). vol 13. issue 5. 2007-06-12. PMID:17103466. |
hydrogen-bond interactions of nicotine and acetylcholine salts: a combined crystallographic, spectroscopic, thermodynamic and theoretical study. |
2007-06-12 |
2023-08-12 |
Not clear |
| Virginie Arnaud, Michel Berthelot, Michel Evain, Jérôme Graton, Jean-Yves Le Queste. Hydrogen-bond interactions of nicotine and acetylcholine salts: a combined crystallographic, spectroscopic, thermodynamic and theoretical study. Chemistry (Weinheim an der Bergstrasse, Germany). vol 13. issue 5. 2007-06-12. PMID:17103466. |
the hydrogen-bond (hb) interactions of the monocharged active forms of nicotine and acetylcholine (ach) have been compared theoretically by using density functional theory (dft) calculations and experimentally on the basis of crystallographic observations and the measurement of equilibrium constants in solution. |
2007-06-12 |
2023-08-12 |
Not clear |
| Morgane Besson, Sylvie Granon, Monica Mameli-Engvall, Isabelle Cloëz-Tayarani, Nicolas Maubourguet, Anne Cormier, Pierre Cazala, Vincent David, Jean-Pierre Changeux, Philippe Faur. Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 19. 2007-06-07. PMID:17470777. |
chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nachrs) that play a key role in the adaptative cellular processes leading to addiction. |
2007-06-07 |
2023-08-12 |
mouse |