| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Josef Buttigieg, Stephen Brown, Min Zhang, Michael Lowe, Alison C Holloway, Colin A Nurs. Chronic nicotine in utero selectively suppresses hypoxic sensitivity in neonatal rat adrenal chromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 5. 2008-05-28. PMID:18070822. |
taken together, these data suggest that the adverse effects of maternal smoking on sympathoadrenal function in the offspring are due in part to a loss or suppression of acute hypoxic sensitivity in adrenal chromaffin cells, triggered by the direct action of nicotine on endogenous nicotinic acetylcholine receptors. |
2008-05-28 |
2023-08-12 |
rat |
| Mahamadou Seydou, Gilles Grégoire, Jean Liquier, J Lemaire, Jean Pierre Schermann, Charles Desfrançoi. Experimental observation of the transition between gas-phase and aqueous solution structures for acetylcholine, nicotine, and muscarine ions. Journal of the American Chemical Society. vol 130. issue 12. 2008-05-27. PMID:18311975. |
experimental observation of the transition between gas-phase and aqueous solution structures for acetylcholine, nicotine, and muscarine ions. |
2008-05-27 |
2023-08-12 |
Not clear |
| Mahamadou Seydou, Gilles Grégoire, Jean Liquier, J Lemaire, Jean Pierre Schermann, Charles Desfrançoi. Experimental observation of the transition between gas-phase and aqueous solution structures for acetylcholine, nicotine, and muscarine ions. Journal of the American Chemical Society. vol 130. issue 12. 2008-05-27. PMID:18311975. |
structural information on acetylcholine and its two agonists, nicotine, and muscarine has been obtained from the interpretation of infrared spectra recorded in the gas-phase or in low ph aqueous solutions. |
2008-05-27 |
2023-08-12 |
Not clear |
| Ju Hyun Moon, Soo Yoon Kim, Hwan Goo Lee, Seung U Kim, Yong Beom Le. Activation of nicotinic acetylcholine receptor prevents the production of reactive oxygen species in fibrillar beta amyloid peptide (1-42)-stimulated microglia. Experimental & molecular medicine. vol 40. issue 1. 2008-05-01. PMID:18305393. |
recent studies have reported that the cholinergic anti-inflammatory pathway regulates peripheral inflammatory responses via alpha7 nicotinic acetylcholine receptors (alpha7 nachrs) and that acetylcholine and nicotine regulate the expression of proinflammatory mediators such as tnf-alpha and prostaglandin e2 in microglial cultures. |
2008-05-01 |
2023-08-12 |
Not clear |
| U Masko. The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology. British journal of pharmacology. vol 153 Suppl 1. 2008-04-28. PMID:18223661. |
the anatomy, physiology, functional and pathological implications of these interactions with the nicotinic subtype of acetylcholine receptors (nachrs) are discussed with a view of the important role of the mpt as a master regulator of nicotinic dopaminergic signalling in the brain, including for nicotine addiction. |
2008-04-28 |
2023-08-12 |
Not clear |
| K J Jackson, B R Martin, J P Changeux, M I Dama. Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs. The Journal of pharmacology and experimental therapeutics. vol 325. issue 1. 2008-04-22. PMID:18184829. |
the effects of nicotine withdrawal are mediated through nicotinic acetylcholine receptors (nachrs); however, the role of nachrs in nicotine withdrawal remains unclear. |
2008-04-22 |
2023-08-12 |
mouse |
| O M Vol'pina, T D Volkova, M A Titova, Iu G Gershovich, N I medvinskaia, A N Samokhin, A V Kamynina, V S Shalgunov, D O Koroev, M P Filatova, M B Oboznaia, N V Bobkov. [New approaches to the immunotherapy of Alzheimer's disease with the synthetic fragments of alpha7 subunit of the acetylcholine receptor]. Bioorganicheskaia khimiia. vol 34. issue 1. 2008-04-17. PMID:18365737. |
the effect of immunization with the synthetic fragments of the alpha7 subunit of the acetylcholine nicotine receptor on the spatial memory of mice subjected to olfactory bulbectomy, which causes the development of the neuro-degenetrative disease of alzheimer's type, was studied. |
2008-04-17 |
2023-08-12 |
mouse |
| Lorise C Gahring, Amber V Osborne-Hereford, Gustavo A Vasquez-Opazo, Scott W Roger. Tumor necrosis factor alpha enhances nicotinic receptor up-regulation via a p38MAPK-dependent pathway. The Journal of biological chemistry. vol 283. issue 2. 2008-03-20. PMID:17977823. |
a response by key neuronal nicotinic acetylcholine receptors (nachrs) to sustained nicotine exposure is up-regulation. |
2008-03-20 |
2023-08-12 |
Not clear |
| Joanna S Zeiger, Brett C Haberstick, Isabel Schlaepfer, Allan C Collins, Robin P Corley, Thomas J Crowley, John K Hewitt, Christian J Hopfer, Jeffrey Lessem, Matthew B McQueen, Soo Hyun Rhee, Marissa A Ehringe. The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco. Human molecular genetics. vol 17. issue 5. 2008-03-14. PMID:18055561. |
neuronal nicotinic acetylcholine receptors have been implicated in various measures of nicotine dependence. |
2008-03-14 |
2023-08-12 |
human |
| Ming-Huan Chan, Yu-Chi Tang, Te-Hsiung Chien, Hwei-Hsien Che. Toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome. Toxicological sciences : an official journal of the Society of Toxicology. vol 101. issue 2. 2008-03-07. PMID:17951610. |
toluene exposure during the brain growth spurt reduced behavioral responses to nicotine in young adult rats: a potential role for nicotinic acetylcholine receptors in fetal solvent syndrome. |
2008-03-07 |
2023-08-12 |
rat |
| Pao-Yun Cheng, Yen-Mei Lee, Kwok-Keung Law, Chia-Wei Lin, Mao-Hsiung Ye. The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro. Biochemical pharmacology. vol 74. issue 12. 2008-02-27. PMID:17869227. |
in addition, nicotine was able to activate ampkalpha phosphorylation in macrophages and this effect was mediated through nicotinic acetylcholine receptors. |
2008-02-27 |
2023-08-12 |
rat |
| Yann S Mineur, Marina R Picciott. Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochemical pharmacology. vol 75. issue 1. 2008-02-26. PMID:17632086. |
genetics of nicotinic acetylcholine receptors: relevance to nicotine addiction. |
2008-02-26 |
2023-08-12 |
mouse |
| Xuesi M Shao, Wenbin Tan, Joanne Xiu, Nyssa Puskar, Carlos Fonck, Henry A Lester, Jack L Feldma. Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 2. 2008-02-08. PMID:18184794. |
acetylcholine and nicotine can modulate respiratory patterns by acting on nicotinic acetylcholine receptors (nachrs) in the prebötzinger complex (prebötc). |
2008-02-08 |
2023-08-12 |
mouse |
| Diane L Carlisle, Xuwan Liu, Toni M Hopkins, Michelle C Swick, Rajiv Dhir, Jill M Siegfrie. Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulmonary pharmacology & therapeutics. vol 20. issue 6. 2008-01-29. PMID:17015027. |
nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. |
2008-01-29 |
2023-08-12 |
Not clear |
| Diane L Carlisle, Xuwan Liu, Toni M Hopkins, Michelle C Swick, Rajiv Dhir, Jill M Siegfrie. Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulmonary pharmacology & therapeutics. vol 20. issue 6. 2008-01-29. PMID:17015027. |
nicotinic acetylcholine receptors (nachr) are expressed on non-neuronal cell types, including normal bronchial epithelial cells, and nicotine has been reported to cause akt activation in cultured normal airway cells. |
2008-01-29 |
2023-08-12 |
Not clear |
| Diane L Carlisle, Xuwan Liu, Toni M Hopkins, Michelle C Swick, Rajiv Dhir, Jill M Siegfrie. Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulmonary pharmacology & therapeutics. vol 20. issue 6. 2008-01-29. PMID:17015027. |
nicotine may play a role in regulating survival of nsclc cells and endogenous acetylcholine released locally in the lung and/or chronic nicotine exposure might play a role in nsclc development. |
2008-01-29 |
2023-08-12 |
Not clear |
| Nadine Kabbani, Matthew P Woll, Robert Levenson, Jon M Lindstrom, Jean-Pierre Changeu. Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18077321. |
nicotine acetylcholine receptors (nachrs) comprise a family of ligand-gated channels widely expressed in the mammalian brain. |
2008-01-28 |
2023-08-12 |
mouse |
| Stephen T Hansen, Gregory P Mar. The nicotinic acetylcholine receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access. Psychopharmacology. vol 194. issue 1. 2008-01-23. PMID:17530475. |
nicotine and cocaine are commonly coabused drugs in humans and recent work in animals suggests that activation of nicotinic acetylcholine receptors (nachr) can increase cocaine self-administration. |
2008-01-23 |
2023-08-12 |
human |
| H van Bronswijk, E A Dubois, F G Zitman, A F Cohe. [New drugs; varenicline]. Nederlands tijdschrift voor geneeskunde. vol 151. issue 45. 2008-01-22. PMID:18062594. |
the effect of nicotine is mediated via nicotinergic acetylcholine receptors of the alpha4beta2 subtype ofwhich varenicline is a partial agonist. |
2008-01-22 |
2023-08-12 |
Not clear |
| Guangrong Zheng, Sangeetha P Sumithran, Agripina G Deaciuc, Linda P Dwoskin, Peter A Crook. Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & medicinal chemistry letters. vol 17. issue 24. 2008-01-18. PMID:17977723. |
a series of tris-azaaromatic quaternary ammonium salts has been synthesized and evaluated for their ability to inhibit neuronal nicotinic acetylcholine receptors (nachrs) mediating nicotine-evoked [(3)h]dopamine release from superfused rat striatal slices and for inhibition of [(3)h]nicotine and [(3)h]methyllycaconitine binding to whole rat brain membranes. |
2008-01-18 |
2023-08-12 |
rat |