| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shupeng Li, Zhaoxia Li, Lin Pei, Anh D Le, Fang Li. The α7nACh-NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking. The Journal of experimental medicine. vol 209. issue 12. 2013-01-22. PMID:23091164. |
nicotine, the main psychoactive drug in tobacco, is one of the most heavily used addictive substances, and its continued use is driven through activation of nicotinic acetylcholine receptors (nachrs). |
2013-01-22 |
2023-08-12 |
rat |
| Massimo Grilli, Maria Summa, Alessia Salamone, Guendalina Olivero, Stefania Zappettini, Silvia Di Prisco, Marco Feligioni, Cesare Usai, Anna Pittaluga, Mario March. In vitro exposure to nicotine induces endocytosis of presynaptic AMPA receptors modulating dopamine release in rat nucleus accumbens nerve terminals. Neuropharmacology. vol 63. issue 5. 2013-01-14. PMID:22771975. |
the nach-ampa receptor-receptor interaction was not limited to dopaminergic terminals since nicotine pre-exposure also affected the presynaptic ampa receptors controlling hippocampal noradrenaline release, but not the presynaptic ampa receptors controlling gaba and acetylcholine release. |
2013-01-14 |
2023-08-12 |
rat |
| Sean H White, Neil S Magosk. Acetylcholine-evoked afterdischarge in Aplysia bag cell neurons. Journal of neurophysiology. vol 107. issue 10. 2013-01-09. PMID:22323635. |
whereas nicotine, choline, carbachol, and glycine did not mimic acetylcholine, tetramethylammonium did produce a similar current. |
2013-01-09 |
2023-08-12 |
aplysia |
| Irakli Intskirveli, Raju Metherat. Nicotinic neuromodulation in auditory cortex requires MAPK activation in thalamocortical and intracortical circuits. Journal of neurophysiology. vol 107. issue 10. 2013-01-09. PMID:22357798. |
activation of nicotinic acetylcholine receptors (nachrs) by systemic nicotine enhances sensory-cognitive function and sensory-evoked cortical responses. |
2013-01-09 |
2023-08-12 |
mouse |
| Thomas J Hopkins, Laura E Rupprecht, Matthew R Hayes, Julie A Blendy, Heath D Schmid. Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22669169. |
galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. |
2013-01-09 |
2023-08-12 |
mouse |
| Thomas J Hopkins, Laura E Rupprecht, Matthew R Hayes, Julie A Blendy, Heath D Schmid. Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22669169. |
these results indicate that increased extracellular acetylcholine levels and/or nicotinic acetylcholine receptor stimulation is sufficient to attenuate nicotine taking and seeking in rats and that these effects are reinforcer selective and not due to adverse malaise symptoms such as nausea. |
2013-01-09 |
2023-08-12 |
mouse |
| Amanda K Woynillowicz, Sandeep Raha, Catherine J Nicholson, Alison C Hollowa. The effect of smoking cessation pharmacotherapies on pancreatic beta cell function. Toxicology and applied pharmacology. vol 265. issue 1. 2013-01-08. PMID:22960054. |
the goal of our study was to evaluate whether drugs currently used for smoking cessation (i.e., nicotine replacement therapy, varenicline [a partial agonist at nicotinic acetylcholine receptors (nachr)] and bupropion [which acts in part as a nachr antagonist]) can affect beta cell function and determine the mechanism(s) of this effect. |
2013-01-08 |
2023-08-12 |
rat |
| Julieta Garduño, Luis Galindo-Charles, Javier Jiménez-Rodríguez, Elvira Galarraga, Dagoberto Tapia, Stefan Mihailescu, Salvador Hernandez-Lope. Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 43. 2013-01-07. PMID:23100436. |
in vitro experiments have demonstrated that nicotine increases the firing activity in the majority of drn 5-ht neurons and that drn contains nicotinic acetylcholine receptors (nachrs) located at both somata and presynaptic elements. |
2013-01-07 |
2023-08-12 |
rat |
| Cristian A Zambrano, Rakel M Salamander, Allan C Collins, Sharon R Grady, Michael J Mark. Regulation of the distribution and function of [(125)I]epibatidine binding sites by chronic nicotine in mouse embryonic neuronal cultures. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22532626. |
chronic nicotine produces up-regulation of α4β2* nicotinic acetylcholine receptors (nachrs) (* denotes that an additional subunit may be part of the receptor). |
2012-12-21 |
2023-08-12 |
mouse |
| Tanuja Bordia, Maya Hrachova, Matthew Chin, J Michael McIntosh, Maryka Qui. Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22550286. |
extensive evidence indicates that varenicline reduces nicotine craving and withdrawal symptoms by modulating dopaminergic function at α4β2* nicotinic acetylcholine receptors (nachrs) (the asterisk indicates the possible presence of other nicotinic subunits in the receptor complex). |
2012-12-21 |
2023-08-12 |
rat |
| Xiomara A Perez, Jason Ly, J Michael McIntosh, Maryka Qui. Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens. The Journal of pharmacology and experimental therapeutics. vol 342. issue 2. 2012-12-21. PMID:22562772. |
although recent work suggests that α6β2* nicotinic acetylcholine receptors (nachrs) play a dominant role in dopaminergic function in rodent nucleus accumbens, the effects of long-term nicotine exposure remain to be determined. |
2012-12-21 |
2023-08-12 |
monkey |
| K Aftab, Atta-Ur-Rahman, S I Ahmed, K Usmanghan. Traditional medicine Cassia absus L. (chaksu)-pharmacological evaluation. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 2. issue 3. 2012-12-03. PMID:23194619. |
in the guinea-pig ileum, ca at a low concentrations significantly reduced the spasmogenic response of nicotine without modifying the effect of acetylcholine. |
2012-12-03 |
2023-08-12 |
rat |
| Maryka Quik, Xiomara A Perez, Tanuja Bordi. Nicotine as a potential neuroprotective agent for Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 8. 2012-11-21. PMID:22693036. |
converging research efforts suggest that nicotine and other drugs that act at nicotinic acetylcholine receptors (nachrs) may be beneficial in the management of parkinson's disease. |
2012-11-21 |
2023-08-12 |
Not clear |
| Jiří Lindovský, Konstantin Petrov, Jan Krůšek, Vladimir S Reznik, Eugeny E Nikolsky, František Vyskoči. Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22634638. |
currents evoked by rapid application of acetylcholine or nicotine were recorded in whole-cell mode by electrophysiological patch-clamp technique 2-4 days after cell transfection by plasmids coding the α3β4 or αβεδ combination of receptor subunits. |
2012-11-16 |
2023-08-12 |
rat |
| Xavier Gallego, Susanna Molas, Alejandro Amador-Arjona, Michael J Marks, Noemí Robles, Patricia Murtra, Lluís Armengol, Rubén D Fernández-Montes, Mònica Gratacòs, Martí Pumarola, Roberto Cabrera, Rafael Maldonado, Josefa Sabrià, Xavier Estivill, Mara Diersse. Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. Amino acids. vol 43. issue 2. 2012-11-06. PMID:22101982. |
nicotinic acetylcholine receptors (nachrs) are ligand-gated pentameric ion channels that account for the effects of nicotine. |
2012-11-06 |
2023-08-12 |
mouse |
| Mohammed H Al-Wadei, Hussein A N Al-Wadei, Hildegard M Schulle. Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. Carcinogenesis. vol 33. issue 9. 2012-10-31. PMID:22791813. |
we have shown that binding of nicotine to nicotinic acetylcholine receptors (nachrs) expressing subunits α7, α3 and α5 in pdac and pancreatic duct epithelial cells in vitro triggered the production of the neurotransmitters noradrenaline and adrenaline by these cells. |
2012-10-31 |
2023-08-12 |
Not clear |
| Helen M Kamens, Nicole R Hoft, Ryan J Cox, Jill H Miyamoto, Marissa A Ehringe. The α6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation. Alcohol (Fayetteville, N.Y.). vol 46. issue 5. 2012-10-29. PMID:22572056. |
recently, the genes that code for the subunits of the nicotinic acetylcholine receptors have been implicated as a common genetic mediator for alcohol and nicotine responses. |
2012-10-29 |
2023-08-12 |
mouse |
| Yoichiro Kashiwagi, Manabu Yanagita, Yuko Kojima, Yoshio Shimabukuro, Shinya Murakam. Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Archives of oral biology. vol 57. issue 5. 2012-10-24. PMID:22119045. |
the aim of this study is to evaluate the effect of nicotine, a major component of cigarette smoke, on interleukin-8 (il-8) production and cellular signalling via nicotinic acetylcholine receptors (nachrs) in human gingival epithelial cells (hgecs). |
2012-10-24 |
2023-08-12 |
human |
| R Aldunate, A N Minniti, D Rebolledo, N C Inestros. Synaptic defects associated with s-inclusion body myositis are prevented by copper. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 25. issue 4. 2012-10-22. PMID:22573194. |
our recent studies show that neuromuscular synaptic transmission is defective in animals that express the aβ-peptide and suggest a specific defect at the nicotine acetylcholine receptors level. |
2012-10-22 |
2023-08-12 |
human |
| Rodrigo C Meza, Fernando C Ortiz, Eduardo Bravo, Patricio Iturriaga-Vásquez, Jaime L Eugenín, Rodrigo Vara. Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body. Neurochemistry international. vol 60. issue 2. 2012-10-19. PMID:22127290. |
in isolated cb cells the nachr agonists nicotine, acetylcholine and cytisine all evoke inward currents with similar potencies. |
2012-10-19 |
2023-08-12 |
rat |