| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reeta Talka, Outi Salminen, Paul Whiteaker, Ronald J Lukas, Raimo K Tuomine. Nicotine-morphine interactions at α4β2, α7 and α3(⁎) nicotinic acetylcholine receptors. European journal of pharmacology. vol 701. issue 1-3. 2013-08-22. PMID:23340223. |
in the sh-sy5y cell line expressing several subtypes of nicotinic acetylcholine receptors morphine had an inhibitory effect on nicotine induced (86)rb(+) ion efflux mediated by α3(⁎) nicotinic acetylcholine receptors. |
2013-08-22 |
2023-08-12 |
Not clear |
| Reiji Yoshimura, Jun Nakamur. [Nicotine dependence and its molecular pharmacology]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 3. 2013-08-22. PMID:23631238. |
mounting evidence indicates that addictive effects of nicotine occur through interaction with its receptors in the mesolimbic dopamine system, particularly ventral tegmental area neurons, where nicotinic acetylcholine receptors (nachrs) act to promote the release of dopamine. |
2013-08-22 |
2023-08-12 |
Not clear |
| Sae Uchida, Harumi Hotta, Hidemi Misawa, Koichiro Kawashim. The missing link between long-term stimulation of nicotinic receptors and the increases of acetylcholine release and vasodilation in the cerebral cortex of aged rats. The journal of physiological sciences : JPS. vol 63. issue 2. 2013-08-12. PMID:23086726. |
in adult rats (4-9 months), chronic nicotine infusion increases the basal level of acetylcholine (ach) release in the cerebral cortex and enhances responses of cortical ach release and cortical vasodilation elicited by nucleus basalis of meynert (nbm) stimulation. |
2013-08-12 |
2023-08-12 |
rat |
| T L Wallace, D Bertran. Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex. Biochemical pharmacology. vol 85. issue 12. 2013-08-09. PMID:23628449. |
nicotinic receptors (nachrs) are a primary site of action for acetylcholine (ach), and the resulting pro-cognitive effects observed by stimulating nachrs with nicotine has long been appreciated by tobacco users, prompting investigation of therapeutic development for diseases (e.g., schizophrenia, alzheimer or attention-deficit-hyperactivity disorder) by targeting the neuronal nachr system. |
2013-08-09 |
2023-08-12 |
Not clear |
| Anton Dawson, Micheal F Miles, M Imad Dama. The β2 nicotinic acetylcholine receptor subunit differentially influences ethanol behavioral effects in the mouse. Alcohol (Fayetteville, N.Y.). vol 47. issue 2. 2013-08-02. PMID:23419392. |
the high co-morbidity between alcohol (ethanol) and nicotine abuse suggests that nicotinic acetylcholine receptors (nachrs), thought to underlie nicotine dependence, may also be involved in alcohol dependence. |
2013-08-02 |
2023-08-12 |
mouse |
| E Stéphan-Blanchard, V Bach, F Telliez, K Chardo. Perinatal nicotine/smoking exposure and carotid chemoreceptors during development. Respiratory physiology & neurobiology. vol 185. issue 1. 2013-07-22. PMID:22743051. |
specifically, nicotine through binding to nicotinic acetylcholine receptors have ubiquitous effects and can affect carotid chemoreception development through structural, functional and neuroregulatory alterations of the neural circuits involved in the chemoafferent pathway, as well as by interfering with the postnatal resetting of the carotid bodies. |
2013-07-22 |
2023-08-12 |
human |
| Marina R Picciotto, Paul J Kenn. Molecular mechanisms underlying behaviors related to nicotine addiction. Cold Spring Harbor perspectives in medicine. vol 3. issue 1. 2013-07-22. PMID:23143843. |
nicotine, the major reinforcing component of tobacco smoke, acts in the brain through the neuronal nicotinic acetylcholine receptors (nachrs). |
2013-07-22 |
2023-08-12 |
mouse |
| Sridevi Balaraman, Ursula H Winzer-Serhan, Rajesh C Mirand. Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. Alcoholism, clinical and experimental research. vol 36. issue 10. 2013-07-12. PMID:22458409. |
opposing actions of ethanol and nicotine on micrornas are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. |
2013-07-12 |
2023-08-12 |
Not clear |
| Jing Ren, Jinghan Sun, Yunpeng Zhang, Tong Liu, Qingzhong Ren, Yan Li, Aike Gu. Down-regulation of Decapping Protein 2 mediates chronic nicotine exposure-induced locomotor hyperactivity in Drosophila. PloS one. vol 7. issue 12. 2013-07-02. PMID:23300696. |
studies in mammalian systems have revealed some key factors involved in the effects of nicotine, including nicotinic acetylcholine receptors (nachrs), dopamine and other neurotransmitters. |
2013-07-02 |
2023-08-12 |
drosophila_melanogaster |
| Snehal Jadey, Prasad Purohit, Anthony Auerbac. Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153. The Journal of general physiology. vol 141. issue 1. 2013-07-01. PMID:23277476. |
action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αg153. |
2013-07-01 |
2023-08-12 |
Not clear |
| Xujiao Zhou, Yonghua Chen, Dengyun Ge, Wenjun Yuan, Jijiang Wan. Nicotine enhances both excitatory and inhibitory synaptic inputs to inspiratory-activated airway vagal preganglionic neurons. Experimental physiology. vol 98. issue 1. 2013-06-17. PMID:22750421. |
the avpns express multiple subunits of nicotinic acetylcholine receptors (nachrs), but the influences of exogenous nicotine and endogenous acetylcholine are unknown. |
2013-06-17 |
2023-08-12 |
Not clear |
| Xujiao Zhou, Yonghua Chen, Dengyun Ge, Wenjun Yuan, Jijiang Wan. Nicotine enhances both excitatory and inhibitory synaptic inputs to inspiratory-activated airway vagal preganglionic neurons. Experimental physiology. vol 98. issue 1. 2013-06-17. PMID:22750421. |
this study examined the effects of nicotine and endogenous acetylcholine on retrogradely labelled, functionally identified inspiratory-activated avpns (ia-avpns) using the patch-clamp technique. |
2013-06-17 |
2023-08-12 |
Not clear |
| Tian-Ying Xu, Ling-Ling Guo, Pei Wang, Jie Song, Ying-Ying Le, Benoit Viollet, Chao-Yu Mia. Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway. PloS one. vol 7. issue 12. 2013-06-11. PMID:23251458. |
chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-stat3 pathway. |
2013-06-11 |
2023-08-12 |
mouse |
| Yong Liu, Janell Richardson, Thao Tran, Nour Al-Muhtasib, Teresa Xie, Venkata Mahidhar Yenugonda, Hannah G Sexton, Amir H Rezvani, Edward D Levin, Niaz Sahibzada, Kenneth J Kellar, Milton L Brown, Yingxian Xiao, Mikell Paig. Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. Journal of medicinal chemistry. vol 56. issue 7. 2013-06-11. PMID:23540678. |
neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be involved in alcohol addiction. |
2013-06-11 |
2023-08-12 |
rat |
| Irina Esterlis, Jonas O Hannestad, Evgenia Perkins, Frederic Bois, D Cyril D'Souza, Rachel F Tyndale, John P Seibyl, Dorothy M Hatsukami, Kelly P Cosgrove, Stephanie S O'Malle. Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. The American journal of psychiatry. vol 170. issue 4. 2013-05-24. PMID:23429725. |
effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. |
2013-05-24 |
2023-08-12 |
human |
| Irina Esterlis, Jonas O Hannestad, Evgenia Perkins, Frederic Bois, D Cyril D'Souza, Rachel F Tyndale, John P Seibyl, Dorothy M Hatsukami, Kelly P Cosgrove, Stephanie S O'Malle. Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers. The American journal of psychiatry. vol 170. issue 4. 2013-05-24. PMID:23429725. |
nicotine promotes smoking partly by binding to β2-containing nicotinic acetylcholine receptors (β2*-nachrs) in the brain. |
2013-05-24 |
2023-08-12 |
human |
| Xiaojing Di, Jingqi Yan, Yan Zhao, Yanzhong Chang, Baolu Zha. L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway. Science China. Life sciences. vol 55. issue 12. 2013-05-17. PMID:23233221. |
l-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway. |
2013-05-17 |
2023-08-12 |
mouse |
| Shawn M Anderson, Darlene H Brunzel. Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice. PloS one. vol 7. issue 11. 2013-05-09. PMID:23144922. |
low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice. |
2013-05-09 |
2023-08-12 |
mouse |
| Shawn M Anderson, Darlene H Brunzel. Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice. PloS one. vol 7. issue 11. 2013-05-09. PMID:23144922. |
nicotine leads to both activation and desensitization (inactivation) of nicotinic acetylcholine receptors (nachrs). |
2013-05-09 |
2023-08-12 |
mouse |
| Rogier B Poorthuis, Bernard Bloem, Matthijs B Verhoog, Huibert D Mansvelde. Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486955. |
nicotine concentrations experienced by smokers are known to desensitize nicotinic acetylcholine receptors (nachrs), but the impact thereof on pfc circuits is poorly understood. |
2013-05-06 |
2023-08-12 |
mouse |