| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre Kuryatov, Jon Lindstro. Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers. Molecular pharmacology. vol 79. issue 1. 2011-01-13. PMID:20923852. |
α6β2β3* acetylcholine receptors (achrs) on dopaminergic neurons are important targets for drugs to treat nicotine addiction and parkinson's disease. |
2011-01-13 |
2023-08-12 |
human |
| Naoya Hirata, Yuko Sekino, Yasunari Kand. Nicotine increases cancer stem cell population in MCF-7 cells. Biochemical and biophysical research communications. vol 403. issue 1. 2011-01-13. PMID:21055391. |
in addition, the effect of nicotine was blocked by treatment with the α7 subunit-selective antagonist of nicotinic acetylcholine receptors (nachr) α-bungarotoxin. |
2011-01-13 |
2023-08-12 |
human |
| Jie W. Double target concept for smoking cessation. Acta pharmacologica Sinica. vol 31. issue 9. 2011-01-04. PMID:20711220. |
after cigarette smoking, nicotine quickly acts on its target, nicotinic acetylcholine receptors (nachrs), which are widely distributed throughout the mammalian central nervous system and are expressed as diverse subtypes on cell bodies, dendrites and/or nerve terminals. |
2011-01-04 |
2023-08-12 |
Not clear |
| Layla Azam, Uwe Maskos, Jean-Pierre Changeux, Cheryl D Dowell, Sean Christensen, Mariella De Biasi, J Michael McIntos. α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 12. 2011-01-04. PMID:20739611. |
α6* (asterisk indicates the presence of additional subunits) nicotinic acetylcholine receptors (nachrs) are broadly implicated in catecholamine-dependent disorders that involve attention, motor movement, and nicotine self-administration. |
2011-01-04 |
2023-08-12 |
mouse |
| Melissa N Symons, Julia Weng, Eric Diehl, Eileen Heo, Morgan L Kleiber, Shiva M Sing. Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice. Behavior genetics. vol 40. issue 5. 2011-01-03. PMID:20496163. |
a site of action for both nicotine and alcohol effects in the brain are neuronal nicotinic acetylcholine receptors (nachr). |
2011-01-03 |
2023-08-12 |
mouse |
| Hideaki Itoh, Yumiko Toyohira, Susumu Ueno, Satoru Saeki, Han Zhang, Yumi Furuno, Kojiro Takahashi, Masato Tsutsui, Kenji Hachisuka, Nobuyuki Yanagihar. Upregulation of norepinephrine transporter function by prolonged exposure to nicotine in cultured bovine adrenal medullary cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 382. issue 3. 2010-12-02. PMID:20676884. |
nicotine acts on nicotinic acetylcholine receptors in the adrenal medulla and brain, thereby stimulating the release of monoamines such as norepinephrine (ne). |
2010-12-02 |
2023-08-12 |
cattle |
| Ermelinda Lomazzo, Linda MacArthur, Robert P Yasuda, Barry B Wolfe, Kenneth J Kella. Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20796176. |
to determine if α4β2 and α4β2α5 nachr subtypes differ in their ligand binding affinities, the α3- and β4-containing receptors were first removed by immunoprecipitation and then, competition studies with acetylcholine, nicotine, cytisine and sazetidine-a against [(3)h]eb were carried out on the remaining α4β2 and α4β2α5 subtypes. |
2010-12-02 |
2023-08-12 |
rat |
| Jibran Y Khokhar, Sharon L Miksys, Rachel F Tyndal. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain research. vol 1348. 2010-11-09. PMID:20599831. |
rat brain cyp2b induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. |
2010-11-09 |
2023-08-12 |
human |
| Jibran Y Khokhar, Sharon L Miksys, Rachel F Tyndal. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain research. vol 1348. 2010-11-09. PMID:20599831. |
we characterized the time course of rat brain cyp2b induction by nicotine and determined if nicotinic acetylcholine receptors (nachrs) mediated this induction. |
2010-11-09 |
2023-08-12 |
human |
| M Westman, S Saha, M Morshed, J Lamp. Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity. Clinical and experimental immunology. vol 162. issue 1. 2010-10-29. PMID:20659128. |
lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity. |
2010-10-29 |
2023-08-12 |
mouse |
| Ping Hua, Wenguang Feng, Shaonin Ji, Leopoldo Raij, Edgar A Jaime. Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers. American journal of physiology. Renal physiology. vol 299. issue 4. 2010-10-26. PMID:20685820. |
we have previously reported that nicotine promotes mesangial cell proliferation and hypertrophy via activation of nonneuronal nicotinic acetylcholine receptors and that nicotine worsens renal injury in a model of acute glomerulonephritis (jaimes e, tian rx, raij l. am j physiol heart circ physiol 292: h76-h82, 2007; jaimes ea, tian rx, joshi m, raij l. am j nephrol 29: 319-326, 2009). |
2010-10-26 |
2023-08-12 |
mouse |
| Andrew T Seipel, Jerrel L Yake. The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the α7 nicotinic receptor. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20598018. |
the frequency dependence of the low dose nicotine inhibition therefore requires functional α7 nachrs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation. |
2010-10-19 |
2023-08-12 |
Not clear |
| Uwe Masko. Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors. Journal of neurochemistry. vol 114. issue 3. 2010-10-06. PMID:20477938. |
nicotinic acetylcholine receptors (nachrs) are pentameric membrane protein receptors activated by the addictive drug, nicotine. |
2010-10-06 |
2023-08-12 |
Not clear |
| Michiko Nakamura, Il-Sung Jan. Presynaptic nicotinic acetylcholine receptors enhance GABAergic synaptic transmission in rat periaqueductal gray neurons. European journal of pharmacology. vol 640. issue 1-3. 2010-10-04. PMID:20465999. |
this facilitatory action of acetylcholine disappeared in the presence of mecamylamine, a nonselective nicotinic receptor antagonist, and mimicked by nicotine, a nicotinic receptor agonist. |
2010-10-04 |
2023-08-12 |
rat |
| Michiko Nakamura, Il-Sung Jan. Presynaptic nicotinic acetylcholine receptors enhance GABAergic synaptic transmission in rat periaqueductal gray neurons. European journal of pharmacology. vol 640. issue 1-3. 2010-10-04. PMID:20465999. |
the results suggest that acetylcholine or nicotine acts presynaptic beta2-containing nicotinic receptors, presumably alpha4beta2 nicotinic receptors, to enhance spontaneous gaba release onto pag neurons. |
2010-10-04 |
2023-08-12 |
rat |
| M R D Improgo, M D Scofield, A R Tapper, P D Gardne. From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene. vol 29. issue 35. 2010-10-04. PMID:20581870. |
these receptors are activated by the neurotransmitter, acetylcholine, and the tobacco alkaloid, nicotine. |
2010-10-04 |
2023-08-12 |
Not clear |
| Matthis Geitmann, Kim Retra, Gerdien E de Kloe, Evert Homan, August B Smit, Iwan J P de Esch, U Helena Danielso. Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein. Biochemistry. vol 49. issue 37. 2010-10-04. PMID:20701394. |
the mechanism of agonist interactions with cys-loop ligand-gated ion channels has been studied using the acetylcholine-binding protein (achbp) from lymnaea stagnalis as a model protein and acetylcholine, nicotine, epibatidine, and a series of substituted quinuclidines as ligands. |
2010-10-04 |
2023-08-12 |
Not clear |
| Steeve Hervé Than. Electrophysiological studies and pharmacological properties of insect native nicotinic acetylcholine receptors. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737788. |
thus pressure application of agonists on cultured cells induced inward currents showing that acetylcholine and nicotine were partial agonists of some cells with a lower efficacy while they were full agonists in other neurons. |
2010-09-30 |
2023-08-12 |
Not clear |
| Angela P Blum, Henry A Lester, Dennis A Doughert. Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 30. 2010-09-27. PMID:20616056. |
nicotinic pharmacophore: the pyridine n of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone nh. |
2010-09-27 |
2023-08-12 |
Not clear |
| Angela P Blum, Henry A Lester, Dennis A Doughert. Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 30. 2010-09-27. PMID:20616056. |
a structure of nicotine bound to the acetylcholine binding protein predicted that the binding partner of the pharmacophore's second component was a water molecule, which also hydrogen bonds to the backbone of the complementary subunit of the receptors. |
2010-09-27 |
2023-08-12 |
Not clear |