| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chih-Wei Fu, Chih-Hsuan Huang, Sok-Keng Tong, Chia-Ying Chu, Ming-Yi Cho. Nicotine reduces social dominance and neutralizes experience-dependent effects during social conflicts in zebrafish (Danio rerio). The Science of the total environment. 2023-06-21. PMID:37343866. |
nicotine, a psychoactive pollutant, binds to nicotinic acetylcholine receptors and disrupts the cholinergic modulation and reward systems of the brain, leading to attention deficit, memory loss, and addiction. |
2023-06-21 |
2023-08-14 |
zebrafish |
| Lieselot L G Carrette, Adam Kimbrough, Pasha A Davoudian, Alex C Kwan, Andres Collazo, Olivier Georg. Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice. eNeuro. 2023-06-09. PMID:37295945. |
chronic nicotine results in dependence with withdrawal symptoms upon discontinuation of use, through desensitization of nicotinic acetylcholine receptors and altered cholinergic neurotransmission. |
2023-06-09 |
2023-08-14 |
mouse |
| Sarah Mondoloni, Claire Nguyen, Eléonore Vicq, Maria Ciscato, Joachim Jehl, Romain Durand-de Cuttoli, Nicolas Torquet, Stefania Tolu, Stéphanie Pons, Uwe Maskos, Fabio Marti, Philippe Faure, Alexandre Mouro. Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus. eLife. vol 12. 2023-05-30. PMID:37249215. |
lastly, using knock-out mice and local gene re-expression, we identified b4-containing nicotinic acetylcholine receptors of ipn neurons as molecular and cellular correlates of nicotine aversion. |
2023-05-30 |
2023-08-14 |
mouse |
| Kechun Yang, Ian McLaughlin, Jessica K Shaw, Natalia Quijano-Cardé, John A Dani, Mariella De Bias. CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal. Neuropharmacology. 2023-04-28. PMID:37116611. |
nicotine is the principal psychoactive component in tobacco that drives addiction through its action on neuronal nicotinic acetylcholine receptors (nachr). |
2023-04-28 |
2023-08-14 |
mouse |
| Michael Wolter, Thomas Lapointe, Nana Baidoo, Krista A Mitchnick, Cassidy Wideman, Boyer D Winters, Francesco Ler. Double dissociation of perirhinal nicotinic acetylcholine receptors and dopamine D2 receptors in modulation of object memory consolidation by nicotine, cocaine and their conditioned stimuli. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 72. 2023-04-22. PMID:37086715. |
double dissociation of perirhinal nicotinic acetylcholine receptors and dopamine d2 receptors in modulation of object memory consolidation by nicotine, cocaine and their conditioned stimuli. |
2023-04-22 |
2023-08-14 |
rat |
| Lieselot L G Carrette, Adam Kimbrough, Pasha A Davoudian, Alex C Kwan, Andres Collazo, Olivier Georg. Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034602. |
chronic nicotine results in dependence with withdrawal symptoms upon discontinuation of use, through desensitization of nicotinic acetylcholine receptors and altered cholinergic neurotransmission. |
2023-04-10 |
2023-08-14 |
mouse |
| Sevil Özger İlhan, Gökçe Sevim Öztürk Fincan, Yağmur Okçay, Derya Sebile Koç, Celil İlker Aşkın, Ayşe Kübra Kibar, İsmail Mert Vural, Yusuf Sarıoğl. Enhancing effect of nicotine on electrical field stimulation elicited contractile responses in isolated rabbit bladder straight muscle; the role of cannabinoid and vanilloid receptors. Turkish journal of medical sciences. vol 52. issue 6. 2023-03-22. PMID:36945969. |
nicotine acts as an agonist of nicotinic acetylcholine receptors (nachr). |
2023-03-22 |
2023-08-14 |
rabbit |
| Marco Leitzk. Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration? Bioelectronic medicine. vol 9. issue 1. 2023-01-17. PMID:36650574. |
the agonist ligand nicotine shows an up to 30-fold higher affinity to nachrs than acetylcholine (ach). |
2023-01-17 |
2023-08-14 |
Not clear |
| Lei Fan, Huan Chen, Yong Liu, Hongwei Hou, Qingyuan H. ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice. Pharmacology, biochemistry, and behavior. 2022-12-24. PMID:36565790. |
nicotine is an addictive compound that interacts with nicotinic acetylcholine receptors (nachrs) in the ventral tegmental area (vta), inducing a release of dopamine in the nucleus accumbens (nac). |
2022-12-24 |
2023-08-14 |
mouse |
| Robin J Keeley, McKenzie E Prillaman, Miranda Scarlata, Antonia Vrana, Pei-Jung Tsai, Juan L Gomez, Jordi Bonaventura, Hanbing Lu, Michael Michaelides, Elliot A Stei. Adolescent nicotine administration increases nicotinic acetylcholine receptor binding and functional connectivity in specific cortico-striatal-thalamic circuits. Brain communications. vol 4. issue 6. 2022-11-28. PMID:36440101. |
nicotine exposure is associated with regional changes in brain nicotinic acetylcholine receptors subtype expression patterns as a function of dose and age at the time of exposure. |
2022-11-28 |
2023-08-14 |
Not clear |
| Robin J Keeley, McKenzie E Prillaman, Miranda Scarlata, Antonia Vrana, Pei-Jung Tsai, Juan L Gomez, Jordi Bonaventura, Hanbing Lu, Michael Michaelides, Elliot A Stei. Adolescent nicotine administration increases nicotinic acetylcholine receptor binding and functional connectivity in specific cortico-striatal-thalamic circuits. Brain communications. vol 4. issue 6. 2022-11-28. PMID:36440101. |
although smoking typically begins in adolescence, developmental changes in brain circuits and nicotinic acetylcholine receptors following chronic nicotine exposure remain minimally investigated. |
2022-11-28 |
2023-08-14 |
Not clear |
| Anaïs Le Mauff, Alison Cartereau, Olivier Plantard, Emiliane Taillebois, Steeve H Than. Effect of the combination of DEET and flupyradifurone on the tick Ixodes ricinus: Repellency bioassay and pharmacological characterization using microtransplantation of synganglion membranes. Ticks and tick-borne diseases. vol 14. issue 1. 2022-11-23. PMID:36417824. |
flu induced an ionic current but was not able to reduce acetylcholine or nicotine evoked currents. |
2022-11-23 |
2023-08-14 |
human |
| Jennifer D Noonan, Robin N Beec. Reconstitution of an N-AChR from Brugia malayi an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites. PLoS pathogens. vol 18. issue 11. 2022-11-14. PMID:36374934. |
the homomeric acr-16 nicotine sensitive acetylcholine receptors (n-achrs) of several helminth species have been characterized in this way. |
2022-11-14 |
2023-08-14 |
xenopus_laevis |
| Lois S Akinola, Deniz Bagdas, Yasmin Alkhlaif, Asti Jackson, Cenk O Gurdap, Elnaz Rahimpour, F Ivy Carroll, Roger L Papke, M Imad Dama. Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice. Journal of psychopharmacology (Oxford, England). 2022-11-02. PMID:36321267. |
because of their implications in several pathological conditions, α4β2* nicotinic acetylcholine receptors (nachrs) are potential targets for the treatment of nicotine dependence, pain, and many psychiatric and neurodegenerative diseases. |
2022-11-02 |
2023-08-14 |
mouse |
| Yujie Shen, Qiang Huang, Mengyou Ji, Chi-Yao Hsueh, Liang Zho. Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas. BMC cancer. vol 22. issue 1. 2022-10-26. PMID:36284268. |
nicotinic acetylcholine receptors (nachrs) are transmembrane receptor proteins and exert their biological effects following activation by nicotine. |
2022-10-26 |
2023-08-14 |
human |
| A M Thasweer, P Renuka Devi, Velusamy Thirunavukkaras. Molecular docking and dynamic simulation studies of α4β2 and α7 nicotinic acetylcholine receptors with tobacco smoke constituents nicotine, NNK and NNN. Journal of biomolecular structure & dynamics. 2022-10-21. PMID:36270967. |
molecular docking and dynamic simulation studies of α4β2 and α7 nicotinic acetylcholine receptors with tobacco smoke constituents nicotine, nnk and nnn. |
2022-10-21 |
2023-08-14 |
Not clear |
| Zoe Li, Kevin C Chan, Jonathan D Nickels, Xiaolin Chen. Electrostatic Contributions to the Binding Free Energy of Nicotine to the Acetylcholine Binding Protein. The journal of physical chemistry. B. 2022-10-19. PMID:36260486. |
electrostatic contributions to the binding free energy of nicotine to the acetylcholine binding protein. |
2022-10-19 |
2023-08-14 |
Not clear |
| Zoe Li, Kevin C Chan, Jonathan D Nickels, Xiaolin Chen. Electrostatic Contributions to the Binding Free Energy of Nicotine to the Acetylcholine Binding Protein. The journal of physical chemistry. B. 2022-10-19. PMID:36260486. |
for example, nicotine is a well-known agonist of nicotinic acetylcholine receptors (nachrs), but the molecular mechanisms for the differential action of nicotine on brain and muscle nachrs remain elusive. |
2022-10-19 |
2023-08-14 |
Not clear |
| Zoe Li, Kevin C Chan, Jonathan D Nickels, Xiaolin Chen. Electrostatic Contributions to the Binding Free Energy of Nicotine to the Acetylcholine Binding Protein. The journal of physical chemistry. B. 2022-10-19. PMID:36260486. |
in this work, we have chosen the acetylcholine binding protein (achbp) in complex with nicotine as a model system to interrogate the electrostatic contributions to nicotine binding. |
2022-10-19 |
2023-08-14 |
Not clear |
| Ji Sun Kim, Oc-Hee Kim, In Soo Ryu, Yong-Hyun Kim, Kyung Oh Jeon, Li-Na Lim, Tae Wan Kim, Sumin Sohn, Sunghyun Kim, Jeong-Wook Seo, Eun Sang Choe, Eun Young Jan. Challenge exposure to whole cigarette smoke condensate upregulates locomotor sensitization by stimulating α4β2 nicotinic acetylcholine receptors in the nucleus accumbens of rats. Pharmacology, biochemistry, and behavior. 2022-10-02. PMID:36183870. |
nicotine, the primary addictive substance in tobacco, produces the psychomotor, rewarding, and reinforcing effects of tobacco dependence by stimulating nicotinic acetylcholine receptors (nachrs) in the brain. |
2022-10-02 |
2023-08-14 |
rat |