| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Beatriz Antolin-Fontes, Kun Li, Jessica L Ables, Michael H Riad, Andreas Görlich, Maya Williams, Cuidong Wang, Sylvia M Lipford, Maria Dao, Jianxi Liu, Henrik Molina, Nathaniel Heintz, Paul J Kenny, Ines Ibañez-Tallo. The habenular G-protein-coupled receptor 151 regulates synaptic plasticity and nicotine intake. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 10. 2020-07-13. PMID:32098843. |
the habenula, an ancient small brain area in the epithalamus, densely expresses nicotinic acetylcholine receptors and is critical for nicotine intake and aversion. |
2020-07-13 |
2023-08-13 |
Not clear |
| Mohammad-Reza Zarrindast, Fatemeh Khakpa. The modulatory role of nicotine on cognitive and non-cognitive functions. Brain research. vol 1710. 2020-06-25. PMID:30529105. |
nicotine exerts its function by activating nicotinic acetylcholine receptors (nachrs) which one highly expressed throughout the nervous system. |
2020-06-25 |
2023-08-13 |
Not clear |
| Mariana R Silva, Gilka J F Gattás, Juliana De Antonio, Isabela Firigato, Otávio A Curioni, Fernanda de Toledo Gonçalve. Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population. Molecular genetics & genomic medicine. vol 7. issue 12. 2020-06-19. PMID:31599127. |
one of the main compounds in cigarettes is nicotine, which binds directly to nicotine acetylcholine receptors (nachrs) in the body, which are encoded by different genes of the chrna family. |
2020-06-19 |
2023-08-13 |
Not clear |
| Matthew C Arvin, Xiao-Tao Jin, Yijin Yan, Yong Wang, Matthew D Ramsey, Veronica J Kim, Nicole A Beckley, Brittany A Henry, Ryan M Drena. Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 22. 2020-06-12. PMID:30867261. |
antagonism of nicotinic acetylcholine receptors (nachrs) in the medial habenula (mhb) or interpeduncular nucleus (ipn) triggers withdrawal-like behaviors in mice chronically exposed to nicotine, implying that nicotine dependence involves the sensitization of nicotinic signaling. |
2020-06-12 |
2023-08-13 |
mouse |
| Wen-Liang Zhou, Xiao-Bing Gao, Marina R Picciott. Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms eNeuro. vol 2. issue 1. 2020-06-04. PMID:26322330. |
nicotine acts through nicotinic acetylcholine receptors (nachrs) to alter firing rate of neurons throughout the brain, leading to addiction-related behaviors. |
2020-06-04 |
2023-08-13 |
mouse |
| Cali A Calarco, Zhiying Li, Seth R Taylor, Somin Lee, Wenliang Zhou, Jeffrey M Friedman, Yann S Mineur, Cecilia Gotti, Marina R Picciott. Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus. The European journal of neuroscience. 2020-06-04. PMID:29791746. |
nicotine, acting through nicotinic acetylcholine receptors (nachrs), increases the firing rate of both orexigenic agouti-related peptide (agrp) and anorexigenic pro-opiomelanocortin (pomc) neurons in the arcuate nucleus of the hypothalamus (arc), yet nicotine and other nachr agonists decrease food intake in mice. |
2020-06-04 |
2023-08-13 |
mouse |
| Christian O'Reilly, Florian Chapotot, Francesca Pittau, Nathalie Mella, Fabienne Picar. Nicotine increases sleep spindle activity. Journal of sleep research. vol 28. issue 4. 2020-05-05. PMID:30565327. |
these results suggest that nicotine can increase spindle activity by acting on nicotinic acetylcholine receptors, and offer an attractive hypothesis for common mechanisms that may support memorisation improvements previously reported to be associated with nicotine and sleep spindles. |
2020-05-05 |
2023-08-13 |
human |
| Caitlin E Askew, Alberto J Lopez, Marcelo A Wood, Raju Metherat. Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex. Synapse (New York, N.Y.). vol 73. issue 9. 2020-04-29. PMID:31081950. |
nicotine activates nicotinic acetylcholine receptors and improves cognitive and sensory function, in part by its actions in cortical regions. |
2020-04-29 |
2023-08-13 |
mouse |
| Vilma Kisnieriene, Indre Lapeikaite, Vilmantas Pupki. Electrical signalling in Nitellopsis obtusa: potential biomarkers of biologically active compounds. Functional plant biology : FPB. vol 45. issue 2. 2020-04-15. PMID:32291027. |
experimental evidence using multiple electrical signals as biomarkers of the effects of bc (acetylcholine, asparagine, glutamate, nicotine, aluminium, nickel and cadmium ions) is provided. |
2020-04-15 |
2023-08-13 |
Not clear |
| Gofarana Wilar, Yasuharu Shinoda, Toshikuni Sasaoka, Kohji Fukunag. Crucial Role of Dopamine D2 Receptor Signaling in Nicotine-Induced Conditioned Place Preference. Molecular neurobiology. vol 56. issue 12. 2020-04-06. PMID:31129809. |
although nicotine dependence is explained by dopamine receptor (dr) signaling together with nicotinic acetylcholine receptors (nachrs), the synaptic molecular mechanism underlying the interaction between dopamine receptor and nachrs remains unclear. |
2020-04-06 |
2023-08-13 |
mouse |
| Juan Pablo González-Gutiérrez, Hernán Armando Pessoa-Mahana, Patricio Ernesto Iturriaga-Vásquez, Miguel Iván Reyes-Parada, Nicolas Esteban Guerra-Díaz, Martin Hodar-Salazar, Franco Viscarra, Pablo Paillali, Gabriel Núñez-Vivanco, Marcos Antonio Lorca-Carvajal, Jaime Mella-Raipán, María Carolina Zúñig. Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters. Molecules (Basel, Switzerland). vol 24. issue 20. 2020-04-06. PMID:31652614. |
in the present work, a series of functionalized esters structurally related to acetylcholine and nicotine were synthesized and pharmacologically assayed with respect to these targets. |
2020-04-06 |
2023-08-13 |
Not clear |
| Taryn E Grieder, Morgane Besson, Geith Maal-Bared, Stéphanie Pons, Uwe Maskos, Derek van der Koo. β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 51. 2020-04-01. PMID:31776253. |
β2* nicotinic acetylcholine receptors (nachr) are necessary and sufficient for the experience of both nicotine reward and aversion in an intra-vta (ventral tegmental area) self-administration paradigm. |
2020-04-01 |
2023-08-13 |
Not clear |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
nicotine prevents alpha-synuclein accumulation in mouse and human ipsc-derived dopaminergic neurons through activation of the dopamine d3- acetylcholine nicotinic receptor heteromer. |
2020-03-24 |
2023-08-13 |
mouse |
| Federica Bono, Veronica Mutti, Paola Savoia, Alessandro Barbon, Arianna Bellucci, Cristina Missale, Chiara Fiorentin. Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer. Neurobiology of disease. vol 129. 2020-03-24. PMID:31051233. |
we recently found that in mouse dopaminergic neurons, the heteromer formed by the dopamine d3 receptor (d3r) and the β2 subunit of acetylcholine nicotinic receptor (nachr) exerts neurotrophic effects when activated by nicotine, leading to neurons with enlarged cell bodies and increased dendrite arborization. |
2020-03-24 |
2023-08-13 |
mouse |
| Jose M Trigo, Bernard Le Fol. Nicotine Self-Administration as Paradigm for Medication Discovery for Smoking Cessation: Recent Findings in Medications Targeting the Cholinergic System. Methods in molecular biology (Clifton, N.J.). vol 2011. 2020-03-19. PMID:31273700. |
in this chapter we describe how the ivsa paradigm has served to further investigate the role of nicotinic acetylcholine receptors (nachrs) in the reinforcing properties of nicotine. |
2020-03-19 |
2023-08-13 |
human |
| Asti B Jackson, Wisam Toma, Katherine M Contreras, Yasmin Alkhlaif, M Imad Dama. The β3 subunit of the nicotinic acetylcholine receptor is required for nicotine withdrawal-induced affective but not physical signs or nicotine reward in mice. Pharmacology, biochemistry, and behavior. vol 183. 2020-03-10. PMID:31145916. |
nicotinic acetylcholine receptors (nachrs) are the primary target for nicotine, the addictive component in tobacco products. |
2020-03-10 |
2023-08-13 |
mouse |
| Chia-Chen Hsu, Kuo-Yang Tsai, Yu-Fu Su, Chu-Yen Chien, Ying-Chen Chen, Yu-Chiao Wu, Shyun-Yeu Liu, Yi-Shing Shie. α7-Nicotine acetylcholine receptor mediated nicotine induced cell survival and cisplatin resistance in oral cancer. Archives of oral biology. vol 111. 2020-02-26. PMID:31935534. |
to investigate the effect of nicotine on cell survival and cisplatin resistance in oral cancer and the possible involvement of α7-nicotinic acetylcholine receptors (α7-nachrs). |
2020-02-26 |
2023-08-13 |
Not clear |
| Lakshmi Ramachandran Nair, Xiu Li. Targeting the Journal of addiction research & therapy. vol 10. issue 2. 2020-02-25. PMID:31404286. |
targeting the nicotine exerts its reinforcing actions via activating the nicotinic acetylcholine receptors (nachrs). |
2020-02-25 |
2023-08-13 |
rat |
| R Manjunatha Kin. Toxins for decoding interface selectivity in nicotinic acetylcholine receptors. The Biochemical journal. vol 476. issue 10. 2020-02-11. PMID:31138769. |
agonists, acetylcholine and nicotine, bind to the interface formed between two α subunits and between α and non-α subunits to activate the nachr and allow cation influx. |
2020-02-11 |
2023-08-13 |
Not clear |
| Juan Pablo Gonzalez-Gutierrez, Martin Hodar, Franco Viscarra, Pablo Paillali, Nicolás Guerra-Díaz, Hernán Pessoa-Mahana, Juan José Hernández-Morantes, Horacio Pérez-Sánchez, Isabel Bermúdez, Miguel Reyes-Parada, Patricio Iturriaga-Vásque. Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-02. PMID:31344816. |
neuronal α4β2 nicotinic acetylcholine receptors (nachrs) are ligand-gated ion channels (lgic) that have been implicated in nicotine addiction, reward, cognition, pain disorders, anxiety, and depression. |
2020-01-02 |
2023-08-13 |
Not clear |