| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christie D Fowler, Luis Tuesta, Paul J Kenn. Role of α5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice. Psychopharmacology. 2021-10-21. PMID:23958943. |
role of α5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice. |
2021-10-21 |
2023-08-12 |
mouse |
| Zheng-Xiong X. Preclinical Pharmacology, Efficacy and Safety of Varenicline in Smoking Cessation and Clinical Utility in High Risk Patients. Drug, healthcare and patient safety. vol 2010. issue 2. 2021-10-20. PMID:21278851. |
mechanism studies suggest that the pleasurable effects of smoking are mediated predominantly by nicotine, which activates the brain reward system by activation of brain α(4)β(2) nicotinic acetylcholine receptors (nachrs). |
2021-10-20 |
2023-08-12 |
Not clear |
| Xiomara A Pérez, Maryka Qui. Focus on α4β2* and α6β2* nAChRs for Parkinson's Disease Therapeutics. Molecular and cellular pharmacology. vol 3. issue 1. 2021-10-20. PMID:21499569. |
nicotine, a drug that acts at nicotinic acetylcholine receptors (nachrs), has been shown to protect against nigrostriatal damage and reduce l-dopa-induced dyskinesias. |
2021-10-20 |
2023-08-12 |
rat |
| Alfonso Claros-Guzmán, Martín G Rodríguez, Birmania Heredia-Rivera, Rodolfo González-Segovi. Three-dimensional analysis of the heart function and effect cholinergic agonists in the cockroach Gromphadorhina portentosa. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 206. issue 6. 2021-10-19. PMID:32955634. |
we used this methodology for assessing the physiological responses of the cockroach heart upon the application of different cholinergic neurotransmitters (acetylcholine, nicotine and muscarine). |
2021-10-19 |
2023-08-13 |
drosophila_melanogaster |
| Alfonso Claros-Guzmán, Martín G Rodríguez, Birmania Heredia-Rivera, Rodolfo González-Segovi. Three-dimensional analysis of the heart function and effect cholinergic agonists in the cockroach Gromphadorhina portentosa. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 206. issue 6. 2021-10-19. PMID:32955634. |
acetylcholine and nicotine induced a biphasic effect on the cardiac frequency. |
2021-10-19 |
2023-08-13 |
drosophila_melanogaster |
| Cecilia Gotti, Francesco Clement. Cytisine and cytisine derivatives. More than smoking cessation aids. Pharmacological research. vol 170. 2021-10-18. PMID:34087351. |
its main targets are neuronal nicotinic acetylcholine receptors (nachrs), and pre-clinical studies have shown that its interactions with various nachr subtypes located in different areas of the central and peripheral nervous systems are neuroprotective, have a wide range of biological effects on nicotine and alcohol addiction, regulate mood, food intake and motor activity, and influence the autonomic and cardiovascular systems. |
2021-10-18 |
2023-08-13 |
Not clear |
| Wen Meng, Ting Xiao, Xiuci Liang, Jie Wen, Xinyi Peng, Jing Wang, Yi Zou, Jiahao Liu, Christie Bialowas, Hairong Luo, Yacheng Zhang, Bilian Liu, Jingjing Zhang, Fang Hu, Meilian Liu, Lily Q Dong, Zhiguang Zhou, Feng Liu, Juli Ba. The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis. JCI insight. vol 6. issue 17. 2021-10-09. PMID:34264867. |
increased acetylcholine expression activated the nicotine acetylcholine receptor in adipocytes, which stimulated pka signaling and consequent thermogenic gene expression. |
2021-10-09 |
2023-08-13 |
mouse |
| Janna K Moen, Anna M Le. Sex Differences in the Nicotinic Acetylcholine Receptor System of Rodents: Impacts on Nicotine and Alcohol Reward Behaviors. Frontiers in neuroscience. vol 15. 2021-10-09. PMID:34621155. |
both alcohol and nicotine require neuronal nicotinic acetylcholine receptors (nachrs) to elicit rewarding effects within the mesolimbic system, representing a shared molecular pathway that likely contributes to the frequent comorbidity of alcohol and nicotine dependence. |
2021-10-09 |
2023-08-13 |
Not clear |
| C N Miller, H M Kamen. The role of nicotinic acetylcholine receptors in alcohol-related behaviors. Brain research bulletin. vol 163. 2021-09-29. PMID:32707263. |
nicotine acts directly at nicotinic acetylcholine receptors (nachr) to have its pharmacological effect. |
2021-09-29 |
2023-08-13 |
human |
| Farren Bs Brigg. Nicotinic acetylcholine receptors α7 and α9 modifies tobacco smoke risk for multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England). vol 27. issue 8. 2021-09-27. PMID:32924781. |
animal studies further support this hypothesis, demonstrating nicotine's protective effect in ms is mediated by the presence and absence of α7 and α9 nicotinic acetylcholine receptors (nachrs), respectively. |
2021-09-27 |
2023-08-13 |
Not clear |
| Skylar Y Cooper, Austin T Akers, Velvet Blair Journigan, Brandon J Henderso. Novel Putative Positive Modulators of α4β2 nAChRs Potentiate Nicotine Reward-Related Behavior. Molecules (Basel, Switzerland). vol 26. issue 16. 2021-09-17. PMID:34443380. |
the popular tobacco and e-cigarette chemical flavorant (-)-menthol acts as a nonselective, noncompetitive antagonist of nicotinic acetylcholine receptors (nachrs), and contributes to multiple physiological effects that exacerbates nicotine addiction-related behavior. |
2021-09-17 |
2023-08-13 |
mouse |
| Lila Buls Wollman, Ralph F Fregos. Chronic, Episodic Nicotine Alters Hypoglossal Motor Neuron Function at a Critical Developmental Time Point in Neonatal Rats. eNeuro. vol 8. issue 4. 2021-09-16. PMID:34193508. |
here, we tested the hypothesis that chronic, episodic dne (edne), which mimics nicotine replacement therapies such as e-cigarettes or nicotine gum, alters the function of nicotinic acetylcholine receptors (nachrs), xiimn intrinsic properties, and tongue muscle function |
2021-09-16 |
2023-08-13 |
rat |
| Xiuxiu Fu, Tingyu Zong, Panyu Yang, Lin Li, Shizhong Wang, Zhibin Wang, Min Li, Xiaolu Li, Yulin Zou, Ying Zhang, Lynn Htet Htet Aung, Yanyan Yang, Tao Y. Nicotine: Regulatory roles and mechanisms in atherosclerosis progression. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 151. 2021-09-14. PMID:33774093. |
nicotine, a selective cholinergic agonist, accelerates the formation of atherosclerosis by stimulating nicotinic acetylcholine receptors (nachrs) located in neuronal and non-neuronal tissues. |
2021-09-14 |
2023-08-13 |
Not clear |
| Ahmed El-Boraie, Rachel F Tyndal. The Role of Pharmacogenetics in Smoking. Clinical pharmacology and therapeutics. vol 110. issue 3. 2021-09-14. PMID:34165800. |
candidate gene studies of smoking phenotypes have identified several pharmacogenes implicated in nicotine's pharmacokinetics (cyp2a6, cyp2b6, cyp2a13, fmos, ugts, and oct2), and nicotine's pharmacodynamic response in the central nervous system (nicotinic acetylcholine receptors, as well as through the dopaminergic and serotonergic systems). |
2021-09-14 |
2023-08-13 |
Not clear |
| Naoya Nishitani, Yu Ohmura, Keita Kobayashi, Taichi Murashita, Takayuki Yoshida, Mitsuhiro Yoshiok. Serotonin neurons in the median raphe nucleus bidirectionally regulate somatic signs of nicotine withdrawal in mice. Biochemical and biophysical research communications. vol 562. 2021-09-08. PMID:34038754. |
in rodent models, chronic exposure to nicotine elicited physical dependence, whereas acute antagonism of nicotinic acetylcholine receptors (nachrs) immediately precipitated withdrawal symptoms. |
2021-09-08 |
2023-08-13 |
mouse |
| Fengqi Duan, Cheng Zeng, Sijun Liu, Jianfeng Gong, Jia Hu, Hongyu Li, Hongmei Ta. α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis. Frontiers in cell and developmental biology. vol 9. 2021-09-08. PMID:34490270. |
nicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nachrs). |
2021-09-08 |
2023-08-13 |
Not clear |
| Claire Nguyen, Sarah Mondoloni, Tinaïg Le Borgne, Ines Centeno, Maxime Come, Joachim Jehl, Clément Solié, Lauren M Reynolds, Romain Durand-de Cuttoli, Stefania Tolu, Sébastien Valverde, Steve Didienne, Bernadette Hannesse, Jean-François Fiancette, Stéphanie Pons, Uwe Maskos, Véronique Deroche-Gamonet, Deniz Dalkara, Jean-Pierre Hardelin, Alexandre Mourot, Fabio Marti, Philippe Faur. Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety. Neuron. vol 109. issue 16. 2021-09-02. PMID:34242565. |
we further show that nicotine mediates anxiety-like behavior by acting on β2-subunit-containing nicotinic acetylcholine receptors of the vta. |
2021-09-02 |
2023-08-13 |
Not clear |
| Francis A Acquah, Matthew Paramel, Adama Kuta, Syed R Hussaini, David R Wallace, Blaine H M Mooer. Simulations of Promising Indolizidine- International journal of molecular sciences. vol 22. issue 15. 2021-08-25. PMID:34360698. |
simulations of promising indolizidine- smoking-cessation drugs bind many off-target nicotinic acetylcholine receptors (nachrs) and cause severe side effects if they are based on nicotine. |
2021-08-25 |
2023-08-13 |
Not clear |
| Lauren Wills, Paul J Kenn. Addiction-related neuroadaptations following chronic nicotine exposure. Journal of neurochemistry. vol 157. issue 5. 2021-08-24. PMID:33742685. |
the addiction-relevant molecular, cellular, and behavioral actions of nicotine are derived from its stimulatory effects on neuronal nicotinic acetylcholine receptors (nachrs) in the central nervous system. |
2021-08-24 |
2023-08-13 |
Not clear |
| Anaïs Le Mauff, Hamza Chouikh, Alison Cartereau, Claude L Charvet, Cédric Neveu, Claude Rispe, Olivier Plantard, Emiliane Taillebois, Steeve H Than. Nicotinic acetylcholine receptors in the synganglion of the tick Ixodes ricinus: Functional characterization using membrane microtransplantation. International journal for parasitology. Drugs and drug resistance. vol 14. 2021-08-20. PMID:33120248. |
we found that oocytes microtransplanted with tick synganglion membranes expressed nicotinic acetylcholine receptor subtypes which were activated by acetylcholine (1 mm) and nicotine (1 mm). |
2021-08-20 |
2023-08-13 |
xenopus_laevis |