| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Linzy M Hendrickson, Melissa J Guildford, Andrew R Tappe. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. Frontiers in psychiatry. vol 4. 2013-05-06. PMID:23641218. |
neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. |
2013-05-06 |
2023-08-12 |
human |
| Linzy M Hendrickson, Melissa J Guildford, Andrew R Tappe. Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. Frontiers in psychiatry. vol 4. 2013-05-06. PMID:23641218. |
while nicotine initiates dependence by binding to and activating neuronal nicotinic acetylcholine receptors (nachrs), ligand-gated cation channels normally activated by endogenous acetylcholine (ach), ethanol is much less specific with the ability to modulate multiple gene products including those encoding voltage-gated ion channels, and excitatory/inhibitory neurotransmitter receptors. |
2013-05-06 |
2023-08-12 |
human |
| Kamel Maouche, Kahina Medjber, Jean-Marie Zahm, Franck Delavoie, Christine Terryn, Christelle Coraux, Stéphanie Pons, Isabelle Cloëz-Tayarani, Uwe Maskos, Philippe Birembaut, Jean-Marie Tournie. Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 10. 2013-05-02. PMID:23431157. |
nicotinic acetylcholine receptors (nachrs) bind nicotine and nicotine-derived nitrosamines and thus mediate many of the tobacco-related deleterious effects in the lung. |
2013-05-02 |
2023-08-12 |
mouse |
| Darlene H Brunzel. Preclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotype. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 14. issue 11. 2013-04-30. PMID:22492084. |
preclinical evidence that activation of mesolimbic alpha 6 subunit containing nicotinic acetylcholine receptors supports nicotine addiction phenotype. |
2013-04-30 |
2023-08-12 |
Not clear |
| Svetlana Semenova, Candice Contet, Amanda J Roberts, Athina Marko. Mice lacking the β4 subunit of the nicotinic acetylcholine receptor show memory deficits, altered anxiety- and depression-like behavior, and diminished nicotine-induced analgesia. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 14. issue 11. 2013-04-30. PMID:22573727. |
the role of β4-containing nicotinic acetylcholine receptors (nachrs) in cognition, anxiety, depression, and analgesia in the absence of nicotine is unclear. |
2013-04-30 |
2023-08-12 |
mouse |
| Takeshi Takarada, Noritaka Nakamichi, Hirofumi Kawagoe, Masato Ogura, Ryo Fukumori, Ryota Nakazato, Koichi Fujikawa, Miki Kou, Yukio Yoned. Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes. Journal of neuroscience research. vol 90. issue 11. 2013-04-15. PMID:22807215. |
the underlying mechanisms are still unclear for the neuroprotective properties of nicotine to date, whereas we have shown functional expression of nicotinic acetylcholine receptors (nachrs) responsible for the influx of extracellular ca(2+) in cultured rat cortical astrocytes. |
2013-04-15 |
2023-08-12 |
rat |
| Jamie K Lau, Kathleen C Brown, Brent A Thornhill, Clayton M Crabtree, Aaron M Dom, Theodore R Witte, W Elaine Hardman, Christopher A McNees, Cody A Stover, A Betts Carpenter, Haitao Luo, Yi C Chen, Brandon S Shiflett, Piyali Dasgupt. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23222296. |
nicotine, the addictive component of cigarettes, accelerates cell proliferation through nicotinic acetylcholine receptors (nachr). |
2013-04-15 |
2023-08-12 |
mouse |
| Alona Gochberg-Sarver, Merav Kedmi, Mali Gana-Weisz, Anat Bar-Shira, Avi Orr-Urtrege. Tnfα, Cox2 and AdipoQ adipokine gene expression levels are modulated in murine adipose tissues by both nicotine and nACh receptors containing the β2 subunit. Molecular genetics and metabolism. vol 107. issue 3. 2013-03-27. PMID:22926197. |
we hypothesized that nicotine affects adipokine gene expression in adipose tissues via specific neuronal nicotinic acetylcholine receptors (nachrs). |
2013-03-27 |
2023-08-12 |
mouse |
| Sulan Luo, Dongting Zhangsun, Yong Wu, Xiaopeng Zhu, Yuanyan Hu, Melissa McIntyre, Sean Christensen, Muharrem Akcan, David J Craik, J Michael McIntos. Characterization of a novel α-conotoxin from conus textile that selectively targets α6/α3β2β3 nicotinic acetylcholine receptors. The Journal of biological chemistry. vol 288. issue 2. 2013-03-26. PMID:23184959. |
α6β2 nicotinic acetylcholine receptors (nachrs) expressed by dopaminergic neurons in the cns are potential therapeutic targets for the treatment of several neuropsychiatric diseases, including nicotine addiction and parkinson disease. |
2013-03-26 |
2023-08-12 |
rat |
| Monica R F Hilario, Jill R Turner, Julie A Blend. Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 12. 2013-03-22. PMID:22828747. |
chronic nicotine is known to up-regulate nachrs (nicotinic acetylcholine receptors) and we found that this up-regulation was maintained for up to 8 days of withdrawal in the striatum and in the hippocampus, but not in the cortex, of animals exposed to multiple nicotine exposure and withdrawal periods. |
2013-03-22 |
2023-08-12 |
mouse |
| Mark G LeSage, David Shelley, Marco Pravetoni, Paul R Pente. Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist. Pharmacology, biochemistry, and behavior. vol 102. issue 1. 2013-03-14. PMID:22503967. |
tobacco addiction requires activation by nicotine of a variety of central nicotinic acetylcholine receptors (nachrs). |
2013-03-14 |
2023-08-12 |
rat |
| Ravi K Sajja, Shafiqur Rahma. Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice. Pharmacology, biochemistry, and behavior. vol 102. issue 1. 2013-03-14. PMID:22741175. |
alcohol and nicotine are commonly abused drugs in humans and evidence suggests that neuronal nicotinic acetylcholine receptors (nachrs) in the midbrain dopamine system are common targets for the neurobehavioral interactions between alcohol (ethanol) and nicotine. |
2013-03-14 |
2023-08-12 |
mouse |
| Arik J Hone, Mick'l Scadden, Joanna Gajewiak, Sean Christensen, Jon Lindstrom, J Michael McIntos. α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors. Molecular pharmacology. vol 82. issue 5. 2013-02-12. PMID:22914547. |
nicotinic acetylcholine receptors (nachrs) containing α6 and β2 subunits modulate dopamine release in the basal ganglia and are therapeutically relevant targets for treatment of neurological and psychiatric disorders including parkinson's disease and nicotine dependence. |
2013-02-12 |
2023-08-12 |
xenopus_laevis |
| Anton L Beer, Devavrat Vartak, Mark W Greenle. Nicotine facilitates memory consolidation in perceptual learning. Neuropharmacology. vol 64. 2013-02-11. PMID:22749926. |
these findings suggest that oral consumption of nicotine enhances the efficacy of nicotinic acetylcholine receptors. |
2013-02-11 |
2023-08-12 |
Not clear |
| Claire Allison, Mohammed Shoai. Nicotine improves performance in an attentional set shifting task in rats. Neuropharmacology. vol 64. 2013-02-11. PMID:22776507. |
the prefrontal cortex (pfc) is thought to be critically involved in the modulation of executive function and these attentional processes are enhanced by nicotine acting at nicotinic acetylcholine receptors. |
2013-02-11 |
2023-08-12 |
rat |
| Osamu Uchiumi, Yoshiyuki Kasahara, Asami Fukui, F Scott Hall, George R Uhl, Ichiro Sor. Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. Neuropharmacology. vol 64. 2013-02-11. PMID:22809709. |
this nicotine effect was blocked by pretreatment with the non-specific nicotinic acetylcholine (nach) receptor antagonist mecamylamine, or the 5-ht1a antagonist way100635. |
2013-02-11 |
2023-08-12 |
mouse |
| Ling-Zong Hong, Pei-Wen Cheng, Wen-Han Cheng, Siang-Ru Chen, Ling-Lin Wang, Ching-Jiunn Tsen. Involvement of NMDA receptors in nicotine-mediated central control of hypotensive effects. The Chinese journal of physiology. vol 55. issue 5. 2013-01-29. PMID:23282208. |
our previous study demonstrated that nicotine decreased blood pressure and heart rate in the nts probably acting via the nicotinic acetylcholine receptors (nachrs)-ca²⁺-calmodulin-enos-no signaling pathway. |
2013-01-29 |
2023-08-12 |
rat |
| Staci E Engle, Hilary J Broderick, Ryan M Drena. Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices. Journal of visualized experiments : JoVE. issue 68. 2013-01-28. PMID:23128482. |
addiction to cigarette smoking is a prevalent neuropsychiatric disorder that stems from the biophysical and cellular actions of nicotine on nicotinic acetylcholine receptors (nachrs) throughout the central nervous system. |
2013-01-28 |
2023-08-12 |
mouse |
| Staci E Engle, Hilary J Broderick, Ryan M Drena. Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices. Journal of visualized experiments : JoVE. issue 68. 2013-01-28. PMID:23128482. |
although whole-cell patch clamp recordings from neurons in brain slices is routinely done by the skilled electrophysiologist, it is challenging to locally apply drugs such as acetylcholine or nicotine to the recorded cell within a brain slice. |
2013-01-28 |
2023-08-12 |
mouse |
| Patrizia Russo, Alessio Cardinale, Stefano Margaritora, Alfredo Cesari. Nicotinic receptor and tobacco-related cancer. Life sciences. vol 91. issue 21-22. 2013-01-24. PMID:22705232. |
nicotine, the addictive constituent of tobacco, and its derived carcinogenic nitrosamines, contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nachr). |
2013-01-24 |
2023-08-12 |
mouse |