| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ma Reina Improgo, Andrew R Tapper, Paul D Gardne. Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21640716. |
nicotine contributes directly to lung carcinogenesis through the activation of nicotinic acetylcholine receptors (nachrs). |
2011-10-21 |
2023-08-12 |
Not clear |
| Luis M Tuesta, Christie D Fowler, Paul J Kenn. Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21740894. |
nicotine acts in the brain through the neuronal nicotinic acetylcholine receptors (nachrs). |
2011-10-21 |
2023-08-12 |
mouse |
| Jie Wu, Ronald J Luka. Naturally-expressed nicotinic acetylcholine receptor subtypes. Biochemical pharmacology. vol 82. issue 8. 2011-10-21. PMID:21787755. |
nicotinic acetylcholine receptors (nachrs) warrant attention, as they play many critical roles in brain and body function and have been implicated in a number of neurological and psychiatric disorders, including nicotine dependence. |
2011-10-21 |
2023-08-12 |
Not clear |
| Derek S Wilkinson, Thomas J Goul. The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21514327. |
galantamine is an acetylcholinesterase inhibitor and allosteric modulator of nicotinic acetylcholine receptors (nachrs) with cognitive enhancing effects that may alleviate cognitive deficits associated with nicotine withdrawal. |
2011-10-18 |
2023-08-12 |
mouse |
| Derek S Wilkinson, Thomas J Goul. The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21514327. |
the ability of galantamine to reverse nicotine withdrawal-deficits in contextual conditioning is likely mediated through enhanced levels of acetylcholine via inhibition of acetylcholinesterase, potentiation of hippocampal α4β2* nachrs, or both. |
2011-10-18 |
2023-08-12 |
mouse |
| Damien Toulorge, Serge Guerreiro, Audrey Hild, Uwe Maskos, Etienne C Hirsch, Patrick P Miche. Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 8. 2011-10-14. PMID:21507900. |
by a pharmacological approach, we demonstrated that the rise in ca(2+)(cyt) was necessary to sensitize dopamine neurons to the action of nicotine through a mechanism involving α-bungarotoxin-sensitive (presumably α7) nicotinic acetylcholine receptors (nachrs) and secondarily t-type voltage-gated calcium channels. |
2011-10-14 |
2023-08-12 |
mouse |
| H Wang, M I Dávila-García, W Yarl, M C Gondré-Lewi. Gestational nicotine exposure regulates expression of AMPA and NMDA receptors and their signaling apparatus in developing and adult rat hippocampus. Neuroscience. vol 188. 2011-10-12. PMID:21596105. |
untimely activation of nicotinic acetylcholine receptors (nachrs) by nicotine results in short- and long-term consequences on learning and behavior. |
2011-10-12 |
2023-08-12 |
rat |
| Qi Li, Hong Lei, Aijun Liu, Yili Yang, Dingfeng Su, Xia Li. The antishock effect of anisodamine requires the upregulation of α7 nicotine acetylcholine receptors by IL-10. Life sciences. vol 89. issue 11-12. 2011-10-12. PMID:21798271. |
the antishock effect of anisodamine requires the upregulation of α7 nicotine acetylcholine receptors by il-10. |
2011-10-12 |
2023-08-12 |
Not clear |
| Tresa M McGranahan, Natalie E Patzlaff, Sharon R Grady, Stephen F Heinemann, T K Booke. α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795541. |
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. |
2011-10-07 |
2023-08-12 |
mouse |
| Tresa M McGranahan, Natalie E Patzlaff, Sharon R Grady, Stephen F Heinemann, T K Booke. α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 30. 2011-10-07. PMID:21795541. |
nicotine is the primary psychoactive substance in tobacco, and it exerts its effects by interaction with various subtypes of nicotinic acetylcholine receptors (nachrs) in the brain. |
2011-10-07 |
2023-08-12 |
mouse |
| Benedict T Green, Kevin D Welch, Daniel Cook, Dale R Gardne. Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors. European journal of pharmacology. vol 662. issue 1-3. 2011-09-30. PMID:21554871. |
potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors. |
2011-09-30 |
2023-08-12 |
cattle |
| Benedict T Green, Kevin D Welch, Daniel Cook, Dale R Gardne. Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors. European journal of pharmacology. vol 662. issue 1-3. 2011-09-30. PMID:21554871. |
the aim of this study was to investigate the effects of mla alone and in combination with acetylcholine, epibatidine, nicotine, and neostigmine for actions other than receptor antagonism in te-671 cells expressing (α(1))(2)β(1)γδ nicotinic acetylcholine receptors. |
2011-09-30 |
2023-08-12 |
cattle |
| Benedict T Green, Kevin D Welch, Daniel Cook, Dale R Gardne. Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors. European journal of pharmacology. vol 662. issue 1-3. 2011-09-30. PMID:21554871. |
however at nanomolar concentrations, it acted as a co-agonist to potentiate te-671 cell responses to acetylcholine, epibatidine, nicotine, and neostigmine. |
2011-09-30 |
2023-08-12 |
cattle |
| Oleg Zaika, Jie Zhang, Mark S Shapir. Functional role of M-type (KCNQ) K⁺ channels in adrenergic control of cardiomyocyte contraction rate by sympathetic neurons. The Journal of physiology. vol 589. issue Pt 10. 2011-09-26. PMID:21486761. |
we excited the sns with nicotine, acting on nicotinic acetylcholine receptors, and monitored the increase in cr in the presence or absence of the specific m-channel opener retigabine, or agonists of bradykinin b2 or purinergic p2y receptors on the sns. |
2011-09-26 |
2023-08-12 |
mouse |
| Irina Esterlis, Effie M Mitsis, Jeffery C Batis, Frederic Bois, Marina R Picciotto, Stephanie M Stiklus, Tracy Kloczynski, Edward Perry, John P Seibyl, Sherry McKee, Julie K Staley, Kelly P Cosgrov. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The international journal of neuropsychopharmacology. vol 14. issue 3. 2011-09-19. PMID:21029513. |
the nicotrol® (pfizer, usa) nicotine inhaler reduces craving by mimicking the behavioural component of cigarettes and delivering controlled doses of nicotine, which binds to the beta-2 subunit-containing nicotinic acetylcholine receptors (β2*-nachrs). |
2011-09-19 |
2023-08-12 |
human |
| Virender K Rehan, Reiko Sakurai, John S Torda. Thirdhand smoke: a new dimension to the effects of cigarette smoke on the developing lung. American journal of physiology. Lung cellular and molecular physiology. vol 301. issue 1. 2011-08-31. PMID:21478255. |
fetal rat lung explants were exposed to nicotine, 1-(n-methyl-n-nitrosamino)-1-(3-pyridinyl)-4-butanal (nna), or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk), the two main tobacco-specific n-nitrosamine constituents of ths, for 24 h. we then determined key markers for alveolar paracrine signaling [epithelial differentiation markers surfactant phospholipid and protein synthesis; mesenchymal differentiation markers peroxisome proliferator-activated receptor γ (ppar-γ), fibronectin and calponin], the bcl-2-to-bax ratio (bcl-2/bax), a marker of apoptosis and the involvement of nicotinic acetylcholine receptors (nachr)-α3 and -α7 in mediating nna's and nnk's effects on the developing lung. |
2011-08-31 |
2023-08-12 |
rat |
| Ami P Rava. Nicotine addiction causes unique detrimental effects on women's brains. Journal of addictive diseases. vol 30. issue 2. 2011-08-18. PMID:21491296. |
nicotine addiction produces diverse physiological effects common to both men and women because of activation of the nicotinic acetylcholine receptors. |
2011-08-18 |
2023-08-12 |
Not clear |
| Jun Hu, Chenlei Zhu, Yuan Liu, Fang Wang, Zuhu Huang, Weimin Fan, Jie W. Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model. Neuroscience letters. vol 494. issue 3. 2011-08-17. PMID:21406211. |
nicotine, a potent agonist of nicotinic acetylcholine receptors (nachrs), excites midbrain dopaminergic neurons and this may contribute to the anti-parkinsonian effects. |
2011-08-17 |
2023-08-12 |
mouse |
| Eugeny M Volkov, Leniz F Nurullin, Michael E Volkov, Eugeny E Nikolsky, Frantisek Vyskoči. Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 158. issue 4. 2011-08-15. PMID:21184841. |
the nicotinic agonists acetylcholine (ach), carbacholine (cch) and nicotine depolarize the rmp at concentrations of 5 μm and higher. |
2011-08-15 |
2023-08-12 |
Not clear |
| Jeremy S Tang, Eugene A Kiyatki. Fluctuations in central and peripheral temperatures induced by intravenous nicotine: central and peripheral contributions. Brain research. vol 1383. 2011-08-02. PMID:21295014. |
nicotine (nic) is a highly addictive substance that interacts with different subtypes of nicotinic acetylcholine receptors widely distributed in the central and peripheral nervous systems. |
2011-08-02 |
2023-08-12 |
rat |