| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen L Alderson, Mary P Latimer, Philip Win. Intravenous self-administration of nicotine is altered by lesions of the posterior, but not anterior, pedunculopontine tegmental nucleus. The European journal of neuroscience. vol 23. issue 8. 2006-07-13. PMID:16630063. |
the reinforcing properties of nicotine involve actions at nicotinic acetylcholine receptors located on dopamine (da) neurons in the ventral tegmental area (vta). |
2006-07-13 |
2023-08-12 |
rat |
| F Ivy Carroll, Xingding Hu, Hernán A Navarro, Jeffrey Deschamps, Galya R Abdrakhmanova, M Imad Damaj, Billy R Marti. Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes. Journal of medicinal chemistry. vol 49. issue 11. 2006-07-12. PMID:16722642. |
(+/-)-pyrido[3,4-b]homotropane [(+/-)-1] is a conformationally rigid analogue of nicotine (2) or nornicotine (3) that showed high affinity for nicotinic acetylcholine receptors. |
2006-07-12 |
2023-08-12 |
mouse |
| David Gonzales, Stephen I Rennard, Mitchell Nides, Cheryl Oncken, Salomon Azoulay, Clare B Billing, Eric J Watsky, Jason Gong, Kathryn E Williams, Karen R Reeve. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial. JAMA. vol 296. issue 1. 2006-07-07. PMID:16820546. |
the alpha4beta2 nicotinic acetylcholine receptors (nachrs) are linked to the reinforcing effects of nicotine and maintaining smoking behavior. |
2006-07-07 |
2023-08-12 |
Not clear |
| Xin Guan, Sakura Nakauchi, Katumi Sumikaw. Nicotine reverses consolidated long-term potentiation in the hippocampal CA1 region. Brain research. vol 1078. issue 1. 2006-07-06. PMID:16564510. |
the effect of nicotine was mediated, in large part, via desensitization of alpha7 nicotinic acetylcholine receptors (nachrs), as an alpha7 nachr-selective antagonist mimicked the nicotine effect. |
2006-07-06 |
2023-08-12 |
Not clear |
| Rodrigo Varas, Viviana Valdés, Patricio Iturriaga-Vásquez, Bruce K Cassels, Rodrigo Iturriaga, Julio Alcayag. Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: effects of cytisine and its bromo derivatives. Brain research. vol 1072. issue 1. 2006-06-30. PMID:16406013. |
petrosal ganglion neurons are depolarized and fire action potentials in response to acetylcholine and nicotine. |
2006-06-30 |
2023-08-12 |
cat |
| Rodrigo Varas, Viviana Valdés, Patricio Iturriaga-Vásquez, Bruce K Cassels, Rodrigo Iturriaga, Julio Alcayag. Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: effects of cytisine and its bromo derivatives. Brain research. vol 1072. issue 1. 2006-06-30. PMID:16406013. |
cytisine, an alkaloid unrelated to nicotine, and its bromo derivatives are agonists exhibiting different affinities, potencies and efficacies at nicotinic acetylcholine receptors containing alpha4 or alpha7 subunits. |
2006-06-30 |
2023-08-12 |
cat |
| Ruey-Kuang Cheng, Warren H Meck, Christina L William. alpha7 Nicotinic acetylcholine receptors and temporal memory: synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock. Learning & memory (Cold Spring Harbor, N.Y.). vol 13. issue 2. 2006-06-29. PMID:16547161. |
alpha7 nicotinic acetylcholine receptors and temporal memory: synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock. |
2006-06-29 |
2023-08-12 |
rat |
| Piyali Dasgupta, Rebecca Kinkade, Bharat Joshi, Christina Decook, Eric Haura, Srikumar Chellappa. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 16. 2006-06-23. PMID:16601104. |
the antiapoptotic effects of nicotine were mediated by dihydro beta-erythroidine-sensitive alpha3-containing nicotinic acetylcholine receptors and required the akt pathway. |
2006-06-23 |
2023-08-12 |
human |
| Jukka S Pakkanen, Jan Stenfors, Eija Jokitalo, Raimo K Tuomine. Effect of chronic nicotine treatment on localization of neuronal nicotinic acetylcholine receptors at cellular level. Synapse (New York, N.Y.). vol 59. issue 7. 2006-06-16. PMID:16485261. |
effect of chronic nicotine treatment on localization of neuronal nicotinic acetylcholine receptors at cellular level. |
2006-06-16 |
2023-08-12 |
mouse |
| Jukka S Pakkanen, Jan Stenfors, Eija Jokitalo, Raimo K Tuomine. Effect of chronic nicotine treatment on localization of neuronal nicotinic acetylcholine receptors at cellular level. Synapse (New York, N.Y.). vol 59. issue 7. 2006-06-16. PMID:16485261. |
chronic nicotine treatment increases the number of neuronal nicotinic acetylcholine receptors (nachrs). |
2006-06-16 |
2023-08-12 |
mouse |
| Elzbieta Nowakowska, Krzysztof Kus, Ewa Florek, Anna Czubak, Jadwiga Jodynis-Lieber. The influence of tobacco smoke and nicotine on antidepressant and memory-improving effects of venlafaxine. Human & experimental toxicology. vol 25. issue 4. 2006-06-14. PMID:16696296. |
nicotinic acetylcholine receptors also mediate the reinforcing properties of nicotine (nic) in tobacco products. |
2006-06-14 |
2023-08-12 |
rat |
| Christina Unger, Marie M Svedberg, Wen-Feng Yu, Monika M Hedberg, Agneta Nordber. Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16354790. |
treatment with nicotine also resulted in less glial fibrillary acidic protein immunoreactive astrocytes around the plaques, increased levels of synaptophysin, and increased number of alpha7 nicotinic acetylcholine receptors (nachrs) in the cortex of appswe transgenic mice. |
2006-05-25 |
2023-08-12 |
mouse |
| Nael Al Koudsi, Rachel F Tyndal. Genetic influences on smoking: a brief review. Therapeutic drug monitoring. vol 27. issue 6. 2006-05-24. PMID:16404798. |
these may include genes involved in the general aspect of dependence (eg, genes within the dopaminergic system) and those more specific to nicotine dependence (eg, genes encoding nicotinic acetylcholine receptors and nicotine-metabolizing enzymes). |
2006-05-24 |
2023-08-12 |
Not clear |
| b' Chuanxiang Li, Shanglong Yao, Hui Nie, Bin L\\xc3\\xb. Effects of isoflurane on the actions of neuromuscular blockers on the muscle nicotine acetylcholine receptors. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 24. issue 6. 2006-05-18. PMID:15791855.' |
effects of isoflurane on the actions of neuromuscular blockers on the muscle nicotine acetylcholine receptors. |
2006-05-18 |
2023-08-12 |
xenopus_laevis |
| M Mugnaini, M Garzotti, I Sartori, M Pilla, P Repeto, C A Heidbreder, M Tessar. Selective down-regulation of [(125)I]Y0-alpha-conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16289885. |
alpha6beta2*-nicotinic acetylcholine receptors are selectively enriched in the mesostriatal dopaminergic system and may play a crucial role in nicotine dependence. |
2006-05-03 |
2023-08-12 |
rat |
| M Mugnaini, M Garzotti, I Sartori, M Pilla, P Repeto, C A Heidbreder, M Tessar. Selective down-regulation of [(125)I]Y0-alpha-conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16289885. |
here we show that chronic nicotine treatment (3mg/kg/day for two weeks, via s.c. osmotic minipumps) caused a significant decrease (36% on average) in the binding of [(125)i]y(0)-alpha-conotoxin mii (a selective ligand for alpha6beta2*-nicotinic acetylcholine receptors in this system) to all the five regions of the rat dopaminergic pathway analyzed in this study. |
2006-05-03 |
2023-08-12 |
rat |
| M Mugnaini, M Garzotti, I Sartori, M Pilla, P Repeto, C A Heidbreder, M Tessar. Selective down-regulation of [(125)I]Y0-alpha-conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16289885. |
in addition, consistent with previous studies reporting an up-regulation of other subtypes of nicotinic acetylcholine receptors, we found that nicotine exposure significantly increased (40% on average) the binding of [(125)i]epibatidine (a non-selective agonist at most neuronal heteromeric nicotinic acetylcholine receptors) in three up to five regions containing only alpha-conotoxin mii-insensitive [(125)i]epibatidine binding sites, namely the primary motor, somatosensory and auditory cortices. |
2006-05-03 |
2023-08-12 |
rat |
| M Mugnaini, M Garzotti, I Sartori, M Pilla, P Repeto, C A Heidbreder, M Tessar. Selective down-regulation of [(125)I]Y0-alpha-conotoxin MII binding in rat mesostriatal dopamine pathway following continuous infusion of nicotine. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16289885. |
in conclusion, this work is the first to demonstrate that alpha6beta2*-nicotinic acetylcholine receptors, unique within the nicotinic acetylcholine receptor family, are down-regulated following chronic nicotine treatment in rat dopaminergic mesostriatal pathway, a finding that may shed new light in the complex mechanisms of nicotine dependence. |
2006-05-03 |
2023-08-12 |
rat |
| N P Visanji, S N Mitchell, M J O'Neill, S Dut. Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and alpha6 and beta3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat. Neuropharmacology. vol 50. issue 1. 2006-05-01. PMID:16153666. |
since chronic nicotine administration is known to result in desensitisation-induced upregulation of nicotinic acetylcholine receptors (nachrs), the present study investigated whether chronic pre-treatment could enhance the response to systemic nicotine and, if so, whether increases in specific nachr subunit mrna levels in the substantia nigra pars compacta (snc) may underlie this effect. |
2006-05-01 |
2023-08-12 |
rat |
| Motohiro Tomizawa, Neil S Millar, John E Casid. Pharmacological profiles of recombinant and native insect nicotinic acetylcholine receptors. Insect biochemistry and molecular biology. vol 35. issue 12. 2006-05-01. PMID:16291090. |
nicotinic acetylcholine receptors (nachrs) are targets for insect-selective neonicotinoid insecticides exemplified by imidacloprid (imi) and mammalian-selective nicotinoids including nicotine and epibatidine (epi). |
2006-05-01 |
2023-08-12 |
rat |