| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brandon J Henderson, Henry A Leste. Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology. vol 96. issue Pt B. 2016-03-22. PMID:25660637. |
upregulation of neuronal nicotinic acetylcholine receptors (achrs) is a venerable result of chronic exposure to nicotine; but it is one of several consequences of pharmacological chaperoning by nicotine and by some other nicotinic ligands, especially agonists. |
2016-03-22 |
2023-08-13 |
Not clear |
| Brian O'Neill, Dana Lauterstein, Jyoti C Patel, Judith T Zelikoff, Margaret E Ric. Striatal dopamine release regulation by the cholinergic properties of the smokeless tobacco, gutkha. ACS chemical neuroscience. vol 6. issue 6. 2016-03-15. PMID:25797409. |
tobacco products influence striatal dopamine (da) release primarily through the actions of nicotine, an agonist of nicotinic acetylcholine receptors (nachr). |
2016-03-15 |
2023-08-13 |
mouse |
| Nils B Kroemer, Franziska Wuttig, Martin Bidlingmaier, Ulrich S Zimmermann, Michael N Smolk. Nicotine enhances modulation of food-cue reactivity by leptin and ghrelin in the ventromedial prefrontal cortex. Addiction biology. vol 20. issue 4. 2016-02-29. PMID:25060944. |
in animal models, nicotine was demonstrated to reduce body weight by attenuating food intake and effects of leptin and ghrelin are partly modulated by nicotinic acetylcholine receptors which hint at potential interactions. |
2016-02-29 |
2023-08-13 |
Not clear |
| Zuo Jun Ren, Shobha Mummalaneni, Jie Qian, Clive M Baumgarten, John A DeSimone, Vijay Lyal. Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. PloS one. vol 10. issue 6. 2016-02-22. PMID:26039516. |
nicotinic acetylcholine receptor (nachr) dependent chorda tympani taste nerve responses to nicotine, ethanol and acetylcholine. |
2016-02-22 |
2023-08-13 |
mouse |
| Zuo Jun Ren, Shobha Mummalaneni, Jie Qian, Clive M Baumgarten, John A DeSimone, Vijay Lyal. Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. PloS one. vol 10. issue 6. 2016-02-22. PMID:26039516. |
the nachrs represent common targets at which acetylcholine, nicotine and ethanol functionally interact in the central nervous system. |
2016-02-22 |
2023-08-13 |
mouse |
| Zuo Jun Ren, Shobha Mummalaneni, Jie Qian, Clive M Baumgarten, John A DeSimone, Vijay Lyal. Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. PloS one. vol 10. issue 6. 2016-02-22. PMID:26039516. |
here, we investigated if the nachrs also represent a common pathway through which the bitter taste of nicotine, ethanol and acetylcholine is transduced. |
2016-02-22 |
2023-08-13 |
mouse |
| Zuo Jun Ren, Shobha Mummalaneni, Jie Qian, Clive M Baumgarten, John A DeSimone, Vijay Lyal. Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. PloS one. vol 10. issue 6. 2016-02-22. PMID:26039516. |
to this end, chorda tympani (ct) taste nerve responses were monitored in rats, wild-type mice and trpm5 knockout (ko) mice following lingual stimulation with nicotine free base, ethanol, and acetylcholine, in the absence and presence of nachr agonists and antagonists. |
2016-02-22 |
2023-08-13 |
mouse |
| Zuo Jun Ren, Shobha Mummalaneni, Jie Qian, Clive M Baumgarten, John A DeSimone, Vijay Lyal. Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. PloS one. vol 10. issue 6. 2016-02-22. PMID:26039516. |
the nachr modulators: mecamylamine, dihydro-β-erythroidine, and cp-601932 (a partial agonist of the α3β4* nachr), inhibited ct responses to nicotine, ethanol, and acetylcholine. |
2016-02-22 |
2023-08-13 |
mouse |
| Zuo Jun Ren, Shobha Mummalaneni, Jie Qian, Clive M Baumgarten, John A DeSimone, Vijay Lyal. Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine. PloS one. vol 10. issue 6. 2016-02-22. PMID:26039516. |
we conclude that nachrs expressed in a subset of taste cells serve as common receptors for the detection of the trpm5-independent bitter taste of nicotine, acetylcholine and ethanol. |
2016-02-22 |
2023-08-13 |
mouse |
| S M Anderson, D H Brunzel. Anxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptors. British journal of pharmacology. vol 172. issue 11. 2016-02-16. PMID:25625469. |
anxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptors. |
2016-02-16 |
2023-08-13 |
Not clear |
| Shafiqur Rahma. Targeting brain nicotinic acetylcholine receptors to treat major depression and co-morbid alcohol or nicotine addiction. CNS & neurological disorders drug targets. vol 14. issue 5. 2016-02-16. PMID:25921743. |
targeting brain nicotinic acetylcholine receptors to treat major depression and co-morbid alcohol or nicotine addiction. |
2016-02-16 |
2023-08-13 |
Not clear |
| Shafiqur Rahma. Targeting brain nicotinic acetylcholine receptors to treat major depression and co-morbid alcohol or nicotine addiction. CNS & neurological disorders drug targets. vol 14. issue 5. 2016-02-16. PMID:25921743. |
there is now compelling evidence that the neuronal nicotinic acetylcholine receptors (nachrs) play an important role in mdd and co-morbid alcohol or nicotine addiction. |
2016-02-16 |
2023-08-13 |
Not clear |
| Jacob G Dubroff, Robert K Doot, Mary Falcone, Robert A Schnoll, Riju Ray, Rachel F Tyndale, Arthur L Brody, Catherine Hou, Alexander Schmitz, Caryn Lerma. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 56. issue 11. 2016-02-16. PMID:26272810. |
nicotine binds directly to nicotinic acetylcholine receptors (nachrs) to exert its psychoactive effects. |
2016-02-16 |
2023-08-13 |
Not clear |
| Pei-Yu Shih, J Michael McIntosh, Ryan M Drena. Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula. Molecular pharmacology. vol 88. issue 6. 2016-02-12. PMID:26429939. |
nicotinic acetylcholine receptors (nachrs) are the molecular target of nicotine. |
2016-02-12 |
2023-08-13 |
human |
| Montana Upton, Shahrdad Lotfipou. α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26111579. |
neuronal nicotinic acetylcholine receptors (nachrs) are the primary binding sites for nicotine within the brain. |
2016-02-09 |
2023-08-13 |
mouse |
| S Sakura Minami, Vivian Shen, David Le, Grietje Krabbe, Rustam Asgarov, Liberty Perez-Celajes, Chih-Hung Lee, Jinhe Li, Diana Donnelly-Roberts, Li Ga. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26206194. |
activation of nicotinic acetylcholine receptors (nachrs) by nicotine or specific α7 nachr agonists reduces neuroinflammation. |
2016-02-09 |
2023-08-13 |
mouse |
| Sybren F de Kloet, Huibert D Mansvelder, Taco J De Vrie. Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26208783. |
in the central nervous system, nicotine acts as an agonist for nicotinic acetylcholine receptors (nachrs) and its effects depend on location and receptor composition. |
2016-02-09 |
2023-08-13 |
Not clear |
| Qing Cheng, Jerrel L Yake. The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26212541. |
nicotinic acetylcholine receptors (nachrs) are expressed widely in the cns, and mediate both synaptic and perisynaptic activities of endogenous cholinergic inputs and pharmacological actions of exogenous compounds (e.g., nicotine and choline). |
2016-02-09 |
2023-08-13 |
Not clear |
| Munir Gunes Kutlu, Thomas J Goul. Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26231942. |
studies clearly demonstrate that nicotine mediates acquisition and extinction of fear as well as anxiety through the modulation of specific subtypes of nicotinic acetylcholine receptors (nachrs) in brain regions involved in emotion processing such as the hippocampus. |
2016-02-09 |
2023-08-13 |
Not clear |
| Yanfen Teng, Khosrow Rezvani, Mariella De Bias. UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP. Biochemical pharmacology. vol 97. issue 4. 2016-02-09. PMID:26265139. |
neuronal nicotinic acetylcholine receptors (nachrs) containing the α3 subunit are known for their prominent role in normal ganglionic transmission while their involvement in the mechanisms underlying nicotine addiction and smoking-related disease has been emerging only in recent years. |
2016-02-09 |
2023-08-13 |
Not clear |