| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prakash Rucktooa, Claire A Haseler, René van Elk, August B Smit, Timothy Gallagher, Titia K Sixm. Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein. The Journal of biological chemistry. vol 287. issue 28. 2012-10-09. PMID:22553201. |
addiction to tobacco smoking results from the binding of nicotine to nicotinic acetylcholine receptors (nachrs) in the brain, in particular the α4β2 receptor. |
2012-10-09 |
2023-08-12 |
aplysia |
| Josef Seifert, Jes Stollber. Antagonism of a neonicotinoid insecticide imidacloprid at neuromuscular receptors. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783562. |
the response of the muscle cells to acetylcholine, nicotine and imidacloprid was monitored as cell contractions. |
2012-10-02 |
2023-08-12 |
chicken |
| Josef Seifert, Jes Stollber. Antagonism of a neonicotinoid insecticide imidacloprid at neuromuscular receptors. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783562. |
acetylcholine was more potent than nicotine (ec(50)=5×10(-8)m versus 6×10(-7)m) in this physiological test system. |
2012-10-02 |
2023-08-12 |
chicken |
| Josef Seifert, Jes Stollber. Antagonism of a neonicotinoid insecticide imidacloprid at neuromuscular receptors. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783562. |
contractions induced by acetylcholine or nicotine were both blocked by α-bungarotoxin (ic(50)=9×10(-7)m). |
2012-10-02 |
2023-08-12 |
chicken |
| Josef Seifert, Jes Stollber. Antagonism of a neonicotinoid insecticide imidacloprid at neuromuscular receptors. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783562. |
imidacloprid itself did not cause cell contractions but at concentrations ≥3.3×10(-6)m prevented or attenuated those induced by acetylcholine (5×10(-7)m and 5×10(-5)m) or nicotine (5×10(-6)m to 5×10(-3)m). |
2012-10-02 |
2023-08-12 |
chicken |
| Josef Seifert, Jes Stollber. Antagonism of a neonicotinoid insecticide imidacloprid at neuromuscular receptors. Environmental toxicology and pharmacology. vol 20. issue 1. 2012-10-02. PMID:21783562. |
the dose response relationship between acetylcholine or nicotine, imidacloprid and cell contractions suggests that imidacloprid is an antagonist at the nacchr of the muscle cells in contrast to its established role as an agonist in its toxic action on insect neural receptors. |
2012-10-02 |
2023-08-12 |
chicken |
| Gabriel Rezonzew, Phillip Chumley, Wenguang Feng, Ping Hua, Gene P Siegal, Edgar A Jaime. Nicotine exposure and the progression of chronic kidney disease: role of the α7-nicotinic acetylcholine receptor. American journal of physiology. Renal physiology. vol 303. issue 2. 2012-10-02. PMID:22552933. |
we have shown that nicotine promotes mesangial cell proliferation and hypertrophy via nonneuronal nicotinic acetylcholine receptors (nachrs). |
2012-10-02 |
2023-08-12 |
rat |
| Raju Metherate, Irakli Intskirveli, Hideki D Kawa. Nicotinic filtering of sensory processing in auditory cortex. Frontiers in behavioral neuroscience. vol 6. 2012-10-02. PMID:22833720. |
nicotine activates nicotinic acetylcholine (ach) receptors (nachrs) that normally are activated by endogenous ach, presumably "hijacking" the cholinergic contribution to multiple cognitive functions, notably attention. |
2012-10-02 |
2023-08-12 |
Not clear |
| Allison A Feduccia, Susmita Chatterjee, Selena E Bartlet. Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22876217. |
neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. |
2012-10-02 |
2023-08-12 |
Not clear |
| Allison A Feduccia, Susmita Chatterjee, Selena E Bartlet. Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22876217. |
ethanol and nicotine are both widely abused drugs that share a common molecular target in the brain, the neuronal nicotinic acetylcholine receptors (nachrs). |
2012-10-02 |
2023-08-12 |
Not clear |
| Lili Guo, Lin Li, Weiqiang Wang, Zhenhua Pan, Qinghua Zhou, Zhihao W. Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells. Biochimica et biophysica acta. vol 1822. issue 6. 2012-09-27. PMID:22349311. |
in addition, we demonstrated that the effect of nicotine in upregulation of hif-1α was mediated by dihydro-β-erythroidine (dhβe)-sensitive nicotine acetylcholine receptors (nachrs) and required synergistic cooperation of akt and mitogen-activated protein kinase (mapk) pathways. |
2012-09-27 |
2023-08-12 |
human |
| Mohammed H Al-Wadei, Hussein A N Al-Wadei, Hildegard M Schulle. Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7. Molecular cancer research : MCR. vol 10. issue 2. 2012-09-24. PMID:22188668. |
the nicotinic agonists acetylcholine, nicotine, and its nitrosated carcinogenic derivative nnk induced the phosphorylation of creb, erk, src, and akt and these responses were inhibited by propranolol. |
2012-09-24 |
2023-08-12 |
Not clear |
| Colin S Cunningham, Martin A Javors, Lance R McMaho. Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22438471. |
these results show that nicotine, varenicline, and cytisine produce discriminative stimulus effects through mecamylamine-sensitive receptors (i.e., nicotinic acetylcholine) in primates, whereas the involvement of dhβe-sensitive receptors (i.e., α4β2) is unclear. |
2012-09-24 |
2023-08-12 |
monkey |
| Zong-Zhuang Li, Qiu-Yan Da. Pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors. Mediators of inflammation. vol 2012. 2012-09-20. PMID:22529515. |
pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors. |
2012-09-20 |
2023-08-12 |
Not clear |
| Zong-Zhuang Li, Qiu-Yan Da. Pathogenesis of abdominal aortic aneurysms: role of nicotine and nicotinic acetylcholine receptors. Mediators of inflammation. vol 2012. 2012-09-20. PMID:22529515. |
additionally, the effects of nicotine are probably dose dependent or associated with the exposure duration and may be partly exerted by its receptors--nicotinic acetylcholine receptors (nachrs). |
2012-09-20 |
2023-08-12 |
Not clear |
| Nicole Duerrschmidt, Anja Hagen, Christiane Gaertner, Alice Wermke, Marcin Nowicki, Katharina Spanel-Borowski, Holger Stepan, Friedrich-Wilhelm Mohr, Stefan Dhei. Nicotine effects on human endothelial intercellular communication via α4β2 and α3β2 nicotinic acetylcholine receptor subtypes. Naunyn-Schmiedeberg's archives of pharmacology. vol 385. issue 6. 2012-09-18. PMID:22349182. |
since previous in vitro experiments revealed that nicotine can impair endothelial intercellular communication via the downregulation of connexin43 (cx43), we wanted to find out which nicotinic acetylcholine receptors are involved in the molecular mechanism of communication failure. |
2012-09-18 |
2023-08-12 |
human |
| Jun Kawamata, Syuuichirou Suzuki, Shun Shimoham. α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease. Current drug targets. vol 13. issue 5. 2012-09-17. PMID:22300030. |
examining the distribution of subtypes of nicotinic acetylcholine receptors (nachrs) in dopaminergic neurons of nigrostriatal system and its change in pd patients is quite important to elucidate possible neuroprotective cascade triggered by nicotine. |
2012-09-17 |
2023-08-12 |
Not clear |
| Smitha Pillai, Srikumar Chellappa. α7 nicotinic acetylcholine receptor subunit in angiogenesis and epithelial to mesenchymal transition. Current drug targets. vol 13. issue 5. 2012-09-17. PMID:22300034. |
the pro-angiogenic activity of nicotine is mediated by nicotinic acetylcholine receptors, particularly the alpha 7 subunit, that are expressed on a variety of non-neuronal cells including those in the vasculature such as endothelial cells and smooth muscle cells. |
2012-09-17 |
2023-08-12 |
Not clear |
| Astrid K Stoker, Berend Olivier, Athina Marko. Role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice. Behavior genetics. vol 42. issue 3. 2012-09-12. PMID:22009521. |
role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice. |
2012-09-12 |
2023-08-12 |
mouse |
| Astrid K Stoker, Berend Olivier, Athina Marko. Role of α7- and β4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice. Behavior genetics. vol 42. issue 3. 2012-09-12. PMID:22009521. |
to assess which nicotinic acetylcholine receptors (nachrs) are involved in the aversive aspects of nicotine withdrawal, brain reward function and the somatic signs of nicotine withdrawal were assessed in mice that lack α7 and β4 nachr subunits. |
2012-09-12 |
2023-08-12 |
mouse |