| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Y-C Wu, R H-C Lee, P-Y Chen, A P-Y Tsai, M-F Chen, J-S Kuo, T J-F Le. L-type calcium channels in sympathetic α3β2-nAChR-mediated cerebral nitrergic neurogenic vasodilation. Acta physiologica (Oxford, England). vol 211. issue 4. 2015-03-30. PMID:24825168. |
nicotine stimulation of α3β2-nicotinic acetylcholine receptors (α3β2-nachrs) located on sympathetic nerves innervating basilar arteries causes calcium-dependent noradrenaline release, leading to activation of parasympathetic nitrergic nerves and dilation of basilar arteries. |
2015-03-30 |
2023-08-13 |
Not clear |
| Yun Zhu, Jingyun Yang, Fawn Yeh, Shelley A Cole, Karin Haack, Elisa T Lee, Barbara V Howard, Jinying Zha. Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study. PloS one. vol 9. issue 7. 2015-03-30. PMID:25036316. |
to achieve this goal, we genotyped 61 tagsnps in seven genes encoding nicotine acetylcholine receptors (nachrs) in 3,665 american indians participating in the strong heart family study. |
2015-03-30 |
2023-08-13 |
Not clear |
| Benjamin S P Schreiner, Ramona Lehmann, Ulrike Thiel, Paul M Ziemba, Leopoldo R Beltrán, Muhammad A Sherkheli, Philippe Jeanbourquin, Alain Hugi, Markus Werner, Günter Gisselmann, Hanns Hat. Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons. European journal of pharmacology. vol 728. 2015-03-02. PMID:24512725. |
nicotine sensory perception is generally thought to be mediated by nicotinic acetylcholine (nach) receptors. |
2015-03-02 |
2023-08-12 |
human |
| Colin S Cunningham, Megan J Moerke, Lance R McMaho. The discriminative stimulus effects of mecamylamine in nicotine-treated and untreated rhesus monkeys. Behavioural pharmacology. vol 25. issue 4. 2015-02-21. PMID:24978703. |
the failure of nicotine to reverse the effects of mecamylamine is consistent with a noncompetitive interaction at nicotinic acetylcholine receptors and indicates that mecamylamine-induced withdrawal cannot be readily modified by nicotine. |
2015-02-21 |
2023-08-13 |
monkey |
| Agnes J Jasinska, Todd Zorick, Arthur L Brody, Elliot A Stei. Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans. Neuropharmacology. vol 84. 2015-02-02. PMID:23474015. |
this research spans from receptor-level pet and spect studies demonstrating nicotine occupancy at nicotinic acetylcholine receptors (nachrs) and upregulation of nachrs induced by chronic smoking; through nicotine's interactions with the mesocorticolimbic dopamine system believed to mediate nicotine's reinforcing effects leading to dependence; to functional activity and connectivity fmri studies documenting nicotine's complex behavioral and cognitive effects manifest by its actions on large-scale brain networks engaged both during task performance and at rest. |
2015-02-02 |
2023-08-12 |
human |
| Rahul Srinivasan, Brandon J Henderson, Henry A Lester, Christopher I Richard. Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease. Pharmacological research. vol 83. 2015-01-12. PMID:24593907. |
chronic exposure to nicotine results in an upregulation of neuronal nicotinic acetylcholine receptors (nachrs) at the cellular plasma membrane. |
2015-01-12 |
2023-08-12 |
Not clear |
| Christine U Vu, Jawed A Siddiqui, Paul Wadensweiler, Jiaur R Gayen, Ennio Avolio, Gautam K Bandyopadhyay, Nilima Biswas, Nai-Wen Chi, Daniel T O'Connor, Sushil K Mahat. Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25051446. |
nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. |
2015-01-05 |
2023-08-13 |
mouse |
| Darlene H Brunzell, J Michael McIntosh, Roger L Papk. Diverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation. Annals of the New York Academy of Sciences. vol 1327. 2014-12-23. PMID:24730978. |
preclinical studies suggest that a diversity of nicotinic acetylcholine receptors (nachrs) with different sensitivities to nicotine may contribute to tobacco addiction. |
2014-12-23 |
2023-08-13 |
Not clear |
| Rishi Sharma, Pradeep Sahota, Mahesh M Thakka. Nicotine administration in the cholinergic basal forebrain increases alcohol consumption in C57BL/6J mice. Alcoholism, clinical and experimental research. vol 38. issue 5. 2014-12-19. PMID:24512005. |
the frequent co-morbidity of alcohol and nicotine addiction has led to the hypothesis that they may act via a common substrate: the nicotinic acetylcholine receptors (nachrs) especially α4β2 and α7 subtypes, the most prevalent nachrs in the brain. |
2014-12-19 |
2023-08-12 |
mouse |
| Ruud Zwart, Merrick Strotton, Jennifer Ching, Peter C Astles, Emanuele She. Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. European journal of pharmacology. vol 726. 2014-12-15. PMID:24485886. |
the non-selective agonist epibatidine did not distinguish α7β2 from α7 nicotinic acetylcholine receptors, but three other non-selective agonists (nicotine, cytisine and varenicline) were less efficacious on α7β2 than on α7. |
2014-12-15 |
2023-08-12 |
xenopus_laevis |
| Sodikdjon A Kodirov, Michael Wehrmeister, Luis V Colo. Modulation of HCN channels in lateral septum by nicotine. Neuropharmacology. vol 81. 2014-12-15. PMID:24582613. |
we demonstrate that nicotine effects persist despite the concurrent application of nicotinic acetylcholine receptors' antagonists - mecamylamine, methyllycaconitine, and dihydro-β-erythroidine. |
2014-12-15 |
2023-08-12 |
rat |
| Xiu Li. Effects of blockade of α4β2 and α7 nicotinic acetylcholine receptors on cue-induced reinstatement of nicotine-seeking behaviour in rats. The international journal of neuropsychopharmacology. vol 17. issue 1. 2014-11-28. PMID:23953129. |
our previous work demonstrated that non-selective blockade of nicotinic acetylcholine receptors (nachrs) reversed the cue-induced reinstatement of nicotine seeking, indicating a role for cholinergic neurotransmission in the mediation of the conditioned incentive properties of nicotine cues. |
2014-11-28 |
2023-08-12 |
rat |
| Emmanuel Som. Nicotinic cholinergic signaling in adipose tissue and pancreatic islets biology: revisited function and therapeutic perspectives. Archivum immunologiae et therapiae experimentalis. vol 62. issue 2. 2014-11-18. PMID:24276790. |
nicotinic acetylcholine receptors (nachrs) are membrane ligand-gated cation channels whose activation is triggered by the binding of the endogenous neurotransmitter acetylcholine or other biologic compounds including nicotine. |
2014-11-18 |
2023-08-12 |
mouse |
| Thomas J Gould, Derek S Wilkinson, Emre Yildirim, Rachel L F Poole, Prescott T Leach, Steven J Simmon. Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory. Neurobiology of learning and memory. vol 109. 2014-10-30. PMID:24457151. |
acute nicotine enhances hippocampus-dependent learning through nicotine binding to β2-containing nicotinic acetylcholine receptors (nachrs), but it is unclear if nicotine is targeting processes involved in short-term memory (stm) leading to a strong long-term memory (ltm) or directly targeting ltm. |
2014-10-30 |
2023-08-12 |
mouse |
| Charles R Wageman, Michael J Marks, Sharon R Grad. Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2- and α4α5β2-nicotinic acetylcholine receptors. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 16. issue 3. 2014-10-22. PMID:24052501. |
nicotine interacts with nicotinic acetylcholine receptors (nachrs) and modifies neuronal functions. |
2014-10-22 |
2023-08-12 |
Not clear |
| Charles R Wageman, Michael J Marks, Sharon R Grad. Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2- and α4α5β2-nicotinic acetylcholine receptors. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 16. issue 3. 2014-10-22. PMID:24052501. |
nicotine, unlike the natural agonist acetylcholine, remains in tissues for hours, and during this extended exposure nachrs desensitize. |
2014-10-22 |
2023-08-12 |
Not clear |
| Xiao-Min Niu, Shun L. Acetylcholine receptor pathway in lung cancer: New twists to an old story. World journal of clinical oncology. vol 5. issue 4. 2014-10-10. PMID:25302169. |
nachrs are membrane ligand-gated cation channels whose activation is triggered by the binding of the endogenous neurotransmitter acetylcholine (ach) or other biologic compounds including nicotine. |
2014-10-10 |
2023-08-13 |
Not clear |
| Alessia Salamone, Elisa Mura, Stefania Zappettini, Massimo Grilli, Guendalina Olivero, Stefania Preda, Stefano Govoni, Mario March. Inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution. European journal of pharmacology. vol 723. 2014-10-07. PMID:24275353. |
in conclusion nicotine administration in vivo elicits hippocampal glu release mostly through α7 nicotinic acetylcholine receptors likely present both on neurons and astrocytes. |
2014-10-07 |
2023-08-12 |
rat |
| Milena Moretti, Michele Zoli, Andrew A George, Ronald J Lukas, Francesco Pistillo, Uwe Maskos, Paul Whiteaker, Cecilia Gott. The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization. Molecular pharmacology. vol 86. issue 3. 2014-09-29. PMID:25002271. |
pharmacological profiles were similar for (α7)5-, (α7)4(β2)1-, and (α7)3(β2)2-nachrs except for diminished efficacy of nicotine (normalized to acetylcholine efficacy) at α7β2- versus α7-nachrs. |
2014-09-29 |
2023-08-13 |
mouse |
| Jian-Ping Yu, Jin He, Dan Liu, Chun-Yu Deng, Xiao-Nan Zhu, Xue-Lan Wang, Yong Wang, Ru-Zhu Che. Noradrenaline release by activation of κ-bungarotoxin-sensitive nicotinic acetylcholine receptors participates in long-term potentiation-like response induced by nicotine. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 6. 2014-09-26. PMID:18157476. |
noradrenaline release by activation of κ-bungarotoxin-sensitive nicotinic acetylcholine receptors participates in long-term potentiation-like response induced by nicotine. |
2014-09-26 |
2023-08-12 |
Not clear |