| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramiro Salas, Renea Sturm, Jim Boulter, Mariella De Bias. Nicotinic receptors in the habenulo-interpeduncular system are necessary for nicotine withdrawal in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 10. 2009-04-10. PMID:19279237. |
using knock-out mice, we previously showed that the beta4, but not the beta2 subunit of nicotinic acetylcholine receptors, is necessary for the somatic manifestations of nicotine withdrawal. |
2009-04-10 |
2023-08-12 |
mouse |
| Maryka Quik, Kathryn O'Leary, Caroline M Tanne. Nicotine and Parkinson's disease: implications for therapy. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 12. 2009-04-08. PMID:18683238. |
accumulating evidence suggests that nicotine, a drug that stimulates nicotinic acetylcholine receptors, may be of therapeutic value in parkinson's disease. |
2009-04-08 |
2023-08-12 |
Not clear |
| Jacques Barik, Susan Wonnacot. Molecular and cellular mechanisms of action of nicotine in the CNS. Handbook of experimental pharmacology. issue 192. 2009-04-07. PMID:19184650. |
nicotine achieves its psychopharmacological effects by interacting with nicotinic acetylcholine receptors (nachrs) in the brain. |
2009-04-07 |
2023-08-12 |
Not clear |
| Nicole R Hoft, Robin P Corley, Matthew B McQueen, Isabel R Schlaepfer, David Huizinga, Marissa A Ehringe. Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 3. 2009-03-30. PMID:18704094. |
neuronal nicotinic acetylcholine receptors are activated by both endogenous acetylcholine and exogenous nicotine, making sequence variations in these receptors likely candidates for association with tobacco phenotypes. |
2009-03-30 |
2023-08-12 |
human |
| Ismail Mert Vural, Gokce Sevim Ozturk Fincan, Nihan Burul Bozkurt, Zeynep Sevim Ercan, Yusuf Sariogl. Role of nicotinic acetylcholine receptor subtypes on nicotine-induced neurogenic contractile response alternation in the rabbit gastric fundus. European journal of pharmacology. vol 602. issue 2-3. 2009-03-30. PMID:19049804. |
nicotine is a nonspecific agonist of nicotinic acetylcholine receptors. |
2009-03-30 |
2023-08-12 |
rabbit |
| Ismail Mert Vural, Gokce Sevim Ozturk Fincan, Nihan Burul Bozkurt, Zeynep Sevim Ercan, Yusuf Sariogl. Role of nicotinic acetylcholine receptor subtypes on nicotine-induced neurogenic contractile response alternation in the rabbit gastric fundus. European journal of pharmacology. vol 602. issue 2-3. 2009-03-30. PMID:19049804. |
the aim of this study is to investigate subtypes of presynaptic nicotinic acetylcholine receptors involved in nicotine induced efs-evoked contractile response alternation in the rabbit gastric fundus. |
2009-03-30 |
2023-08-12 |
rabbit |
| Masatoshi Ohnishi, Hiroshi Katsuki, Mikako Takagi, Toshiaki Kume, Akinori Akaik. Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures. European journal of pharmacology. vol 602. issue 2-3. 2009-03-30. PMID:19063881. |
based on emerging evidence that stimulation of nicotinic acetylcholine receptors provides neuroprotective effects and also suppresses cytotoxic properties of activated microglia, we investigated the effect of nicotine on thrombin-induced pathological changes in cortico-striatal slice cultures. |
2009-03-30 |
2023-08-12 |
Not clear |
| Fu-Dong Shi, Wen-Hua Piao, Yen-Ping Kuo, Denise I Campagnolo, Timothy L Vollmer, Ronald J Luka. Nicotinic attenuation of central nervous system inflammation and autoimmunity. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 3. 2009-03-30. PMID:19155522. |
the expression of nicotinic acetylcholine receptors by neurons, microglia, and astrocytes suggests possibly diverse mechanisms by which natural nicotinic cholinergic signaling and exposure to nicotine could modulate immune responses within the cns. |
2009-03-30 |
2023-08-12 |
mouse |
| Edward D Levin, Susan Slade, Michael Johnson, Ann Petro, Kofi Horton, Paul Williams, Amir H Rezvani, Jed E Ros. Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats. European journal of pharmacology. vol 600. issue 1-3. 2009-03-27. PMID:18950618. |
in addition to primary effects on nicotinic acetylcholine receptors, nicotine has cascading effects, which may also underlie its neurobehavioral actions. |
2009-03-27 |
2023-08-12 |
rat |
| Lisa Chang, Stanley I Rapoport, Henry N Nguyen, Dede Greenstein, Mei Chen, Mireille Basseli. Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 3. 2009-03-23. PMID:19142197. |
nicotine exerts its central effects by activating pre- and postsynaptic nicotinic acetylcholine receptors (nachrs). |
2009-03-23 |
2023-08-12 |
rat |
| Freda Patterson, Christopher Jepson, Andrew A Strasser, James Loughead, Kenneth A Perkins, Ruben C Gur, Joseph M Frey, Steven Siegel, Caryn Lerma. Varenicline improves mood and cognition during smoking abstinence. Biological psychiatry. vol 65. issue 2. 2009-03-20. PMID:18842256. |
neuronal nicotinic acetylcholine receptors (nachrs) are a key target in medication development for various neuropsychiatric disorders, including nicotine dependence. |
2009-03-20 |
2023-08-12 |
Not clear |
| B A Patel, J J Galligan, G M Swain, X Bia. Electrochemical monitoring of nitric oxide released by myenteric neurons of the guinea pig ileum. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 11. 2009-03-03. PMID:18694441. |
in the lmmp preparation, no release was evoked by superfusion of 1 mumol l(-1) nicotine, which activates nicotinic acetylcholine receptors expressed by myenteric neurons and myenteric nerve endings. |
2009-03-03 |
2023-08-12 |
Not clear |
| Albino J Oliveira-Maia, Jennifer R Stapleton-Kotloski, Vijay Lyall, Tam-Hao T Phan, Shobha Mummalaneni, Pamela Melone, John A Desimone, Miguel A L Nicolelis, Sidney A Simo. Nicotine activates TRPM5-dependent and independent taste pathways. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 5. 2009-02-27. PMID:19164511. |
here, rats and mice were used to determine whether nicotine activates peripheral and central taste pathways via trpm5-dependent mechanisms, which are essential for responses to other bitter tastants such as quinine, and/or via nicotinic acetylcholine receptors (nachrs). |
2009-02-27 |
2023-08-12 |
mouse |
| G I Nezhinskaia, A L Vladykin, N S Saprono. [Effects of cholinergic drugs and blood plasma proteins on the development of Arthus reaction]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 6. 2009-02-23. PMID:19140513. |
the effects of methacine (2 mg/kg), ipratropium bromide (0.01 mg/kg), their combinations with neostigmine (0.02 mg/kg), hexamethonium (10 mg/kg), acetylcholine (2 microg/kg), nicotine (0.5 mg/kg), gamma globulin and crp (both 1 mg/kg), and albumin (500 mg/kg) on dth reaction development, b cell functions and arthus reaction were investigated. |
2009-02-23 |
2023-08-12 |
mouse |
| G I Nezhinskaia, A L Vladykin, N S Saprono. [Effects of cholinergic drugs and blood plasma proteins on the development of Arthus reaction]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 6. 2009-02-23. PMID:19140513. |
the administration of acetylcholine, nicotine, and combinations of muscarinic antagonists with neostigmine, as well as gamma globulin and albumin resulted in the later onset of arthus reaction. |
2009-02-23 |
2023-08-12 |
mouse |
| Faye T C Lau, Roy C Y Choi, Heidi Q Xie, K Wing Leung, Vicky P Chen, Judy T T Zhu, Cathy W C Bi, Glanice K Y Chu, Karl W K Tsi. Myocyte enhancer factor 2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes. Molecular and cellular neurosciences. vol 39. issue 3. 2009-01-29. PMID:18718538. |
to reveal the regulatory role of muscular activity on colq expression, acetylcholine and nicotine were applied onto c2c12 muscle cells: the challenge increased the expression of colq-1/colq-1a mrnas. |
2009-01-29 |
2023-08-12 |
Not clear |
| Yan Qi Liang, Xiao Tian Huang, Xi Can Tan. Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats. Cellular and molecular neurobiology. vol 28. issue 1. 2009-01-28. PMID:17636406. |
likewise, this treatment ameliorated the beta-amyloid peptide-(1-40)-induced deficits in extracellular acetylcholine, dopamine, and norepinephrine (though not 5-hydroxytryptamine) in medial prefrontal cortex, and lessened the reduction in nicotine or methoctramine-stimulated release of acetylcholine and k(+)-evoked releases of acetylcholine and dopamine. |
2009-01-28 |
2023-08-12 |
rat |
| Edwin G Pérez, Bruce K Cassels, Gerald Zapata-Torre. Molecular modeling of the alpha9alpha10 nicotinic acetylcholine receptor subtype. Bioorganic & medicinal chemistry letters. vol 19. issue 1. 2009-01-28. PMID:19013796. |
this study reports the comparative molecular modeling, docking and dynamic simulations of human alpha9alpha10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and alpha-conotoxin rgia, using as templates the crystal structures of aplysia californica and lymnaea stagnalis acetylcholine binding proteins. |
2009-01-28 |
2023-08-12 |
human |
| b' V V Kravtsova, T M Drabkina, A V Prokof\'ev, I V Kubasov, A N Vasil\'ev, I I Krivo\\xc4\\xa. [Effect of nicotine on electrogenic contribution of the Na,K-ATPase isoforms and contractile characteristics of the rat skeletal muscle]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 94. issue 10. 2009-01-23. PMID:19065831.' |
similar hyperpolarization was induced by nicotine and acetylcholine in the rat soleus muscle. |
2009-01-23 |
2023-08-12 |
rat |
| Manabu Yanagita, Yoichiro Kashiwagi, Ryohei Kobayashi, Miki Tomoeda, Yoshio Shimabukuro, Shinya Murakam. Nicotine inhibits mineralization of human dental pulp cells. Journal of endodontics. vol 34. issue 9. 2009-01-12. PMID:18718366. |
nicotine is a major component of tobacco smoke, and signals via nicotinic acetylcholine receptors (nachr). |
2009-01-12 |
2023-08-12 |
human |