| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W E Melroy-Greif, J A Stitzel, M A Ehringe. Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. Genes, brain, and behavior. vol 15. issue 1. 2016-10-20. PMID:26351737. |
nicotinic acetylcholine receptors are ligand-gated ion channels that exogenously bind nicotine. |
2016-10-20 |
2023-08-13 |
human |
| Alain Ríos, Rafael Barrientos, Alberto Alatorre, Alfonso Delgado, Teresa Perez-Capistran, Eliezer Chuc-Meza, Martha García-Ramirez, Enrique Querejet. Dopamine-dependent modulation of rat globus pallidus excitation by nicotine acetylcholine receptors. Experimental brain research. vol 234. issue 2. 2016-10-19. PMID:26563165. |
dopamine-dependent modulation of rat globus pallidus excitation by nicotine acetylcholine receptors. |
2016-10-19 |
2023-08-13 |
rat |
| Munir Gunes Kutlu, Thomas J Goul. Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory. Physiology & behavior. vol 155. 2016-10-17. PMID:26687895. |
importantly, nicotine and activation of nicotinic acetylcholine receptors (nachrs) can alter hippocampal plasticity and these changes may occur through modulation of hippocampal kinases and transcription factors. |
2016-10-17 |
2023-08-13 |
Not clear |
| Angelika Schedel, Kerstin Kaiser, Stefanie Uhlig, Florian Lorenz, Anip Sarin, Julian Starigk, Dennis Hassmann, Karen Bieback, Peter Buger. Megakaryocytes and platelets express nicotinic acetylcholine receptors but nicotine does not affect megakaryopoiesis or platelet function. Platelets. vol 27. issue 1. 2016-10-12. PMID:25902378. |
megakaryocytes and platelets express nicotinic acetylcholine receptors but nicotine does not affect megakaryopoiesis or platelet function. |
2016-10-12 |
2023-08-13 |
Not clear |
| Li Wen, Keran Jiang, Wenji Yuan, Wenyan Cui, Ming D L. Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. Molecular neurobiology. vol 53. issue 1. 2016-10-07. PMID:25471942. |
nicotine exerts its physiological and pharmacological roles in the brain through neuronal nicotinic acetylcholine receptors (nachrs), which are ligand-gated ion channels consisting of five membrane-spanning subunits that can modulate the release of neurotransmitters, such as dopamine, glutamate, and gaba and mediate fast signal transmission at synapses. |
2016-10-07 |
2023-08-13 |
Not clear |
| Kang Chen, Sakura Nakauchi, Hailing Su, Saki Tanimoto, Katumi Sumikaw. Early postnatal nicotine exposure disrupts the α2* nicotinic acetylcholine receptor-mediated control of oriens-lacunosum moleculare cells during adolescence in rats. Neuropharmacology. vol 101. 2016-09-22. PMID:26386153. |
early postnatal nicotine exposure disrupts the α2* nicotinic acetylcholine receptor-mediated control of oriens-lacunosum moleculare cells during adolescence in rats. |
2016-09-22 |
2023-08-13 |
rat |
| Xiaoli Wei, Jie Gao, Changyou Zhan, Cao Xie, Zhilan Chai, Danni Ran, Man Ying, Ping Zheng, Weiyue L. Liposome-based glioma targeted drug delivery enabled by stable peptide ligands. Journal of controlled release : official journal of the Controlled Release Society. vol 218. 2016-09-22. PMID:26428462. |
(d)cdx is a d-peptide ligand of nicotine acetylcholine receptors (nachrs) on the bbb, and c(rgdyk) is a ligand of integrin highly expressed on the bbtb and glioma cells. |
2016-09-22 |
2023-08-13 |
mouse |
| Arunnjah Vivekanandarajah, Karen A Waters, Rita Machaalan. Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 47. issue Pt B. 2016-09-16. PMID:26440997. |
postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem. |
2016-09-16 |
2023-08-13 |
Not clear |
| Arunnjah Vivekanandarajah, Karen A Waters, Rita Machaalan. Postnatal nicotine effects on the expression of nicotinic acetylcholine receptors in the developing piglet hippocampus and brainstem. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 47. issue Pt B. 2016-09-16. PMID:26440997. |
nicotine, the major neurotoxic component of cigarette smoke, induces its actions by binding to nicotinic acetylcholine receptors (nachr). |
2016-09-16 |
2023-08-13 |
Not clear |
| Kiran Bamel, Rajendra Gupta, Shrish C Gupt. Nicotine promotes rooting in leaf explants of in vitro raised seedlings of tomato, Lycopersicon esculentum Miller var. Pusa Ruby. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26363975. |
since nicotine is an agonist of one of the two acetylcholine receptors in animals, its ability to simulate ach action in a plant system suggests the presence of the same molecular mechanism operative in both, animal and plant cells. |
2016-09-14 |
2023-08-13 |
Not clear |
| Sebastian Ternes, Katja Trinkaus, Ivonne Bergen, Sven Knaack, Michael Gelinsky, Olaf Kilian, Christian Heiss, Katrin Susanne Lip. Impact of acetylcholine and nicotine on human osteoclastogenesis in vitro. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26386154. |
impact of acetylcholine and nicotine on human osteoclastogenesis in vitro. |
2016-09-14 |
2023-08-13 |
human |
| Sebastian Ternes, Katja Trinkaus, Ivonne Bergen, Sven Knaack, Michael Gelinsky, Olaf Kilian, Christian Heiss, Katrin Susanne Lip. Impact of acetylcholine and nicotine on human osteoclastogenesis in vitro. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26386154. |
thus, aim of the present study was to determine whether the application of acetylcholine (ach, 10(−4) m), nicotine (10(−6) m), mineralized collagen membranes or brain derived neurotrophic factor (bdnf, 40 ng/ml) influences the mrna regulation of molecular components of the nncs and the neurotrophin family during osteoclastogenesis. |
2016-09-14 |
2023-08-13 |
human |
| Joshua S Beckmann, Andrew C Meyer, M Pivavarchyk, David B Horton, Guangrong Zheng, Andrew M Smith, Thomas E Wooters, J Michael McIntosh, Peter A Crooks, Michael T Bardo, Linda P Dwoski. r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochemical research. vol 40. issue 10. 2016-09-02. PMID:26227997. |
α6β2* nicotinic acetylcholine receptors (nachrs) expressed by dopaminergic neurons mediate nicotine-evoked dopamine (da) release and nicotine reinforcement. |
2016-09-02 |
2023-08-13 |
rat |
| Alexandra T K Lee, Zhihong Xu, Srinivasa P Pothula, Mishaal B Patel, Romano C Pirola, Jeremy S Wilson, Minoti V Apt. Alcohol and cigarette smoke components activate human pancreatic stellate cells: implications for the progression of chronic pancreatitis. Alcoholism, clinical and experimental research. vol 39. issue 11. 2016-08-18. PMID:26463405. |
this study aimed to (a) determine whether human pscs (hpscs) and rat pscs express nicotinic acetylcholine receptors (nachrs), which are known to bind 2 important components of cigarette smoke, namely nicotine and nicotine-derived nitrosamine ketone (nnk), and (b) examine the effects of cigarette smoke components in the presence and absence of alcohol on psc activation in vitro. |
2016-08-18 |
2023-08-13 |
human |
| Ayman K Hamouda, Farah Deba, Ze-Jun Wang, Jonathan B Cohe. Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator. Molecular pharmacology. vol 89. issue 5. 2016-08-15. PMID:26976945. |
positive allosteric modulators (pams) of nicotinic acetylcholine (ach) receptors (nachrs) have potential clinical applications in the treatment of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity, and 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1h-pyrrazol-4-yl)isoxazole (cmpi) has been identified as a pam selective for neuronal nachrs containing theα4 subunit. |
2016-08-15 |
2023-08-13 |
human |
| Paula L Vieira-Brock, Lisa M McFadden, Shannon M Nielsen, Misty D Smith, Glen R Hanson, Annette E Fleckenstei. Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits. The international journal of neuropsychopharmacology. vol 18. issue 12. 2016-08-10. PMID:26164716. |
furthermore, extensive evidence indicates that nicotine prevents and/or improves memory deficits in different models of cognitive dysfunction and these nicotinic effects might be mediated by hippocampal or cortical nicotinic acetylcholine receptors. |
2016-08-10 |
2023-08-13 |
rat |
| Syam Das S, Saritha S Nair, S Kavitha, John Febi, M Indir. Atorvastatin improves Y-maze learning behaviour in nicotine treated male albino rats. Pharmacology, biochemistry, and behavior. vol 138. 2016-07-28. PMID:26409179. |
the activity of acetylcholine esterase was significantly increased in the nicotine treated group. |
2016-07-28 |
2023-08-13 |
rat |
| Brandon J Henderson, Teagan R Wall, Beverley M Henley, Charlene H Kim, Weston A Nichols, Ruin Moaddel, Cheng Xiao, Henry A Leste. Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 10. 2016-07-19. PMID:26961950. |
upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nachrs) is implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to upregulate β2* nachrs more than nonmenthol cigarette smokers. |
2016-07-19 |
2023-08-13 |
mouse |
| Munir Gunes Kutlu, Vinay Parikh, Thomas J Goul. Nicotine Addiction and Psychiatric Disorders. International review of neurobiology. vol 124. 2016-07-18. PMID:26472530. |
in this chapter, we review the studies from animal and human research examining the bidirectional relationship between nicotine and attention deficit hyperactivity disorder, anxiety disorders, and depression as well as studies examining the roles of specific subunits of nicotinic acetylcholine receptors (nachrs) in the interaction between nicotine and these mental illnesses. |
2016-07-18 |
2023-08-13 |
human |
| Shenyan Gu, Jose A Matta, Brian Lord, Anthony W Harrington, Steven W Sutton, Weston B Davini, David S Bred. Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO. Neuron. vol 89. issue 5. 2016-07-13. PMID:26875622. |
nicotine exerts its behavioral and additive actions through a family of brain nicotinic acetylcholine receptors (nachrs). |
2016-07-13 |
2023-08-13 |
mouse |