| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lise Bréthous, Noemi Garcia-Delgado, Julian Schwartz, Sonia Bertrand, Daniel Bertrand, Jean-Louis Reymon. Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). Journal of medicinal chemistry. vol 55. issue 10. 2012-09-07. PMID:22591063. |
the libraries were scored using structure-based (docking to the nicotine binding site of the acetylcholine binding protein 1uw6.pdb) or ligand-based (similarity to the parent drugs) methods, and the top-scoring virtual ligands were inspected for easily accessible synthetic targets. |
2012-09-07 |
2023-08-12 |
human |
| Sarah E McCallum, Matthew A Cowe, Samuel W Lewis, Stanley D Glic. α3β4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo. Neuropharmacology. vol 63. issue 3. 2012-08-27. PMID:22561751. |
α3β4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo. |
2012-08-27 |
2023-08-12 |
rat |
| Maryka Quik, Keon Min Park, Maya Hrachova, Archana Mallela, Luping Z Huang, J Michael McIntosh, Sharon R Grad. Role for α6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice. Neuropharmacology. vol 63. issue 3. 2012-08-27. PMID:22579614. |
few treatment options are available to manage dyskinesias; however,recent studies show that nicotine reduces these abnormal involuntary movements (aims) in parkinsonian animals by acting at nicotinic acetylcholine receptors (nachrs). |
2012-08-27 |
2023-08-12 |
mouse |
| Nicole K Horst, Christopher J Heath, Nichole M Neugebauer, Eyal Y Kimchi, Mark Laubach, Marina R Picciott. Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion. Behavioural brain research. vol 231. issue 1. 2012-08-20. PMID:22433585. |
this suggests that nicotine disrupts auditory pathways via nicotinic acetylcholine receptors (nachrs) that are expressed at an early stage of development. |
2012-08-20 |
2023-08-12 |
mouse |
| Lawrence Toll, Nurulain T Zaveri, Willma E Polgar, Faming Jiang, Taline V Khroyan, Wei Zhou, Xinmin Simon Xie, Gregory B Stauber, Matthew R Costello, Frances M Lesli. AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22278092. |
genomic and pharmacologic data have suggested the involvement of the α3β4 subtype of nicotinic acetylcholine receptors (nachrs) in drug seeking to nicotine and other drugs of abuse. |
2012-08-14 |
2023-08-12 |
rat |
| Simona E Budulac, Judith M Vonk, Dirkje S Postma, Mateusz Siedlinski, Wim Timens, Marike H Boeze. Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD. PloS one. vol 7. issue 3. 2012-08-13. PMID:22438921. |
genome-wide association studies identified single nucleotide polymorphisms (snps) in the nicotinic acetylcholine receptors (nachrs) cluster as a risk factor for nicotine dependency and copd. |
2012-08-13 |
2023-08-12 |
Not clear |
| Xavier Gallego, Jessica Ruiz-Medina, Olga Valverde, Susanna Molas, Noemí Robles, Josefa Sabrià, John C Crabbe, Mara Diersse. Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice. Alcohol (Fayetteville, N.Y.). vol 46. issue 3. 2012-07-30. PMID:22459873. |
some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nachrs). |
2012-07-30 |
2023-08-12 |
mouse |
| Sharon R Grady, Charles R Wageman, Natalie E Patzlaff, Michael J Mark. Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include α5 or α6 subunits and that mediate synaptosomal neurotransmitter release. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22239849. |
low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include α5 or α6 subunits and that mediate synaptosomal neurotransmitter release. |
2012-07-23 |
2023-08-12 |
mouse |
| Thomas J Gould, George S Portugal, Jessica M André, Matthew P Tadman, Michael J Marks, Justin W Kenney, Emre Yildirim, Michael Adof. The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22285742. |
chronic nicotine treatment upregulates nicotinic acetylcholine receptors (nachr); however, it is unknown whether upregulation is related to the observed withdrawal-induced cognitive deficits. |
2012-07-23 |
2023-08-12 |
mouse |
| Junko Kimura-Kuroda, Yukari Komuta, Yoichiro Kuroda, Masaharu Hayashi, Hitoshi Kawan. Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons from neonatal rats. PloS one. vol 7. issue 2. 2012-07-23. PMID:22393406. |
with similar chemical structures to nicotine, neonicotinoids also share agonist activity at nicotinic acetylcholine receptors (nachrs). |
2012-07-23 |
2023-08-12 |
human |
| Darlene H Brunzell, J Michael McIntos. Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 5. 2012-07-20. PMID:22169946. |
alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia. |
2012-07-20 |
2023-08-12 |
rat |
| Ning Guo, Wei Yao, Shi-Rong Wang, Jun Zhu, Dong Huang, Pan-Li Zuo, Xin-Jiang Kang, Chong-Luo Fu, Zhuan Zhou, Bo Zhan. Nicotine dynamically modulates dopamine clearance in rat striatum in vivo. Neurochemistry international. vol 60. issue 4. 2012-07-05. PMID:22310173. |
nicotine binds to nicotinic acetylcholine receptors on dopaminergic terminals to evoke dopamine (da) release. |
2012-07-05 |
2023-08-12 |
rat |
| Yoshiaki Miyamoto, Ryosuke Sakai, Chiharu Maeda, Tsuyoshi Takata, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanab. Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells. Nitric oxide : biology and chemistry. vol 25. issue 3. 2012-06-29. PMID:21742048. |
however, nicotine treatment failed to enhance erk1/2 phosphorylation when npc12 cells were pretreated with several selective inhibitors of nos, the nicotinic acetylcholine receptors, l-type voltage-dependent ca(2+) channels, protein kinase c, src, epidermal growth factor receptor, and mek. |
2012-06-29 |
2023-08-12 |
Not clear |
| Danielle S Counotte, Natalia A Goriounova, Milena Moretti, Marek T Smoluch, Hubertus Irth, Francesco Clementi, Anton N M Schoffelmeer, Huibert D Mansvelder, August B Smit, Cecilia Gotti, Sabine Spijke. Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 26. issue 5. 2012-06-29. PMID:22308197. |
we investigated whether adolescent nicotine exposure in rats modifies expression of nicotinic acetylcholine receptors (nachrs) in medial prefrontal cortex (mpfc) in the short and/or long term, and whether this has functional consequences. |
2012-06-29 |
2023-08-12 |
rat |
| Cherry Wongtrakool, Ningshan Wang, Dallas M Hyde, Jesse Roman, Eliot R Spinde. Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors. American journal of respiratory cell and molecular biology. vol 46. issue 5. 2012-06-25. PMID:22246862. |
the objectives of this study were to determine whether exposure to nicotine prenatally leads to alterations in pulmonary function and airway geometry in offspring, and whether α7 nicotinic acetylcholine receptors (nachrs) mediate these effects. |
2012-06-25 |
2023-08-12 |
mouse |
| Kelly P Cosgrove, Irina Esterlis, Sherry A McKee, Frederic Bois, John P Seibyl, Carolyn M Mazure, Suchitra Krishnan-Sarin, Julie K Staley, Marina R Picciotto, Stephanie S O'Malle. Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers. Archives of general psychiatry. vol 69. issue 4. 2012-06-12. PMID:22474108. |
sex differences in availability of nicotinic acetylcholine receptors containing the β(2) subunit (β(2)*-nachrs) may underlie differential nicotine and tobacco smoking effects and related behaviors in women vs men. |
2012-06-12 |
2023-08-12 |
Not clear |
| Magalie Lenoir, Eugene A Kiyatki. Critical role of peripheral actions of intravenous nicotine in mediating its central effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 10. 2012-06-04. PMID:21654739. |
in addition to its direct action on central neurons, nicotine (nic) activates multiple nicotinic acetylcholine receptors localized on afferent terminals of sensory nerves at the sites of its administration. |
2012-06-04 |
2023-08-12 |
rat |
| Morgane Besson, Vincent David, Mathieu Baudonnat, Pierre Cazala, Jean-Philippe Guilloux, Christelle Reperant, Isabelle Cloez-Tayarani, Jean-Pierre Changeux, Alain M Gardier, Sylvie Grano. Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice. Psychopharmacology. vol 220. issue 1. 2012-06-04. PMID:21901321. |
nicotine is the main addictive component of tobacco and modifies brain function via its action on neuronal acetylcholine nicotinic receptors (nachrs). |
2012-06-04 |
2023-08-12 |
mouse |
| Brandon J Henderson, Crina M Orac, Iwona Maciagiewicz, Stephen C Bergmeier, Dennis B McKa. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. Bioorganic & medicinal chemistry letters. vol 22. issue 4. 2012-05-31. PMID:22285942. |
subtype selective molecules for α4β2 neuronal nicotinic acetylcholine receptors (nachrs) have been sought as novel therapeutics for nicotine cessation. |
2012-05-31 |
2023-08-12 |
human |
| Anthony Renda, Raad Nashm. Spectral confocal imaging of fluorescently tagged nicotinic receptors in knock-in mice with chronic nicotine administration. Journal of visualized experiments : JoVE. issue 60. 2012-05-25. PMID:22349092. |
chronic nicotine exposure in both rodents and humans results in increased numbers of nicotinic acetylcholine receptors (nachrs) in brain tissue. |
2012-05-25 |
2023-08-12 |
mouse |