| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Nasehi, Fatemeh Mafi, Shahrbanoo Oryan, Sima Nasri, Mohammad Reza Zarrindas. The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response. Pharmacology, biochemistry, and behavior. vol 98. issue 3. 2011-07-28. PMID:21354200. |
nicotine, an active alkaloid of tobacco has an acetylcholine property that alters anxiety-like behaviors in rodents. |
2011-07-28 |
2023-08-12 |
mouse |
| Shafiqur Rahma. Brain nicotinic receptors as emerging targets for drug addiction: neurobiology to translational research. Progress in molecular biology and translational science. vol 98. 2011-07-27. PMID:21199776. |
a growing body of preclinical and clinical evidence suggests that mammalian brain nicotinic acetylcholine receptors (nachrs), the heterogeneous family of ion channels, play a pivotal role in drug addiction, including nicotine and alcohol dependence. |
2011-07-27 |
2023-08-12 |
Not clear |
| Sandeep Singh, Smitha Pillai, Srikumar Chellappa. Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. Journal of oncology. vol 2011. 2011-07-14. PMID:21541211. |
these effects of nicotine are mediated through the nicotinic acetylcholine receptors that are expressed on a variety of neuronal and nonneuronal cells. |
2011-07-14 |
2023-08-12 |
human |
| Sandeep Singh, Smitha Pillai, Srikumar Chellappa. Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. Journal of oncology. vol 2011. 2011-07-14. PMID:21541211. |
this paper examines the historical data connecting nicotine tumor progression and the recent efforts to target the nicotinic acetylcholine receptors to combat cancer. |
2011-07-14 |
2023-08-12 |
human |
| Rubing Zhao-Shea, Liwang Liu, Lindsey G Soll, Ma Reina Improgo, Erin E Meyers, J Michael McIntosh, Sharon R Grady, Michael J Marks, Paul D Gardner, Andrew R Tappe. Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 5. 2011-07-13. PMID:21289604. |
nicotine activation of nicotinic acetylcholine receptors (nachrs) within the dopaminergic (daergic) neuron-rich ventral tegmental area (vta) is necessary and sufficient for nicotine reinforcement. |
2011-07-13 |
2023-08-12 |
mouse |
| Helene Dederer, Margaret Werr, Thomas Il. Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor α1 and α2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides. Insect biochemistry and molecular biology. vol 41. issue 1. 2011-06-29. PMID:20933086. |
nicotinic acetylcholine receptors (nachrs) are the binding sites for nicotinoid drugs, such as nicotine and epibatidine, and are the molecular targets of the selectively insecticidal neonicotinoids. |
2011-06-29 |
2023-08-12 |
cat |
| Helene Dederer, Margaret Werr, Thomas Il. Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor α1 and α2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides. Insect biochemistry and molecular biology. vol 41. issue 1. 2011-06-29. PMID:20933086. |
particularly remarkable was the finding that cfα1/ggβ2 was far more sensitive to acetylcholine, nicotine and neonicotinoid agonists than either cfα2/ggβ2 or ggα4/ggβ2: for the anti flea neonicotinoid market compound imidacloprid the respective ec₅₀s were 0.02 μm, 1.31 μm and 10 μm. |
2011-06-29 |
2023-08-12 |
cat |
| Helen M Kamens, Jimena Andersen, Marina R Picciott. Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. Psychopharmacology. vol 208. issue 4. 2011-06-21. PMID:20072781. |
nicotinic acetylcholine receptors (nachrs) in the mesolimbic dopamine system are important in mediating nicotine response, and several studies suggest that alcohol may also interact with these nachrs. |
2011-06-21 |
2023-08-12 |
mouse |
| Mario Marchi, Massimo Grill. Presynaptic nicotinic receptors modulating neurotransmitter release in the central nervous system: functional interactions with other coexisting receptors. Progress in neurobiology. vol 92. issue 2. 2011-06-01. PMID:20558239. |
the understanding of these interactions may allow a better evaluation not only of the pharmacological effects of nicotine, but also of the normal physiological role of the natural neurotransmitter acetylcholine. |
2011-06-01 |
2023-08-12 |
Not clear |
| Ma Reina D Improgo, Michael D Scofield, Andrew R Tapper, Paul D Gardne. The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Progress in neurobiology. vol 92. issue 2. 2011-06-01. PMID:20685379. |
nicotine addiction is initiated by the binding of nicotine to nicotinic acetylcholine receptors, ligand-gated cation channels activated by the endogenous neurotransmitter, acetylcholine. |
2011-06-01 |
2023-08-12 |
Not clear |
| Ying-Feng Liu, Xin Ge, Ling-Ying Wen, Xiao-Jing Wan. Targeting nicotinic acetylcholine receptor to treat smoking-related periodontitis. Medical hypotheses. vol 76. issue 2. 2011-05-23. PMID:21041033. |
nicotine, the major component in tobacco smoke, has been considered playing an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nachrs) expressed by non-neuronal cells. |
2011-05-23 |
2023-08-12 |
Not clear |
| Hua Yu, Ying-Hua Yang, Rajesh Rajaiah, Kamal D Moudgi. Nicotine-induced differential modulation of autoimmune arthritis in the Lewis rat involves changes in interleukin-17 and anti-cyclic citrullinated peptide antibodies. Arthritis and rheumatism. vol 63. issue 4. 2011-05-23. PMID:21305506. |
nicotine is a major component of cigarette smoke, and it stimulates the α7 nicotinic acetylcholine receptors. |
2011-05-23 |
2023-08-12 |
human |
| Christos Stergiou, Paraskevi Zisimopoulou, Socrates J Tzarto. Expression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits in the yeast Pichia pastoris: glycosylation is not required for ligand binding. The Journal of biological chemistry. vol 286. issue 11. 2011-05-16. PMID:21252231. |
in addition, (125)i-epibatidine binding was blocked by nicotine, cytisine, acetylcholine, and carbamylcholine with inhibition constants (k(i)) of 20.64, 3.24, 242, and 2,254 nm, respectively. |
2011-05-16 |
2023-08-12 |
human |
| Jessica M André, Prescott T Leach, Thomas J Goul. Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus. Neuropharmacology. vol 60. issue 4. 2011-05-12. PMID:21167848. |
nicotine ameliorates nmda receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus. |
2011-05-12 |
2023-08-12 |
mouse |
| Salvatore Lecca, Miriam Melis, Antonio Luchicchi, Maria Grazia Ennas, Maria Paola Castelli, Anna Lisa Muntoni, Marco Pisti. Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 3. 2011-05-09. PMID:21048703. |
conversely, nicotine robustly excited putative rmtg neurons and enhanced epscs, an effect mediated by α7-containing nicotinic acetylcholine receptors. |
2011-05-09 |
2023-08-12 |
rat |
| P Russo, A Cesario, S Rutella, G Veronesi, L Spaggiari, D Galetta, S Margaritora, P Granone, D S Greenber. Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment. Current medicinal chemistry. vol 18. issue 1. 2011-05-03. PMID:21110812. |
impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment. |
2011-05-03 |
2023-08-12 |
Not clear |
| Victoria Maneu, Guillermo Gerona, Laura Fernández, Nicolás Cuenca, Pedro La. Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells. Visual neuroscience. vol 27. issue 5-6. 2011-04-25. PMID:20932358. |
functional nachrs were studied by examining the ca2+ transients elicited by nicotine and acetylcholine stimulation in fura-2-loaded cells. |
2011-04-25 |
2023-08-12 |
rat |
| Victoria Maneu, Guillermo Gerona, Laura Fernández, Nicolás Cuenca, Pedro La. Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells. Visual neuroscience. vol 27. issue 5-6. 2011-04-25. PMID:20932358. |
a small subpopulation of rpe cultured cells showed functional nachrs, as evidenced by the selective response elicited by nicotine and acetylcholine stimulation. |
2011-04-25 |
2023-08-12 |
rat |
| Jill R Turner, Laura M Castellano, Julie A Blend. Parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 13. issue 1. 2011-04-14. PMID:21097981. |
parallel anxiolytic-like effects and upregulation of neuronal nicotinic acetylcholine receptors following chronic nicotine and varenicline. |
2011-04-14 |
2023-08-12 |
Not clear |
| Rahul Srinivasan, Rigo Pantoja, Fraser J Moss, Elisha D W Mackey, Cagdas D Son, Julie Miwa, Henry A Leste. Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. The Journal of general physiology. vol 137. issue 1. 2011-04-07. PMID:21187334. |
the up-regulation of α4β2* nicotinic acetylcholine receptors (nachrs) by chronic nicotine is a cell-delimited process and may be necessary and sufficient for the initial events of nicotine dependence. |
2011-04-07 |
2023-08-12 |
Not clear |