| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshio Takahash. Roles of nAChR and Wnt signaling in intestinal stem cell function and inflammation. International immunopharmacology. vol 81. 2021-01-07. PMID:32007796. |
nicotinic acetylcholine receptors (nachrs) are ligand-gated ion channels that signal using endogenous acetylcholine (ach) and the agonist, nicotine. |
2021-01-07 |
2023-08-13 |
Not clear |
| Xiaopeng Zhu, Si Pan, Manyu Xu, Lu Zhang, Jinfang Yu, Jinpeng Yu, Yong Wu, Yingxu Fan, Haonan Li, Igor E Kasheverov, Denis S Kudryavtsev, Victor I Tsetlin, Yi Xue, Dongting Zhangsun, Xinquan Wang, Sulan Lu. High Selectivity of an α-Conotoxin LvIA Analogue for α3β2 Nicotinic Acetylcholine Receptors Is Mediated by β2 Functionally Important Residues. Journal of medicinal chemistry. vol 63. issue 22. 2020-12-31. PMID:33196189. |
the α3β2 and α3β4 nicotinic acetylcholine receptors (nachrs) are widely expressed in the central and peripheral nervous systems, playing critical roles in various physiological processes and in such pathologies as addiction to nicotine and other drugs of abuse. |
2020-12-31 |
2023-08-13 |
Not clear |
| Fawaz Alasmari, Laura E Crotty Alexander, Alaa M Hammad, Austin Horton, Hasan Alhaddad, Isaac T Schiefer, John Shin, Alexander Moshensky, Youssef Sar. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Chemico-biological interactions. vol 333. 2020-12-29. PMID:33242460. |
e-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. |
2020-12-29 |
2023-08-13 |
mouse |
| Fawaz Alasmari, Laura E Crotty Alexander, Alaa M Hammad, Austin Horton, Hasan Alhaddad, Isaac T Schiefer, John Shin, Alexander Moshensky, Youssef Sar. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Chemico-biological interactions. vol 333. 2020-12-29. PMID:33242460. |
nicotine exposure increases the release of glutamate in part through stimulatory effects on pre-synaptic nicotinic acetylcholine receptors (nachrs). |
2020-12-29 |
2023-08-13 |
mouse |
| Petra Scholze, Sigismund Huc. The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2 Frontiers in synaptic neuroscience. vol 12. 2020-12-22. PMID:33343327. |
the α5 nicotinic acetylcholine receptor subunit differentially modulates α4β2 nicotine, the principal reinforcing compound in tobacco, acts in the brain by activating neuronal nicotinic acetylcholine receptors (nachrs). |
2020-12-22 |
2023-08-13 |
Not clear |
| Rachel Dean, Erika Duperreault, Dustin Newton, Jeffrey Krook, Erica Ingraham, Joshua Gallup, Brian C Franczak, Trevor J Hamilto. Opposing effects of acute and repeated nicotine exposure on boldness in zebrafish. Scientific reports. vol 10. issue 1. 2020-12-01. PMID:32444782. |
nicotine is an addictive compound that activates neuronal nicotinic acetylcholine receptors (nachrs) and causes behavioural effects that vary with dose, schedule of administration, and animal model. |
2020-12-01 |
2023-08-13 |
zebrafish |
| Tsai-Der Chuang, Aamir Ansari, Celia Yu, Reiko Sakurai, Amir Harb, Jie Liu, Omid Khorram, Virender K Reha. Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring. American journal of physiology. Heart and circulatory physiology. vol 319. issue 3. 2020-11-24. PMID:32795172. |
nicotine treatment of isolated primary neonatal rat cardiac fibroblasts suggested that these effects were mediated via nicotinic acetylcholine receptors including α7 and the induced collagens accumulation was reversed by a gain-of function of mir-29 family. |
2020-11-24 |
2023-08-13 |
rat |
| Abdalla M Wedn, Sahar M El-Gowilly, Mahmoud M El-Ma. The α7-nAChR/heme oxygenase-1/carbon monoxide pathway mediates the nicotine counteraction of renal inflammation and vasoconstrictor hyporeactivity in endotoxic male rats. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 69. issue 2. 2020-11-20. PMID:31897506. |
the objective of the study was to test the hypothesis that nicotine guards against endotoxemia-associated renal inflammation and vasoconstrictor dysfunction via the activation of α7-nicotinic acetylcholine receptors (α7-nachrs)/heme oxygenase-1 (ho-1) cascade. |
2020-11-20 |
2023-08-13 |
rat |
| Leanna A Marquart, Matthew W Turner, Owen M McDouga. Qualitative Assay to Detect Dopamine Release by Ligand Action on Nicotinic Acetylcholine Receptors. Toxins. vol 11. issue 12. 2020-11-13. PMID:31757080. |
results are presented for the action of nachr agonists (acetylcholine, nicotine, and cytisine), and antagonists (α-conotoxins (α-ctxs) mii, imi, lvia, and peia) that demonstrate a luminescence response correlating to the increase or decrease of dopamine release. |
2020-11-13 |
2023-08-13 |
rat |
| Tingting Han, Qi Wang, Ruihe Lai, Dalong Zhang, Yao Diao, Yafu Yi. Nicotine Induced Neurocognitive Protection and Anti-inflammation Effect by Activating α 4β 2 Nicotinic Acetylcholine Receptors in Ischemic Rats. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 22. issue 6. 2020-10-23. PMID:31403667. |
nicotine induced neurocognitive protection and anti-inflammation effect by activating α 4β 2 nicotinic acetylcholine receptors in ischemic rats. |
2020-10-23 |
2023-08-13 |
rat |
| Shuang Xu, Huaner Ni, Hangwei Chen, Qiuyan Da. The interaction between STAT3 and nAChRα1 interferes with nicotine-induced atherosclerosis via Akt/mTOR signaling cascade. Aging. vol 11. issue 19. 2020-10-20. PMID:31612866. |
during atherosclerosis development, nicotine and its α1 nicotinic acetylcholine receptors (nachrα1) activate atherogenic inflammation. |
2020-10-20 |
2023-08-13 |
Not clear |
| Zhihua Sun, Manqi Zhangsun, Shuai Dong, Yiqiao Liu, Jiang Qian, Dongting Zhangsun, Sulan Lu. Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA. Marine drugs. vol 18. issue 1. 2020-10-13. PMID:31963558. |
differential expression of nicotine acetylcholine receptors associates with human breast cancer and mediates antitumor activity of αo-conotoxin gexiva. |
2020-10-13 |
2023-08-13 |
human |
| Darlene H Brunzell, Alexandra M Stafford, Claire I Dixo. Nicotinic receptor contributions to smoking: insights from human studies and animal models. Current addiction reports. vol 2. issue 1. 2020-10-01. PMID:26301171. |
nicotine is a constituent of tobacco smoke that exerts its psychoactive effects via binding to nicotinic acetylcholine receptors (nachrs) in brain. |
2020-10-01 |
2023-08-13 |
human |
| Ningning Dang, Xianguang Meng, Haiyan Son. Nicotinic acetylcholine receptors and cancer. Biomedical reports. vol 4. issue 5. 2020-10-01. PMID:27123240. |
nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nachrs), which are membrane ligand-gated cation channels. |
2020-10-01 |
2023-08-13 |
human |
| Jamie K Lau, Kathleen C Brown, Piyali Dasgupt. Measurement of Acetylcholine from Cell Lines. Bio-protocol. vol 3. issue 24. 2020-10-01. PMID:27390758. |
our published data shows that nicotine promotes the production of acetylcholine (ach) in human bronchioalveolar carcinoma cells (bacs) (lau |
2020-10-01 |
2023-08-13 |
human |
| Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshiok. The data set describing cognitive performance after varenicline administration in a 3-choice serial reaction time task in rats. Data in brief. vol 11. 2020-10-01. PMID:28337467. |
our interpretation and discussion of these data were described in the article "varenicline provokes impulsive action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner" (ohmura et al., 2017) [1]. |
2020-10-01 |
2023-08-13 |
rat |
| Anna Zakrzewicz, Katrin Richter, Alisa Agné, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Mike Althaus, Winfried Padberg, Arik J Hone, J Michael McIntosh, Veronika Gra. Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28725182. |
in peripheral blood mononuclear cells from nachr gene-deficient mice, we demonstrated that inhibition of atp-dependent release of il-1β by acetylcholine (ach), nicotine and pc depends on subunits α7, α9 and α10. |
2020-10-01 |
2023-08-13 |
mouse |
| Hai-Ji Sun, Yan-Fei Jia, Xiao-Li M. Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28878681. |
nicotine and nicotinic acetylcholine receptors (nachrs) are considered to be involved in lung cancer risk, onset and progression, but their precise physiological roles in these contexts remain unclear. |
2020-10-01 |
2023-08-13 |
Not clear |
| Nazeer Muhammad, Muhammad Sharif, Javeria Amin, Riffat Mehboob, Syed Amir Gilani, Nargis Bibi, Hasnain Javed, Naseer Ahme. Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review. Frontiers in pediatrics. vol 6. 2020-10-01. PMID:29423392. |
several studies conducted in the past decade have confirmed neuropathological and neurochemical anomalies related to serotonin transporter, substance p, acetylcholine α7 nicotine receptors, etc., in sudden unexplained fetal and infant deaths. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. |
2020-10-01 |
2023-08-13 |
Not clear |