| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizade. Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers. Journal of controlled release : official journal of the Controlled Release Society. 2022-03-18. PMID:35301054. |
d8 possesses high affinity towards nicotine acetylcholine receptors (nachrs), overexpressed on brain capillary endothelial cells (bcecs), and can penetrate through bbb with high efficiency. |
2022-03-18 |
2023-08-13 |
mouse |
| Mi Zhou, Yiting Hu, Ruoyan Huang, Yang Zhou, Xiaoyan Xie, Shidi Zhang, Shaodi Jia, Yunmiao Zhang, Ting Xue, Fang Dong, Xiaoqi Lu, Kai Yuan, Dahua Y. Right arcuate fasciculus and left uncinate fasciculus abnormalities in young smoker. Addiction biology. vol 27. issue 2. 2022-03-01. PMID:35229948. |
exposure to nicotine disrupts neurodevelopment during adolescence, possibly by disrupting the trophic effects of acetylcholine. |
2022-03-01 |
2023-08-13 |
Not clear |
| Hong-Wei Wang, Xian-Hua Jin, Ying-Han Xu, Chun-Ping Chu, Fu-Yang Pei, Xiao-Ping Song, De-Lai Qi. Nicotine depresses facial stimulation-evoked molecular layer interneuron-Purkinje cell synaptic transmission via α7 nicotinic acetylcholine receptors in mouse cerebellar cortex. European journal of pharmacology. 2022-03-01. PMID:35231469. |
nicotine depresses facial stimulation-evoked molecular layer interneuron-purkinje cell synaptic transmission via α7 nicotinic acetylcholine receptors in mouse cerebellar cortex. |
2022-03-01 |
2023-08-13 |
mouse |
| Hong-Wei Wang, Xian-Hua Jin, Ying-Han Xu, Chun-Ping Chu, Fu-Yang Pei, Xiao-Ping Song, De-Lai Qi. Nicotine depresses facial stimulation-evoked molecular layer interneuron-Purkinje cell synaptic transmission via α7 nicotinic acetylcholine receptors in mouse cerebellar cortex. European journal of pharmacology. 2022-03-01. PMID:35231469. |
nicotine modulates cerebellar physiology function by interacting with nicotinic acetylcholine receptors (nachrs) and is involved in modulation of cerebellar cortical circuitry functions. |
2022-03-01 |
2023-08-13 |
mouse |
| Michelle Ren, Shahrdad Lotfipour, Frances Lesli. Unique effects of nicotine across the lifespan. Pharmacology, biochemistry, and behavior. 2022-02-05. PMID:35122768. |
nicotine exerts unique effects on specific brain regions during distinct developmental periods due to the dynamic expression of nicotinic acetylcholine receptors (nachrs) throughout the lifespan. |
2022-02-05 |
2023-08-13 |
Not clear |
| Lauren Wills, Jessica L Ables, Kevin M Braunscheidel, Stephanie P B Caligiuri, Karim S Elayouby, Clementine Fillinger, Masago Ishikawa, Janna K Moen, Paul J Kenn. Neurobiological Mechanisms of Nicotine Reward and Aversion. Pharmacological reviews. vol 74. issue 1. 2022-01-12. PMID:35017179. |
neuronal nicotinic acetylcholine receptors (nachrs) regulate the rewarding actions of nicotine contained in tobacco that establish and maintain the smoking habit. |
2022-01-12 |
2023-08-13 |
Not clear |
| Yuya Kanauchi, Takeshi Yamamoto, Minako Yoshida, Yue Zhang, Jaemin Lee, Shusaku Hayashi, Makoto Kadowak. Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells. Scientific reports. vol 12. issue 1. 2022-01-08. PMID:34997096. |
several studies have demonstrated that α7 nicotinic acetylcholine receptors (α7nachrs) exert anti-inflammatory effects on immune cells and nicotine suppress uc onset and relapse. |
2022-01-08 |
2023-08-13 |
mouse |
| Biswajit Panda, Gianluigi Alban. Synthetic Methods for the Preparation of Conformationally Restricted Analogues of Nicotine. Molecules (Basel, Switzerland). vol 26. issue 24. 2021-12-24. PMID:34946630. |
in the context of naturally occurring nitrogen heterocycles, nicotine is a chiral alkaloid present in tobacco plants, which can target and stimulate nicotinic acetylcholine receptors (nachrs), a class of ligand-gated ion channels commonly located throughout the human brain. |
2021-12-24 |
2023-08-13 |
human |
| Hiromu Kawasaki, Hayato Hino, Fusako Takayama, Yoshihisa Kitamura, Toshiaki Sendou, Shingo Takator. Regulatory effects of nicotine on neurite outgrowth in rat superior cervical ganglia cells. Journal of pharmacological sciences. vol 148. issue 1. 2021-12-20. PMID:34924113. |
we have reported that nicotine has a neurotrophic action on peripheral adrenergic nerves in vivo, which is mediated by α7 nicotinic acetylcholine receptors (nachrs). |
2021-12-20 |
2023-08-13 |
rat |
| Joyal Xavier, Sanjiv Singh, Priyanka Kumari, V Ravichandira. Neurological Repercussions of Neonatal Nicotine Exposure: A Review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2021-12-16. PMID:34913189. |
prenatal nicotine exposure alters the neurological route of neurotransmitters, acetylcholine, and dopamine. |
2021-12-16 |
2023-08-13 |
Not clear |
| Kartheek Gavini, Euitaek Yang, Kodeeswaran Parameshwara. Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain research bulletin. vol 176. 2021-12-10. PMID:34358612. |
developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. |
2021-12-10 |
2023-08-13 |
mouse |
| Kartheek Gavini, Euitaek Yang, Kodeeswaran Parameshwara. Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain research bulletin. vol 176. 2021-12-10. PMID:34358612. |
furthermore, acetylcholine levels in the hippocampus of nicotine exposed mice were reduced along with reduced activity of acetylcholinesterase enzyme. |
2021-12-10 |
2023-08-13 |
mouse |
| Kartheek Gavini, Euitaek Yang, Kodeeswaran Parameshwara. Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain research bulletin. vol 176. 2021-12-10. PMID:34358612. |
analysis of transcripts for proteins that are known to regulate acetylcholine levels revealed a decline in mrna levels of high affinity choline transporters in the hippocampus of nicotine exposed mice but those of vesicular acetylcholine transporter, choline acetyltransferase, and α7-nicotinic acetylcholine receptors were not altered. |
2021-12-10 |
2023-08-13 |
mouse |
| Wenbin Jia, Gofarana Wilar, Ichiro Kawahata, An Cheng, Kohji Fukunag. Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice. Molecular neurobiology. vol 58. issue 5. 2021-11-19. PMID:33411237. |
nicotine causes psychological dependence through its interactions with nicotinic acetylcholine receptors in the brain. |
2021-11-19 |
2023-08-13 |
mouse |
| Gintaras Zaleskis, Vita Pasukoniene, Dainius Characiejus, Vincas Urbona. Do the benefits of being a smoker hint at the existence of PD-1/PD-L1 sensitizers for patients on single-agent immunotherapy? Journal for immunotherapy of cancer. vol 9. issue 8. 2021-11-19. PMID:34413168. |
a significant immunomodulatory effect of nicotine via acetylcholine receptors is well documented. |
2021-11-19 |
2023-08-13 |
Not clear |
| Hoi-Hin Kwok, Boning Gao, Koon-Ho Chan, Mary Sau-Man Ip, John Dorrance Minna, David Chi-Leung La. Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells. Cancers. vol 13. issue 21. 2021-11-18. PMID:34771509. |
nicotine in cigarettes can induce addiction, and its derivatives become potent carcinogens after metabolic activation and activate oncogenic signaling in lung epithelial cells through their expressed nicotinic acetylcholine receptors (nachrs). |
2021-11-18 |
2023-08-13 |
human |
| Xiaoying Tan, Kent Vrana, Zheng-Ming Din. Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions. Frontiers in behavioral neuroscience. vol 15. 2021-11-10. PMID:34744656. |
nicotine is considered as the major tobacco alkaloid causing addiction through its actions on nicotinic acetylcholine receptors (nachrs). |
2021-11-10 |
2023-08-13 |
Not clear |
| Janna K Moen, Margot C DeBaker, Julia E Myjak, Kevin Wickman, Anna M Le. Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε. Addiction biology. vol 26. issue 3. 2021-11-01. PMID:32776643. |
nicotinic acetylcholine receptors (nachrs) containing the α6 and β3 subunits are expressed in neural reward circuits and are critical for nicotine and alcohol reward. |
2021-11-01 |
2023-08-13 |
Not clear |
| Julie M Miw. Lynx1 prototoxins: critical accessory proteins of neuronal nicotinic acetylcholine receptors. Current opinion in pharmacology. vol 56. 2021-10-25. PMID:33254061. |
nicotinic receptors of the cholinergic system are ligand-gated ion channels, responding to the excitatory neurotransmitter, acetylcholine, and the addictive component of tobacco, nicotine. |
2021-10-25 |
2023-08-13 |
Not clear |
| John A Dani, Daniel Jenson, John I Broussard, Mariella De Bias. Neurophysiology of Nicotine Addiction. Journal of addiction research & therapy. vol S1. issue 1. 2021-10-21. PMID:22454789. |
nicotine binds to nicotinic acetylcholine receptors (nachr) to produce its initial effects. |
2021-10-21 |
2023-08-12 |
Not clear |