| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A M Thasweer, P Renuka Devi, Velusamy Thirunavukkaras. Molecular docking and dynamic simulation studies of α4β2 and α7 nicotinic acetylcholine receptors with tobacco smoke constituents nicotine, NNK and NNN. Journal of biomolecular structure & dynamics. 2022-10-21. PMID:36270967. |
molecular docking and dynamic simulation studies of α4β2 and α7 nicotinic acetylcholine receptors with tobacco smoke constituents nicotine, nnk and nnn. |
2022-10-21 |
2023-08-14 |
Not clear |
| Zoe Li, Kevin C Chan, Jonathan D Nickels, Xiaolin Chen. Electrostatic Contributions to the Binding Free Energy of Nicotine to the Acetylcholine Binding Protein. The journal of physical chemistry. B. 2022-10-19. PMID:36260486. |
electrostatic contributions to the binding free energy of nicotine to the acetylcholine binding protein. |
2022-10-19 |
2023-08-14 |
Not clear |
| Zoe Li, Kevin C Chan, Jonathan D Nickels, Xiaolin Chen. Electrostatic Contributions to the Binding Free Energy of Nicotine to the Acetylcholine Binding Protein. The journal of physical chemistry. B. 2022-10-19. PMID:36260486. |
for example, nicotine is a well-known agonist of nicotinic acetylcholine receptors (nachrs), but the molecular mechanisms for the differential action of nicotine on brain and muscle nachrs remain elusive. |
2022-10-19 |
2023-08-14 |
Not clear |
| Zoe Li, Kevin C Chan, Jonathan D Nickels, Xiaolin Chen. Electrostatic Contributions to the Binding Free Energy of Nicotine to the Acetylcholine Binding Protein. The journal of physical chemistry. B. 2022-10-19. PMID:36260486. |
in this work, we have chosen the acetylcholine binding protein (achbp) in complex with nicotine as a model system to interrogate the electrostatic contributions to nicotine binding. |
2022-10-19 |
2023-08-14 |
Not clear |
| Ji Sun Kim, Oc-Hee Kim, In Soo Ryu, Yong-Hyun Kim, Kyung Oh Jeon, Li-Na Lim, Tae Wan Kim, Sumin Sohn, Sunghyun Kim, Jeong-Wook Seo, Eun Sang Choe, Eun Young Jan. Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats. Pharmacology, biochemistry, and behavior. 2022-10-02. PMID:36183870. |
nicotine, the primary addictive substance in tobacco, produces the psychomotor, rewarding, and reinforcing effects of tobacco dependence by stimulating nicotinic acetylcholine receptors (nachrs) in the brain. |
2022-10-02 |
2023-08-14 |
rat |
| Alice Servonnet, Saleem M Nicol. Dips in dopamine say "no" to nicotine. Neuron. vol 110. issue 18. 2022-09-22. PMID:36137519. |
show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nachrs) that activate midbrain dopamine neurons and activation of low-affinity nachrs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (ldt). |
2022-09-22 |
2023-08-14 |
Not clear |
| Chuan-Hsiu Liu, Mei-Ying Chen, Jack Cheng, Tsai-Ni Chuang, Hsin-Ping Liu, Wei-Yong Li. Imidacloprid Impairs Glutamatergic Synaptic Plasticity and Desensitizes Mechanosensitive, Nociceptive, and Photogenic Response of International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077576. |
imidacloprid impairs glutamatergic synaptic plasticity and desensitizes mechanosensitive, nociceptive, and photogenic response of imidacloprid (imd) is a widely used neonicotinoid-targeting insect nicotine acetylcholine receptors (nachrs). |
2022-09-09 |
2023-08-14 |
drosophila_melanogaster |
| Steven Decker, Gregory Davis, Imran Vahora, Alen Vukovic, Parth Patel, Asha Suryanarayana. Desformylflustrabromine (dFBr), a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors decreases voluntary ethanol consumption and preference in male and female Sprague-Dawley rats. PloS one. vol 17. issue 9. 2022-09-09. PMID:36084045. |
alcohol and nicotine are commonly co-abused, and there is evidence that neuronal nicotinic acetylcholine receptors (nachrs) play a role in both alcohol and nicotine dependence. |
2022-09-09 |
2023-08-14 |
rat |
| Byungjo Lee, Min Kyoung Shin, Taegun Kim, Yu Jeong Shim, Jong Wha J Joo, Jung-Suk Sung, Wonhee Jan. Prediction models for identifying ion channel-modulating peptides via knowledge transfer approaches. IEEE journal of biomedical and health informatics. vol PP. 2022-09-07. PMID:36070258. |
in this study, we present primp, prediction models for screening imps that can target sodium, potassium, and calcium ion channels, as well as nicotine acetylcholine receptors (nachrs). |
2022-09-07 |
2023-08-14 |
Not clear |
| Garrett D Santis, Naoya Takeda, Keisuke Hirata, Kazuya Tsuruta, Shun-Ichi Ishiuchi, Sotiris S Xantheas, Masaaki Fuji. Structure of Gas Phase Monohydrated Nicotine: Implications for Nicotine's Native Structure in the Acetylcholine Binding Protein. Journal of the American Chemical Society. 2022-08-31. PMID:36043852. |
structure of gas phase monohydrated nicotine: implications for nicotine's native structure in the acetylcholine binding protein. |
2022-08-31 |
2023-08-14 |
Not clear |
| Giuseppe Angellotti, Giulia Di Prima, Amalia Giulia Scarpaci, Fabio D'Agostino, Giuseppina Campisi, Viviana De Car. Spray-Dried Cytisine-Loaded Matrices: Development of Transbuccal Sustained-Release Tablets as a Promising Tool in Smoking Cessation Therapy. Pharmaceutics. vol 14. issue 8. 2022-08-26. PMID:36015209. |
cytisine (cyt) has emerged as a promising molecule to treat nicotine addiction, since it acts as a partial agonist of nicotinic acetylcholine receptors. |
2022-08-26 |
2023-08-14 |
Not clear |
| Stephanie K Jones, Bethany J Wolf, Brett Froeliger, Kristin Wallace, Matthew J Carpenter, Anthony J Alber. A systematic review of genetic variation within nicotinic acetylcholine receptor genes and cigarette smoking cessation. Drug and alcohol dependence. vol 239. 2022-08-18. PMID:35981468. |
nicotine produces its effects by binding to nicotinic acetylcholine receptors (nachrs). |
2022-08-18 |
2023-08-14 |
Not clear |
| Julia K Brynildsen, Kechun Yang, Crystal Lemchi, John A Dani, Mariella De Biasi, Julie A Blend. A common SNP in Chrna5 enhances morphine reward in female mice. Neuropharmacology. 2022-08-16. PMID:35973602. |
the single nucleotide polymorphism (snp) d398n (rs16969968) in chrna5, the gene encoding the α5 subunit of the nicotinic acetylcholine receptors (nachr), has been associated with both nicotine and opiate dependence in human populations. |
2022-08-16 |
2023-08-14 |
mouse |
| Qi Sun, Danqi Chen, Amna Raja, Gabriele Grunig, Judith Zelikoff, Chunyuan Ji. Downregulation of Stem-loop binding protein by nicotine via α7-nicotinic acetylcholine receptor and its role in nicotine-induced cell transformation. Toxicological sciences : an official journal of the Society of Toxicology. 2022-08-05. PMID:35929799. |
we show that nicotine-induced slbp depletion is reversed by an inhibitor of α7-nicotinic acetylcholine receptors (α7-nachr) or sirna specific for α7-nachr, indicating a nachr-dependent reduction of slbp by nicotine. |
2022-08-05 |
2023-08-14 |
mouse |
| Namita Pandey, Jonita Chongtham, Soumyadip Pal, Ashraf Ali, Sanjeev Lalwani, Deepali Jain, Anant Mohan, Tapasya Srivastav. When "No-Smoking" is not enough: Hypoxia and nicotine acetylcholine receptor signaling may drive lung adenocarcinoma progression in never-smokers. Biochimica et biophysica acta. Molecular cell research. 2022-06-01. PMID:35649481. |
our study gives a plausible explanation for the equally worse prognosis of lung adenocarcinoma in never-smokers wherein the nachr signaling is enhanced in hypoxia by acetylcholine in the absence of nicotine. |
2022-06-01 |
2023-08-13 |
Not clear |
| Zhila Khodabandeh, Mohammad Valilo, Kobra Velaei, Abbas Pirpour Tazehkan. The potential role of nicotine in breast cancer initiation, development, angiogenesis, invasion, metastasis, and resistance to therapy. Breast cancer (Tokyo, Japan). 2022-05-18. PMID:35583594. |
nicotine generally acts through the induction of the nicotinic acetylcholine receptors (nachrs), although the contribution of other receptor subunits has also been reported. |
2022-05-18 |
2023-08-13 |
Not clear |
| Zhila Khodabandeh, Mohammad Valilo, Kobra Velaei, Abbas Pirpour Tazehkan. The potential role of nicotine in breast cancer initiation, development, angiogenesis, invasion, metastasis, and resistance to therapy. Breast cancer (Tokyo, Japan). 2022-05-18. PMID:35583594. |
current study aims to review the mechanistic function of nicotine in the initiation, development, angiogenesis, invasion, metastasis, and apoptosis of breast cancer with the main focus on nicotine acetylcholine receptors (nachrs) and nachr-mediated signaling pathways as well as on its potential for the development of an effective treatment against breast cancer. |
2022-05-18 |
2023-08-13 |
Not clear |
| Viktor A Stratilov, Oleg V Vetrovoy, Ekaterina I Tyulkov. Prenatal Hypoxia Affects Nicotine Consumption and Withdrawal in Adult Rats via Impairment of the Glutamate System in the Brain. Molecular neurobiology. 2022-05-17. PMID:35581520. |
after 2 weeks of chronic treatment with nicotine via osmotic minipump (9 mg/kg per day), we assessed the symptoms of withdrawal in the conditioned place aversion test after mecamylamine (an antagonist of nicotinic acetylcholine receptors, nachr) treatment. |
2022-05-17 |
2023-08-13 |
rat |
| Danylo I Kravchuk, Ganna V Sotkis, Mykola M Shcherbatiuk, Ruslan M Kravchuk, Vassili G Nazarenko, Petro P Gorbyk, Yaroslav M Shub. Induction of A549 Non-small Cell Lung Cancer Cells Proliferation by Photoreleased Nicotine. Photochemistry and photobiology. 2022-05-15. PMID:35569087. |
in the present study we show that rubi-caged nicotine can be used as a source of free nicotine to induce proliferation of a549 non-small cell lung cancer (nsclc) cells by acting on nicotinic acetylcholine receptors expressed in these cells. |
2022-05-15 |
2023-08-13 |
Not clear |
| Lila B Wollman, Emily G Flanigan, Ralph F Fregos. Chronic, episodic developmental nicotine exposure alters GABAergic synaptic transmission to hypoglossal motor neurons at a critical developmental age in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555119. |
the adverse effects of nicotine exposure on brain structural and functional development is attributed to its action on the nicotinic acetylcholine receptors (nachrs). |
2022-05-13 |
2023-08-13 |
human |