| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcelo O Ortells, Hugo R Aria. Neuronal networks of nicotine addiction. The international journal of biochemistry & cell biology. vol 42. issue 12. 2011-04-01. PMID:20833261. |
nicotine is the main psychoactive substance present in tobacco, targeting neuronal nicotinic acetylcholine receptors. |
2011-04-01 |
2023-08-12 |
Not clear |
| Rachel E Penton, Michael W Quick, Robin A J Leste. Short- and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 7. 2011-04-01. PMID:21325526. |
re-exposure to nicotine in vitro restores hippocampal function to control levels via activation of high-affinity nicotinic acetylcholine receptors after 1 d of withdrawal, but not at times >4 weeks. |
2011-04-01 |
2023-08-12 |
rat |
| Mee Wah Lo, Kenjiro Matsumoto, Masumi Iwai, Kimihito Tashima, Mariko Kitajima, Syunji Horie, Hiromitsu Takayam. Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum. Journal of natural medicines. vol 65. issue 1. 2011-03-31. PMID:21042867. |
on the other hand, the iboga-type alkaloids did not inhibit the contractions induced by 3 μm acetylcholine and 300 μm nicotine. |
2011-03-31 |
2023-08-12 |
mouse |
| Piyali Dasgupta, Wasia Rizwani, Smitha Pillai, Rebecca Davis, Sarmistha Banerjee, Kevin Hug, Mark Lloyd, Domenico Coppola, Eric Haura, Srikumar P Chellappa. ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. Journal of the National Cancer Institute. vol 103. issue 4. 2011-03-28. PMID:21212384. |
nicotine induces the proliferation of non-small cell lung cancer (nsclc) cells via nicotinic acetylcholine receptors and the arrestin, β1 (arrb1) protein. |
2011-03-28 |
2023-08-12 |
human |
| Ryoji Kawahara, Masashi Yasuda, Hiroshi Hashimura, Kikuko Amagase, Shinichi Kato, Koji Takeuch. Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20969854. |
nicotine (0.3-3mg/kg) and pnu-282987 (a selective agonist of α7 nicotinic acetylcholine receptors; 1-10mg/kg) were administered i.p. |
2011-03-24 |
2023-08-12 |
mouse |
| Ryoji Kawahara, Masashi Yasuda, Hiroshi Hashimura, Kikuko Amagase, Shinichi Kato, Koji Takeuch. Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20969854. |
twice, at 0.5h before and 8h after indomethacin treatment, while methyllycaconitine (a selective antagonist of α7 nicotinic acetylcholine receptors; 10mg/kg was administered twice, at 0.5h before each nicotine treatment. |
2011-03-24 |
2023-08-12 |
mouse |
| Ching-Shyang Chen, Chia-Hwa Lee, Chang-Da Hsieh, Chi-Tang Ho, Min-Hsiung Pan, Ching-Shui Huang, Shih-Hsin Tu, Ying-Jan Wang, Li-Ching Chen, Yu-Jia Chang, Po-Li Wei, Yi-Yuan Yang, Chih-Hsiung Wu, Yuan-Soon H. Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast cancer research and treatment. vol 125. issue 1. 2011-03-21. PMID:20229177. |
previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (nic) through nicotinic acetylcholine receptors increases cyclin d1 promoter activity and protein expression. |
2011-03-21 |
2023-08-12 |
mouse |
| Xiao Wen Fu, Kelsey Wood, Eliot R Spinde. Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. American journal of respiratory cell and molecular biology. vol 44. issue 2. 2011-03-14. PMID:20448051. |
nicotinic acetylcholine receptors (nachrs) expressed in bronchial epithelial cells (becs) mediate the effects of nicotine on lung development and function. |
2011-03-14 |
2023-08-12 |
monkey |
| Daniel Bertran. Neurocircuitry of the nicotinic cholinergic system. Dialogues in clinical neuroscience. vol 12. issue 4. 2011-03-08. PMID:21319492. |
the natural alkaloid nicotine contained in tobacco leaves acts as an agonist with a subclass of acetylcholine receptors, and provides an interesting tool to approach brain functions. |
2011-03-08 |
2023-08-12 |
Not clear |
| Yann S Mineur, Marina R Picciott. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends in pharmacological sciences. vol 31. issue 12. 2011-03-04. PMID:20965579. |
nicotine in tobacco binds, activates and desensitizes nicotinic acetylcholine receptors (nachrs), but it is not known whether activation or desensitization is more important for the effects of nicotine on depressive symptoms. |
2011-03-04 |
2023-08-12 |
Not clear |
| Yann S Mineur, Marina R Picciott. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends in pharmacological sciences. vol 31. issue 12. 2011-03-04. PMID:20965579. |
the endogenous neurotransmitter for nachrs is acetylcholine, and the effects of nicotine on depression-like behaviors support the idea that dysregulation of the cholinergic system might contribute to the etiology of major depressive disorder. |
2011-03-04 |
2023-08-12 |
Not clear |
| Junran Cao, James D Belluzzi, Sandra E Loughlin, Jasmin M Dao, Yiling Chen, Frances M Lesli. Locomotor and stress responses to nicotine differ in adolescent and adult rats. Pharmacology, biochemistry, and behavior. vol 96. issue 1. 2011-02-23. PMID:20423718. |
the unique responses of adolescents to nicotine are consistent with an immature function of nicotinic acetylcholine receptors at this age. |
2011-02-23 |
2023-08-12 |
rat |
| Fernando Berrendero, Patricia Robledo, José Manuel Trigo, Elena Martín-García, Rafael Maldonad. Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neuroscience and biobehavioral reviews. vol 35. issue 2. 2011-02-17. PMID:20170672. |
the adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role in the establishment of dependence. |
2011-02-17 |
2023-08-12 |
Not clear |
| Christopher J Heath, Sarah L King, Cecilia Gotti, Michael J Marks, Marina R Picciott. Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through α4/β2/α5 nicotinic acetylcholine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 12. 2011-02-16. PMID:20736992. |
cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through α4/β2/α5 nicotinic acetylcholine receptors. |
2011-02-16 |
2023-08-12 |
mouse |
| D Bai, H Erdbrugger, H Breer, D B Sattell. Acetylcholine receptors of thoracic dorsal midline neurones in the cockroach, Periplaneta Americana. Archives of insect biochemistry and physiology. vol 21. issue 4. 2011-02-15. PMID:21313780. |
the actions of acetylcholine and cholinergic ligands have been studied using dorsal midline neurones from the rnetathoracic ganglion of the cockroach periplaneta americana.both nicotine and oxotremorine depolarized dorsal midline neuronal cell bodies.dose-response curves for nicotine and oxotremorine saturated at different levels. |
2011-02-15 |
2023-08-12 |
Not clear |
| A Anuvarbekova, G S O Fincan, I M Vural, S I Ozger, Z S Ercan, T Utkan, Y Sariogl. Investigation of enhancement effects of nicotine on cholinergic neurotransmission in isolated rabbit gastric fundus: role of antioxidants. Autonomic & autacoid pharmacology. vol 30. issue 3. 2011-02-14. PMID:20085573. |
nicotine having influence on the neuronal acetylcholine receptors (nachrs) increases release of most certain neurotransmitters from the nerve endings. |
2011-02-14 |
2023-08-12 |
rabbit |
| A Anuvarbekova, G S O Fincan, I M Vural, S I Ozger, Z S Ercan, T Utkan, Y Sariogl. Investigation of enhancement effects of nicotine on cholinergic neurotransmission in isolated rabbit gastric fundus: role of antioxidants. Autonomic & autacoid pharmacology. vol 30. issue 3. 2011-02-14. PMID:20085573. |
in addition, we aimed to investigate the interaction between release of acetylcholine, induced by nicotine, and the effects of reactive oxygen species. |
2011-02-14 |
2023-08-12 |
rabbit |
| Jill E MacLeod, Megan M Vucovich, David J Bucc. Differential effects of nicotinic acetylcholine receptor stimulation on negative occasion setting. Behavioral neuroscience. vol 124. issue 5. 2011-02-09. PMID:20939665. |
the goal of the present study was to identify the behavioral mechanism through which nicotine affects this form of learning, and to determine which subtype(s) of nicotinic acetylcholine receptors mediate the effects of nicotine. |
2011-02-09 |
2023-08-12 |
rat |
| Iku Tsutsui-Kimura, Yu Ohmura, Takeshi Izumi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshiok. Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats. European journal of pharmacology. vol 641. issue 2-3. 2011-01-31. PMID:20639140. |
nicotine has been well established as an impulsive action-inducing agent, but it remains unknown whether endogenous acetylcholine affects impulsive action via nicotinic acetylcholine receptors. |
2011-01-31 |
2023-08-12 |
rat |
| Alexander Kuryatov, Wade Berrettini, Jon Lindstro. Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function. Molecular pharmacology. vol 79. issue 1. 2011-01-13. PMID:20881005. |
genomic studies have identified a d398n variation in the α5 subunit of nicotinic acetylcholine receptors (achrs) that increases risk of nicotine dependence and lung cancer. |
2011-01-13 |
2023-08-12 |
Not clear |