| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula L Vieira-Brock, Lisa M McFadden, Shannon M Nielsen, Jonathan D Ellis, Elliot T Walters, Kristen A Stout, J Michael McIntosh, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits. The Journal of pharmacology and experimental therapeutics. vol 355. issue 3. 2016-02-09. PMID:26391161. |
this interaction is of interest because preclinical studies demonstrate that nicotine can be neuroprotective, perhaps owing to effects involving α4β2 and α6β2 nicotinic acetylcholine receptors (nachrs). |
2016-02-09 |
2023-08-13 |
Not clear |
| Iain C Wilkie, Dario Fassini, Emanuele Cullorà, Alice Barbaglio, Serena Tricarico, Michela Sugni, Luca Del Giacco, M Daniela Candia Carneval. Mechanical properties of the compass depressors of the sea-urchin Paracentrotus lividus (Echinodermata, Echinoidea) and the effects of enzymes, neurotransmitters and synthetic tensilin-like protein. PloS one. vol 10. issue 3. 2016-02-08. PMID:25786033. |
acetylcholine, the muscarinic agonists arecoline and methacholine, and the nicotinic agonists nicotine and 1-[1-(3,4-dimethyl-phenyl)-ethyl]-piperazine produced an abrupt increase in cd viscosity; the cds were not differentially sensitive to muscarinic or nicotinic agonists. |
2016-02-08 |
2023-08-13 |
Not clear |
| Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy, Sergei A Grand. Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors. BMC cancer. vol 15. 2016-01-22. PMID:25885699. |
mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors. |
2016-01-22 |
2023-08-13 |
Not clear |
| Ashley M Fox, Faruk H Moonschi, Christopher I Richard. The nicotine metabolite, cotinine, alters the assembly and trafficking of a subset of nicotinic acetylcholine receptors. The Journal of biological chemistry. vol 290. issue 40. 2016-01-11. PMID:26269589. |
the nicotine metabolite, cotinine, alters the assembly and trafficking of a subset of nicotinic acetylcholine receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Meilin Wu, Clare A Puddifoot, Palmer Taylor, William J Joine. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. The Journal of biological chemistry. vol 290. issue 40. 2016-01-11. PMID:26276394. |
α4β2 nicotinic acetylcholine receptors (nachrs) are abundantly expressed throughout the central nervous system and are thought to be the primary target of nicotine, the main addictive substance in cigarette smoking. |
2016-01-11 |
2023-08-13 |
Not clear |
| Andrea Cippitelli, Gloria Brunori, Kelly A Gaiolini, Nurulain T Zaveri, Lawrence Tol. Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001. Neuropharmacology. vol 93. 2016-01-01. PMID:25689019. |
genetic and pharmacological evidence suggests that the nicotinic acetylcholine receptors (nachrs) containing the α3 and β4 subunits play a role in alcohol as well as nicotine addiction. |
2016-01-01 |
2023-08-13 |
rat |
| Erin E Meyers, Esteban C Loetz, Michael J Mark. Differential expression of the beta4 neuronal nicotinic receptor subunit affects tolerance development and nicotinic binding sites following chronic nicotine treatment. Pharmacology, biochemistry, and behavior. vol 130. 2015-12-23. PMID:25560939. |
the role of neuronal nicotinic acetylcholine receptors (nachr) containing the β4 subunit in tolerance development and nicotinic binding site levels following chronic nicotine treatment was investigated. |
2015-12-23 |
2023-08-13 |
mouse |
| Andrea Cippitelli, Jinhua Wu, Kelly A Gaiolini, Daniela Mercatelli, Jennifer Schoch, Michelle Gorman, Alejandra Ramirez, Roberto Ciccocioppo, Taline V Khroyan, Dennis Yasuda, Nurulain T Zaveri, Conrado Pascual, Xinmin Simon Xie, Lawrence Tol. AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. British journal of pharmacology. vol 172. issue 7. 2015-12-22. PMID:25440006. |
the α3β4 subtype of nicotinic acetylcholine receptors (nachrs) has been implicated in mediating nicotine reinforcement processes. |
2015-12-22 |
2023-08-13 |
rat |
| Sarah S Sanjakdar, Pretal P Maldoon, Michael J Marks, Darlene H Brunzell, Uwe Maskos, J Michael McIntosh, M Scott Bowers, M Imad Dama. Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 2. 2015-12-18. PMID:25035086. |
mesolimbic α6* nicotinic acetylcholine receptors (nachrs) are thought to have an important role in nicotine behavioral effects. |
2015-12-18 |
2023-08-13 |
mouse |
| Fang He, Bing Li, Zhuxiang Zhao, Yumin Zhou, Guoping Hu, Weifeng Zou, Wei Hong, Yimin Zou, Changbin Jiang, Dongxing Zhao, Pixin Ra. The pro-proliferative effects of nicotine and its underlying mechanism on rat airway smooth muscle cells. PloS one. vol 9. issue 4. 2015-12-17. PMID:24690900. |
the activation of akt by nicotine occurred within minutes and depended upon the nicotinic acetylcholine receptors (nachrs). |
2015-12-17 |
2023-08-13 |
rat |
| N Mine, W Taniguchi, N Nishio, N Izumi, N Miyazaki, H Yamada, T Nakatsuka, M Yoshid. Synaptic modulation of excitatory synaptic transmission by nicotinic acetylcholine receptors in spinal ventral horn neurons. Neuroscience. vol 290. 2015-12-15. PMID:25613686. |
the application of nicotine or acetylcholine generated slow inward currents and increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sepscs). |
2015-12-15 |
2023-08-13 |
rat |
| N Mine, W Taniguchi, N Nishio, N Izumi, N Miyazaki, H Yamada, T Nakatsuka, M Yoshid. Synaptic modulation of excitatory synaptic transmission by nicotinic acetylcholine receptors in spinal ventral horn neurons. Neuroscience. vol 290. 2015-12-15. PMID:25613686. |
slow inward currents by acetylcholine or nicotine were not inhibited by tetrodotoxin (ttx) or glutamate receptor antagonists. |
2015-12-15 |
2023-08-13 |
rat |
| N Mine, W Taniguchi, N Nishio, N Izumi, N Miyazaki, H Yamada, T Nakatsuka, M Yoshid. Synaptic modulation of excitatory synaptic transmission by nicotinic acetylcholine receptors in spinal ventral horn neurons. Neuroscience. vol 290. 2015-12-15. PMID:25613686. |
in the presence of ttx, the frequency and amplitude of miniature excitatory postsynaptic currents (mepscs) were also increased by acetylcholine or nicotine. |
2015-12-15 |
2023-08-13 |
rat |
| Manivannan Subramaniyan, John A Dan. Dopaminergic and cholinergic learning mechanisms in nicotine addiction. Annals of the New York Academy of Sciences. vol 1349. 2015-12-07. PMID:26301866. |
nicotine binds to nicotinic acetylcholine receptors that are normally activated by the endogenous neurotransmitter acetylcholine. |
2015-12-07 |
2023-08-13 |
Not clear |
| Carson Kai-Kwong Ley, Alexander Kuryatov, Jingyi Wang, Jon Martin Lindstro. Efficient expression of functional (α6β2)2β3 AChRs in Xenopus oocytes from free subunits using slightly modified α6 subunits. PloS one. vol 9. issue 7. 2015-12-04. PMID:25068303. |
human (α6β2)(α4β2)β3 nicotinic acetylcholine receptors (achrs) are essential for addiction to nicotine and a target for drug development for smoking cessation. |
2015-12-04 |
2023-08-13 |
human |
| Tasnim S Mohamed, Selwyn S Jayakar, Ayman K Hamoud. Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation. Frontiers in molecular neuroscience. vol 8. 2015-12-04. PMID:26635524. |
because the role of neuronal nicotinic acetylcholine receptors (nachr) in nicotine addiction is well established, nachr based therapeutics remain the leading strategy for smoking cessation. |
2015-12-04 |
2023-08-13 |
Not clear |
| Kahina Medjber, Mohamed Lamine Freidja, Simon Grelet, Marianne Lorenzato, Kamel Maouche, Béatrice Nawrocki-Raby, Philippe Birembaut, Myriam Polette, Jean-Marie Tournie. Role of nicotinic acetylcholine receptors in cell proliferation and tumour invasion in broncho-pulmonary carcinomas. Lung cancer (Amsterdam, Netherlands). vol 87. issue 3. 2015-11-16. PMID:25601486. |
nicotine and its associated nicotinic acetylcholine receptors (nachrs) are believed to be involved in the progression of lung carcinomas. |
2015-11-16 |
2023-08-13 |
human |
| Xiaoli Wei, Changyou Zhan, Qing Shen, Wei Fu, Cao Xie, Jie Gao, Chunmei Peng, Ping Zheng, Weiyue L. A D-peptide ligand of nicotine acetylcholine receptors for brain-targeted drug delivery. Angewandte Chemie (International ed. in English). vol 54. issue 10. 2015-11-13. PMID:25600241. |
a d-peptide ligand of nicotine acetylcholine receptors for brain-targeted drug delivery. |
2015-11-13 |
2023-08-13 |
Not clear |
| Joanne Avraam, Gary Cohen, John Drago, Peter B Frappel. Prenatal nicotine exposure increases hyperventilation in α4-knock-out mice during mild asphyxia. Respiratory physiology & neurobiology. vol 208. 2015-11-12. PMID:25596543. |
prenatal nicotine exposure alters breathing and ventilatory responses to stress through stimulation of nicotine acetylcholine receptors (nachrs). |
2015-11-12 |
2023-08-13 |
mouse |
| Richard Exley, Michael A Clements, Henrike Hartung, J Michael McIntosh, Michael Franklin, Isabel Bermudez, Stephanie J Crag. Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens. The European journal of neuroscience. vol 38. issue 7. 2015-10-30. PMID:23841846. |
nicotine directly regulates striatal dopamine (da) neurotransmission via presynaptic nicotinic acetylcholine receptors (nachrs) that are α6β2 and/or α4β2 subunit-containing, depending on region. |
2015-10-30 |
2023-08-12 |
mouse |