| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marios Zouridakis, Paraskevi Zisimopoulou, Konstantinos Poulas, Socrates J Tzarto. Recent advances in understanding the structure of nicotinic acetylcholine receptors. IUBMB life. vol 61. issue 4. 2009-07-16. PMID:19319967. |
nicotinic acetylcholine receptors (nachrs), members of the cys-loop ligand-gated ion channels (lgics) superfamily, are involved in signal transduction upon binding of the neurotransmitter acetylcholine or exogenous ligands, such as nicotine. |
2009-07-16 |
2023-08-12 |
mouse |
| Y S Mineur, D H Brunzell, S R Grady, J M Lindstrom, J M McIntosh, M J Marks, S L King, M R Picciott. Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. Genes, brain, and behavior. vol 8. issue 3. 2009-07-14. PMID:19077117. |
high-affinity, beta2-subunit-containing (beta2*) nicotinic acetylcholine receptors (nachrs) are essential for nicotine reinforcement; however, these nachrs are found on both gamma-aminobutyric acid (gaba) and dopaminergic (da) neurons in the ventral tegmental area (vta) and also on terminals of glutamatergic and cholinergic neurons projecting from the pedunculopontine tegmental area and the laterodorsal tegmental nucleus. |
2009-07-14 |
2023-08-12 |
mouse |
| Sae Uchida, Harumi Hotta, Koichiro Kawashim. Long-term nicotine treatment reduces cerebral cortical vasodilation mediated by alpha4beta2-like nicotinic acetylcholine receptors in rats. European journal of pharmacology. vol 609. issue 1-3. 2009-07-13. PMID:19285493. |
long-term nicotine treatment reduces cerebral cortical vasodilation mediated by alpha4beta2-like nicotinic acetylcholine receptors in rats. |
2009-07-13 |
2023-08-12 |
rat |
| Jennifer B Dwyer, Susan C McQuown, Frances M Lesli. The dynamic effects of nicotine on the developing brain. Pharmacology & therapeutics. vol 122. issue 2. 2009-07-10. PMID:19268688. |
consistent with a dynamic developmental role for acetylcholine, exogenous nicotine produces effects that are unique to the period of exposure and that impact the developing structures regulated by acetylcholine at that time. |
2009-07-10 |
2023-08-12 |
human |
| Jennifer B Dwyer, Susan C McQuown, Frances M Lesli. The dynamic effects of nicotine on the developing brain. Pharmacology & therapeutics. vol 122. issue 2. 2009-07-10. PMID:19268688. |
here we present a review of the evidence, available from both the clinical literature and preclinical animal models, which suggests that the diverse effects of nicotine exposure are best evaluated in the context of regional and temporal expression patterns of nachrs during sensitive maturational periods, and disruption of the normal developmental influences of acetylcholine. |
2009-07-10 |
2023-08-12 |
human |
| Miriam Hernández-Morales, Jesús García-Colung. Effects of nicotine on K+ currents and nicotinic receptors in astrocytes of the hippocampal CA1 region. Neuropharmacology. vol 56. issue 6-7. 2009-07-07. PMID:19371581. |
nicotine, the main addictive substance in tobacco, interacts with muscle and neuronal nicotinic acetylcholine receptors (nachrs) that are also localized in astrocytes. |
2009-07-07 |
2023-08-12 |
rat |
| Xiao Wen Fu, Jon Lindstrom, Eliot R Spinde. Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. American journal of respiratory cell and molecular biology. vol 41. issue 1. 2009-06-25. PMID:19097990. |
nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. |
2009-06-25 |
2023-08-12 |
monkey |
| Laura Paleari, Eva Negri, Alessia Catassi, Michele Cilli, Denis Servent, Rolando D'Angelillo, Alfredo Cesario, Patrizia Russo, Massimo Fin. Inhibition of nonneuronal alpha7-nicotinic receptor for lung cancer treatment. American journal of respiratory and critical care medicine. vol 179. issue 12. 2009-06-23. PMID:19151195. |
studies strongly suggest that the nicotinic acetylcholine receptors for nicotine (nachrs) play a significant role in lung cancer predisposition and natural history. |
2009-06-23 |
2023-08-12 |
Not clear |
| D Delbro, A Westerlund, U Björklund, E Hansso. In inflammatory reactive astrocytes co-cultured with brain endothelial cells nicotine-evoked Ca(2+) transients are attenuated due to interleukin-1beta release and rearrangement of actin filaments. Neuroscience. vol 159. issue 2. 2009-06-17. PMID:19171179. |
the aim of this study was to investigate whether nicotine acetylcholine receptors (nachrs) are expressed in a more pronounced way in astrocytes co-cultured with microvascular endothelial cells from adult rat brain, compared with monocultured astrocytes, as a sign of a more developed signal transduction system. |
2009-06-17 |
2023-08-12 |
rat |
| Marimuthu Parthiban, Mohan Babu Rajasekaran, Suryanarayanarao Ramakumar, Piramanayagam Shanmughave. Molecular modeling of human pentameric alpha(7) neuronal nicotinic acetylcholine receptor and its interaction with its agonist and competitive antagonist. Journal of biomolecular structure & dynamics. vol 26. issue 5. 2009-06-15. PMID:19236104. |
agonists such as acetylcholine, nicotine, which are used in a diverse array of biological activities, such as enhancements of cognitive performances, were also docked with the theoretical model of human alpha(7)nachr. |
2009-06-15 |
2023-08-12 |
human |
| J D Raybuck, T J Goul. Nicotine withdrawal-induced deficits in trace fear conditioning in C57BL/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors. The European journal of neuroscience. vol 29. issue 2. 2009-06-12. PMID:19200240. |
nicotine withdrawal-induced deficits in trace fear conditioning in c57bl/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors. |
2009-06-12 |
2023-08-12 |
mouse |
| K G Common. Alpha4 containing nicotinic receptors are positioned to mediate postsynaptic effects on 5-HT neurons in the rat dorsal raphe nucleus. Neuroscience. vol 153. issue 3. 2009-06-08. PMID:18403129. |
nicotinic acetylcholine receptors containing the alpha4 and beta2 subunits constitute the most abundant high-affinity binding site of nicotine in the brain and are critical for the addictive qualities of nicotine. |
2009-06-08 |
2023-08-12 |
rat |
| Arthur L Brody, Mark A Mandelkern, Matthew R Costello, Anna L Abrams, David Scheibal, Judah Farahi, Edythe D London, Richard E Olmstead, Jed E Rose, Alexey G Mukhi. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. The international journal of neuropsychopharmacology. vol 12. issue 3. 2009-06-08. PMID:18706128. |
our group recently reported that smoking a regular cigarette (1.2-1.4 mg nicotine) resulted in 88% occupancy of brain alpha4beta2* nicotinic acetylcholine receptors (nachrs). |
2009-06-08 |
2023-08-12 |
Not clear |
| Roger L Papke, William R Kem, Ferenc Soti, Gretchen Y López-Hernández, Nicole A Horenstei. Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. The Journal of pharmacology and experimental therapeutics. vol 329. issue 2. 2009-05-22. PMID:19223664. |
activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. |
2009-05-22 |
2023-08-12 |
Not clear |
| Bernard Le Foll, Svetlana I Chefer, Alane S Kimes, Dean Shumway, Elliot A Stein, Alexey G Mukhin, Steven R Goldber. Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. Biological psychiatry. vol 65. issue 8. 2009-05-19. PMID:19095220. |
baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. |
2009-05-19 |
2023-08-12 |
Not clear |
| Bernard Le Foll, Svetlana I Chefer, Alane S Kimes, Dean Shumway, Elliot A Stein, Alexey G Mukhin, Steven R Goldber. Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. Biological psychiatry. vol 65. issue 8. 2009-05-19. PMID:19095220. |
the midbrain alpha4beta2* subtype of nicotinic acetylcholine receptors (nachrs) has been implicated in mediation of the reinforcing effects of nicotine responsible for dependence. |
2009-05-19 |
2023-08-12 |
Not clear |
| Xinan Xiu, Nyssa L Puskar, Jai A P Shanata, Henry A Lester, Dennis A Doughert. Nicotine binding to brain receptors requires a strong cation-pi interaction. Nature. vol 458. issue 7237. 2009-05-08. PMID:19252481. |
nicotine addiction begins with high-affinity binding of nicotine to acetylcholine (ach) receptors in the brain. |
2009-05-08 |
2023-08-12 |
Not clear |
| John P Cooke, Yohannes T Ghebremaria. Endothelial nicotinic acetylcholine receptors and angiogenesis. Trends in cardiovascular medicine. vol 18. issue 7. 2009-05-07. PMID:19232953. |
the receptors may be stimulated by endogenous agonists such as acetylcholine, or exogenous chemicals such as nicotine, to activate physiologic angiogenesis (such as in wound healing) or pathologic angiogenesis (such as retinal neovascularization or tumor angiogenesis). |
2009-05-07 |
2023-08-12 |
Not clear |
| Richard D Egleton, Kathleen C Brown, Piyali Dasgupt. Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases. Pharmacology & therapeutics. vol 121. issue 2. 2009-04-21. PMID:19063919. |
the pro-angiogenic activity of nicotine is mediated by nicotinic acetylcholine receptors, which have been found to be expressed on several types of cells in the vasculature like endothelial cells, smooth muscle cells and immune cells. |
2009-04-21 |
2023-08-12 |
Not clear |
| Christopher J Heath, Marina R Picciott. Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing. Neuropharmacology. vol 56 Suppl 1. 2009-04-15. PMID:18692078. |
consequently, we hypothesize that nicotinic acetylcholine receptors (nachrs) are important for setting and refining the strength of corticothalamic-thalamocortical loops during critical periods of development and that disruption of this process by developmental nicotine exposure can result in long-lasting dysregulation of sensory processing. |
2009-04-15 |
2023-08-12 |
Not clear |