| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koji Mizuno, Kazuhiro Kurokawa, Seitaro Ohkum. Nicotinic acetylcholine receptors regulate type 1 inositol 1,4,5-trisphosphate receptor expression via calmodulin kinase IV activation. Journal of neuroscience research. vol 93. issue 4. 2015-10-30. PMID:25430056. |
nicotine induced dose- and time-dependent upregulation of ip3 r-1 protein following its mrna increase, and the latter was significantly suppressed by a nonselective nicotinic acetylcholine receptors (nachr) antagonist, mecamylamine. |
2015-10-30 |
2023-08-13 |
mouse |
| Susanna Molas, Thomas Gener, Jofre Güell, Mairena Martín, Inmaculada Ballesteros-Yáñez, Maria V Sanchez-Vives, Mara Diersse. Hippocampal changes produced by overexpression of the human CHRNA5/A3/B4 gene cluster may underlie cognitive deficits rescued by nicotine in transgenic mice. Acta neuropathologica communications. vol 2. 2015-10-26. PMID:25384568. |
here, we propose that the genetic locus of susceptibility to nicotine addiction, the chrna5/a3/b4 gene cluster, encoding the α5, α3 and β4 subunits of the nicotinic acetylcholine receptors (nachrs), may influence nicotine-induced neuroadaptations. |
2015-10-26 |
2023-08-13 |
mouse |
| Hong Xu, Jeffery A Boychuk, Carie R Boychuk, Victor V Uteshev, Bret N Smit. Nicotine enhances inhibition of mouse vagal motor neurons by modulating excitability of premotor GABAergic neurons in the nucleus tractus solitarii. Journal of neurophysiology. vol 113. issue 4. 2015-10-23. PMID:25429117. |
previous studies have demonstrated that the majority of caudal nts neurons that project to the dmv respond robustly to nicotine and express nicotinic acetylcholine receptors (nachrs). |
2015-10-23 |
2023-08-13 |
mouse |
| Miriam Sciaccaluga, Claudia Moriconi, Katiuscia Martinello, Myriam Catalano, Isabel Bermudez, Jerry A Stitzel, Uwe Maskos, Sergio Fucil. Crucial role of nicotinic α5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25911614. |
neuronal nicotinic acetylcholine receptors (nachrs) containing the α5 subunit modulate nicotine consumption, and the human chrna5 rs16969968 polymorphism, causing the replacement of the aspartic acid residue at position 398 with an asparagine (α5dn), has recently been associated with increased use of tobacco and higher incidence of lung cancer. |
2015-10-19 |
2023-08-13 |
mouse |
| Shingo Kawazoe, Takahiro Shinka. [Nicotine dependence]. Nihon rinsho. Japanese journal of clinical medicine. vol 73. issue 9. 2015-10-16. PMID:26394514. |
as for physical nicotine dependence, nicotine produces rewarding effects by interacting with nicotinic acetylcholine receptors on neurons in the brain's reward system. |
2015-10-16 |
2023-08-13 |
Not clear |
| Gabe Haller, Ping Li, Caroline Esch, Simon Hsu, Alison M Goate, Joe Henry Steinbac. Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. PloS one. vol 9. issue 5. 2015-10-07. PMID:24804708. |
voltage-clamp was used to obtain acetylcholine and nicotine concentration-response curves and qrt-pcr, western blots and cell-surface elisas were performed to assess expression levels. |
2015-10-07 |
2023-08-13 |
human |
| Gabe Haller, Ping Li, Caroline Esch, Simon Hsu, Alison M Goate, Joe Henry Steinbac. Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. PloS one. vol 9. issue 5. 2015-10-07. PMID:24804708. |
we find that there is a highly significant correlation between carrier status weighted by either acetylcholine ec50 (β = -0.67, r2 = 0.017, p = 2 × 10(-4)) or by response to low nicotine (β = -0.29, r2 = 0.02, p = 6 × 10(-5)) when variants are expressed with the α3 subunit. |
2015-10-07 |
2023-08-13 |
human |
| Maegan M Weltzin, Marvin K Schult. Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit. The Journal of pharmacology and experimental therapeutics. vol 354. issue 2. 2015-09-15. PMID:26025967. |
alterations in expression patterns of α4β2 nicotinic acetylcholine receptors have been demonstrated to alter cholinergic neurotransmission and are implicated in neurologic disorders, including autism, nicotine addiction, alzheimer's disease, and parkinson's disease. |
2015-09-15 |
2023-08-13 |
xenopus_laevis |
| Hoai T Ton, Amanda E Smart, Brittany L Aguilar, Thao T Olson, Kenneth J Kellar, Gerard P Aher. Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors. Molecular pharmacology. vol 88. issue 2. 2015-09-10. PMID:25964258. |
coapplication of menthol with acetylcholine or nicotine increased desensitization, demonstrated by an increase in the rate and magnitude of the current decay and a reduction of the current integral. |
2015-09-10 |
2023-08-13 |
mouse |
| Theodore A Slotkin, Frederic J Seidle. Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?". Brain research bulletin. vol 110. 2015-09-09. PMID:25510202. |
we evaluated indices for acetylcholine (ach) synaptic function throughout adolescence, young adulthood and later adulthood, in brain regions possessing the majority of ach projections and cell bodies; we measured nicotinic ach receptor binding, hemicholinium-3 binding to the presynaptic choline transporter and choline acetyltransferase activity, all known targets for the adverse developmental effects of nicotine and chlorpyrifos given individually. |
2015-09-09 |
2023-08-13 |
human |
| Kelly P Cosgrove, Irina Esterlis, Christine Sandiego, Ryan Petrulli, Evan D Morri. Imaging Tobacco Smoking with PET and SPECT. Current topics in behavioral neurosciences. vol 24. 2015-09-08. PMID:25638332. |
nicotine, the primary addictive chemical in tobacco smoke, enters the brain, activates beta2-nicotinic acetylcholine receptors (β2*-nachrs) and, like most drugs of abuse, elicits dopamine (da) release in the ventral striatum. |
2015-09-08 |
2023-08-13 |
human |
| Julie-Anne Tanner, Meghan J Chenoweth, Rachel F Tyndal. Pharmacogenetics of nicotine and associated smoking behaviors. Current topics in behavioral neurosciences. vol 23. 2015-09-08. PMID:25655887. |
binding of nicotine to neuronal nicotinic acetylcholine receptors (nachrs) mediates the release of several neurotransmitters including dopamine and serotonin. |
2015-09-08 |
2023-08-13 |
Not clear |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
functional upregulation of α4* nicotinic acetylcholine receptors in vta gabaergic neurons increases sensitivity to nicotine reward. |
2015-08-19 |
2023-08-13 |
mouse |
| Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D Gardner, Andrew R Tappe. Functional Upregulation of α4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 22. 2015-08-19. PMID:26041923. |
interestingly, chronic nicotine use induces functional upregulation of nicotinic acetylcholine receptors (nachrs) in the mesocorticolimbic reward pathway potentially linking upregulation to increased drug sensitivity. |
2015-08-19 |
2023-08-13 |
mouse |
| Jingyi Wang, Alexander Kuryatov, Aarati Sriram, Zhuang Jin, Theodore M Kamenecka, Paul J Kenny, Jon Lindstro. An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors. The Journal of biological chemistry. vol 290. issue 22. 2015-08-18. PMID:25869137. |
neuronal nicotinic acetylcholine receptors containing α4, β2, and sometimes other subunits (α4β2* nachrs) regulate addictive and other behavioral effects of nicotine. |
2015-08-18 |
2023-08-13 |
xenopus_laevis |
| Heidi C Meyer, Rachel B Putney, David J Bucc. Inhibitory learning is modulated by nicotinic acetylcholine receptors. Neuropharmacology. vol 89. 2015-07-15. PMID:25445487. |
the findings indicate that nicotinic acetylcholine receptors may be active during negative occasion setting and that nicotine can potentiate learned inhibition. |
2015-07-15 |
2023-08-13 |
rat |
| Beatriz Balsera, José Mulet, Asia Fernández-Carvajal, Roberto de la Torre-Martínez, Antonio Ferrer-Montiel, José G Hernández-Jiménez, Judith Estévez-Herrera, Ricardo Borges, Andiara E Freitas, Manuela G López, M Teresa García-López, Rosario González-Muñiz, María Jesús Pérez de Vega, Luis M Valor, Lucie Svobodová, Salvador Sala, Francisco Sala, Manuel Criad. Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: a new target for a privileged structure. European journal of medicinal chemistry. vol 86. 2015-06-29. PMID:25232969. |
the α7 acetylcholine nicotine receptor is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain and inflammation among other diseases. |
2015-06-29 |
2023-08-13 |
Not clear |
| Emma Ghazavi, Rona David, Tina Hinton, Angela Makris, Annemarie Hennessy, Rita Machaalan. PP007. Nicotinic acetylcholine receptor subunits in the pre-eclamptic and cigarette smoke exposed human placenta. Pregnancy hypertension. vol 3. issue 2. 2015-06-25. PMID:26105867. |
nicotine, a major constituent of cigarette smoke, binds to nicotinic acetylcholine receptors (nachrs). |
2015-06-25 |
2023-08-13 |
human |
| María Guerra-Álvarez, Ana J Moreno-Ortega, Elisa Navarro, José Carlos Fernández-Morales, Javier Egea, Manuela G López, María F Cano-Aba. Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25650007. |
[ca(2+) ]cyt , cytosolic ca(2+) concentration; [ca(2+) ]er , endoplasmic reticulum ca(2+) concentration; α7 nachr, α7 isoform of nicotinic acetylcholine receptors; α7-sh, sh-sy5y stably overexpressing α7 nachrs cells; c-sh, control sh-sy5y cells; nic, nicotine; pnu12, pnu120596. |
2015-06-22 |
2023-08-13 |
human |
| Seung Soo Yoo, Su Man Lee, Sook Kyung Do, Won Kee Lee, Dong Sun Kim, Jae Yong Par. Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). vol 86. issue 1. 2015-06-10. PMID:25172267. |
nicotine, the principal tobacco alkaloid, directly contributes to lung carcinogenesis through the activation of nicotinic acetylcholine receptors (nachrs). |
2015-06-10 |
2023-08-13 |
Not clear |