| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Tirgar, A Rezayof, M-R Zarrindas. Central amygdala nicotinic and 5-HT1A receptors mediate the reversal effect of nicotine and MDMA on morphine-induced amnesia. Neuroscience. vol 277. 2015-06-08. PMID:25050820. |
the present study was designed to investigate possible involvement of the central amygdala (cea) nicotinic acetylcholine (nach) and 5-hydroxytryptamine 1a (5-ht1a) receptors in the reversal effect of nicotine and 3,4-methylenedioxy-n-methylamphetamine (mdma or ecstasy) on morphine-induced amnesia. |
2015-06-08 |
2023-08-13 |
rat |
| Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Ma. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733557. |
pi3k/akt-independent nos/ho activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. |
2015-05-28 |
2023-08-13 |
rat |
| Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Ma. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733557. |
dose-vasodilatory response curves of acetylcholine (0.01-2.43 nmol) were established in isolated phenylephrine-preconstricted perfused kidneys obtained from rats treated with or without nicotine (0.5-4.0 mg/kg/day, 2 weeks). |
2015-05-28 |
2023-08-13 |
rat |
| Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Ma. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733557. |
acetylcholine vasodilations were potentiated by low nicotine doses (0.5 and 1 mg/kg/day) in contrast to no effect for higher doses (2 and 4 mg/kg/day). |
2015-05-28 |
2023-08-13 |
rat |
| Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Ma. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733557. |
the facilitatory effect of nicotine was acetylcholine specific because it was not observed with other vasodilators such as 5'-n-ethylcarboxamidoadenosine (neca, adenosine receptor agonist) or papaverine. |
2015-05-28 |
2023-08-13 |
rat |
| Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Ma. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733557. |
we also show that the presence of the two ovarian hormones is necessary for the nicotine augmentation of acetylcholine vasodilations to manifest because nicotine facilitation was lost in kidneys of ovariectomized (ovx) and restored after combined, but not individual, supplementation with medroxyprogesterone acetate (mpa) and estrogen (e2). |
2015-05-28 |
2023-08-13 |
rat |
| Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Ma. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. vol 9. issue 4. 2015-05-28. PMID:24733557. |
together, the data suggests that chronic nicotine potentiates acetylcholine renal vasodilation in female rats via, at least partly, akt-independent ho-1 upregulation. |
2015-05-28 |
2023-08-13 |
rat |
| K Bonnett, R Zweig, E J Aamodt, D S Dwye. Food deprivation and nicotine correct akinesia and freezing in Na(+) -leak current channel (NALCN)-deficient strains of Caenorhabditis elegans. Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:24995777. |
the effects of food deprivation were mimicked by nicotine, which suggested that acetylcholine mediated the response. |
2015-05-22 |
2023-08-13 |
human |
| Steven J Simmons, Thomas J Goul. Involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. Journal of clinical pharmacy and therapeutics. vol 39. issue 5. 2015-05-12. PMID:24828779. |
involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. |
2015-05-12 |
2023-08-13 |
Not clear |
| Steven J Simmons, Thomas J Goul. Involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. Journal of clinical pharmacy and therapeutics. vol 39. issue 5. 2015-05-12. PMID:24828779. |
nicotine binds to nicotinic acetylcholine receptors (nachrs), which can cause addiction and withdrawal symptoms upon cessation of nicotine administration. |
2015-05-12 |
2023-08-13 |
Not clear |
| Ida Nymann Petersen, François Crestey, Anders A Jensen, Dinesh C Indurthi, Henrik Pedersen, Jesper T Andreasen, Thomas Balle, Jesper L Kristense. Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. ACS medicinal chemistry letters. vol 6. issue 4. 2015-05-05. PMID:25941557. |
tying up nicotine: new selective competitive antagonist of the neuronal nicotinic acetylcholine receptors. |
2015-05-05 |
2023-08-13 |
Not clear |
| Ida Nymann Petersen, François Crestey, Anders A Jensen, Dinesh C Indurthi, Henrik Pedersen, Jesper T Andreasen, Thomas Balle, Jesper L Kristense. Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. ACS medicinal chemistry letters. vol 6. issue 4. 2015-05-05. PMID:25941557. |
conformational restriction of the pyrrolidine nitrogen in nicotine by the introduction of an ethylene bridge provided a potent and selective antagonist of the α4β2-subtype of the nicotinic acetylcholine receptors. |
2015-05-05 |
2023-08-13 |
Not clear |
| Sara Falasca, Vaclav Ranc, Filomena Petruzziello, Abbas Khani, Robert Kretz, Xiaozhe Zhang, Gregor Raine. Altered neurochemical levels in the rat brain following chronic nicotine treatment. Journal of chemical neuroanatomy. vol 59-60. 2015-04-23. PMID:24915436. |
we observed a marked decrease of acetylcholine levels in the dorsal striatum (22.88%, p<0.01), reflecting the impact of chronic nicotine in local interneuron circuits. |
2015-04-23 |
2023-08-13 |
rat |
| Jie Wu, Ming Gao, Devin H Taylo. Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence. Acta pharmacologica Sinica. vol 35. issue 3. 2015-04-22. PMID:24464050. |
interestingly, alcohol and nicotine are often co-abused, which suggests that neuronal nicotinic acetylcholine receptors (nachrs), the molecular targets for nicotine, may also contribute to alcohol's abusive properties. |
2015-04-22 |
2023-08-12 |
Not clear |
| Blake A Kimmey, Laura E Rupprecht, Matthew R Hayes, Heath D Schmid. Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats. Addiction biology. vol 19. issue 4. 2015-04-20. PMID:23231479. |
collectively, these results indicate that increased extracellular acetylcholine levels are sufficient to attenuate nicotine taking and seeking in rats and that these effects are not due to adverse malaise symptoms such as nausea. |
2015-04-20 |
2023-08-12 |
human |
| Luis M Carcoba, James E Orfila, Luis A Natividad, Oscar V Torres, Joseph A Pipkin, Patrick L Ferree, Eddie Castañeda, Donald E Moss, Laura E O'Del. Cholinergic transmission during nicotine withdrawal is influenced by age and pre-exposure to nicotine: implications for teenage smoking. Developmental neuroscience. vol 36. issue 3-4. 2015-04-17. PMID:24854235. |
the first study compared extracellular levels of acetylcholine (ach) in the nucleus accumbens (nac) during nicotine exposure and precipitated withdrawal using microdialysis procedures. |
2015-04-17 |
2023-08-13 |
rat |
| Lizheng Wu, Yongchuan Zhou, Zhifei Zhou, Yingfeng Liu, Yudi Bai, Xianghui Xing, Xiaojing Wan. Nicotine induces the production of IL-1β and IL-8 via the α7 nAChR/NF-κB pathway in human periodontal ligament cells: an in vitro study. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 34. issue 2. 2015-04-13. PMID:25059554. |
we previously demonstrated that nicotine could induce the expression of α7 nicotinic acetylcholine receptors (α7 nachr) in human and rat periodontal tissues. |
2015-04-13 |
2023-08-13 |
human |
| Eric M Hogan, Alison P Casserly, Michael D Scofield, Zhongming Mou, Rubing Zhao-Shea, Chris W Johnson, Andrew R Tapper, Paul D Gardne. miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family. RNA (New York, N.Y.). vol 20. issue 12. 2015-04-10. PMID:25344397. |
nicotine binds to and activates a family of ligand-gated ion channels, neuronal nicotinic acetylcholine receptors (nachrs). |
2015-04-10 |
2023-08-13 |
mouse |
| Sean H White, Christopher J Carter, Neil S Magosk. A potentially novel nicotinic receptor in Aplysia neuroendocrine cells. Journal of neurophysiology. vol 112. issue 2. 2015-03-30. PMID:24740855. |
while testing the agonist profile of the cholinergic response, we observed a second current that appeared to be gated only by nicotine and not acetylcholine. |
2015-03-30 |
2023-08-13 |
aplysia |
| Sean H White, Christopher J Carter, Neil S Magosk. A potentially novel nicotinic receptor in Aplysia neuroendocrine cells. Journal of neurophysiology. vol 112. issue 2. 2015-03-30. PMID:24740855. |
the acetylcholine-induced current, but not the nicotine current, was reduced by double-strand rna treatment targeted to both subunits apachr-c and -e. conversely, the nicotine-evoked current, but not the acetylcholine current, was lessened by targeting both subunits apachr-h and -p. to the best of our knowledge, this is the first report suggesting that a nicotinic receptor is not gated by acetylcholine. |
2015-03-30 |
2023-08-13 |
aplysia |