| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Tortora, Silvia Corsini, Andrea Nistr. Nicotinic receptors modulate the onset of reactive oxygen species production and mitochondrial dysfunction evoked by glutamate uptake block in the rat hypoglossal nucleus. Neuroscience letters. vol 639. 2017-12-19. PMID:28007649. |
our recent study has demonstrated that brainstem hypoglossal motoneurons, which are very vulnerable to this damage, were neuroprotected from excitotoxicity with nicotine application through the activation of nicotinic acetylcholine receptors (nachrs) and subsequent inhibition of ros and mitochondrial dysfunction. |
2017-12-19 |
2023-08-13 |
rat |
| John J Maurer, Karin Sandager-Nielsen, Heath D Schmid. Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283. Psychopharmacology. vol 234. issue 3. 2017-12-13. PMID:27844094. |
the rewarding and reinforcing effects of nicotine are produced, in large part, by activation of neuronal α4β2* nicotinic acetylcholine receptors (nachrs), pentameric protein complexes comprised of different stoichiometries of α4 and β2 subunits. |
2017-12-13 |
2023-08-13 |
rat |
| Anna M Lavezzi, Stefano Ferrero, Luca Roncati, Francesco Piscioli, Luigi Matturri, Teresa Pusio. Nicotinic Receptor Abnormalities in the Cerebellar Cortex of Sudden Unexplained Fetal and Infant Death Victims-Possible Correlation With Maternal Smoking. ASN neuro. vol 9. issue 4. 2017-12-08. PMID:28735558. |
nicotinic acetylcholine receptors (nachrs) are cationic channels of the neuronal cell membrane, differentially expressed in the central nervous system which, when activated by endogenous acetylcholine or exogenous nicotine, are able to enhance cholinergic transmission. |
2017-12-08 |
2023-08-13 |
human |
| Valentina G Safronova, Catherine A Vulfius, Irina V Shelukhina, Valentina N Mal'tseva, Alexey V Berezhnov, Eugeniya I Fedotova, Regina G Miftahova, Elena V Kryukova, Andrey A Grinevich, Victor I Tsetli. Nicotinic receptor involvement in regulation of functions of mouse neutrophils from inflammatory site. Immunobiology. vol 221. issue 7. 2017-12-04. PMID:26965141. |
nicotine and acetylcholine (ach) modified respiratory burst induced by a chemotactic peptide n-formyl-mlf in neutrophils of male (but not female) mice. |
2017-12-04 |
2023-08-13 |
mouse |
| Fernando B de Moura, Lance R McMaho. The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice. Psychopharmacology. vol 234. issue 5. 2017-11-30. PMID:28028600. |
the contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice. |
2017-11-30 |
2023-08-13 |
mouse |
| Branden L Eggan, Sarah E McCallu. α3β4 nicotinic receptors in the medial habenula and substance P transmission in the interpeduncular nucleus modulate nicotine sensitization. Behavioural brain research. vol 316. 2017-11-24. PMID:27531501. |
to identify mhb and ipn receptors that play a role in nicotine reward, we studied receptors prevalent in these nuclei, including nicotinic acetylcholine receptors (nachrs) and the receptor for substance p (neuokinin-1; nk1 receptor) using a model of behavioral and neurochemical sensitization to nicotine. |
2017-11-24 |
2023-08-13 |
Not clear |
| L Hondebrink, A H A Verboven, W S Drega, S Schmeink, M W G D M de Groot, R G D M van Kleef, F M J Wijnolts, A de Groot, J Meulenbelt, R H S Westerin. Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings. Neurotoxicology. vol 55. 2017-11-17. PMID:27149913. |
neuronal activity is concentration-dependently affected following exposure to six neurotransmitters (glutamate, gaba, serotonin, dopamine, acetylcholine and nicotine). |
2017-11-17 |
2023-08-13 |
Not clear |
| L Wen, Z Yang, W Cui, M D L. Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. Translational psychiatry. vol 6. issue 6. 2017-11-17. PMID:27327258. |
nicotine exerts its pharmacological roles through nicotinic acetylcholine receptors (nachrs), which are ligand-gated ion channels consisting of five membrane-spanning subunits. |
2017-11-17 |
2023-08-13 |
mouse |
| Eliot R Spinde. Cholinergic Targets in Lung Cancer. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818857. |
because activation of machr and nachr stimulates growth; tumor growth can be stimulated by both locally synthesized acetylcholine as well as acetylcholine from distal sources and from nicotine in the high percentage of lung cancer patients who are smokers. |
2017-11-16 |
2023-08-13 |
Not clear |
| Vanessa Mucchietto, Arianna Crespi, Francesca Fasoli, Francesco Clementi, Cecilia Gott. Neuronal Acetylcholine Nicotinic Receptors as New Targets for Lung Cancer Treatment. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26845123. |
most of these effects are a result of nicotine binding and activation of cell-surface neuronal nicotinic acetylcholine receptors (nachrs) and downstream intracellular signalling cascades, and many are blocked by nachr subtype-selective antagonists. |
2017-11-16 |
2023-08-13 |
Not clear |
| Naofumi Kunisawa, Higor A Iha, Yuji Nomura, Misaki Onishi, Nami Matsubara, Saki Shimizu, Yukihiro Ohn. Serotonergic modulation of nicotine-induced kinetic tremor in mice. Journal of pharmacological sciences. vol 134. issue 2. 2017-11-16. PMID:28647281. |
we previously demonstrated that nicotine elicited kinetic tremor by elevating the neural activity of the inferior olive via α7 nicotinic acetylcholine (nach) receptors. |
2017-11-16 |
2023-08-13 |
mouse |
| Josephine R Tarren, Selena E Bartlet. Alcohol and nicotine interactions: pre-clinical models of dependence. The American journal of drug and alcohol abuse. vol 43. issue 2. 2017-11-13. PMID:27740856. |
while it is agreed that multiple pathways orchestrate the complex reward profile of alcohol and nicotine co-addiction, several lines of evidence suggest the convergent site of action is within the mesolimbic dopaminergic system, at neuronal nicotinic acetylcholine receptors (nachrs). |
2017-11-13 |
2023-08-13 |
Not clear |
| Sarah J Cross, Kay E Linker, Frances M Lesli. Sex-dependent effects of nicotine on the developing brain. Journal of neuroscience research. vol 95. issue 1-2. 2017-11-13. PMID:27870426. |
the deleterious effects of nicotine are not restricted to adulthood, as nicotinic acetylcholine receptors regulate critical aspects of neural development. |
2017-11-13 |
2023-08-13 |
Not clear |
| Michelle G Baladi, Shannon M Nielsen, J Michael McIntosh, Glen R Hanson, Annette E Fleckenstei. Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behavioural pharmacology. vol 27. issue 5. 2017-11-08. PMID:26871405. |
prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. |
2017-11-08 |
2023-08-13 |
rat |
| Oguz Gozen, Tanseli Nesil, Lutfiye Kanit, Ersin O Koylu, Sakire Pogu. Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. The American journal of drug and alcohol abuse. vol 42. issue 5. 2017-11-06. PMID:27428758. |
nicotine exerts its central actions through nicotinic acetylcholine receptors (nachrs), which in turn regulate major neurotransmitter systems including dopamine. |
2017-11-06 |
2023-08-13 |
rat |
| Tristan D McClure-Begley, Irina Esterlis, Kathryn L Stone, TuKiet T Lam, Sharon R Grady, Christopher M Colangelo, Jon M Lindstrom, Michael J Marks, Marina R Picciott. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro. vol 3. issue 4. 2017-10-25. PMID:27559543. |
evaluation of the nicotinic acetylcholine receptor-associated proteome at baseline and following nicotine exposure in human and mouse cortex. |
2017-10-25 |
2023-08-13 |
mouse |
| Tristan D McClure-Begley, Irina Esterlis, Kathryn L Stone, TuKiet T Lam, Sharon R Grady, Christopher M Colangelo, Jon M Lindstrom, Michael J Marks, Marina R Picciott. Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro. vol 3. issue 4. 2017-10-25. PMID:27559543. |
nicotinic acetylcholine receptors (nachrs) support the initiation and maintenance of smoking, but the long-term changes occurring in the protein complex as a result of smoking and the nicotine in tobacco are not known. |
2017-10-25 |
2023-08-13 |
mouse |
| Whitney E Melroy-Greif, Matthew A Simonson, Robin P Corley, Sharon M Lutz, John E Hokanson, Marissa A Ehringe. Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 19. issue 4. 2017-10-20. PMID:27613895. |
nicotinic acetylcholine receptors (nachrs) are bound by nicotine and upregulated in response to chronic exposure to nicotine. |
2017-10-20 |
2023-08-13 |
Not clear |
| Glenn E Kirsch, Nikolai B Fedorov, Yuri A Kuryshev, Zhiqi Liu, Lucas C Armstrong, Michael S Or. Electrophysiology-Based Assays to Detect Subtype-Selective Modulation of Human Nicotinic Acetylcholine Receptors. Assay and drug development technologies. vol 14. issue 6. 2017-10-03. PMID:27505073. |
nicotine acts by mimicking the neurotransmitter acetylcholine on neuronal nicotinic acetylcholine receptors (nachrs), which function as ion channels in cholinergic modulation of neurotransmission. |
2017-10-03 |
2023-08-13 |
human |
| Can Peng, Staci E Engle, Yijin Yan, Marcus M Weera, Jennifer N Berry, Matthew C Arvin, Guiqing Zhao, J Michael McIntosh, Julia A Chester, Ryan M Drena. Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain. PloS one. vol 12. issue 7. 2017-09-28. PMID:28759616. |
nicotinic acetylcholine receptors containing α4 subunits (α4β2* nachrs) are critical for nicotinic cholinergic transmission and the addictive action of nicotine. |
2017-09-28 |
2023-08-13 |
mouse |