| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela P Blum, Henry A Lester, Dennis A Doughert. Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 30. 2010-09-27. PMID:20616056. |
we find evidence for the hydrogen bond with the agonists nicotine, acetylcholine, carbamylcholine, and epibatidine. |
2010-09-27 |
2023-08-12 |
Not clear |
| Enric Carcereny, Jose Luis Ramirez, Maria Sanchez-Ronco, Dolores Isla, Manuel Cobo, Teresa Moran, Itziar de Aguirre, Tatsuro Okamoto, Jia Wei, Mariano Provencio, Guillermo Lopez-Vivanco, Carlos Camps, Manuel Domine, Vicente Alberola, Jose Miguel Sanchez, Bartomeu Massuti, Pedro Mendez, Miquel Taron, Rafael Rosel. Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients. Lung cancer (Amsterdam, Netherlands). vol 68. issue 3. 2010-09-21. PMID:19733931. |
nicotine acetylcholine receptors (nachrs) are associated with resistance to gemcitabine, cisplatin and paclitaxel in non-small-cell lung cancer (nsclc) cell lines. |
2010-09-21 |
2023-08-12 |
Not clear |
| Juan Andrés Abin-Carriquiry, Margot Paulino Zunini, Bruce K Cassels, Susan Wonnacott, Federico Daja. In silico characterization of cytisinoids docked into an acetylcholine binding protein. Bioorganic & medicinal chemistry letters. vol 20. issue 12. 2010-09-13. PMID:20493692. |
in the present work we docked cytisine, n-methylcytisine, and several pyridone ring-substituted cytisinoids into the crystallographic structure of the lymnaea stagnalis acetylcholine binding protein (achbp) co-crystallized with nicotine (1uw6). |
2010-09-13 |
2023-08-12 |
Not clear |
| Darlene H Brunzell, Karen E Boschen, Elizabeth S Hendrick, Patrick M Beardsley, J Michael McIntos. Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890263. |
alpha-conotoxin mii-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine. |
2010-09-07 |
2023-08-12 |
rat |
| Darlene H Brunzell, Karen E Boschen, Elizabeth S Hendrick, Patrick M Beardsley, J Michael McIntos. Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 3. 2010-09-07. PMID:19890263. |
beta2 subunit containing nicotinic acetylcholine receptors (beta2(*)nachrs; asterisk ((*)) denotes assembly with other subunits) are critical for nicotine self-administration and nicotine-associated dopamine (da) release that supports nicotine reinforcement. |
2010-09-07 |
2023-08-12 |
rat |
| A Lajtha, H Sershe. Nicotine: alcohol reward interactions. Neurochemical research. vol 35. issue 8. 2010-09-07. PMID:20499168. |
these opposing effects include those on locomotion, acetylcholine metabolism, nicotine binding, opiate peptides, glutamate transporters and endocannabinoid content among others. |
2010-09-07 |
2023-08-12 |
Not clear |
| Hisatsugu Miyat. [Current trends of nicotine dependence]. Nihon rinsho. Japanese journal of clinical medicine. vol 68. issue 8. 2010-09-02. PMID:20715483. |
these psychopharmacological effects of nicotine may be produced by the ability of nicotine to promote the release of catecholamines, acetylcholine, beta-endorphin, glucocorticoid, and other hormones. |
2010-09-02 |
2023-08-12 |
Not clear |
| Neerad C Mishra, Jules Rir-sima-ah, R Thomas Boyd, Shashi P Singh, Sravanthi Gundavarapu, Raymond J Langley, Seddigheh Razani-Boroujerdi, Mohan L Sopor. Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 1. 2010-09-01. PMID:20505147. |
using alpha-bungarotoxin binding and quantitative pcr and pcr product sequencing, we showed that the rat mast/basophil cell line rbl-2h3 expresses nicotinic acetylcholine receptors (nachrs) alpha7, alpha9, and alpha10; exposure to exceedingly low concentrations of nicotine (nanomolar), but not the biologically inactive metabolite cotinine, for > or = 8 h suppressed the late phase (leukotriene/cytokine production) but not degranulation (histamine and hexosaminidase release). |
2010-09-01 |
2023-08-12 |
rat |
| Lorise C Gahring, Gustavo A Vasquez-Opazo, Scott W Roger. Choline promotes nicotinic receptor alpha4 + beta2 up-regulation. The Journal of biological chemistry. vol 285. issue 26. 2010-08-24. PMID:20392695. |
neuronal nicotinic acetylcholine receptors (nachr) composed of alpha4 + beta2 subunits, the high affinity nicotine-binding site in the mammalian brain, up-regulate in response to chronic nicotine exposure. |
2010-08-24 |
2023-08-12 |
Not clear |
| Marcelo O Ortells, Georgina E Barrante. Tobacco addiction: a biochemical model of nicotine dependence. Medical hypotheses. vol 74. issue 5. 2010-08-18. PMID:19962246. |
nicotine is the main psychoactive substance present in tobacco, targeting in the cns the nicotinic acetylcholine receptors (nachr). |
2010-08-18 |
2023-08-12 |
Not clear |
| Thomas E Wooters, Rick A Bevins, Michael T Bard. Neuropharmacology of the interoceptive stimulus properties of nicotine. Current drug abuse reviews. vol 2. issue 3. 2010-08-13. PMID:20443771. |
early reports confirmed that nicotinic acetylcholine receptors (nachrs) are critical for transduction of the nicotine cue. |
2010-08-13 |
2023-08-12 |
Not clear |
| Milena Moretti, Manolo Mugnaini, Michela Tessari, Michele Zoli, Annalisa Gaimarri, Irene Manfredi, Francesco Pistillo, Francesco Clementi, Cecilia Gott. A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes. Molecular pharmacology. vol 78. issue 2. 2010-08-03. PMID:20439469. |
long-term nicotine exposure changes neuronal acetylcholine nicotinic receptor (nachr) subtype expression in the brains of smokers and experimental animals. |
2010-08-03 |
2023-08-12 |
rat |
| Xiao-Jing Wang, Ying-Feng Liu, Qing-Yu Wang, Morito Tsuruoka, Kazumasa Ohta, Sheng-Xi Wu, Masashi Yakushiji, Takashi Inou. Functional expression of alpha 7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat periodontal tissues. Cell and tissue research. vol 340. issue 2. 2010-07-21. PMID:20309583. |
recent reports proposed that nicotine plays an important role in tobacco-related morbidity by acting through the nicotinic acetylcholine receptors (nachrs) expressed by non-neuronal cells. |
2010-07-21 |
2023-08-12 |
human |
| K J Jackson, M J Marks, R E Vann, X Chen, T F Gamage, J A Warner, M I Dama. Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. The Journal of pharmacology and experimental therapeutics. vol 334. issue 1. 2010-07-13. PMID:20400469. |
role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. |
2010-07-13 |
2023-08-12 |
mouse |
| Iku Tsutsui-Kimura, Yu Ohmura, Takeshi Izumi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshiok. Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. Psychopharmacology. vol 209. issue 4. 2010-07-08. PMID:20238211. |
nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. |
2010-07-08 |
2023-08-12 |
Not clear |
| Iku Tsutsui-Kimura, Yu Ohmura, Takeshi Izumi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshiok. Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex. Psychopharmacology. vol 209. issue 4. 2010-07-08. PMID:20238211. |
nicotine, a major addictive component of tobacco, has been suggested to provoke impulsivity by activating central alpha4beta2 nicotinic acetylcholine receptors (nachrs). |
2010-07-08 |
2023-08-12 |
Not clear |
| Rong-Jane Chen, Yuan-Soon Ho, How-Ran Guo, Ying-Jan Wan. Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 115. issue 1. 2010-07-06. PMID:20106947. |
furthermore, nicotine mobilized stat3 signaling, resulting in the loss of extracellular signal-regulated protein kinase 1/2 (erk 1/2) activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors. |
2010-07-06 |
2023-08-12 |
human |
| Amy K Eppolito, Susan E Bachus, Craig G McDonald, James H Meador-Woodruff, Robert F Smit. Late emerging effects of prenatal and early postnatal nicotine exposure on the cholinergic system and anxiety-like behavior. Neurotoxicology and teratology. vol 32. issue 3. 2010-07-02. PMID:20060465. |
analysis of mrna for the alpha4, alpha7, and beta2 subunits of nicotinic acetylcholine receptors revealed lower expression of these subunits in the adult hippocampus and medial prefrontal cortex following pre- and postnatal nicotine exposure, suggesting that nicotine altered the developmental trajectory of the brain. |
2010-07-02 |
2023-08-12 |
rat |
| Amanda M Struthers, Jamie L Wilkinson, Linda P Dwoskin, Peter A Crooks, Rick A Bevin. Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacology, biochemistry, and behavior. vol 94. issue 2. 2010-06-29. PMID:19778551. |
the present work investigated the potential role nicotinic acetylcholine receptors play in the cs effects of nicotine (0.4mg/kg) using antagonists with differential selectivity for beta2*, alpha7*, alpha6beta2*, and alpha3beta4* receptors. |
2010-06-29 |
2023-08-12 |
Not clear |
| Amanda M Struthers, Jamie L Wilkinson, Linda P Dwoskin, Peter A Crooks, Rick A Bevin. Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacology, biochemistry, and behavior. vol 94. issue 2. 2010-06-29. PMID:19778551. |
these results indicate that beta2* and potentially alpha3beta4* nicotinic acetylcholine receptors play a role in the cs effects of nicotine and are potential targets for the development of nicotine cessation aids. |
2010-06-29 |
2023-08-12 |
Not clear |