| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nadine Kabbani, Matthew P Woll, Robert Levenson, Jon M Lindstrom, Jean-Pierre Changeu. Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 51. 2008-01-28. PMID:18077321. |
nicotine acetylcholine receptors (nachrs) comprise a family of ligand-gated channels widely expressed in the mammalian brain. |
2008-01-28 |
2023-08-12 |
mouse |
| Stephen T Hansen, Gregory P Mar. The nicotinic acetylcholine receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access. Psychopharmacology. vol 194. issue 1. 2008-01-23. PMID:17530475. |
nicotine and cocaine are commonly coabused drugs in humans and recent work in animals suggests that activation of nicotinic acetylcholine receptors (nachr) can increase cocaine self-administration. |
2008-01-23 |
2023-08-12 |
human |
| H van Bronswijk, E A Dubois, F G Zitman, A F Cohe. [New drugs; varenicline]. Nederlands tijdschrift voor geneeskunde. vol 151. issue 45. 2008-01-22. PMID:18062594. |
the effect of nicotine is mediated via nicotinergic acetylcholine receptors of the alpha4beta2 subtype ofwhich varenicline is a partial agonist. |
2008-01-22 |
2023-08-12 |
Not clear |
| Guangrong Zheng, Sangeetha P Sumithran, Agripina G Deaciuc, Linda P Dwoskin, Peter A Crook. Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & medicinal chemistry letters. vol 17. issue 24. 2008-01-18. PMID:17977723. |
a series of tris-azaaromatic quaternary ammonium salts has been synthesized and evaluated for their ability to inhibit neuronal nicotinic acetylcholine receptors (nachrs) mediating nicotine-evoked [(3)h]dopamine release from superfused rat striatal slices and for inhibition of [(3)h]nicotine and [(3)h]methyllycaconitine binding to whole rat brain membranes. |
2008-01-18 |
2023-08-12 |
rat |
| Wang-Ping Hu, Shi-Yu Ma, Ji-Liang Wu, Zhi-Wang L. 5-Hydroxytryptamine directly inhibits neuronal nicotinic acetylcholine receptors in rat trigeminal ganglion neurons. European journal of pharmacology. vol 574. issue 2-3. 2008-01-17. PMID:17698057. |
inward currents (i(nic)) caused by externally-applied nicotine were observed in majority of the examined neurons, which were mediated by alpha-bungarotoxin-insensitive nicotinic acetylcholine receptors. |
2008-01-17 |
2023-08-12 |
rat |
| Wang-Ping Hu, Shi-Yu Ma, Ji-Liang Wu, Zhi-Wang L. 5-Hydroxytryptamine directly inhibits neuronal nicotinic acetylcholine receptors in rat trigeminal ganglion neurons. European journal of pharmacology. vol 574. issue 2-3. 2008-01-17. PMID:17698057. |
5-ht inhibited nicotinic acetylcholine receptors in a non-competitive manner, as 5-ht decreased the maximal current response to nicotine but had no effect on the threshold and ec(50). |
2008-01-17 |
2023-08-12 |
rat |
| Ioana Munteanu, Cristian Didilesc. [Nicotine addiction--diagnosis and treatment]. Pneumologia (Bucharest, Romania). vol 56. issue 3. 2008-01-15. PMID:18019977. |
nicotine attaches to specific acetylcholine receptors (nachr) and their stimulation determines the active substances release. |
2008-01-15 |
2023-08-12 |
Not clear |
| Ortrud K Steinlei. Human disorders caused by the disruption of the regulation of excitatory neurotransmission. Results and problems in cell differentiation. vol 44. 2008-01-11. PMID:17589814. |
they are widely distributed in both the nervous system and non-neuronal tissues, and can be activated by endogenous agonists such as acetylcholine or exogenous ligands such as nicotine. |
2008-01-11 |
2023-08-12 |
human |
| James H Chin, Frederick W Tse, Kim Harris, Jack H Jhamanda. Beta-amyloid enhances intracellular calcium rises mediated by repeated activation of intracellular calcium stores and nicotinic receptors in acutely dissociated rat basal forebrain neurons. Brain cell biology. vol 35. issue 2-3. 2008-01-11. PMID:17957482. |
focal applications of nicotine (0.5-20 mm), evoked dose-dependent increases in intracellular [ca(2+)](i) that were mediated by the entry of extracellular ca(2+) via nicotinic acetylcholine receptors, and the release of intracellular ca(2+) from stores. |
2008-01-11 |
2023-08-12 |
rat |
| P Vezina, D S McGehee, W N Gree. Exposure to nicotine and sensitization of nicotine-induced behaviors. Progress in neuro-psychopharmacology & biological psychiatry. vol 31. issue 8. 2008-01-08. PMID:17936462. |
it is thus necessary to gain an understanding of the long-term effects of exposure to nicotine on nicotinic acetylcholine receptors (nachrs), neuronal excitability and behavior. |
2008-01-08 |
2023-08-12 |
Not clear |
| Leslie K Jacobsen, Marina R Picciotto, Christopher J Heath, Stephen J Frost, Kristen A Tsou, Rita A Dwan, Marcel P Jackowski, Robert T Constable, W Einar Menc. Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057207. |
preclinical studies have demonstrated that exposure to nicotine disrupts neurodevelopment during gestation and adolescence, possibly by disrupting the trophic effects of acetylcholine. |
2007-12-27 |
2023-08-12 |
human |
| Reinhard Zeidler, Kaj Albermann, Stephan Lan. Nicotine and apoptosis. Apoptosis : an international journal on programmed cell death. vol 12. issue 11. 2007-12-21. PMID:17846896. |
by binding to nicotinic acetylcholine receptors, nicotine deregulates essential biological processes like angiogenesis, apoptosis, and cell-mediated immunity. |
2007-12-21 |
2023-08-12 |
Not clear |
| Ryan F Yoshimura, Derk J Hogenkamp, Wen Y Li, Minhtam B Tran, James D Belluzzi, Edward R Whittemore, Frances M Leslie, Kelvin W Ge. Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats. The Journal of pharmacology and experimental therapeutics. vol 323. issue 3. 2007-12-17. PMID:17873105. |
negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats. |
2007-12-17 |
2023-08-12 |
rat |
| Theodore A Slotkin, Ian T Ryde, Frederic J Seidle. Separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions. Brain research bulletin. vol 74. issue 1-3. 2007-11-13. PMID:17683794. |
separate or sequential exposure to nicotine prenatally and in adulthood: persistent effects on acetylcholine systems in rat brain regions. |
2007-11-13 |
2023-08-12 |
rat |
| Cecilia Gotti, Milena Moretti, Annalisa Gaimarri, Alessio Zanardi, Franceso Clementi, Michele Zol. Heterogeneity and complexity of native brain nicotinic receptors. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17597586. |
they consist of homologous subunits encoded by a large multigene family, and their opening is physiologically controlled by the acetylcholine neurotransmitter or exogenous ligands such as nicotine. |
2007-11-06 |
2023-08-12 |
mouse |
| Raad Nashmi, Henry Leste. Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17662697. |
chronic nicotine exposure, in smokers or in experimental rodents administered nicotine, produces elevated levels of nicotinic acetylcholine receptors in several brain regions. |
2007-11-06 |
2023-08-12 |
mouse |
| John Dunlop, Renza Roncarati, Brian Jow, Hendrick Bothmann, Tim Lock, Dianne Kowal, Mark Bowlby, Georg C Terstappe. In vitro screening strategies for nicotinic receptor ligands. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17706607. |
using gh4c1 cells expressing the rat alpha7 nicotinic receptor, both acetylcholine and nicotine produced concentration-dependent elevations of intracellular calcium with ec(50) values of 5.5 and 1.6 microm, respectively. |
2007-11-06 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Zara M Fagen, Ben Chang, Robert Mitchum, Daniel S McGehe. Bupropion inhibits the cellular effects of nicotine in the ventral tegmental area. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17868653. |
nicotinic acetylcholine receptors in the ventral tegmental area (vta) mediate nicotine's stimulation of da release, as well as its rewarding effects. |
2007-11-06 |
2023-08-12 |
Not clear |
| Jianguo Tan, James J Galligan, Robert M Hollingwort. Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neurons. Neurotoxicology. vol 28. issue 4. 2007-10-31. PMID:17561262. |
the agonist actions of seven commercial neonicotinoid insecticides and nicotine were studied on nicotinic acetylcholine receptors (nachrs) expressed by neurons isolated from the three thoracic ganglia of the american cockroach, periplaneta americana. |
2007-10-31 |
2023-08-12 |
Not clear |
| Jianguo Tan, James J Galligan, Robert M Hollingwort. Agonist actions of neonicotinoids on nicotinic acetylcholine receptors expressed by cockroach neurons. Neurotoxicology. vol 28. issue 4. 2007-10-31. PMID:17561262. |
acetylcholine, nicotine and all neonicotinoids tested, except thiamethoxam, caused inward currents which were blocked reversibly by methyllycaconitine, a nachr antagonist. |
2007-10-31 |
2023-08-12 |
Not clear |