| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle Ren, Shahrdad Lotfipou. Nicotine Gateway Effects on Adolescent Substance Use. The western journal of emergency medicine. vol 20. issue 5. 2019-12-30. PMID:31539325. |
the developing brain is particularly vulnerable to the harmful effects of drugs of abuse, including tobacco and nicotine products, which activate nicotinic acetylcholine receptors (nachrs). |
2019-12-30 |
2023-08-13 |
Not clear |
| Michelle Ren, Shahrdad Lotfipou. Nicotine Gateway Effects on Adolescent Substance Use. The western journal of emergency medicine. vol 20. issue 5. 2019-12-30. PMID:31539325. |
disruption of nachr development with early nicotine use may influence the function and pharmacology of the receptor subunits and alter the release of reward-related neurotransmitters, including acetylcholine, dopamine, gaba, serotonin, and glutamate. |
2019-12-30 |
2023-08-13 |
Not clear |
| Rayane I Tabbara, Paul J Fletche. Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. Neuropharmacology. vol 148. 2019-12-27. PMID:30550794. |
nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. |
2019-12-27 |
2023-08-13 |
rat |
| Rayane I Tabbara, Paul J Fletche. Nicotine enhances responding for conditioned reinforcement via α4β2 nicotinic acetylcholine receptors in the ventral tegmental area, but not the nucleus accumbens or the prefrontal cortex. Neuropharmacology. vol 148. 2019-12-27. PMID:30550794. |
to determine if nicotinic acetylcholine receptors (nachrs) in the vta, nacc, prl cortex, or il cortex mediate nicotine-enhanced responding for a crf, the α4β2 nachr antagonist dihydro-beta-erythroidine (dhβe; 10 nmol/0.5 μl) was infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; sc). |
2019-12-27 |
2023-08-13 |
rat |
| José Luis Cedillo, Anna Bordas, Francisco Arnalich, Isabel Esteban-Rodríguez, Carolina Martín-Sánchez, María Extremera, Gema Atienza, Juan J Rios, Raquel L Arribas, Carmen Montie. Anti-tumoral activity of the human-specific duplicated form of α7-nicotinic receptor subunit in tobacco-induced lung cancer progression. Lung cancer (Amsterdam, Netherlands). vol 128. 2019-12-20. PMID:30642446. |
by activating α7 nicotinic acetylcholine receptors (α7-nachrs) in these tumors nicotine and its tobacco-derived nitrosamine, nnk, contribute to these oncogenic processes. |
2019-12-20 |
2023-08-13 |
Not clear |
| Jieun Kim, Ju Hwan Yang, In Soo Ryu, Sumin Sohn, Sunghyun Kim, Eun Sang Cho. Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration. International journal of molecular sciences. vol 20. issue 12. 2019-11-29. PMID:31208140. |
in the striatum, glutamate release is increased when α7 nicotinic acetylcholine receptors expressed in the glutamatergic terminals are exposed to nicotine, and over-stimulates glutamate receptors in gamma amino-butyric acid (gaba)ergic neurons. |
2019-11-29 |
2023-08-13 |
Not clear |
| Lila Buls Wollman, Richard B Levine, Ralph F Fregos. Developmental plasticity of GABAergic neurotransmission to brainstem motoneurons. The Journal of physiology. vol 596. issue 23. 2019-11-25. PMID:29352468. |
developmental nicotine exposure (dne) alters how gabaergic neurotransmission is modulated by acute activation of nicotinic acetylcholine receptors, which may provide insight into mechanisms by which nicotine exposure alters motor function under conditions that result in increased release of gaba, such as hypoxia, or endogenous acetylcholine, as occurs in the transition from nrem to rem sleep, or in response to exogenous nicotine. |
2019-11-25 |
2023-08-13 |
Not clear |
| Martin Chaumont, Benjamin de Becker, Wael Zaher, Antoine Culié, Guillaume Deprez, Christian Mélot, Florence Reyé, Pierre Van Antwerpen, Cédric Delporte, Nadia Debbas, Karim Zouaoui Boudjeltia, Philippe van de Born. Differential Effects of E-Cigarette on Microvascular Endothelial Function, Arterial Stiffness and Oxidative Stress: A Randomized Crossover Trial. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:29991814. |
in contrast, vaping with nicotine: 1) impaired acetylcholine mediated vasodilation (mean ± standard error mean) (area under curve, perfusion unit (pu), 3385 ± 27pu to 2271 ± 27pu, p < 0.0001); 2) increased indices of arterial stiffness, namely augmentation index corrected for heart rhythm (-3.5 ± 1.5% to 1.9 ± 2.3%; p = 0.013) and pulse wave velocity (4.9 ± 0.1 m.s |
2019-11-25 |
2023-08-13 |
Not clear |
| Shivani Choudhary, Djordje S Marjianović, Colin R Wong, Xiaoyu Zhang, Melanie Abongwa, Joel R Coats, Saša M Trailović, Richard J Martin, Alan P Robertso. Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors. International journal for parasitology. Drugs and drug resistance. vol 9. 2019-11-21. PMID:30682641. |
interestingly, further experiments revealed that both 0.1 μm and 10 μm menthol potentiated acetylcholine and levamisole responses in the levamisole sensitive receptor but not the nicotine sensitive receptor. |
2019-11-21 |
2023-08-13 |
xenopus_laevis |
| D.H. Johnson, O. Blomqvist, J.A. Engel, B. Söderpal. Subchronic intermittent nicotine treatment enhances ethanol-induced locomotor stimulation and dopamine turnover in mice. Behavioural pharmacology. vol 6. issue 2. 2019-11-20. PMID:11224328. |
it has been suggested that both ethanol and nicotine interfere with central nicotinic acetylcholine receptors located on brain dopamine neurons, a mechanism of action that may provide a basis for the often observed co-administration of these drugs of abuse. |
2019-11-20 |
2023-08-12 |
mouse |
| J Andrés Abin-Carriquiry, Ronald McGregor-Armas, Gustavo Costa, Jessika Urbanavicius, Federico Daja. Presynaptic involvement in the nicotine prevention of the dopamine loss provoked by 6-OHDA administration in the substantia nigra. Neurotoxicity research. vol 4. issue 2. 2019-11-20. PMID:12829413. |
while nicotine, through stimulation of a specific sub-population of nicotinic acetylcholine receptors (nachr) appears to protect cells in culture against a variety of insults, studies in vivo show controversial results. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jed E Rose, Ozra Dehkordi, Kebreten F Manaye, Richard M Millis, Salman Ameri Cianaki, Annapurni Jayam-Trout. The Sensory Impact of Nicotine on Noradrenergic and Dopaminergic Neurons of the Nicotine Reward - Addiction Neurocircuitry. Journal of addiction research & therapy. vol 7. issue 2. 2019-11-20. PMID:27347434. |
the sensory experience of smoking is a key component of nicotine addiction known to result, in part, from stimulation of nicotinic acetylcholine receptors (nachrs) at peripheral sensory nerve endings. |
2019-11-20 |
2023-08-13 |
mouse |
| Lingjun Zuo, Rolando Garcia-Milian, Xiaoyun Guo, Chunlong Zhong, Yunlong Tan, Zhiren Wang, Jijun Wang, Xiaoping Wang, Longli Kang, Lu Lu, Xiangning Chen, Chiang-Shan R Li, Xingguang Lu. Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes. vol 7. issue 11. 2019-11-20. PMID:27827986. |
it has been hypothesized that the nicotinic acetylcholine receptors (nachrs) play important roles in nicotine dependence (nd) and influence the number of cigarettes smoked per day (cpd) in smokers. |
2019-11-20 |
2023-08-13 |
Not clear |
| Anna Bordas, José Luis Cedillo, Francisco Arnalich, Isabel Esteban-Rodriguez, Laura Guerra-Pastrián, Javier de Castro, Carolina Martín-Sánchez, Gema Atienza, Carmen Fernández-Capitan, Juan José Rios, Carmen Montie. Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers. Oncotarget. vol 8. issue 40. 2019-11-20. PMID:28978081. |
because nicotine and tobacco-specific nitrosamines contribute to carcinogenesis by activating nicotinic acetylcholine receptors (nachrs) on lung tumors and epithelial cells, we investigated whether differential expression of nachr subtypes in these tumors could explain their different association with smoking. |
2019-11-20 |
2023-08-13 |
Not clear |
| Frédéric De Nardi, Claudie Lefort, Dimitri Bréard, Pascal Richomme, Christian Legros, Nathalie C Guérinea. Monitoring the Secretory Behavior of the Rat Adrenal Medulla by High-Performance Liquid Chromatography-Based Catecholamine Assay from Slice Supernatants. Frontiers in endocrinology. vol 8. 2019-11-20. PMID:28993760. |
nicotine is, however, more efficient than acetylcholine to evoke ne release. |
2019-11-20 |
2023-08-13 |
rat |
| Chunxiao Wang, Wenwen Niu, Hui Chen, Ni Shi, Dian He, Min Zhang, Lihua Ge, Zhenchuan Tian, Moci Qi, Tong Chen, Xiaofei Tan. Nicotine suppresses apoptosis by regulating α7nAChR/Prx1 axis in oral precancerous lesions. Oncotarget. vol 8. issue 43. 2019-11-20. PMID:29088845. |
nicotine, a tumor promoter in tobacco, can increase peroxiredoxin (prx1) and nicotinic acetylcholine receptors (nachrs) in oral squamous cell carcinoma (oscc). |
2019-11-20 |
2023-08-13 |
Not clear |
| Namita Pandey, Soumyadip Pal, Lokesh Kumar Sharma, Randeep Guleria, Anant Mohan, Tapasya Srivastav. SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population Asian Pacific journal of cancer prevention : APJCP. vol 18. issue 11. 2019-11-20. PMID:29172281. |
snp rs16969968 as a strong predictor of nicotine dependence and lung cancer risk in a north indian population background: the 15q24-25 loci contain genes (chrna5 and chrna3) encoding nicotinic acetylcholine receptorsubunits. |
2019-11-20 |
2023-08-13 |
human |
| Mami Noda, A I Kobayash. Correction to: Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors. The journal of physiological sciences : JPS. vol 68. issue 6. 2019-11-20. PMID:29679307. |
correction to: nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mami Noda, A I Kobayash. Correction to: Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors. The journal of physiological sciences : JPS. vol 68. issue 6. 2019-11-20. PMID:29679307. |
the article nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors, written by mami noda and ai kobayashi, was originally published online first without open access. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hui Wen Ng, Carmine Leggett, Sugunadevi Sakkiah, Bohu Pan, Hao Ye, Leihong Wu, Chandrabose Selvaraj, Weida Tong, Huixiao Hon. Competitive docking model for prediction of the human nicotinic acetylcholine receptor α7 binding of tobacco constituents. Oncotarget. vol 9. issue 24. 2019-11-20. PMID:29682193. |
nicotinic acetylcholine receptors (nachrs) are the targets of nicotine and are responsible for addiction to tobacco products. |
2019-11-20 |
2023-08-13 |
human |