| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liwang Liu, Rubing Zhao-Shea, J Michael McIntosh, Paul D Gardner, Andrew R Tappe. Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22222765. |
nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. |
2012-05-07 |
2023-08-12 |
mouse |
| Liwang Liu, Rubing Zhao-Shea, J Michael McIntosh, Paul D Gardner, Andrew R Tappe. Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing α4 and α6 subunits. Molecular pharmacology. vol 81. issue 4. 2012-05-07. PMID:22222765. |
however, nicotine concentrations that are routinely self-administered by smokers are predicted to desensitize high-affinity α4β2 neuronal nicotinic acetylcholine receptors (nachrs) in seconds. |
2012-05-07 |
2023-08-12 |
mouse |
| Deepak Cyril D'Souza, Irina Esterlis, Michelle Carbuto, Maegan Krasenics, John Seibyl, Frederic Bois, Brian Pittman, Mohini Ranganathan, Kelly Cosgrove, Julie Stale. Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia. The American journal of psychiatry. vol 169. issue 3. 2012-04-25. PMID:22193533. |
nicotine's actions in the brain are mediated through nicotinic acetylcholine receptors. |
2012-04-25 |
2023-08-12 |
Not clear |
| Koutilya Buchapudi, Xiaohe Xu, Yeganeh Ataian, Hai-Feng Ji, Marvin Schult. Micromechanical measurement of AChBP binding for label-free drug discovery. The Analyst. vol 137. issue 1. 2012-04-17. PMID:22046583. |
the modified microcantilever was found to bend on application of the naturally occurring agonist (acetylcholine) or the antagonist (nicotine and d-tubocurarine). |
2012-04-17 |
2023-08-12 |
Not clear |
| Koutilya Buchapudi, Xiaohe Xu, Yeganeh Ataian, Hai-Feng Ji, Marvin Schult. Micromechanical measurement of AChBP binding for label-free drug discovery. The Analyst. vol 137. issue 1. 2012-04-17. PMID:22046583. |
control experiments show that microcantilevers modified without achbp do not respond to acetylcholine, nicotine, and d-tubocurarine. |
2012-04-17 |
2023-08-12 |
Not clear |
| Koutilya Buchapudi, Xiaohe Xu, Yeganeh Ataian, Hai-Feng Ji, Marvin Schult. Micromechanical measurement of AChBP binding for label-free drug discovery. The Analyst. vol 137. issue 1. 2012-04-17. PMID:22046583. |
k(d) values obtained for acetylcholine, nicotine, and d-tubocurarine are similar to those obtained from radio-ligand binding assays. |
2012-04-17 |
2023-08-12 |
Not clear |
| Kaisu Keskitalo-Vuokko, Janne Pitkäniemi, Ulla Broms, Markku Heliövaara, Arpo Aromaa, Markus Perola, Samuli Ripatti, Outi Salminen, Veikko Salomaa, Anu Loukola, Jaakko Kapri. Associations of nicotine intake measures with CHRN genes in Finnish smokers. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 13. issue 8. 2012-04-12. PMID:21498873. |
as the physiological effects of nicotine are mediated by nicotinic acetylcholine receptors (nachrs), we aimed at examining whether single nucleotide polymorphisms (snps) residing in nachr subunit (chrn) genes, other than chrna3/chrna5/chrnb4 gene cluster previously showing association in our sample, are associated with smoking quantity or serum cotinine levels. |
2012-04-12 |
2023-08-12 |
Not clear |
| Alessandra Giarola, Alessia Auber, Cristiano Chiamuler. Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats. Behavioural pharmacology. vol 22. issue 1. 2012-04-06. PMID:21116174. |
the purpose of this study was to investigate whether ache-is with nicotinic acetylcholine receptor-positive allosteric modulator properties generalize to the discriminative stimulus effect of nicotine in rats. |
2012-04-06 |
2023-08-12 |
rat |
| Anna Chikova, Sergei A Grand. Naturally occurring variants of human Α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation. PloS one. vol 6. issue 11. 2012-04-02. PMID:22125646. |
these results suggested that α9 nachr plays important roles in regulation of bronchial cell growth by endogenous acetylcholine and exogenous nicotine, and susceptibility to nnk-induced carcinogenic transformation. |
2012-04-02 |
2023-08-12 |
mouse |
| Anitha P Govind, Heather Walsh, William N Gree. Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323734. |
nicotine causes changes in brain nicotinic acetylcholine receptors (nachrs) during smoking that initiate addiction. |
2012-03-27 |
2023-08-12 |
rat |
| Zoraida Verde, Catalina Santiago, José Miguel Rodríguez González-Moro, Pilar de Lucas Ramos, Soledad López Martín, Fernando Bandrés, Alejandro Lucia, Félix Gómez-Galleg. 'Smoking genes': a genetic association study. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046326. |
overall, our results suggest that genetic variants potentially involved in nicotine metabolization (mainly, cyp2a6 polymorphisms) are those showing the strongest association with smoking-related phenotypes, as opposed to genetic variants influencing the brain effects of nicotine, e.g., through nicotinic acetylcholine (chrna5), serotoninergic (htr2a), opioid (oprm1) or cannabinoid receptors (cnr1). |
2012-03-26 |
2023-08-12 |
Not clear |
| Junpei Soeda, Maelle Morgan, Chad McKee, Angelina Mouralidarane, Chingi Lin, Tania Roskams, Jude A Obe. Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22108052. |
nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells. |
2012-03-22 |
2023-08-12 |
human |
| Junpei Soeda, Maelle Morgan, Chad McKee, Angelina Mouralidarane, Chingi Lin, Tania Roskams, Jude A Obe. Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells. Biochemical and biophysical research communications. vol 417. issue 1. 2012-03-22. PMID:22108052. |
among the many chemicals in cs is nicotine - which affects cells through nicotinic acetylcholine receptors (nachr). |
2012-03-22 |
2023-08-12 |
human |
| David C L Lam, John D Minn. How do we safely get people to stop smoking? Cancer prevention research (Philadelphia, Pa.). vol 4. issue 11. 2012-03-12. PMID:22052339. |
however, the discoveries of functional nicotinic acetylcholine receptors (nachr) on lung epithelial and cancer cells and of nachr polymorphisms associated with lung cancer risk, in addition to a large number of preclinical studies indicating that nicotine may promote or facilitate cancer development and growth, have prompted concern that nrt, although important for smoking cessation, may actually augment lung carcinogenesis. |
2012-03-12 |
2023-08-12 |
mouse |
| Seddigheh Razani-Boroujerdi, Raymond J Langley, Shashi P Singh, Juan Carlos Pena-Philippides, Jules Rir-sima-ah, Sravanthi Gundavarapu, Neerad C Mishra, Mohan L Sopor. The role of IL-1β in nicotine-induced immunosuppression and neuroimmune communication. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 6. issue 4. 2012-02-29. PMID:21671006. |
chronic nicotine (nt) suppresses both adaptive and innate immune responses, and the effects are partly mediated by the nicotinic acetylcholine receptors in the brain; however, the mechanism of neuroimmune communication is not clear. |
2012-02-29 |
2023-08-12 |
mouse |
| Satomi Onoue, Noriyuki Yamamoto, Yoshiki Seto, Shizuo Yamad. Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS. Drug metabolism and pharmacokinetics. vol 26. issue 4. 2012-02-16. PMID:21566343. |
however, nicotine was found to be predominant in cortex and bladder, where nicotinic acetylcholine receptors were expressed for neuronal control of voiding function. |
2012-02-16 |
2023-08-12 |
rat |
| Manoranjan S D'Souza, Athina Marko. Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments. Addiction science & clinical practice. vol 6. issue 1. 2012-02-09. PMID:22003417. |
this article focuses on the neural substrates, especially nicotinic acetylcholine receptors, that mediate the reinforcing effects of nicotine and the development of nicotine dependence. |
2012-02-09 |
2023-08-12 |
Not clear |
| G L Gergalova, M V Sko. [Nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 83. issue 5. 2012-02-09. PMID:22276424. |
[nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors]. |
2012-02-09 |
2023-08-12 |
mouse |
| G L Gergalova, M V Sko. [Nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). vol 83. issue 5. 2012-02-09. PMID:22276424. |
introduction of nicotine, choline, acetylcholine or synthetic alpha7 nachr agonist pnu 282987 into the incubation medium inhibited ca2+ accumulation in mitochondria, although the doses of agonists were too low to activate the alpha7 nachr ion channel. |
2012-02-09 |
2023-08-12 |
mouse |
| Eleonora Palma, Maurizio Inghilleri, Luca Conti, Cristina Deflorio, Vittorio Frasca, Alessia Manteca, Floriana Pichiorri, Cristina Roseti, Gregorio Torchia, Cristina Limatola, Francesca Grassi, Ricardo Miled. Physiological characterization of human muscle acetylcholine receptors from ALS patients. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 50. 2012-02-01. PMID:22128328. |
we found that als acetylcholine receptors (achrs) retain their native physiological characteristics, being activated by ach and nicotine and blocked by α-bungarotoxin (α-butx), d-tubocurarine (dtc), and galantamine. |
2012-02-01 |
2023-08-12 |
mouse |