| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishnu Hosur, Scott Leppanen, Adham Abutaha, Ralph H Lorin. Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. Journal of neurochemistry. vol 111. issue 3. 2009-11-06. PMID:19732285. |
alpha4beta2 nicotinic acetylcholine receptors play an important role in the reward pathways for nicotine. |
2009-11-06 |
2023-08-12 |
Not clear |
| Rachel E Penton, Robin A J Leste. Cellular events in nicotine addiction. Seminars in cell & developmental biology. vol 20. issue 4. 2009-10-08. PMID:19560047. |
in the 25 years since the observation that chronic exposure to nicotine could regulate the number and function of high affinity nicotine binding sites in the brain there has been a major effort to link alterations in nicotinic acetylcholine receptors (nachrs) to nicotine-induced behaviors that drive the addiction to tobacco products. |
2009-10-08 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, Marjolijn Mertz, Lorna W Rol. Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Seminars in cell & developmental biology. vol 20. issue 4. 2009-10-08. PMID:19560048. |
the addictive activity of nicotine is due to potent interactions with nicotinic acetylcholine receptors (nachrs) on neurons in the reinforcement and reward circuits of the brain. |
2009-10-08 |
2023-08-12 |
Not clear |
| Serguei S Sidach, Nikolai B Fedorov, Patrick M Lippiello, Merouane Bencheri. Development and optimization of a high-throughput electrophysiology assay for neuronal alpha4beta2 nicotinic receptors. Journal of neuroscience methods. vol 182. issue 1. 2009-09-30. PMID:19481112. |
for example, the concentration-response relationships obtained for alpha4beta2 receptor activation by acetylcholine and nicotine were best described by biphasic hill equations, and the inhibition of alpha4beta2 receptor currents by the nicotinic antagonist dihydro-beta-erythroidine was consistent with previously published results. |
2009-09-30 |
2023-08-12 |
xenopus_laevis |
| Cécile Givelet, Thierry Buffeteau, Françoise Arnaud-Neu, Véronique Hubscher-Bruder, Brigitte Biba. A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine. The Journal of organic chemistry. vol 74. issue 14. 2009-09-28. PMID:19459648. |
a hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine. |
2009-09-28 |
2023-08-12 |
Not clear |
| Cécile Givelet, Thierry Buffeteau, Françoise Arnaud-Neu, Véronique Hubscher-Bruder, Brigitte Biba. A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine. The Journal of organic chemistry. vol 74. issue 14. 2009-09-28. PMID:19459648. |
selective recognition of acetylcholine (ach) against other aliphatic ammoniums is achieved by this flat receptor, which also forms complexes with epibatidine and nicotine. |
2009-09-28 |
2023-08-12 |
Not clear |
| Maryka Quik, Luping Z Huang, Neeraja Parameswaran, Tanuja Bordia, Carla Campos, Xiomara A Pere. Multiple roles for nicotine in Parkinson's disease. Biochemical pharmacology. vol 78. issue 7. 2009-09-21. PMID:19433069. |
nicotine, a drug that stimulates nicotinic acetylcholine receptors (nachrs), influences several functions relevant to parkinson's disease. |
2009-09-21 |
2023-08-12 |
Not clear |
| Andon N Placzek, Tao A Zhang, John A Dan. Age dependent nicotinic influences over dopamine neuron synaptic plasticity. Biochemical pharmacology. vol 78. issue 7. 2009-09-21. PMID:19464268. |
addictive drugs, including nicotine, exert powerful influences over the mesolimbic da system by activating and desensitizing nicotinic acetylcholine receptors (nachrs) in a subtype-dependent manner. |
2009-09-21 |
2023-08-12 |
Not clear |
| Hiromu Kawasaki, Shinji Eguchi, Satoko Miyashita, Shu Chan, Kazuhiro Hirai, Narumi Hobara, Ayako Yokomizo, Hidetoshi Fujiwara, Yoshito Zamami, Toshihiro Koyama, Xin Jin, Yoshihisa Kitamur. Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery. The Journal of pharmacology and experimental therapeutics. vol 330. issue 3. 2009-09-21. PMID:19483072. |
nicotine stimulates presynaptic nicotinic acetylcholine receptors in perivascular adrenergic nerves and releases unknown transmitter(s) that activate transient receptor potential vanilloid-1 (trpv1) located on calcitonin gene-related peptide (cgrp)-containing (cgrpergic) nerves, resulting in vasodilation. |
2009-09-21 |
2023-08-12 |
rat |
| Anitha P Govind, Paul Vezina, William N Gree. Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochemical pharmacology. vol 78. issue 7. 2009-09-21. PMID:19540212. |
in this commentary, we review how nicotinic acetylcholine receptors (nachrs) are upregulated by nicotine exposure, the potential posttranslational events that appear to cause it and how upregulation is linked to nicotine addiction. |
2009-09-21 |
2023-08-12 |
Not clear |
| Eva-Maria Nicolussi, Sigismund Huck, Hans Lassmann, Monika Brad. The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation. Neurobiology of disease. vol 35. issue 1. 2009-09-14. PMID:19344760. |
stimulation of the nicotinic alpha7 acetylcholine receptor (nachralpha7) by nicotine or acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural inhibition of inflammation. |
2009-09-14 |
2023-08-12 |
mouse |
| Bin Tu, Zhenglin Gu, Jian-Xin Shen, Patricia W Lamb, Jerrel L Yake. Characterization of a nicotine-sensitive neuronal population in rat entorhinal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 33. 2009-09-11. PMID:19692619. |
the entorhinal cortex (ec) is a part of the hippocampal complex that is essential to learning and memory, and nicotine affects memory by activating nicotinic acetylcholine receptors (nachrs) in the hippocampal complex. |
2009-09-11 |
2023-08-12 |
rat |
| Darlene H Brunzell, Yann S Mineur, Rachael L Neve, Marina R Picciott. Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 8. 2009-09-02. PMID:19212318. |
the ability of nicotine to alter firing of dopamine neurons is the first step leading to nicotine reward, but activation of intracellular signaling pathways downstream of nicotinic acetylcholine receptors is likely to be critical for longer-term consequences of nicotine exposure, including conditioned reward. |
2009-09-02 |
2023-08-12 |
mouse |
| Jennifer A Davis, Thomas J Goul. Hippocampal nAChRs mediate nicotine withdrawal-related learning deficits. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 8. 2009-09-02. PMID:19278836. |
the role of hippocampal nicotinic acetylcholine receptors (nachrs) in the effects of acute, chronic and withdrawal from chronic nicotine on learning was assessed via intrahippocampal drug infusion in mice. |
2009-09-02 |
2023-08-12 |
mouse |
| Isabel R Schlaepfer, Nicole R Hoft, Marissa A Ehringe. The genetic components of alcohol and nicotine co-addiction: from genes to behavior. Current drug abuse reviews. vol 1. issue 2. 2009-08-28. PMID:19492010. |
recent work from human genetics studies has provided evidence that neuronal nicotinic acetylcholine receptors (nachr) genes may have a role in mediating early behaviors that are risk factors for alcohol and nicotine dependence, such as age of initiation and early subjective responses to the drugs. |
2009-08-28 |
2023-08-12 |
mouse |
| Orlando B C Swayne, James T H Teo, Richard J Greenwood, John C Rothwel. The facilitatory effects of intermittent theta burst stimulation on corticospinal excitability are enhanced by nicotine. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 120. issue 8. 2009-08-28. PMID:19640784. |
in animal models, agonists of nicotinic acetylcholine receptors have been shown to modulate or induce ltp; we thus sought to test whether nicotine may modulate the effects of itbs on corticospinal excitability in humans. |
2009-08-28 |
2023-08-12 |
human |
| Sean C Barron, James T McLaughlin, Jennifer A See, Vanessa L Richards, Robert L Rosenber. An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. Molecular pharmacology. vol 76. issue 2. 2009-08-17. PMID:19411608. |
nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including nicotine addiction, alzheimer's, schizophrenia, and depression. |
2009-08-17 |
2023-08-12 |
Not clear |
| O I Bondarenko, V F Sahac. [Modulation of electrical responses of endothelial cells by nicotinic cholinoreceptors]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 55. issue 2. 2009-08-10. PMID:19526844. |
because the sustained component of hyperpolarization of endothelial cells evoked by acetylcholine in isolated rat aorta may partially be mediated by the reversed na(+)-ca(2+) exchanger and na(+)-k(+) atpase, the mechanisms which transport na(+) out of cells, we compared the electrical responses of endothelial cells from isolated rat aorta to acetylcholine with other ca(2+) mobilizing agents and studied the effect of nicotine on endothelial membrane potential in order to asses the functional activity of nicotinic cholinoreceptors. |
2009-08-10 |
2023-08-12 |
rat |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
nicotine binds to alpha4beta2 and alpha7 nicotinic acetylcholine receptors (nachrs) located on dopaminergic, glutamatergic and gabaergic neurons in the mesolimbic dopamine (da) system, which causes an increase in extracellular da in the nucleus accumbens (nac). |
2009-07-31 |
2023-08-12 |
Not clear |
| Zheng-xiong Xi, Krista Spiller, Eliot L Gardne. Mechanism-based medication development for the treatment of nicotine dependence. Acta pharmacologica Sinica. vol 30. issue 6. 2009-07-31. PMID:19434058. |
accordingly, pharmacological agents that target brain acetylcholine, da, glutamate, gaba, or endocannabonoid signaling systems have been proposed to interrupt nicotine action. |
2009-07-31 |
2023-08-12 |
Not clear |