| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Wen, Haijun Han, Qiang Liu, Kunkai Su, Zhongli Yang, Wenyan Cui, Wenji Yuan, Yunlong Ma, Rongli Fan, Jiali Chen, Keran Jiang, Xianzhong Jiang, Thomas J Payne, Jundong Wang, Ming D L. Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population. Scientific reports. vol 7. issue 1. 2019-04-17. PMID:28851948. |
although numerous studies have revealed significant associations between variants in the nicotinic acetylcholine receptors (nachr) subunits and nicotine dependence (nd), only few studies were performed in chinese subjects. |
2019-04-17 |
2023-08-13 |
human |
| Svetlana Semenova, Xinchun Jin, Tristan D McClure-Begley, Matthew Philip Tadman, Michael J Marks, Athina Marko. Differential effects of withdrawal from intermittent and continuous nicotine exposure on reward deficit and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in Wistar male rats. Pharmacology, biochemistry, and behavior. vol 171. 2019-04-17. PMID:29908200. |
chronic nicotine exposure produces neuroadaptations in brain reward systems and α4β2 nicotinic acetylcholine receptors (nachrs) in the corticolimbic brain areas. |
2019-04-17 |
2023-08-13 |
rat |
| Amal A Halawa, Joanne C Damborsky, G Simona Slaton, Ursula H Winzer-Serha. Activation of immediate early genes by nicotine after chronic neonatal nicotine exposure in brain areas involved in stress and anxiety responses. Brain research. vol 1687. 2019-04-09. PMID:29496477. |
in rat pups, acute nicotine stimulation activates brain regions associated with stress and anxiety, but chronic nicotine exposure could desensitize of nicotinic acetylcholine receptors, the molecular target of nicotine. |
2019-04-09 |
2023-08-13 |
rat |
| Roger L Papke, Can Peng, Ashok Kumar, Clare Stoke. NS6740, an α7 nicotinic acetylcholine receptor silent agonist, disrupts hippocampal synaptic plasticity. Neuroscience letters. vol 677. 2019-04-09. PMID:29679680. |
long-term potentiation (ltp) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nachr). |
2019-04-09 |
2023-08-13 |
xenopus_laevis |
| Arunnjah Vivekanandarajah, Karen A Waters, Rita Machaalan. Cigarette smoke exposure effects on the brainstem expression of nicotinic acetylcholine receptors (nAChRs), and on cardiac, respiratory and sleep physiologies. Respiratory physiology & neurobiology. vol 259. 2019-04-03. PMID:30031221. |
one proposed mechanism leading to adverse effects is the interaction between nicotine and its nicotinic acetylcholine receptors (nachrs). |
2019-04-03 |
2023-08-13 |
human |
| Cinzia Cameli, Elena Bacchelli, Maria De Paola, Giuliano Giucastro, Stefano Cifiello, Ginetta Collo, Maria Michela Cainazzo, Luigi Alberto Pini, Elena Maestrini, Michele Zol. Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment. European journal of human genetics : EJHG. vol 26. issue 12. 2019-03-28. PMID:30089821. |
the role of nicotinic acetylcholine receptors (nachr) in nicotine dependence (nd) is well established; chrna7, encoding the α7 subunit, has a still uncertain role in nd, although it is implicated in a wide range of neuropsychiatric conditions. |
2019-03-28 |
2023-08-13 |
Not clear |
| Rieko Shimizu, Soichiro Ibaragi, Takanori Eguchi, Daisuke Kuwajima, Shinichi Kodama, Takashi Nishioka, Tatsuo Okui, Kyoichi Obata, Kiyofumi Takabatake, Hotaka Kawai, Kisho Ono, Kuniaki Okamoto, Hitoshi Nagatsuka, Akira Sasak. Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma. International journal of oncology. vol 54. issue 1. 2019-03-14. PMID:30431077. |
nicotine in blood binds to nicotinic acetylcholine receptor (nachr) in the central nervous system and serves a crucial role in tobacco addiction. |
2019-03-14 |
2023-08-13 |
Not clear |
| Ranjithkumar Chellian, Vijayapandi Pand. Protective effect of α-asarone against nicotine-induced seizures in mice, but not by its interaction with nicotinic acetylcholine receptors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-11. PMID:30372861. |
the seizures induced by nicotine is mediated through the activation of nicotinic acetylcholine receptors (nachrs) and stimulation of nmda receptors. |
2019-03-11 |
2023-08-13 |
mouse |
| Lucas C Armstrong, Glenn E Kirsch, Nikolai B Fedorov, Caiyun Wu, Yuri A Kuryshev, Abby L Sewell, Zhiqi Liu, Arianne L Motter, Carmine S Leggett, Michael S Or. High-Throughput Patch Clamp Screening in Human α6-Containing Nicotinic Acetylcholine Receptors. SLAS discovery : advancing life sciences R & D. vol 22. issue 6. 2019-02-21. PMID:28298165. |
nicotine, the addictive component of tobacco products, is an agonist at nicotinic acetylcholine receptors (nachrs) in the brain. |
2019-02-21 |
2023-08-13 |
human |
| Yann S Mineur, Emma L Cahuzac, Tenna N Mose, Matthew P Bentham, Margreet E Plantenga, David C Thompson, Marina R Picciott. Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 10. 2019-02-21. PMID:29472646. |
acetylcholine (ach), like the nicotine in tobacco, acts at nicotinic acetylcholine receptors (nachrs) to regulate behaviors related to anxiety and depression. |
2019-02-21 |
2023-08-13 |
mouse |
| Charles S Bockman, Wanyun Zeng, Jamie Hall, Beth Mittelstet, Liz Schwarzkopf, Dustin J Stair. Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats. Psychopharmacology. vol 235. issue 5. 2019-02-20. PMID:29464302. |
nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats. |
2019-02-20 |
2023-08-13 |
rat |
| Celina Mojica, Yu Bai, Shahrdad Lotfipou. Maternal nicotine exposure effects on adolescent learning and memory are abolished in alpha(α)2* nicotinic acetylcholine receptor-null mutant mice. Neuropharmacology. vol 135. 2019-02-20. PMID:29677582. |
maternal nicotine exposure effects on adolescent learning and memory are abolished in alpha(α)2* nicotinic acetylcholine receptor-null mutant mice. |
2019-02-20 |
2023-08-13 |
mouse |
| Gloria Brunori, Jennifer Schoch, Daniela Mercatelli, Akihiko Ozawa, Lawrence Toll, Andrea Cippitell. Influence of neuropathic pain on nicotinic acetylcholine receptor plasticity and behavioral responses to nicotine in rats. Pain. vol 159. issue 11. 2019-02-19. PMID:29939964. |
here, we describe experiments aimed at understanding whether a chronic pain state induces neuroadaptations into the brain or peripheral nerves that involve nicotinic acetylcholine receptors (nachrs) and whether these neuroadaptations directly lead to increased vulnerability to nicotine addiction or to the development of coping strategies to relieve pain symptoms. |
2019-02-19 |
2023-08-13 |
human |
| Abdul-Fattah Salah Fararjeh, Shih-Hsin Tu, Li-Ching Chen, Tzu-Chun Cheng, Yun-Ru Liu, Hang-Lung Chang, Hui-Wen Chang, Chi-Cheng Huang, Hwa-Chain Robert Wang, Wendy W Hwang-Verslues, Chih-Hsiung Wu, Yuan-Soon H. Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathway. Environmental toxicology. vol 34. issue 1. 2019-01-28. PMID:30259641. |
long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated signaling pathway. |
2019-01-28 |
2023-08-13 |
Not clear |
| João Pedro Gomes, Abdulla Watad, Yehuda Shoenfel. Nicotine and autoimmunity: The lotus' flower in tobacco. Pharmacological research. vol 128. 2018-12-14. PMID:29051105. |
nicotine, the major component of cigarettes, has demonstrated conflicting impact on the immune system: some authors suggest that increases pro-inflammatory cytokines and provokes cellular apoptosis of neutrophils, releasing intracellular components that act as auto-antigens; others claimed that nicotine has a protective and anti-inflammatory effects, especially by binding to α7 subunit of nicotinic acetylcholine receptors. |
2018-12-14 |
2023-08-13 |
Not clear |
| Jenny E Ozga, Karen G Anderso. Reduction in delay discounting due to nicotine and its attenuation by cholinergic antagonists in Lewis and Fischer 344 rats. Psychopharmacology. vol 235. issue 1. 2018-12-11. PMID:28971227. |
nicotine acts as an agonist for nicotinic acetylcholine receptors (nachrs), and mecamylamine, a nonselective nachr antagonist, attenuates effects of nicotine on delay discounting in some rat strains; whether nicotine's attenuation is specific to nachr antagonism is unknown. |
2018-12-11 |
2023-08-13 |
rat |
| Paul Faulkner, Nicole Petersen, Dara G Ghahremani, Chelsea M Cox, Rachel F Tyndale, Gerhard S Hellemann, Edythe D Londo. Sex differences in tobacco withdrawal and responses to smoking reduced-nicotine cigarettes in young smokers. Psychopharmacology. vol 235. issue 1. 2018-12-11. PMID:29022071. |
cigarettes with nicotine yields as low as 0.05 mg produce substantial occupancy of nicotinic acetylcholine receptors (26%), but women and men respond differently to these cigarettes. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jay Kardani, Ratnika Sethi, Ipsita Ro. Nicotine slows down oligomerisation of α-synuclein and ameliorates cytotoxicity in a yeast model of Parkinson's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-26. PMID:28167231. |
this has mostly been attributed to the neuroprotective role of nicotine in stimulating nicotinic acetylcholine receptors and dopaminergic neurons which are damaged in pd. |
2018-11-26 |
2023-08-13 |
Not clear |
| Stefania Tolu, Fabio Marti, Carole Morel, Carole Perrier, Nicolas Torquet, Stephanie Pons, Renaud de Beaurepaire, Philippe Faur. Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. Scientific reports. vol 7. 2018-11-14. PMID:28332590. |
nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. |
2018-11-14 |
2023-08-13 |
mouse |
| Stefania Tolu, Fabio Marti, Carole Morel, Carole Perrier, Nicolas Torquet, Stephanie Pons, Renaud de Beaurepaire, Philippe Faur. Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors. Scientific reports. vol 7. 2018-11-14. PMID:28332590. |
evidences support the hypothesis that distinct nicotinic acetylcholine receptors (nachrs), the molecular target of acetylcholine (ach) and exogenous nicotine, are also in addition implicated in the response to alcohol. |
2018-11-14 |
2023-08-13 |
mouse |