| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Steven L Parker, Yitong Fu, Kathleen McAllen, Jianhong Luo, J Michael McIntosh, Jon M Lindstrom, Burt M Shar. Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the alpha6 subunit. Molecular pharmacology. vol 65. issue 3. 2004-03-23. PMID:14978239. |
in male rats continually self-administering nicotine (approximately 1.5 mg free base/kg/day), we found a significant increase of nicotinic acetylcholine receptors (nachrs) labeled by epibatidine (epb) in 11 brain areas. |
2004-03-23 |
2023-08-12 |
rat |
| Monika Göõz, Miklós Tóth, Olli Vakkuri, Pal Göõz, Adam J Smolka, Rudolf de Châtel, Katalin Sz Szala. Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells. Life sciences. vol 74. issue 17. 2004-03-22. PMID:14969716. |
the ganglionic blockers hexamethonium and mecamylamine further potentiated the effect of nicotine, implicating nicotinic acetylcholine receptors (nachrs) in regulation of olf secretion. |
2004-03-22 |
2023-08-12 |
rat |
| Non M Evans, Suchira Bose, Giovanni Benedetti, Ruud Zwart, Kathy H Pearson, Gordon I McPhie, Peter J Craig, Jason P Benton, Stephen G Volsen, Emanuele Sher, Lisa M Broa. Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties. European journal of pharmacology. vol 466. issue 1-2. 2004-03-08. PMID:12679139. |
they displayed an agonist rank order potency of epibatidinez.>>1,1-dimethyl-4-phenylpiperazinium (dmpp)>/=cytisine>acetylcholine>nicotine measured in a fluorescent imaging plate reader assay. |
2004-03-08 |
2023-08-12 |
human |
| Non M Evans, Suchira Bose, Giovanni Benedetti, Ruud Zwart, Kathy H Pearson, Gordon I McPhie, Peter J Craig, Jason P Benton, Stephen G Volsen, Emanuele Sher, Lisa M Broa. Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties. European journal of pharmacology. vol 466. issue 1-2. 2004-03-08. PMID:12679139. |
nicotine, cytisine, dmpp and epibatidine displayed partial agonist properties whilst alpha-conotoxin mii and methyllycaconitine blocked the functional responses elicited by acetylcholine stimulation. |
2004-03-08 |
2023-08-12 |
human |
| Jérôme Graton, Michel Berthelot, Jean-François Gal, Christian Laurence, Jacques Lebreton, Jean-Yves Le Questel, Pierre-Charles Maria, Richard Robin. The nicotinic pharmacophore: thermodynamics of the hydrogen-bonding complexation of nicotine, nornicotine, and models. The Journal of organic chemistry. vol 68. issue 21. 2004-03-04. PMID:14535805. |
the thermodynamics of the hydrogen-bonding complexation of the acetylcholine agonists nicotine and nornicotine and of model pyridines, pyrrolidines, and n-methylpyrrolidines has been measured in ccl(4) by ftir spectrometry toward a reference hydrogen-bond donor, 4-fluorophenol. |
2004-03-04 |
2023-08-12 |
Not clear |
| Jérôme Graton, Michel Berthelot, Jean-François Gal, Christian Laurence, Jacques Lebreton, Jean-Yves Le Questel, Pierre-Charles Maria, Richard Robin. The nicotinic pharmacophore: thermodynamics of the hydrogen-bonding complexation of nicotine, nornicotine, and models. The Journal of organic chemistry. vol 68. issue 21. 2004-03-04. PMID:14535805. |
when monoprotonated on their sp(3) nitrogen, nicotine and nornicotine keep, through their sp(2) nitrogen, a significant hydrogen-bond basicity which is greater than that of the ester group of acetylcholine. |
2004-03-04 |
2023-08-12 |
Not clear |
| Tony P George, Stephanie S O'Malle. Current pharmacological treatments for nicotine dependence. Trends in pharmacological sciences. vol 25. issue 1. 2004-02-17. PMID:14723978. |
recent developments in our understanding of the neurobiology of nicotine dependence have identified several neurotransmitter systems that might contribute to the process of smoking maintenance and relapse, including dopamine, noradrenaline, 5-hydroxytryptamine, acetylcholine, endogenous opioids, gaba, glutamate and endocannabinoids. |
2004-02-17 |
2023-08-12 |
Not clear |
| A FLECKENSTEIN, H HILLE, W E ADA. [Neutralization of the contractile effect of depolarized catelectronics by repolarization in anelectrotonus; the anode as antagonist of acetylcholine, choline, nicotine, coniine, veratrine, potassium and rubidium salts]. Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere. vol 253. issue 3. 2004-02-15. PMID:14833861. |
[neutralization of the contractile effect of depolarized catelectronics by repolarization in anelectrotonus; the anode as antagonist of acetylcholine, choline, nicotine, coniine, veratrine, potassium and rubidium salts]. |
2004-02-15 |
2023-08-12 |
Not clear |
| M WADA, T ARAI, T TAKAGAKI, T NAKAGAW. Axon reflex mechanism in sweat responses to nicotine, acetylcholine and sodium chloride. Journal of applied physiology. vol 4. issue 9. 2004-02-15. PMID:14917620. |
axon reflex mechanism in sweat responses to nicotine, acetylcholine and sodium chloride. |
2004-02-15 |
2023-08-12 |
Not clear |
| A JULLIEN, J RIPPLINGE. [Comparative effects of acetylcholine, atropine, cocaine, eserine and nicotine on the heart of some salt-water fish]. Journal de physiologie. vol 43. issue 4. 2004-02-15. PMID:14918127. |
[comparative effects of acetylcholine, atropine, cocaine, eserine and nicotine on the heart of some salt-water fish]. |
2004-02-15 |
2023-08-12 |
Not clear |
| Zara M Fagen, Huibert D Mansvelder, J Russel Keath, Daniel S McGehe. Short- and long-term modulation of synaptic inputs to brain reward areas by nicotine. Annals of the New York Academy of Sciences. vol 1003. 2004-02-13. PMID:14684446. |
furthermore, nicotinic acetylcholine receptors in the ventral tegmental area emerge as a possible common target for the behavioral and cellular actions not only of nicotine, but also of several other drugs of abuse. |
2004-02-13 |
2023-08-12 |
human |
| Lisa S Middleton, Wayne A Cass, Linda P Dwoski. Nicotinic receptor modulation of dopamine transporter function in rat striatum and medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 308. issue 1. 2004-02-11. PMID:14563785. |
nicotine activates nicotinic acetylcholine receptors (nachrs) on dopamine (da) terminals to evoke da release, which subsequently is taken back up into the terminal via the da transporter (dat). |
2004-02-11 |
2023-08-12 |
rat |
| Henry N Nguyen, Bruce A Rasmussen, David C Perr. Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography. The Journal of pharmacology and experimental therapeutics. vol 307. issue 3. 2004-01-29. PMID:14560040. |
subtypes of neuronal nicotinic acetylcholine receptors (nachrs) are differentially sensitive to up-regulation by chronic nicotine exposure in vitro. |
2004-01-29 |
2023-08-12 |
rat |
| Marc Rogers, Peter B Sargen. Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve-released transmitter. The European journal of neuroscience. vol 18. issue 11. 2004-01-29. PMID:14656290. |
nicotine's ability to enhance neurotransmitter release has implicated presynaptic nicotinic acetylcholine receptors (nachrs) in synaptic modulation, but there aze few examples where presynaptic nachrs are known to be activated by nerve-released transmitter. |
2004-01-29 |
2023-08-12 |
chicken |
| Jingli Cai, Aiwu Cheng, Yongquan Luo, Chengbiao Lu, Mark P Mattson, Mahendra S Rao, Katsutoshi Furukaw. Membrane properties of rat embryonic multipotent neural stem cells. Journal of neurochemistry. vol 88. issue 1. 2004-01-29. PMID:14675165. |
electrophysiological examination showed that fetal nscs respond to acetylcholine and its agonists, such as nicotine and muscarine. |
2004-01-29 |
2023-08-12 |
rat |
| P M Lang, R Burgstahler, W Sippel, D Irnich, B Schlotter-Weigel, P Graf. Characterization of neuronal nicotinic acetylcholine receptors in the membrane of unmyelinated human C-fiber axons by in vitro studies. Journal of neurophysiology. vol 90. issue 5. 2004-01-22. PMID:12878715. |
the following rank order of potency for agonists was found: epibatidine >> 5-iodo-a-85380 > 1,1-dimethyl-4-phenylpiperazinium iodide > nicotine > cytisine > acetylcholine; choline had no effect. |
2004-01-22 |
2023-08-12 |
human |
| Christopher T Simons, Satoko Sudo, Makoto Sudo, E Carsten. Mecamylamine reduces nicotine cross-desensitization of trigeminal caudalis neuronal responses to oral chemical irritation. Brain research. vol 991. issue 1-2. 2004-01-22. PMID:14575899. |
we investigated the role of neuronal nicotinic acetylcholine receptors (nachrs) in nicotine cross-desensitization of chemonociceptive responses of trigeminal subnucleus caudalis (vc) neurons in rats. |
2004-01-22 |
2023-08-12 |
rat |
| S Tucci, R F Genn, E Marco, S E Fil. Do different mechanisms underlie two anxiogenic effects of systemic nicotine? Behavioural pharmacology. vol 14. issue 4. 2004-01-21. PMID:12838038. |
alpha7 nicotinic acetylcholine receptors (alpha7 nachrs) and 5-hydroxytryptamine 1a (5-ht1a) receptors have been implicated in the anxiogenic effects of centrally administered nicotine, but the receptors that mediate the anxiogenic effects of systemic nicotine are not known. |
2004-01-21 |
2023-08-12 |
Not clear |
| Gregory O Dussor, Anthony S Leong, Nicholas B Gracia, Sonja Kilo, Theodore J Price, Kenneth M Hargreaves, Christopher M Flore. Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine. The European journal of neuroscience. vol 18. issue 9. 2004-01-16. PMID:14622152. |
in many tissues, nicotine, acting through nicotinic acetylcholine receptors (nachrs), has been shown to increase the release of the pro-inflammatory mediator calcitonin gene-related peptide (cgrp) thereby potentially contributing to neurogenic inflammation. |
2004-01-16 |
2023-08-12 |
rat |
| J Brek Eaton, Jian-Hong Peng, Katherine M Schroeder, Andrew A George, John D Fryer, Chandra Krishnan, Lori Buhlman, Yen-Ping Kuo, Ortrud Steinlein, Ronald J Luka. Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645658. |
naturally expressed nicotinic acetylcholine receptors composed of alpha4 and beta2 subunits (alpha4beta2-nachr) are the predominant form of high affinity nicotine binding site in the brain implicated in nicotine reward, mediation of nicotinic cholinergic transmission, modulation of signaling through other chemical messages, and a number of neuropsychiatric disorders. |
2004-01-16 |
2023-08-12 |
human |