| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming D Li, Qing Xu, Xiang-Yang Lou, Thomas J Payne, Tianhua Niu, Jennie Z M. Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 3. 2010-06-23. PMID:19859904. |
several previous genome-wide and targeted association studies revealed that variants in the chrna5-chrna3-chrnb4 (chrna5/a3/b4) gene cluster on chromosome 15 that encode the alpha5, alpha3, and beta4 subunits of the nicotinic acetylcholine receptors (nachrs) are associated with nicotine dependence (nd) in european americans (eas) or others of european origin. |
2010-06-23 |
2023-08-12 |
Not clear |
| Ravi K Pasumarthi, Jim Fade. Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20236223. |
stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. |
2010-06-15 |
2023-08-12 |
rat |
| Ravi K Pasumarthi, Jim Fade. Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20236223. |
here, we used in vivo microdialysis to determine the effect of acute systemic or local nicotine on glutamate, acetylcholine, and gaba efflux in the lh/pfa of rats. |
2010-06-15 |
2023-08-12 |
rat |
| Ravi K Pasumarthi, Jim Fade. Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20236223. |
local administration of nicotine significantly increased acetylcholine and glutamate, but not gaba, in the lh/pfa. |
2010-06-15 |
2023-08-12 |
rat |
| Ravi K Pasumarthi, Jim Fade. Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20236223. |
these data suggest that both acetylcholine and glutamate may mediate the effects of acute nicotine on the activity of hypothalamic neurons, including orexin/hypocretin cells. |
2010-06-15 |
2023-08-12 |
rat |
| Marcos Aldea, Mar Castillo, José Mulet, Salvador Sala, Manuel Criado, Francisco Sal. Role of the extracellular transmembrane domain interface in gating and pharmacology of a heteromeric neuronal nicotinic receptor. Journal of neurochemistry. vol 113. issue 4. 2010-06-15. PMID:20420581. |
we also show that mutations at these domains, particularly loop 2 of the alpha3 subunit, change the pharmacological profile of alpha3beta4 nachrs, decreasing nicotine's and increasing cytisine's effectiveness relative to acetylcholine. |
2010-06-15 |
2023-08-12 |
xenopus_laevis |
| R Wickströ. Effects of nicotine during pregnancy: human and experimental evidence. Current neuropharmacology. vol 5. issue 3. 2010-06-11. PMID:19305804. |
nicotine interacts with endogenous acetylcholine receptors in the brain and lung, and exposure during development interferes with normal neurotransmitter function, thus evoking neurodevelopmental abnormalities by disrupting the timing of neurotrophic actions. |
2010-06-11 |
2023-08-12 |
human |
| Lei Phillip Wang, Fei Li, Xiaoming Shen, Joe Z Tsie. Conditional knockout of NMDA receptors in dopamine neurons prevents nicotine-conditioned place preference. PloS one. vol 5. issue 1. 2010-05-20. PMID:20062537. |
it is known that nicotine triggers tobacco addiction by activating nicotine acetylcholine receptors (nachrs) in the midbrain dopaminergic reward system, primarily via the ventral tegmental area. |
2010-05-20 |
2023-08-12 |
mouse |
| Yousheng Jia, Yoshihiko Yamazaki, Sakura Nakauchi, Ken-Ichi Ito, Katumi Sumikaw. Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca2+ entry through non-alpha7 nicotinic acetylcholine receptors. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20113344. |
nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via ca2+ entry through non-alpha7 nicotinic acetylcholine receptors. |
2010-05-17 |
2023-08-12 |
Not clear |
| Yousheng Jia, Yoshihiko Yamazaki, Sakura Nakauchi, Ken-Ichi Ito, Katumi Sumikaw. Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca2+ entry through non-alpha7 nicotinic acetylcholine receptors. The European journal of neuroscience. vol 31. issue 3. 2010-05-17. PMID:20113344. |
because many interneurons in the hippocampus express nicotinic acetylcholine receptors (nachrs), we explored whether exposure to nicotine promotes ltp induction in these interneurons. |
2010-05-17 |
2023-08-12 |
Not clear |
| Cord M Brundage, Carla A Nelson, Barbara E Taylo. Cholinergic sensitivity of the developing bullfrog (Rana catesbeiana) does not explain vulnerability to chronic nicotine exposure. Advances in experimental medicine and biology. vol 669. 2010-05-14. PMID:20217330. |
this would suggest that the developmental increase in nicotine sensitivity does not enhance vulnerability to chronic exposure, and that acute nicotine acts via endogenous acetylcholine pathways to depress neuroventilation and hypercapnic drive. |
2010-05-14 |
2023-08-12 |
Not clear |
| Cecilia Gotti, Stefania Guiducci, Vincenzo Tedesco, Silvia Corbioli, Lara Zanetti, Milena Moretti, Alessio Zanardi, Roberto Rimondini, Manolo Mugnaini, Francesco Clementi, Christian Chiamulera, Michele Zol. Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 15. 2010-05-14. PMID:20392953. |
nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement. |
2010-05-14 |
2023-08-12 |
rat |
| Vinay Parikh, Jinzhao Ji, Michael W Decker, Martin Sarte. Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203212. |
nicotine and, more robustly, selective agonists at alpha4beta2* nicotinic acetylcholine receptors (nachrs) enhance cue detection and attentional performance by augmenting prefrontal cholinergic activity. |
2010-05-05 |
2023-08-12 |
mouse |
| Donnie Eddins, Daniel Cerutti, Paul Williams, Elwood Linney, Edward D Levi. Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits. Neurotoxicology and teratology. vol 32. issue 1. 2010-04-22. PMID:19268529. |
to elucidate the contributions of nicotinic and muscarinic acetylcholine receptors to developmental cpf-mediated effects, the effects of developmental nicotine and pilocarpine exposure throughout the first five days after fertilization were determined. |
2010-04-22 |
2023-08-12 |
rat |
| Edward D Levin, Amir H Rezvani, Yingxian Xiao, Susan Slade, Marty Cauley, Corinne Wells, Dawn Hampton, Ann Petro, Jed E Rose, Milton L Brown, Mikell A Paige, Brian E McDowell, Kenneth J Kella. Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. The Journal of pharmacology and experimental therapeutics. vol 332. issue 3. 2010-04-13. PMID:20007754. |
in addition to activating nicotinic acetylcholine receptors, nicotine also desensitizes them. |
2010-04-13 |
2023-08-12 |
rat |
| Eva Drews, Andreas Zimme. Modulation of alcohol and nicotine responses through the endogenous opioid system. Progress in neurobiology. vol 90. issue 1. 2010-04-06. PMID:19800387. |
nicotine specifically activates ligand-gated ion channels in the brain, which are normally gated by acetylcholine, while alcohol interacts with various neurotransmitter receptors. |
2010-04-06 |
2023-08-12 |
Not clear |
| Gokce Sevim Ozturk Fincan, Ismail Mert Vural, Zeynep Sevim Ercan, Yusuf Sariogl. Enhancement effects of nicotine on neurogenic relaxation responses in the corpus cavernosum in rabbits: the role of nicotinic acetylcholine receptor subtypes. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19878666. |
nicotine acts as an agonist of nicotinic acetylcholine receptors, which belong to a superfamily of neurotransmitter-gated ion channels. |
2010-04-05 |
2023-08-12 |
rabbit |
| Gokce Sevim Ozturk Fincan, Ismail Mert Vural, Zeynep Sevim Ercan, Yusuf Sariogl. Enhancement effects of nicotine on neurogenic relaxation responses in the corpus cavernosum in rabbits: the role of nicotinic acetylcholine receptor subtypes. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19878666. |
we previously demonstrated that nicotine increases the electrical field stimulation (efs)-evoked nitrergic relaxation responses via activation of nicotinic acetylcholine receptors. |
2010-04-05 |
2023-08-12 |
rabbit |
| Anna L B Jacob-Ferreira, Ana C T Palei, Stefany B Cau, Heitor Moreno, Marcio L L Martinez, Tatiane C Izidoro-Toledo, Raquel F Gerlach, Jose E Tanus-Santo. Evidence for the involvement of matrix metalloproteinases in the cardiovascular effects produced by nicotine. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19879865. |
nicotine impaired of the endothelium-dependent responses to acetylcholine, and treatment with doxycycline increased the potency (pd2) by approximately 25% (p<0.05). |
2010-04-05 |
2023-08-12 |
rat |
| Thomas McCormack, Robert M Petrovich, Kelly A Mercier, Eugene F DeRose, Matthew J Cuneo, Jason Williams, Katina L Johnson, Patricia W Lamb, Robert E London, Jerrel L Yake. Identification and functional characterization of a novel acetylcholine-binding protein from the marine annelid Capitella teleta. Biochemistry. vol 49. issue 10. 2010-03-25. PMID:20136097. |
nmr experiments show that acetylcholine, nicotine, and alpha-bungarotoxin bind to ct-achbp with high affinity, with k(d) values of 28.7 microm, 209 nm, and 110 nm, respectively. |
2010-03-25 |
2023-08-12 |
Not clear |