| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Qian, Shobha K Mummalaneni, Reem M Alkahtani, Sunila Mahavadi, Karnam S Murthy, John R Grider, Vijay Lyal. Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells. PloS one. vol 11. issue 11. 2017-06-21. PMID:27846263. |
in addition to the t2r bitter taste receptors, neuronal nicotinic acetylcholine receptors (nachrs) have recently been shown to be involved in the bitter taste transduction of nicotine, acetylcholine and ethanol. |
2017-06-21 |
2023-08-13 |
Not clear |
| Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshiok. Varenicline provokes impulsive action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner. Pharmacology, biochemistry, and behavior. vol 154. 2017-06-21. PMID:28087221. |
varenicline provokes impulsive action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner. |
2017-06-21 |
2023-08-13 |
rat |
| Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshiok. Varenicline provokes impulsive action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner. Pharmacology, biochemistry, and behavior. vol 154. 2017-06-21. PMID:28087221. |
because nicotine administration enhances impulsivity, the effects of stop-smoking aids stimulating nicotinic acetylcholine receptors (nachrs) on impulsivity must be determined in different conditions. |
2017-06-21 |
2023-08-13 |
rat |
| Xueyan Pang, Liwang Liu, Jennifer Ngolab, Rubing Zhao-Shea, J Michael McIntosh, Paul D Gardner, Andrew R Tappe. Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors. Neuropharmacology. vol 107. 2017-06-19. PMID:27020042. |
habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors. |
2017-06-19 |
2023-08-13 |
mouse |
| JianGang Wang, YaLi Wang, FangLi Guo, ZhiBo Feng, XiangFang Wang, ChengBiao L. Nicotinic modulation of Ca2+ oscillations in rat cortical neurons in vitro. American journal of physiology. Cell physiology. vol 310. issue 9. 2017-05-26. PMID:26843531. |
application of nicotine enhanced [ca(2+)]i oscillation frequency and amplitude, which were reduced by the selective α4β2-nicotinic acetylcholine receptors (nachrs) antagonist dihydro-β-erythroidine (dhβe) hydrobromide, and the selective α7-nachrs antagonist methyllycaconitine citrate (mla, 20 nm). |
2017-05-26 |
2023-08-13 |
rat |
| Michael R Post, Henry A Lester, Dennis A Doughert. Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. Biochemistry. vol 56. issue 13. 2017-05-15. PMID:28287260. |
we previously reported that in α6β2 receptors, acetylcholine makes a functional cation-π interaction with trp149, but nicotine and tc299423 do not, suggesting a distinctive binding site. |
2017-05-15 |
2023-08-13 |
Not clear |
| Michael R Post, Henry A Lester, Dennis A Doughert. Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. Biochemistry. vol 56. issue 13. 2017-05-15. PMID:28287260. |
at α6(t150tah)β2, nicotine shows a 24-fold loss of function, tc299423 shows a modest loss, and acetylcholine shows no effect. |
2017-05-15 |
2023-08-13 |
Not clear |
| Tommy S Tillman, Frances J D Alvarez, Nathan J Reinert, Chuang Liu, Dawei Wang, Yan Xu, Kunhong Xiao, Peijun Zhang, Pei Tan. Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli. The Journal of biological chemistry. vol 291. issue 35. 2017-05-12. PMID:27385587. |
moreover, the purified α7nachr injected into xenopus oocytes can be activated by acetylcholine, choline, and nicotine, inhibited by the channel blockers qx-222 and phencyclidine, and potentiated by the α7nachr specific modulators pnu-120596 and tqs. |
2017-05-12 |
2023-08-13 |
human |
| Mami Noda, A I Kobayash. Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors. The journal of physiological sciences : JPS. vol 67. issue 1. 2017-05-09. PMID:27256075. |
nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors. |
2017-05-09 |
2023-08-13 |
Not clear |
| Bo Lin, Shihua Xiang, Mengsen L. Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs. Marine drugs. vol 14. issue 10. 2017-05-02. PMID:27727162. |
nicotinic acetylcholine receptors (nachrs) are targets for developing new drugs to treat severe pain, nicotine addiction, alzheimer disease, epilepsy, etc. |
2017-05-02 |
2023-08-13 |
Not clear |
| Jirawoot Srisontiyakul, Hanna E Kastman, Elena V Krstew, Piyarat Govitrapong, Andrew J Lawrenc. The Nicotinic α6-Subunit Selective Antagonist bPiDI Reduces Alcohol Self-Administration in Alcohol-Preferring Rats. Neurochemical research. vol 41. issue 12. 2017-03-15. PMID:27573375. |
nicotine primarily acts in the brain on nicotinic acetylcholine receptors (nachr), which are also a target for alcohol. |
2017-03-15 |
2023-08-13 |
rat |
| Cassie Yu, Jon McClella. Genetics of Substance Use Disorders. Child and adolescent psychiatric clinics of North America. vol 25. issue 3. 2017-03-13. PMID:27338962. |
nicotine use disorders are associated with polymorphisms in a cluster of nicotinic acetylcholine receptors on chromosome 15q24, and mutations that reduce the enzymatic activity of cyp2a6. |
2017-03-13 |
2023-08-13 |
Not clear |
| Jose P Silva, Guerline Lambert, Derek van Booven, Claes Wahlested. Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring. Genome medicine. vol 8. issue 1. 2017-03-06. PMID:27609221. |
furthermore, hypothalamic pomc neurons were recently found to mediate the anorectic effects of nicotine through activation of acetylcholine receptors. |
2017-03-06 |
2023-08-13 |
Not clear |
| Alexander M Herman, Joshua Ortiz-Guzman, Mikhail Kochukov, Isabella Herman, Kathleen B Quast, Jay M Patel, Burak Tepe, Jeffrey C Carlson, Kevin Ung, Jennifer Selever, Qingchun Tong, Benjamin R Arenkie. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. vol 538. issue 7624. 2017-02-28. PMID:27698417. |
acetylcholine has long been proposed to influence feeding owing in part to the functional similarity between acetylcholine and nicotine, a known appetite suppressant. |
2017-02-28 |
2023-08-13 |
mouse |
| Alexander M Herman, Joshua Ortiz-Guzman, Mikhail Kochukov, Isabella Herman, Kathleen B Quast, Jay M Patel, Burak Tepe, Jeffrey C Carlson, Kevin Ung, Jennifer Selever, Qingchun Tong, Benjamin R Arenkie. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. vol 538. issue 7624. 2017-02-28. PMID:27698417. |
nicotine is an exogenous agonist for acetylcholine receptors, suggesting that endogenous cholinergic signalling may play a part in normal physiological regulation of feeding. |
2017-02-28 |
2023-08-13 |
mouse |
| Bernard Le Foll, Svetlana I Chefer, Alane S Kimes, Elliot A Stein, Steven R Goldberg, Alexey G Mukhi. Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates. Psychopharmacology. vol 233. issue 10. 2017-02-22. PMID:26911381. |
impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates. |
2017-02-22 |
2023-08-13 |
Not clear |
| Bernard Le Foll, Svetlana I Chefer, Alane S Kimes, Elliot A Stein, Steven R Goldberg, Alexey G Mukhi. Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates. Psychopharmacology. vol 233. issue 10. 2017-02-22. PMID:26911381. |
although nicotine exposure upregulates the α4β2* subtype of nicotinic acetylcholine receptors (nachrs), the upregulation of nachrs in non-human primates voluntarily self-administering nicotine has never been demonstrated. |
2017-02-22 |
2023-08-13 |
Not clear |
| Arunnjah Vivekanandarajah, Yik Lung Chan, Hui Chen, Rita Machaalan. Prenatal cigarette smoke exposure effects on apoptotic and nicotinic acetylcholine receptor expression in the infant mouse brainstem. Neurotoxicology. vol 53. 2016-12-19. PMID:26746805. |
nicotine, the major neurotoxic component of cigarette smoke, induces its actions by binding to nicotinic acetylcholine receptors (nachr), with one downstream effect being increased apoptosis. |
2016-12-19 |
2023-08-13 |
mouse |
| Fawaz Alasmari, Salim S Al-Rejaie, Shakir D AlSharari, Youssef Sar. Targeting glutamate homeostasis for potential treatment of nicotine dependence. Brain research bulletin. vol 121. 2016-12-13. PMID:26589642. |
changes in glutamate release might be associated with stimulatory effect of nicotinic acetylcholine receptors (nachrs) via nicotine exposure. |
2016-12-13 |
2023-08-13 |
Not clear |
| Vinay Parikh, Munir Gunes Kutlu, Thomas J Goul. nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives. Schizophrenia research. vol 171. issue 1-3. 2016-12-13. PMID:26803692. |
this study systematically reviews the evidence highlighting the contribution of nicotinic acetylcholine receptors (nachrs) to nicotine abuse in schizophrenia. |
2016-12-13 |
2023-08-13 |
Not clear |