| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Fu, Keyu Shen, Hao Wang, Shun Wang, Xufeng Wang, Le Zhu, Yan Zheng, Tiantian Zou, Hongfei Ci, Qiongzhu Dong, Lun-Xiu Qi. Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis. Signal transduction and targeted therapy. vol 9. issue 1. 2024-03-07. PMID:38453934. |
acetylcholine promoted icc metastasis through interacting with its receptor, alpha 5 nicotine acetylcholine receptor subunits (chrna5). |
2024-03-07 |
2024-03-10 |
Not clear |
| Aden Dhana Rizkita, Sintia Ayu Dewi, Taufik Muhammad Fakih, Cheng-Chung Le. Effectiveness of sesquiterpene derivatives from Cinnamomum genus in nicotine replacement therapy through blocking acetylcholine nicotinate: a computational analysis. Journal of biomolecular structure & dynamics. 2024-01-25. PMID:38268238. |
effectiveness of sesquiterpene derivatives from cinnamomum genus in nicotine replacement therapy through blocking acetylcholine nicotinate: a computational analysis. |
2024-01-25 |
2024-01-27 |
Not clear |
| Kumboyono Kumboyono, Indah N Chomsy, Nadya N Shalshabilla, Hidayat Sujuti, Arie Srihardyastutie, Cholid T Tjahjono, Teuku Heriansyah, Titin A Wihastut. Nicotine is associated with smoking dependence and vascular inflammation through cotinine: A mediation analysis. Tobacco induced diseases. vol 22. 2024-01-22. PMID:38250634. |
cotinine, a metabolite of nicotine, is capable of causing dependence effects through endless mechanisms modulated by the ion channel nicotinic acetylcholine receptors nachrs. |
2024-01-22 |
2024-01-24 |
Not clear |
| Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. |
competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. |
2023-12-30 |
2024-01-05 |
Not clear |
| Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. |
nicotine released in a sustained manner attaches to the nicotine acetylcholine receptors (nachr) to release dopamine for controlling the withdrawal challenges such as anxiety, irritability, cravings, disturbed sleep pattern, etc. |
2023-12-30 |
2024-01-05 |
Not clear |
| Chhatrapal Patel, Richa Patel, Vaibhav Maturkar, Nishant Sudhir Jai. Central cholinergic transmission affects the compulsive-like behavior of mice in marble-burying test. Brain research. 2023-12-14. PMID:38097126. |
injection of acetylcholine (0.01 µg) (subeffective: 0.1 and 0.5 µg), cholinesterase inhibitor, neostigmine (0.1, 0.3, 0.5 µg/mouse) and neuronal nicotinic acetylcholine receptor agonist, nicotine (0.1, 2 µg/mouse) significantly attenuated the number of marbles buried by mice in mbb test without affecting basal locomotor activity. |
2023-12-14 |
2023-12-17 |
mouse |
| Takemori Yamawak. [Nicotine, pesticides, and tobacco, in Three Act Tragedy]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 12. 2023-12-14. PMID:38097217. |
when nicotine enters the body, it binds to acetylcholine receptors and causes various symptoms. |
2023-12-14 |
2023-12-17 |
Not clear |
| Niyati A Borkar, Michael A Thompson, Colleen M Bartman, Latifa Khalfaoui, Steven M Sine, Venkatachalem Sathish, Y S Prakash, Christina M Pabelic. Nicotinic Receptors in Airway Disease. American journal of physiology. Lung cellular and molecular physiology. 2023-12-12. PMID:38084408. |
there is now increasing evidence that alpha7 nicotinic acetylcholine receptors (α7nachrs) are critical players in nicotine effects on airways, but the mechanisms by which α7nachr influences different airway cell types have not been widely explored. |
2023-12-12 |
2023-12-17 |
Not clear |
| Yuqin Xu, Juan Wang, Zihan He, Zihan Rao, Zhongwei Zhang, Jianming Zhou, Tong Zhou, Huai Wan. A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine. Biochemical pharmacology. 2023-12-11. PMID:38081368. |
nicotine, the principal tobacco alkaloid, would exert its role of contribution to gastric cancer development and progression through nicotinic acetylcholine receptors (nachrs) and β-adrenergic receptors (β-ars), which then promote cancer cell proliferation, migration and invasion. |
2023-12-11 |
2023-12-17 |
Not clear |
| Hind Al Khashali, Ban Darweesh, Ravel Ray, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Stuti Goel, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer Cells. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067204. |
in addition to binding to nicotinic acetylcholine receptors (nachrs), nicotine is known to regulate the β-adrenergic receptors (β-ars) promoting oncogenic signaling. |
2023-12-09 |
2023-12-17 |
human |
| Chuyue Pan, Jun Liu, Yingsheng Gao, Maohui Yang, Haiyang Hu, Chang Liu, Minyi Qian, Hai-Yang Yuan, Song Yang, Ming-Hua Zheng, Lirui Wan. Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans. Cell metabolism. vol 35. issue 12. 2023-12-06. PMID:38056431. |
we further revealed that during mash development, acetylcholine released from immune cells or nicotine derived from smoking functioned as an agonist to activate hepatocyte-intrinsic chrna4, inducing calcium influx and activation of inflammatory signaling. |
2023-12-06 |
2023-12-10 |
mouse |
| Niyati A Borkar, Michael A Thompson, Colleen M Bartman, Venkatachalem Sathish, Y S Prakash, Christina M Pabelic. Nicotine Affects Mitochondrial Structure and Function in Human Airway Smooth Muscle Cells. American journal of physiology. Lung cellular and molecular physiology. 2023-11-07. PMID:37933473. |
nicotine exerts its functional activity via nicotinic acetylcholine receptors (nachrs) and the alpha7 subtype (α7nachr) has recently been shown to adversely affect airway dynamics. |
2023-11-07 |
2023-11-08 |
human |
| Julie A Mustard, Rachel Dobb, Geraldine A Wrigh. Chronic nicotine exposure influences learning and memory in the honey bee. Journal of insect physiology. 2023-11-02. PMID:37918514. |
in insects, nicotine activates nicotinic acetylcholine receptors, which are expressed throughout the central nervous system. |
2023-11-02 |
2023-11-08 |
bee |
| Khalid Boussaine, Maria Taha, Cáinà Nìng, Alison Cartereau, Sabine Rakotobe, Lourdes Mateos-Hernandez, Emiliane Taillebois, Ladislav Šimo, Steeve H Than. Isolation and electrophysiological recording of Ixodes ricinus synganglion neurons. Journal of pharmacological and toxicological methods. 2023-10-22. PMID:37866797. |
method: we developed a simple protocol for synganglion neuron isolation and used a whole-cell patch clamp to measure ionic currents induced by acetylcholine, nicotine and muscarine. |
2023-10-22 |
2023-11-08 |
Not clear |
| Gerald Wölkart, Alexander Kollau, Michael Russwurm, Doris Koesling, Astrid Schrammel, Bernd Maye. Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling. Scientific reports. vol 13. issue 1. 2023-09-22. PMID:37739972. |
at a dilution of 1:3, cse almost entirely inhibited the relaxation of rat aortas and porcine coronary arteries to acetylcholine and bradykinin, respectively, while undiluted eve, with a 15-fold higher nicotine concentration, had no significant effect. |
2023-09-22 |
2023-10-07 |
rat |
| Markus M Hilscher, Sanja Mikulovic, Sharn Perry, Stina Lundberg, Klas Kullande. The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells. Pharmacological research. 2023-08-31. PMID:37652281. |
nicotinic acetylcholine receptors (nachrs) play crucial roles in various human disorders, with the α7, α4, α6, and α3-containing nachr subtypes extensively studied in relation to conditions such as alzheimer's disease, parkinson's disease, nicotine dependence, mood disorders, and stress disorders. |
2023-08-31 |
2023-09-07 |
human |
| Wojciech Świątkowski, Barbara Budzyńska, Monika Maciąg, Agnieszka Świątkowska, Przemko Tylżanowski, Mansur Rahnama-Hezavah, Piotr Stachurski, Renata Chała. Nicotine and Cytisine Embryotoxicity in the Experimental Zebrafish Model. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569468. |
like nicotine, cytisine is a plant alkaloid, signaling through nicotinic acetylcholine receptors. |
2023-08-12 |
2023-08-16 |
zebrafish |
| Irida Papapostolou, Daniela Ross-Kaschitza, Florian Bochen, Christine Peinelt, Maria Constanza Maldifass. Contribution of the α5 nAChR Subunit and α5SNP to Nicotine-Induced Proliferation and Migration of Human Cancer Cells. Cells. vol 12. issue 15. 2023-08-11. PMID:37566079. |
nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy resistance through the activation of nicotinic acetylcholine receptors (nachrs). |
2023-08-11 |
2023-08-16 |
human |
| María Elena Quintanilla, Mario Rivera-Meza, Pablo Berríos-Cárcamo, Bruce K Cassel. Reduction of nicotine and ethanol intake in alcohol-preferring (UChB) female rats by the α4β2 nicotinic acetylcholine receptor partial agonists 5-bromocytisine and cytisine. Drug and alcohol dependence. vol 250. 2023-07-29. PMID:37515828. |
neuronal nicotinic acetylcholine receptors (nachrs) are implicated in the reinforcing effects of nicotine and ethanol. |
2023-07-29 |
2023-08-14 |
rat |
| Murat Oz, Justin R King, Keun-Hang Susan Yang, Sarah Khushaish, Yulia Tchugunova, Maitham A Khajah, Yunus A Luqmani, Nadine Kabban. α7 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling. PloS one. vol 18. issue 7. 2023-07-25. PMID:37490473. |
nicotine activates nicotinic acetylcholine receptors (nachrs) that are expressed in cancer cell lines. |
2023-07-25 |
2023-08-14 |
Not clear |