| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul Faulkner, Nicole Petersen, Dara G Ghahremani, Chelsea M Cox, Rachel F Tyndale, Gerhard S Hellemann, Edythe D Londo. Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers. Psychopharmacology. vol 235. issue 1. 2018-12-11. PMID:29022071. |
cigarettes with nicotine yields as low as 0.05 mg produce substantial occupancy of nicotinic acetylcholine receptors (26%), but women and men respond differently to these cigarettes. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jay Kardani, Ratnika Sethi, Ipsita Ro. Nicotine slows down oligomerisation of α-synuclein and ameliorates cytotoxicity in a yeast model of Parkinson's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28167231. |
this has mostly been attributed to the neuroprotective role of nicotine in stimulating nicotinic acetylcholine receptors and dopaminergic neurons which are damaged in pd. |
2018-11-26 |
2023-08-13 |
Not clear |
| Stefania Tolu, Fabio Marti, Carole Morel, Carole Perrier, Nicolas Torquet, Stephanie Pons, Renaud de Beaurepaire, Philippe Faur. Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. Scientific reports. vol 7. 2018-11-14. PMID:28332590. |
nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. |
2018-11-14 |
2023-08-13 |
mouse |
| Stefania Tolu, Fabio Marti, Carole Morel, Carole Perrier, Nicolas Torquet, Stephanie Pons, Renaud de Beaurepaire, Philippe Faur. Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. Scientific reports. vol 7. 2018-11-14. PMID:28332590. |
evidences support the hypothesis that distinct nicotinic acetylcholine receptors (nachrs), the molecular target of acetylcholine (ach) and exogenous nicotine, are also in addition implicated in the response to alcohol. |
2018-11-14 |
2023-08-13 |
mouse |
| Ashley M Fox-Loe, Faruk H Moonschi, Christopher I Richard. Organelle-specific single-molecule imaging of α4β2 nicotinic receptors reveals the effect of nicotine on receptor assembly and cell-surface trafficking. The Journal of biological chemistry. vol 292. issue 51. 2018-11-14. PMID:29074617. |
in addition to the endogenous neurotransmitter acetylcholine, nicotine also binds and activates nachrs and influences their trafficking and expression on the cell surface. |
2018-11-14 |
2023-08-13 |
Not clear |
| Jillienne C Touchette, Jamie J Maertens, Margaret M Mason, Kyu Y O'Rourke, Anna M Le. The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption. Neuropharmacology. vol 133. 2018-11-13. PMID:29355641. |
the nicotinic acetylcholine receptors (nachrs) are critical for both alcohol and nicotine addiction mechanisms, since nachr drugs that reduce nicotine consumption have been shown to also reduce alcohol consumption. |
2018-11-13 |
2023-08-13 |
mouse |
| Romain Durand-de Cuttoli, Sarah Mondoloni, Alexandre Mouro. [Optically dissecting brain nicotinic receptor function with photo-controllable designer receptors]. Biologie aujourd'hui. vol 211. issue 2. 2018-10-26. PMID:29236669. |
these receptors are activated by the endogenous neurotransmitter acetylcholine, or by nicotine, the alkaloid found in tobacco leaves. |
2018-10-26 |
2023-08-13 |
mouse |
| Andrew C Harris, Peter Muelken, John R Smethells, Katrina Yershova, Irina Stepanov, Thao Tran Olson, Kenneth J Kellar, Mark G LeSag. Effects of nicotine-containing and "nicotine-free" e-cigarette refill liquids on intracranial self-stimulation in rats. Drug and alcohol dependence. vol 185. 2018-09-18. PMID:29413432. |
we also compared effects of "nicotine-free" varieties of these ec liquids on icss, as well as binding affinity and/or functional activity of nicotine alone, nicotine-containing ec liquids, and "nicotine-free" ec liquids at nicotinic acetylcholine receptors (nachrs). |
2018-09-18 |
2023-08-13 |
human |
| Dana Zeid, Munir Gunes Kutlu, Thomas J Goul. Differential Effects of Nicotine Exposure on the Hippocampus Across Lifespan. Current neuropharmacology. vol 16. issue 4. 2018-09-13. PMID:28714396. |
nicotine exposure affects the hippocampus through activation of hippocampal nicotinic acetylcholine receptors (nachrs), which are present throughout excitatory and inhibitory hippocampal circuitry. |
2018-09-13 |
2023-08-13 |
Not clear |
| Wuyi Liu, Ming D L. Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment. Current neuropharmacology. vol 16. issue 4. 2018-09-13. PMID:28762314. |
many nachr subunits have been identified and shown to be involved in signal transduction on binding to them of either the neurotransmitter acetylcholine or exogenous ligands such as nicotine. |
2018-09-13 |
2023-08-13 |
Not clear |
| Deniz Bagdas, Mine S Gurun, Pamela Flood, Roger L Papke, M Imad Dama. New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs. Current neuropharmacology. vol 16. issue 4. 2018-09-13. PMID:28820052. |
nicotine and nicotinic acetylcholine receptors (nachrs) have been explored for the past three decades as targets for pain control. |
2018-09-13 |
2023-08-13 |
Not clear |
| Naofumi Kunisawa, Saki Shimizu, Masaki Kato, Higor A Iha, Chihiro Iwai, Mai Hashimura, Mizuki Ogawa, Shohei Kawaji, Kazuma Kawakita, Keisuke Abe, Yukihiro Ohn. Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. Journal of pharmacological sciences. vol 137. issue 2. 2018-09-07. PMID:29945769. |
we previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors. |
2018-09-07 |
2023-08-13 |
mouse |
| Jiradanai Sarasamkan, Steffen Fischer, Winnie Deuther-Conrad, Friedrich-Alexander Ludwig, Matthias Scheunemann, Kuntarat Arunrungvichian, Opa Vajragupta, Peter Brus. Radiosynthesis of (S)-[ Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 124. 2018-08-27. PMID:28365525. |
radiosynthesis of (s)-[ recent pharmacologic data revealed the implication of α3β4 nicotinic acetylcholine receptors (nachrs) in nicotine and drug addiction. |
2018-08-27 |
2023-08-13 |
Not clear |
| Liping Liu, Hongxian Wu, Qunan Cao, Zhenzhen Guo, Anmin Ren, Qiuyan Da. Stimulation of Alpha7 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Upregulation of MMP, MCP-1, and RANTES through Modulating ERK1/2/AP-1 Signaling Pathway in RAW264.7 and MOVAS Cells. Mediators of inflammation. vol 2017. 2018-08-27. PMID:29348704. |
vagus nerve stimulation through alpha7 nicotine acetylcholine receptors ( |
2018-08-27 |
2023-08-13 |
Not clear |
| Chun Zhang, Ping Yu, Liang Zhu, Qingnan Zhao, Xiaotong Lu, Shuhong B. Blockade of α7 nicotinic acetylcholine receptors inhibit nicotine-induced tumor growth and vimentin expression in non-small cell lung cancer through MEK/ERK signaling way. Oncology reports. vol 38. issue 6. 2018-07-20. PMID:29039603. |
nicotine can stimulate the progression of non-small cell lung cancer (nsclc) through nicotinic acetylcholine receptors (nachrs). |
2018-07-20 |
2023-08-13 |
mouse |
| Jie Qian, Shobha Mummalaneni, James Larsen, John R Grider, Andrew I Spielman, Mehmet Hakan Özdener, Vijay Lyal. Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells. PloS one. vol 13. issue 3. 2018-07-10. PMID:29513745. |
a subset of hbo cells responded to nicotine, acetylcholine and atp with a transient increase in [ca2+]i. nicotine effects on [ca2+]i were mecamylamine sensitive. |
2018-07-10 |
2023-08-13 |
human |
| D Bagdas, D Ergun, A Jackson, W Toma, M K Schulte, M I Dama. Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain. European journal of pain (London, England). vol 22. issue 1. 2018-07-03. PMID:28809075. |
allosteric modulation of α4β2* nicotinic acetylcholine receptors: desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain. |
2018-07-03 |
2023-08-13 |
mouse |
| Wanhong Zuo, Cheng Xiao, Ming Gao, F Woodward Hopf, Krešimir Krnjević, J Michael McIntosh, Rao Fu, Jie Wu, Alex Bekker, Jiang-Hong Y. Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms. Scientific reports. vol 6. 2018-06-27. PMID:27596561. |
several neurotransmitter systems are implicated in nicotine's actions, but very little is known about how nicotinic acetylcholine receptors (nachrs) regulate lhb activity. |
2018-06-27 |
2023-08-13 |
mouse |
| Connor F Laule, Cameron R Wing, Evan J Odean, Jacob A Wilcox, Jeffrey S Gilbert, Jean F Rega. Effect of nicotine on placental ischemia-induced complement activation and hypertension in the rat. Journal of immunotoxicology. vol 14. issue 1. 2018-06-21. PMID:29185370. |
nicotine, a major component of cigarettes, stimulates the efferent cholinergic anti-inflammatory pathway through peripherally expressed nicotinic acetylcholine receptors (nachr) and is known to attenuate ischemia-reperfusion injury in kidney and liver. |
2018-06-21 |
2023-08-13 |
rat |
| Manish Rauthan, Jianke Gong, Jinzhi Liu, Zhaoyu Li, Seth A Wescott, Jianfeng Liu, X Z Shawn X. MicroRNA Regulation of nAChR Expression and Nicotine-Dependent Behavior in C. elegans. Cell reports. vol 21. issue 6. 2018-06-20. PMID:29117550. |
chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nachrs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. |
2018-06-20 |
2023-08-13 |
Not clear |