| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Machaalani, E Ghazavi, T Hinton, K A Waters, A Henness. Cigarette smoking during pregnancy regulates the expression of specific nicotinic acetylcholine receptor (nAChR) subunits in the human placenta. Toxicology and applied pharmacology. vol 276. issue 3. 2014-06-07. PMID:24607864. |
nicotine, a major pathogenic compound of cigarette smoke, binds to the nicotinic acetylcholine receptors (nachrs). |
2014-06-07 |
2023-08-12 |
human |
| N Hagino, J W Le. Effect of maternal nicotine on the development of sites for [(3)H]nicotine binding in the fetal brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 3. issue 5. 2014-06-02. PMID:24874966. |
furthermore, a possible effect of nicotine in pregnant rats may be the facilitation of the development of nicotine acetylcholine receptors in the fetal brain. |
2014-06-02 |
2023-08-13 |
rat |
| C Larsson, A Nordberg, Y Falkeborn, P Å Lundber. Regional [(3)H]acetylcholine and [(3)H]nicotine binding in developing mouse brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 3. issue 6. 2014-06-02. PMID:24875112. |
regional [(3)h]acetylcholine and [(3)h]nicotine binding in developing mouse brain. |
2014-06-02 |
2023-08-13 |
mouse |
| C Larsson, A Nordberg, Y Falkeborn, P Å Lundber. Regional [(3)H]acetylcholine and [(3)H]nicotine binding in developing mouse brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 3. issue 6. 2014-06-02. PMID:24875112. |
two different nicotinic cholinergic ligands, namely [(3)h]acetylcholine ([(3)h]ach) and [(3)h]nicotine ([(3)h]nic) were used to detect the nicotine-like binding sites in in vitro binding assays. |
2014-06-02 |
2023-08-13 |
mouse |
| Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailesc. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. vol 98. 2014-05-30. PMID:23872451. |
serotonin release inside drn was mediated by α4β2 nicotinic acetylcholine receptors since the selective antagonist of these receptors dihydro-β-erytroidine hydrobromide (dhβe, 100nm) blocked the inhibitory effects of nicotine 5-ht drn neurons. |
2014-05-30 |
2023-08-12 |
rat |
| Shaolin Wang, Andrew D van der Vaart, Qing Xu, Chamindi Seneviratne, Ovide F Pomerleau, Cynthia S Pomerleau, Thomas J Payne, Jennie Z Ma, Ming D L. Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. Human genetics. vol 133. issue 5. 2014-05-30. PMID:24253422. |
the direct physiological effects that promote nicotine dependence (nd) are mediated by nicotinic acetylcholine receptors (nachrs). |
2014-05-30 |
2023-08-12 |
Not clear |
| Yuexiang Wang, Jang-Won Lee, Gyeon Oh, Sharon R Grady, J Michael McIntosh, Darlene H Brunzell, Jason R Cannon, Ryan M Drena. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function α6* nAChRs. Journal of neurochemistry. vol 129. issue 2. 2014-05-27. PMID:24266758. |
α6β2* nicotinic acetylcholine receptors (nachrs)s in the ventral tegmental area to nucleus accumbens (nac) pathway are implicated in the response to nicotine, and recent work suggests these receptors play a role in the rewarding action of ethanol. |
2014-05-27 |
2023-08-12 |
mouse |
| Yuexiang Wang, Jang-Won Lee, Gyeon Oh, Sharon R Grady, J Michael McIntosh, Darlene H Brunzell, Jason R Cannon, Ryan M Drena. Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function α6* nAChRs. Journal of neurochemistry. vol 129. issue 2. 2014-05-27. PMID:24266758. |
here, we studied mice expressing gain-of-function α6β2* nachrs (α6l9's mice) that are hypersensitive to nicotine and endogenous acetylcholine. |
2014-05-27 |
2023-08-12 |
mouse |
| Dang Q Dao, Erika E Perez, Yanfen Teng, John A Dani, Mariella De Bias. Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 12. 2014-05-08. PMID:24647947. |
the medial habenula (mhb) densely expresses nicotinic acetylcholine receptors (nachrs) and participates in nicotine-related behaviors such as nicotine withdrawal and regulating nicotine intake. |
2014-05-08 |
2023-08-12 |
mouse |
| Edilson Dantas da Silva Júnior, Bruno Palmieri de Souza, Juliano Quintela Dantas Rodrigues, Afonso Caricati-Neto, Aron Jurkiewicz, Neide Hyppolito Jurkiewic. Functional characterization of acetylcholine receptors and calcium signaling in rat testicular capsule contraction. European journal of pharmacology. vol 714. issue 1-3. 2014-05-06. PMID:23872374. |
efficacy (emax) of acetylcholine and carbachol to induce contractions corresponded to 95% and 97% of emax for kcl, but emax for nicotine was very low (8% of emax for kcl). |
2014-05-06 |
2023-08-12 |
rat |
| Manuel Faundez-Parraguez, Nicolas Farias-Rabelo, Juan Pablo Gonzalez-Gutierrez, Alvaro Etcheverry-Berrios, Jans Alzate-Morales, Francisco Adasme-Carreño, Rodrigo Varas, Isabel Bermudez, Patricio Iturriaga-Vasque. Neonicotinic analogues: selective antagonists for α4β2 nicotinic acetylcholine receptors. Bioorganic & medicinal chemistry. vol 21. issue 10. 2014-05-01. PMID:23561269. |
nicotine is an agonist of nicotinic acetylcholine receptors (nachrs) that has been extensively used as a template for the synthesis of α4β2-preferring nachrs. |
2014-05-01 |
2023-08-12 |
human |
| Manuel Faundez-Parraguez, Nicolas Farias-Rabelo, Juan Pablo Gonzalez-Gutierrez, Alvaro Etcheverry-Berrios, Jans Alzate-Morales, Francisco Adasme-Carreño, Rodrigo Varas, Isabel Bermudez, Patricio Iturriaga-Vasque. Neonicotinic analogues: selective antagonists for α4β2 nicotinic acetylcholine receptors. Bioorganic & medicinal chemistry. vol 21. issue 10. 2014-05-01. PMID:23561269. |
we increased the distance between the basic nitrogen and aromatic group of nicotine by introducing an ester functionality that also mimics acetylcholine (fig. |
2014-05-01 |
2023-08-12 |
human |
| John A Dani, David J K Balfou. Historical and current perspective on tobacco use and nicotine addiction. Trends in neurosciences. vol 34. issue 7. 2014-04-30. PMID:21696833. |
although the addictive influence of tobacco was recognized very early, the modern concepts of nicotine addiction have relied on knowledge of cholinergic neurotransmission and nicotinic acetylcholine receptors (nachrs). |
2014-04-30 |
2023-08-12 |
Not clear |
| Roberto Nocente, Mario Vitali, Giuseppe Balducci, Domenico Enea, Henry R Kranzler, Mauro Ceccant. Varenicline and neuronal nicotinic acetylcholine receptors: a new approach to the treatment of co-occurring alcohol and nicotine addiction? The American journal on addictions. vol 22. issue 5. 2014-04-25. PMID:23952890. |
varenicline and neuronal nicotinic acetylcholine receptors: a new approach to the treatment of co-occurring alcohol and nicotine addiction? |
2014-04-25 |
2023-08-12 |
Not clear |
| Miguel Moyano, Angel Porteros, John E Dowlin. The effects of nicotine on cone and rod b-wave responses in larval zebrafish. Visual neuroscience. vol 30. issue 4. 2014-04-22. PMID:23809941. |
the effects of acetylcholine on bipolar cells are not known, and here we report the effects of nicotine on the b-wave of the electroretinogram in larval zebrafish. |
2014-04-22 |
2023-08-12 |
zebrafish |
| b' Mikl\\xc3\\xb3s Palotai, Zsolt Bagosi, Mikl\\xc3\\xb3s J\\xc3\\xa1szber\\xc3\\xa9nyi, Krisztina Csabafi, Roberta Dochnal, M\\xc3\\xa1t\\xc3\\xa9 Manczinger, Gyula Telegdy, Gyula Szab\\xc3\\xb. Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum. Neurochemistry international. vol 63. issue 4. 2014-04-02. PMID:23831084.' |
nicotine activates the mesencephalic dopaminergic neurons via nicotinic acetylcholine receptors (nachr). |
2014-04-02 |
2023-08-12 |
rat |
| T D McClure-Begley, R L Papke, K L Stone, C Stokes, A D Levy, J Gelernter, P Xie, J Lindstrom, M R Picciott. Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics. vol 348. issue 3. 2014-04-02. PMID:24385388. |
nicotine, the primary psychoactive component in tobacco smoke, produces its behavioral effects through interactions with neuronal nicotinic acetylcholine receptors (nachrs). |
2014-04-02 |
2023-08-12 |
human |
| Andrew W Halff, David Gómez-Varela, Danielle John, Darwin K Ber. A novel mechanism for nicotinic potentiation of glutamatergic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501347. |
pharmacological and genetic manipulation of the cells, in combination with fluorescence-recovery-after-photobleaching experiments, revealed that nicotine, acting through α7-containing nicotinic acetylcholine receptors on the postsynaptic neuron, induces the stabilization and accumulation of glua1-containing ampa receptors on dendritic spines. |
2014-04-01 |
2023-08-12 |
mouse |
| b' Mikl\\xc3\\xb3s Palotai, Zsolt Bagosi, Mikl\\xc3\\xb3s J\\xc3\\xa1szber\\xc3\\xa9nyi, Krisztina Csabafi, Roberta Dochnal, M\\xc3\\xa1t\\xc3\\xa9 Manczinger, Gyula Telegdy, Gyula Szab\\xc3\\xb. Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala. Neurochemical research. vol 38. issue 10. 2014-03-28. PMID:23836294.' |
ghrelin and nicotine activates the mesolimbicocortical dopaminergic pathways via growth hormone secretagogue receptors (ghs-r1a) and nicotinic acetylcholine receptors (nachr), respectively, resulting in the release of dopamine in the nucleus accumbens, the amygdala and the prefrontal cortex. |
2014-03-28 |
2023-08-12 |
rat |
| Venkata M Yenugonda, Yingxian Xiao, Edward D Levin, Amir H Rezvani, Thao Tran, Nour Al-Muhtasib, Niaz Sahibzada, Teresa Xie, Corinne Wells, Susan Slade, Joshua E Johnson, Sivanesan Dakshanamurthy, Hye-Sik Kong, York Tomita, Yong Liu, Mikell Paige, Kenneth J Kellar, Milton L Brow. Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. Journal of medicinal chemistry. vol 56. issue 21. 2014-03-18. PMID:24047231. |
developing novel and selective compounds that desensitize α4β2 nicotinic acetylcholine receptors (nachrs) could provide new effective treatments for nicotine addiction, as well as other disorders. |
2014-03-18 |
2023-08-12 |
rat |