| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tristan D McClure-Begley, Kathy L Stone, Michael J Marks, Sharon R Grady, Christopher M Colangelo, Jon M Lindstrom, Marina R Picciott. Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice. Genomics, proteomics & bioinformatics. vol 11. issue 4. 2014-03-11. PMID:23891776. |
neuronal nicotinic acetylcholine receptors (nachrs) containing α4 and β2 subunits are the principal receptors in the mammalian central nervous system that bind nicotine with high affinity. |
2014-03-11 |
2023-08-12 |
mouse |
| Jinhua Wu, Yaohong Zhang, Laura E Maida, Radleigh G Santos, Gregory S Welmaker, Travis M LaVoi, Adel Nefzi, Yongping Yu, Richard A Houghten, Lawrence Toll, Marc A Giulianott. Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies. Journal of medicinal chemistry. vol 56. issue 24. 2014-03-04. PMID:24274400. |
nicotine binds to nicotinic acetylcholine receptors (nachr), which can exist as many different subtypes. |
2014-03-04 |
2023-08-12 |
Not clear |
| Shafiqur Rahma. Nicotinic receptors as therapeutic targets for drug addictive disorders. CNS & neurological disorders drug targets. vol 12. issue 5. 2014-03-03. PMID:23574176. |
evidence from preclinical and clinical studies suggests that brain nicotinic acetylcholine receptors (nachrs), play a critical role in various addictive disorders, including nicotine addiction and alcoholism. |
2014-03-03 |
2023-08-12 |
Not clear |
| Jacob C Nordman, Pretal Muldoon, Sarah Clark, M Imad Damaj, Nadine Kabban. The α4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response. Molecular pharmacology. vol 85. issue 1. 2014-03-03. PMID:24107512. |
chronic nicotine exposure is known to activate nicotinic acetylcholine receptors (nachrs) in immune cells. |
2014-03-03 |
2023-08-12 |
mouse |
| Michael Graupner, Reinoud Maex, Boris Gutki. Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine. PLoS computational biology. vol 9. issue 8. 2014-02-27. PMID:23966848. |
nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nachrs) and boosting dopamine (da) output from the ventral tegmental area (vta). |
2014-02-27 |
2023-08-12 |
Not clear |
| Michael Graupner, Reinoud Maex, Boris Gutki. Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine. PLoS computational biology. vol 9. issue 8. 2014-02-27. PMID:23966848. |
together our results delineate the mechanisms by which the vta mediates the acute rewarding properties of nicotine and suggest an acetylcholine dependence hypothesis for nicotine reinforcement. |
2014-02-27 |
2023-08-12 |
Not clear |
| Bo Shen, Mei-Qi Shi, Ma-Qing Zheng, Sai-Nan Hu, Jia Chen, Ji-Feng Fen. Correlation between polymorphisms of nicotine acetylcholine acceptor subunit CHRNA3 and lung cancer susceptibility. Molecular medicine reports. vol 6. issue 6. 2014-02-26. PMID:23023782. |
correlation between polymorphisms of nicotine acetylcholine acceptor subunit chrna3 and lung cancer susceptibility. |
2014-02-26 |
2023-08-12 |
Not clear |
| Arthur A Nery, Margaret H Magdesian, Cleber A Trujillo, Luciana B Sathler, Maria A Juliano, Luiz Juliano, Henning Ulrich, Sergio T Ferreir. Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype. PloS one. vol 8. issue 7. 2014-02-24. PMID:23894286. |
rescue of amyloid-beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype. |
2014-02-24 |
2023-08-12 |
Not clear |
| Qing Cheng, Jerrel L Yake. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 1. 2014-02-24. PMID:24381273. |
nicotinic acetylcholine receptors (nachrs) are expressed widely in the cns, and mediate both synaptic and perisynaptic activities of endogenous cholinergic inputs and pharmacological actions of exogenous compounds (e.g., nicotine and choline). |
2014-02-24 |
2023-08-12 |
mouse |
| S Alijanpour, A Rezayo. Involvement of dorsal hippocampal and medial septal nicotinic receptors in cross state-dependent memory between WIN55, 212-2 and nicotine or ethanol in mice. Neuroscience. vol 245. 2014-02-19. PMID:23624371. |
the present study examined whether nicotinic acetylcholine receptors (nachrs) of the ca1 regions of the dorsal hippocampus and medial septum (ms) are involved in cross state-dependent memory retrieval between win55, 212-2 (win, a non-selective cb1/cb2 receptor agonist) and nicotine or ethanol. |
2014-02-19 |
2023-08-12 |
mouse |
| Junran Cao, Shaolin Wang, Ju Wang, Wenyan Cui, Tanseli Nesil, Michael Vigorito, Sulie L Chang, Ming D L. RNA deep sequencing analysis reveals that nicotine restores impaired gene expression by viral proteins in the brains of HIV-1 transgenic rats. PloS one. vol 8. issue 7. 2014-02-19. PMID:23874651. |
because nicotine, a natural agonist of nicotinic acetylcholine receptors, exhibits a neuroprotective effect, we presently tested the hypothesis that nicotine restores the expression of altered genes in the cns of hiv-1tg rats. |
2014-02-19 |
2023-08-12 |
rat |
| Ethan B Van Arnam, Emily E Blythe, Henry A Lester, Dennis A Doughert. An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline. Molecular pharmacology. vol 84. issue 2. 2014-02-06. PMID:23680636. |
we also evaluate binding to the complementary face of the receptor's binding site by varenicline, the endogenous agonist acetylcholine, and the potent nicotine analog epibatidine. |
2014-02-06 |
2023-08-12 |
Not clear |
| Shuo Wang, Koichi Takayama, Kentaro Tanaka, Masafumi Takeshita, Noriaki Nakagaki, Kayo Ijichi, Heyan Li, Yoichi Nakanish. Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by α1 nicotinic acetylcholine receptor-mediated activation in PC9 cells. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 8. issue 6. 2014-01-09. PMID:23625155. |
nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by α1 nicotinic acetylcholine receptor-mediated activation in pc9 cells. |
2014-01-09 |
2023-08-12 |
Not clear |
| Shuo Wang, Koichi Takayama, Kentaro Tanaka, Masafumi Takeshita, Noriaki Nakagaki, Kayo Ijichi, Heyan Li, Yoichi Nakanish. Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by α1 nicotinic acetylcholine receptor-mediated activation in PC9 cells. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. vol 8. issue 6. 2014-01-09. PMID:23625155. |
nicotine, the major component among the 4000 identified chemicals in cigarette smoke, binds to nicotinic acetylcholine receptors (nachrs) on non-small-cell lung cancer (nsclc) cells and regulates cellular proliferation by activating mitogen-activated protein kinases [aq: mapk has been expanded to mitogen-activated protein kinases. |
2014-01-09 |
2023-08-12 |
Not clear |
| Aysegul Keser, Tanseli Nesil, Lutfiye Kanit, Sakire Pogu. Brain nitric oxide metabolites in rats preselected for nicotine preference and intake. Neuroscience letters. vol 545. 2014-01-06. PMID:23643897. |
the present study aimed to assess no activity, by measuring its stable metabolites, in three brain regions that express high levels of nicotinic acetylcholine receptors in rats preselected for nicotine preference. |
2014-01-06 |
2023-08-12 |
rat |
| Karem H Alzoubi, Marisa Srivareerat, Trinh T Tran, Karim A Alkadh. Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory. The international journal of neuropsychopharmacology. vol 16. issue 5. 2014-01-03. PMID:23067572. |
in this study, we have investigated the role of α7- and α4β2-nicotinic acetylcholine receptors (nachrs) in the protective effect of nicotine during chronic stress conditions. |
2014-01-03 |
2023-08-12 |
rat |
| Xavier Gallego, Ryan J Cox, James R Laughlin, Jerry A Stitzel, Marissa A Ehringe. Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression. PloS one. vol 8. issue 5. 2013-12-30. PMID:23691088. |
several lines of evidence suggest nicotinic acetylcholine receptors as common sites of action for nicotine and alcohol. |
2013-12-30 |
2023-08-12 |
Not clear |
| Andrés P Varani, Marta C Antonelli, Graciela N Baleri. Mecamylamine-precipitated nicotine withdrawal syndrome and its prevention with baclofen: an autoradiographic study of α4β2 nicotinic acetylcholine receptors in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23500668. |
mecamylamine-precipitated nicotine withdrawal syndrome and its prevention with baclofen: an autoradiographic study of α4β2 nicotinic acetylcholine receptors in mice. |
2013-12-18 |
2023-08-12 |
mouse |
| Liwang Liu, Rubing Zhao-Shea, J Michael McIntosh, Andrew R Tappe. Nicotinic acetylcholine receptors containing the α6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23811312. |
recent evidence indicates that nicotinic acetylcholine receptors (nachrs), ligand-gated cation channels activated by ach and nicotine, may contribute to ethanol-mediated activation of vta daergic neurons although the nachr subtype(s) involved has not been fully elucidated. |
2013-12-17 |
2023-08-12 |
mouse |
| Sara Francesca Colombo, Francesca Mazzo, Fancesco Pistillo, Cecilia Gott. Biogenesis, trafficking and up-regulation of nicotinic ACh receptors. Biochemical pharmacology. vol 86. issue 8. 2013-12-17. PMID:23830821. |
chronic nicotine exposure gives rise to neural adaptations that change whole cell physiology and behaviour mainly by interacting with neuronal nicotinic acetylcholine receptors (nachrs). |
2013-12-17 |
2023-08-12 |
Not clear |