| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
nicotine hijacks nicotinic acetylcholine receptors (nachrs) and interferes with physiological function of the cholinergic system. |
2020-10-01 |
2023-08-13 |
Not clear |
| Josephine R Tarren, Henry A Lester, Arnauld Belmer, Selena E Bartlet. Acute Ethanol Administration Upregulates Synaptic α4-Subunit of Neuronal Nicotinic Acetylcholine Receptors within the Nucleus Accumbens and Amygdala. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29114204. |
previous data show that chronic exposure to nicotine upregulates high-affinity nicotinic acetylcholine receptors (nachrs) in several brain areas. |
2020-09-30 |
2023-08-13 |
mouse |
| Barbara Budzynska, Artur Wnorowski, Katarzyna Kaszubska, Grazyna Biala, Marta Kruk-Słomka, Jacek Kurzepa, Anna Boguszewska-Czubar. Acute MDMA and Nicotine Co-administration: Behavioral Effects and Oxidative Stress Processes in Mice. Frontiers in behavioral neuroscience. vol 12. 2020-09-30. PMID:30116179. |
as mdma and nicotine activate the same neuronal pathways, we examined the influence of co-administration of nicotine (0.05 mg/kg) and mdma (1 mg/kg) on cognitive processes, nicotine-induced behavioral sensitization and on processes linked with oxidative stress and α7 nicotinic acetylcholine receptors (nachrs) expression in the brain of male swiss mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Wan-Li Cheng, Kuan-Yuan Chen, Kang-Yun Lee, Po-Hao Feng, Sheng-Ming W. Nicotinic-nAChR signaling mediates drug resistance in lung cancer. Journal of Cancer. vol 11. issue 5. 2020-09-30. PMID:31956359. |
nicotine, the primary addictive constituent of cigarettes, contributes to cancer progression through activation of nicotinic acetylcholine receptors (nachrs), which are membrane ligand-gated ion channels. |
2020-09-30 |
2023-08-13 |
Not clear |
| Anna Maria Lavezz. Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death. Toxics. vol 6. issue 4. 2020-09-29. PMID:30340403. |
among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic projections in perinatal life. |
2020-09-29 |
2023-08-13 |
Not clear |
| Anna Maria Lavezz. Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death. Toxics. vol 6. issue 4. 2020-09-29. PMID:30340403. |
immunohistochemical procedures for analysing formalin-fixed and paraffin-embedded brainstem samples from 68 fetuses and early newborns, with smoking and non-smoking mothers, who died of known and unknown causes, were carried out in order to determine if nicotine had activated the α7-nicotinic acetylcholine receptors. |
2020-09-29 |
2023-08-13 |
Not clear |
| Raj Kumar Tiwari, Vikas Sharma, Ravindra Kumar Pandey, Shiv Shankar Shukl. Nicotine Addiction: Neurobiology and Mechanism. Journal of pharmacopuncture. vol 23. issue 1. 2020-09-28. PMID:32322429. |
nicotine mainly shows its action through specific nicotinic acetylcholine receptors located in brain. |
2020-09-28 |
2023-08-13 |
Not clear |
| Raj Kumar Tiwari, Vikas Sharma, Ravindra Kumar Pandey, Shiv Shankar Shukl. Nicotine Addiction: Neurobiology and Mechanism. Journal of pharmacopuncture. vol 23. issue 1. 2020-09-28. PMID:32322429. |
further, the neurobiological pathway to nicotine dependence might perhaps be appropriate to the attachment of nicotine to nicotinic acetylcholine receptors, peruse by stimulation of dopaminergic system and activation of general pharmacological changes that might be responsible for nicotine addiction. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ali Abbaszadeh-Kasbi, Nazgol-Sadat Haddadi, Amir Dehdashtian, Khashayar Afshari, Seyedeh Zarifeh Jazaeri, Naser Khodaei, Majid Momeni, Ahmad-Reza Dehpou. Acute Activation of α7-Nicotinic Receptors by Nicotine Improves Rodent Skin Flap Survival Through Nitrergic System. Annals of plastic surgery. vol 83. issue 2. 2020-09-25. PMID:30844823. |
recent reports have identified angiogenic, anti-inflammatory, and antioxidant properties of acute treatment with nicotine via activation of nicotinic acetylcholine receptors (nachrs). |
2020-09-25 |
2023-08-13 |
Not clear |
| Yayoi Aoki, Tomoya Ikeda, Naoto Tani, Alissa Shida, Shigeki Oritani, Takaki Ishikaw. Evaluation of the distribution of nicotine intravenous injection: an adult autopsy case report with a review of literature. International journal of legal medicine. vol 134. issue 1. 2020-09-14. PMID:30955048. |
the distributions of nicotine and cotinine, as indicated by the intravenous injection, were related to the distribution of organs that metabolize nicotine and the distribution of nicotinic acetylcholine receptors. |
2020-09-14 |
2023-08-13 |
Not clear |
| Christie D Fowler, Jill R Turner, M Imad Dama. Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. Handbook of experimental pharmacology. vol 258. 2020-09-14. PMID:31267166. |
in this chapter, we review the field's current understanding of nicotine's actions in the brain, the neurocircuitry underlying drug dependence, factors that modulate the function of nicotinic acetylcholine receptors, and the role of specific genes in mitigating the vulnerability to develop nicotine dependence. |
2020-09-14 |
2023-08-13 |
Not clear |
| Zeyi Huang, Daichao Wu, Xilin Qu, Meixiang Li, Ju Zou, Sijie Ta. BDNF and nicotine dependence: associations and potential mechanisms. Reviews in the neurosciences. 2020-09-05. PMID:32887210. |
although it is well known that nicotine binds to the nicotinic acetylcholine receptors (nachrs) and activates the mesolimbic dopaminergic system (mds) to generate the pleasant and rewarding effects, the molecular mechanisms of nicotine addiction are not fully understood. |
2020-09-05 |
2023-08-13 |
Not clear |
| Cali A Calarco, Marina R Picciott. Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine's Effects on Food Intake. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 22. issue 2. 2020-08-25. PMID:30690485. |
nicotine, acting through nicotinic acetylcholine receptors (nachrs), increases the firing rate of both orexigenic agouti-related peptide and anorexigenic proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus (arc). |
2020-08-25 |
2023-08-13 |
Not clear |
| M J Moerke, L R McMahon, J L Wilkerso. More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder. Pharmacological reviews. vol 72. issue 2. 2020-08-18. PMID:32205338. |
accordingly, most pharmacotherapies for smoking cessation target nicotinic acetylcholine receptors (nachrs), nicotine's major site of action in the brain. |
2020-08-18 |
2023-08-13 |
Not clear |
| Hiroki Toyod. Nicotinic activity layer specifically modulates synaptic potentiation in the mouse insular cortex. The European journal of neuroscience. vol 50. issue 3. 2020-08-07. PMID:29405451. |
nicotinic acetylcholine receptors (nachrs) in the insular cortex play an important role in nicotine addiction, but its cellular and synaptic mechanisms underlying nicotine addiction still remain unresolved. |
2020-08-07 |
2023-08-13 |
mouse |
| Hong Xing, Kristin W Andrud, Ferenc Soti, Anne Rouchaud, Stephan C Jahn, Ziang Lu, Yeh-Hyon Cho, Sophia Habibi, Patrick Corsino, Svetoslav Slavov, James R Rocca, Jon M Lindstrom, Ron J Lukas, William R Ke. A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in Its Interactions with Molecular pharmacology. vol 98. issue 2. 2020-08-03. PMID:32474444. |
a methyl scan of the pyrrolidinium ring of nicotine reveals significant differences in its interactions with the two major nicotinic acetylcholine receptors (nachrs) in the brain are the |
2020-08-03 |
2023-08-13 |
Not clear |
| Shashi P Singh, Hitendra S Chand, Santanu Banerjee, Hemant Agarwal, Veena Raizada, Sabita Roy, Mohan Sopor. Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis. Digestive diseases and sciences. vol 65. issue 1. 2020-07-14. PMID:31643033. |
acetylcholine and nicotine stimulate mucus production and suppress th2 inflammation through nicotinic receptors in lungs but uc is rarely observed in smokers and the mechanism of the protection is unclear. |
2020-07-14 |
2023-08-13 |
Not clear |
| Yen-Chu Chen, James P Fowler, Jing Wang, Christy J W Watson, Yasmine Sherafat, Andres Staben, Philip Lazarus, Travis T Denton, Christie D Fowle. The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. The Journal of pharmacology and experimental therapeutics. vol 372. issue 1. 2020-07-13. PMID:31628204. |
together, along with the analysis of nicotine metabolites during self-administration, these findings support the contention that blocking hepatic nicotine metabolism would allow for similar activation of nicotinic acetylcholine receptors at lower nicotine doses. |
2020-07-13 |
2023-08-13 |
mouse |
| Jing Zhao, Surim Park, Jong-Won Kim, Jing Qi, Zixiong Zhou, Chae Woong Lim, Bumseok Ki. Nicotine attenuates concanavalin A-induced liver injury in mice by regulating the α7-nicotinic acetylcholine receptor in Kupffer cells. International immunopharmacology. vol 78. 2020-07-13. PMID:31835083. |
nicotine, a potent parasympathomimetic alkaloid, manifests anti-inflammatory properties by activating nicotinic acetylcholine receptors (nachrs). |
2020-07-13 |
2023-08-13 |
mouse |