| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deanna L Kelly, Robert P McMahon, Elaine Weiner, Douglas L Boggs, Dwight Dickinson, Robert R Conley, Robert W Buchana. Lack of beneficial galantamine effect for smoking behavior: a double-blind randomized trial in people with schizophrenia. Schizophrenia research. vol 103. issue 1-3. 2008-09-26. PMID:18550339. |
galantamine is an acetylcholinesterase inhibitor that acts as a positive allosteric modulator of nicotine acetylcholine receptors including both the alpha4beta2 and alpha7 subunits. |
2008-09-26 |
2023-08-12 |
human |
| Edgar Buhl, Klaus Schildberger, Paul A Stevenso. A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight. The Journal of experimental biology. vol 211. issue Pt 14. 2008-09-25. PMID:18587129. |
in deafferented locusts, fictive flight was initiated by bath application of the muscarinic agonist pilocarpine, the acetylcholine analogue carbachol, and the acetylcholinesterase blocker eserine, but not by nicotine. |
2008-09-25 |
2023-08-12 |
Not clear |
| Sameera M Kassam, Patrick M Herman, Nathalie M Goodfellow, Nyresa C Alves, Evelyn K Lamb. Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 35. 2008-09-18. PMID:18753377. |
a level of nicotine similar to that found in the blood of smokers elicits a stable inward current in layer vi neurons, yet this exposure desensitizes approximately 50% of the subsequent current elicited by acetylcholine. |
2008-09-18 |
2023-08-12 |
rat |
| Menahem B Doura, Allison B Gold, Ashleigh B Keller, David C Perr. Adult and periadolescent rats differ in expression of nicotinic cholinergic receptor subtypes and in the response of these subtypes to chronic nicotine exposure. Brain research. vol 1215. 2008-09-04. PMID:18474362. |
chronic nicotine exposure alters expression of nicotinic acetylcholine receptors (nachrs), changing the pattern of nicotine responsiveness. |
2008-09-04 |
2023-08-12 |
rat |
| Sevil Ozger Ilhan, Yusuf Sarioglu, Ismail Mert Vural, Ergin Dileköz, Gökçe Sevim Oztürk, Zeynep Sevim Erca. Hydrogen peroxide and antioxidizing enzymes involved in modulation of transient facilitatory effects of nicotine on neurogenic contractile responses in rat gastric fundus. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18455720. |
nicotine acts as an agonist of nicotinic acetylcholine receptors. |
2008-08-25 |
2023-08-12 |
rat |
| Pingfang Song, Harmanjatinder S Sekhon, Xiao Wen Fu, Michelle Maier, Yibing Jia, Jie Duan, Becky J Proskosil, Courtney Gravett, Jon Lindstrom, Gregory P Mark, Saurabh Saha, Eliot R Spinde. Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer research. vol 68. issue 12. 2008-08-18. PMID:18559515. |
the binding of exogenous nicotine to nicotinic acetylcholine (ach) receptors (nachr) and the binding of endogenous ach to both nachr and muscarinic ach receptors (machr) stimulate growth of both small cell and non-small cell lung carcinomas. |
2008-08-18 |
2023-08-12 |
mouse |
| Caiping Mao, Xin Yuan, Hong Zhang, Juanxiu Lv, Junchang Guan, Liyan Miao, Linqi Chen, Yuying Zhang, Lubo Zhang, Zhice X. The effect of prenatal nicotine on mRNA of central cholinergic markers and hematological parameters in rat fetuses. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 5. 2008-07-31. PMID:18407449. |
this study determined the expression of choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), and high-affinity choline transporter (cht1) in the forebrain and hindbrain following chronic prenatal nicotine exposure in the rat fetus (maternal rats were subcutaneously injected with nicotine at different gestation periods). |
2008-07-31 |
2023-08-12 |
rat |
| Marina R Picciotto, Nii A Addy, Yann S Mineur, Darlene H Brunzel. It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress in neurobiology. vol 84. issue 4. 2008-07-30. PMID:18242816. |
it is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. |
2008-07-30 |
2023-08-12 |
Not clear |
| Marina R Picciotto, Nii A Addy, Yann S Mineur, Darlene H Brunzel. It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress in neurobiology. vol 84. issue 4. 2008-07-30. PMID:18242816. |
nicotine can both activate and desensitize/inactivate nicotinic acetylcholine receptors (nachrs). |
2008-07-30 |
2023-08-12 |
Not clear |
| Isabel R Schlaepfer, Nicole R Hoft, Allan C Collins, Robin P Corley, John K Hewitt, Christian J Hopfer, Jeffrey M Lessem, Matthew B McQueen, Soo Hyun Rhee, Marissa A Ehringe. The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biological psychiatry. vol 63. issue 11. 2008-07-16. PMID:18163978. |
one potential site of convergence of the nicotine and alcohol actions is the family of the neuronal nicotinic acetylcholine receptors. |
2008-07-16 |
2023-08-12 |
Not clear |
| Renza Roncarati, Tamara Seredenina, Brian Jow, Flora Jow, Silvia Papini, Angela Kramer, Hendrick Bothmann, John Dunlop, Georg C Terstappe. Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. Assay and drug development technologies. vol 6. issue 2. 2008-07-09. PMID:18471073. |
nicotine and acetylcholine induced rapid desensitizing currents with 50% effective concentration values of 14 and 37 microm, respectively, with agonist-evoked currents detected in approximately 75% of the cell population. |
2008-07-09 |
2023-08-12 |
human |
| George S Portugal, Justin W Kenney, Thomas J Goul. Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiology of learning and memory. vol 89. issue 2. 2008-07-03. PMID:17584502. |
beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. |
2008-07-03 |
2023-08-12 |
mouse |
| George S Portugal, Justin W Kenney, Thomas J Goul. Beta2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning. Neurobiology of learning and memory. vol 89. issue 2. 2008-07-03. PMID:17584502. |
however, the nicotinic acetylcholine receptors (nachr) that are involved in nicotine withdrawal deficits in contextual fear conditioning are unknown. |
2008-07-03 |
2023-08-12 |
mouse |
| Xinli Liu, Yechun Xu, Xicheng Wang, Francisco J Barrantes, Hualiang Jian. Unbinding of nicotine from the acetylcholine binding protein: steered molecular dynamics simulations. The journal of physical chemistry. B. vol 112. issue 13. 2008-06-26. PMID:18327929. |
unbinding of nicotine from the acetylcholine binding protein: steered molecular dynamics simulations. |
2008-06-26 |
2023-08-12 |
Not clear |
| Katsuji Kiuchi, Masato Matsuoka, Jenny C Wu, Raquel Lima e Silva, Muralitharan Kengatharan, Mary Verghese, Shinji Ueno, Katsutoshi Yokoi, Naw Htee Khu, John P Cooke, Peter A Campochiar. Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization. Investigative ophthalmology & visual science. vol 49. issue 4. 2008-06-24. PMID:18385094. |
acetylcholine is their endogenous ligand, but they are also stimulated by nicotine. |
2008-06-24 |
2023-08-12 |
Not clear |
| Theodore A Slotki. If nicotine is a developmental neurotoxicant in animal studies, dare we recommend nicotine replacement therapy in pregnant women and adolescents? Neurotoxicology and teratology. vol 30. issue 1. 2008-06-23. PMID:18380035. |
over the past two decades, animal models of prenatal nicotine exposure have demonstrated that nicotine is a neurobehavioral teratogen that disrupts brain development by preempting the natural, neurotrophic roles of acetylcholine. |
2008-06-23 |
2023-08-12 |
Not clear |
| Lyudmyla M Koval, Alla S Zverkova, Regis Grailhe, Yuriy N Utkin, Victor I Tsetlin, Sergiy V Komisarenko, Maryna V Sko. Nicotinic acetylcholine receptors alpha4beta2 and alpha7 regulate myelo- and erythropoiesis within the bone marrow. The international journal of biochemistry & cell biology. vol 40. issue 5. 2008-06-20. PMID:18083057. |
nicotine consumed upon smoking affects numerous physiological processes through nicotinic acetylcholine receptors, which mediate cholinergic regulation by the neuronal and endogenous acetylcholine. |
2008-06-20 |
2023-08-12 |
mouse |
| Li Jiang, Lorna W Rol. Facilitation of cortico-amygdala synapses by nicotine: activity-dependent modulation of glutamatergic transmission. Journal of neurophysiology. vol 99. issue 4. 2008-06-17. PMID:18272879. |
the basolateral nucleus of the amygdala (bla) receives cholinergic innervation from the basal forebrain and nicotine, via activation of neuronal nicotinic acetylcholine receptors (nachrs), can improve performance in amygdala-based learning tasks. |
2008-06-17 |
2023-08-12 |
mouse |
| Jirí Lindovský, Martina Kaniaková, Lucie Svobodová, Frantisek Vyskocil, Jan Krůse. Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors. Biochimica et biophysica acta. vol 1778. issue 4. 2008-06-09. PMID:18249185. |
the application of acetylcholine (ach), nicotine (nic), cytisine (cyt), carbamylcholine (cch) and epibatidine (epi) to cells clamped at -40 mv produced inward currents which displayed biphasic desensitization. |
2008-06-09 |
2023-08-12 |
rat |
| Norikazu Kiguchi, Takehiko Maeda, Mie Tsuruga, Akihiro Yamamoto, Chizuko Yamamoto, Masanobu Ozaki, Shiroh Kishiok. Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice. Brain research. vol 1189. 2008-06-02. PMID:18048009. |
nicotine is neuronal stimulating drug in the central nervous system and elicits various effects through nicotinic acetylcholine receptors. |
2008-06-02 |
2023-08-12 |
mouse |