| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Yan Wang, Yao Liu, Xiao Yan Ni, Zhen Huan Bai, Qiong Yun Chen, Ye Zhang, Feng Guang Ga. Nicotine promotes cell proliferation and induces resistance to cisplatin by α7 nicotinic acetylcholine receptor‑mediated activation in Raw264.7 and El4 cells. Oncology reports. vol 31. issue 3. 2014-09-26. PMID:24399025. |
nicotine promotes cell proliferation and induces resistance to cisplatin by α7 nicotinic acetylcholine receptor‑mediated activation in raw264.7 and el4 cells. |
2014-09-26 |
2023-08-12 |
human |
| Kristin Lees, Andrew K Jones, Kazuhiko Matsuda, Miki Akamatsu, David B Sattelle, Debra J Woods, Alan S Bowma. Functional characterisation of a nicotinic acetylcholine receptor α subunit from the brown dog tick, Rhipicephalus sanguineus. International journal for parasitology. vol 44. issue 1. 2014-09-12. PMID:24291321. |
when co-expressed with chicken β2 nachr, rsanα1 evoked concentration-dependent, inward currents in response to acetylcholine (ach) and showed sensitivity to nicotine (100 μm) and choline (100 μm). |
2014-09-12 |
2023-08-12 |
human |
| Michael J Marks, Sharon R Grady, Outi Salminen, Miranda A Paley, Charles R Wageman, J Michael McIntosh, Paul Whiteake. α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration. Journal of neurochemistry. vol 130. issue 2. 2014-09-10. PMID:24661093. |
α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration. |
2014-09-10 |
2023-08-12 |
human |
| Eugene A Kiyatki. Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure. Reviews in the neurosciences. vol 25. issue 2. 2014-09-08. PMID:24535300. |
it is well established that the reinforcing properties of nicotine (nic) depend on its action on nicotinic acetylcholine receptors expressed by brain neurons. |
2014-09-08 |
2023-08-12 |
human |
| Liwang Liu, Linzy M Hendrickson, Melissa J Guildford, Rubing Zhao-Shea, Paul D Gardner, Andrew R Tappe. Nicotinic acetylcholine receptors containing the α4 subunit modulate alcohol reward. Biological psychiatry. vol 73. issue 8. 2014-09-01. PMID:23141806. |
although nicotine elicits reward by activating ventral tegmental area dopaminergic (daergic) neurons via high-affinity neuronal nicotinic acetylcholine receptors (nachrs), the mechanism by which alcohol activates these neurons is unclear. |
2014-09-01 |
2023-08-12 |
Not clear |
| Craig D C Bailey, Michael K Tian, Lily Kang, Ryan O'Reilly, Evelyn K Lamb. Chrna5 genotype determines the long-lasting effects of developmental in vivo nicotine exposure on prefrontal attention circuitry. Neuropharmacology. vol 77. 2014-08-26. PMID:24055499. |
these prefrontal layer vi neurons would be likely targets because they are developmentally excited and morphologically sculpted by a population of nicotinic acetylcholine receptors (nachrs) that are sensitive to activation and/or desensitization by nicotine. |
2014-08-26 |
2023-08-12 |
mouse |
| Christopher B Marotta, Crystal N Dilworth, Henry A Lester, Dennis A Doughert. Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor. Neuropharmacology. vol 77. 2014-08-26. PMID:24144909. |
nicotinic acetylcholine receptors (nachrs) containing the α5 subunit are of interest because genome-wide association studies and candidate gene studies have identified polymorphisms in the α5 gene that are linked to an increased risk for nicotine dependence, lung cancer, and/or alcohol addiction. |
2014-08-26 |
2023-08-12 |
Not clear |
| Eric G Mohler, Stanley R Franklin, Lynne E Ruete. Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats. Psychopharmacology. vol 231. issue 1. 2014-08-18. PMID:23925734. |
neuronal α4β2* nicotinic acetylcholine receptors mediate cognition, pain, and the discriminative and reinforcing effects of nicotine. |
2014-08-18 |
2023-08-12 |
rat |
| Andreas H Rasmussen, Dorte Strøbæk, Tino Dyhring, Marianne L Jensen, Dan Peters, Morten Grunnet, Daniel B Timmermann, Philip K Ahrin. Biophysical and pharmacological characterization of α6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Brain research. vol 1542. 2014-08-15. PMID:24157862. |
nicotinic acetylcholine receptors (nachr's) containing the α6 subunit (α6) are putative drug targets of relevance to parkinson's disease and nicotine addiction. |
2014-08-15 |
2023-08-12 |
human |
| Brandon J Henderson, Rahul Srinivasan, Weston A Nichols, Crystal N Dilworth, Diana F Gutierrez, Elisha D W Mackey, Sheri McKinney, Ryan M Drenan, Christopher I Richards, Henry A Leste. Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. The Journal of general physiology. vol 143. issue 1. 2014-08-15. PMID:24378908. |
chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nachrs) in the brain. |
2014-08-15 |
2023-08-12 |
mouse |
| Xiaoli Ma, Yanfei Jia, Shanshan Zu, Ruisheng Li, Ying Jia, Yun Zhao, Dongjie Xiao, Ningning Dang, Yunshan Wan. α5 Nicotinic acetylcholine receptor mediates nicotine-induced HIF-1α and VEGF expression in non-small cell lung cancer. Toxicology and applied pharmacology. vol 278. issue 2. 2014-08-05. PMID:24793809. |
by binding to nicotinic acetylcholine receptors (nachrs), nicotine induces the proliferation and apoptosis of non-small cell lung cancer (nsclc). |
2014-08-05 |
2023-08-13 |
Not clear |
| Benzidane Yassine, Xavier Leray, Charlotte Falaise, Sophie Quinchard, José Pedro Ceron-Carrasco, Denis Jacquemin, Jérôme Graton, Jean-Yves Le Questel, Steeve H Than. Pretreatment of the cockroach cercal afferent/giant interneuron synapses with nicotinoids and neonicotinoids differently affects acetylcholine and nicotine-induced ganglionic depolarizations. Invertebrate neuroscience : IN. vol 13. issue 2. 2014-08-01. PMID:23467815. |
the present work therefore suggests, in agreement with previous studies, that nornicotine and cotinine bind to distinct cockroach postsynaptic nachrs, whereas acetamiprid and imidacloprid have competitive effects with acetylcholine and nicotine on ganglionic depolarization. |
2014-08-01 |
2023-08-12 |
Not clear |
| Xia Li, Svetlana Semenova, Manoranjan S D'Souza, Astrid K Stoker, Athina Marko. Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23752091. |
nicotine binds to nicotinic acetylcholine receptors (nachrs) in the brain, resulting in the release of a wide range of neurotransmitters, including glutamate and γ-aminobutyric acid (gaba). |
2014-07-29 |
2023-08-12 |
Not clear |
| Cristiano Termine, Claudia Selvini, Giorgio Rossi, Umberto Balotti. Emerging treatment strategies in Tourette syndrome: what's in the pipeline? International review of neurobiology. vol 112. 2014-07-14. PMID:24295630. |
however, several studies have investigated the efficacy and tolerability of alternative pharmacological agents that may be efficacious, including the newest atypical antipsychotic agents (e.g., paliperidone, sertindole), tetrabenazine, drugs that modulate acetylcholine (e.g., nicotine) and gaba (e.g., baclofen, levetiracetam), tetrahydrocannabinol, botulinum toxin injections, anticonvulsant drugs (e.g., topiramate, carbamazepine), naloxone, lithium, norepinephrine, steroid 5α reductase, and other neuroactive agents (buspirone, metoclopramide, phytostigmine, and spiradoline mesylate). |
2014-07-14 |
2023-08-12 |
Not clear |
| Sergei A Grand. Connections of nicotine to cancer. Nature reviews. Cancer. vol 14. issue 6. 2014-07-10. PMID:24827506. |
the nicotinic acetylcholine receptors (nachrs), which are activated by nicotine, can activate several signalling pathways that can have tumorigenic effects, and these receptors might be able to be targeted for cancer therapy or prevention. |
2014-07-10 |
2023-08-13 |
Not clear |
| Kiyofumi Yamamoto, Katsuko Ebihara, Noriaki Koshikawa, Masayuki Kobayash. Reciprocal regulation of inhibitory synaptic transmission by nicotinic and muscarinic receptors in rat nucleus accumbens shell. The Journal of physiology. vol 591. issue 22. 2014-06-24. PMID:24018951. |
carbachol-induced uipsc suppression was antagonised by 100 μm atropine, and was mimicked by pilocarpine (1 μm) and acetylcholine (1 μm) but not nicotine (1 μm). |
2014-06-24 |
2023-08-12 |
rat |
| Kiyofumi Yamamoto, Katsuko Ebihara, Noriaki Koshikawa, Masayuki Kobayash. Reciprocal regulation of inhibitory synaptic transmission by nicotinic and muscarinic receptors in rat nucleus accumbens shell. The Journal of physiology. vol 591. issue 22. 2014-06-24. PMID:24018951. |
in contrast, fsn→msn connections showed that pilocarpine had little effect on the uipsc amplitude, whereas both nicotine and acetylcholine facilitated uipsc amplitude, with decreases in failure rate and paired-pulse ratio, suggesting that nicotine-induced uipsc facilitation is mediated by presynaptic mechanisms. |
2014-06-24 |
2023-08-12 |
rat |
| Xiu Li. Positive allosteric modulation of α4β2 nicotinic acetylcholine receptors as a new approach to smoking reduction: evidence from a rat model of nicotine self-administration. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23712602. |
positive allosteric modulation of α4β2 nicotinic acetylcholine receptors as a new approach to smoking reduction: evidence from a rat model of nicotine self-administration. |
2014-06-23 |
2023-08-12 |
human |
| Xiu Li. Positive allosteric modulation of α4β2 nicotinic acetylcholine receptors as a new approach to smoking reduction: evidence from a rat model of nicotine self-administration. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23712602. |
the α4β2 subtype of nicotinic acetylcholine receptors (nachrs) plays a central role in the mediation of nicotine reinforcement. |
2014-06-23 |
2023-08-12 |
human |
| G Patrick Hussmann, Kristen E DeDominicis, Jill R Turner, Robert P Yasuda, Jacquelyn Klehm, Patrick A Forcelli, Yingxian Xiao, Janell R Richardson, Niaz Sahibzada, Barry B Wolfe, Jon Lindstrom, Julie A Blendy, Kenneth J Kella. Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. Journal of neurochemistry. vol 129. issue 4. 2014-06-15. PMID:24422997. |
chronic nicotine administration increases the density of brain α4β2* nicotinic acetylcholine receptors (nachrs), which may contribute to nicotine addiction by exacerbating withdrawal symptoms associated with smoking cessation. |
2014-06-15 |
2023-08-12 |
mouse |